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Unresectable Lung Adenocarcinoma

MedGen UID:
1772480
•Concept ID:
C5420823
•
Neoplastic Process

Definition

Lung adenocarcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Lung Adenocarcinoma

Professional guidelines

PubMed

Predictive factors for treatment response using dual-energy computed tomography in patients with advanced lung adenocarcinoma.
Hong SR, Hur J, Moon YW, Han K, Chang S, Kim JY, Im DJ, Suh YJ, Hong YJ, Lee HJ, Kim YJ, Choi BW
Eur J Radiol 2018 Apr;101:118-123. Epub 2018 Feb 17 doi: 10.1016/j.ejrad.2018.02.019. PMID: 29571784

Recent clinical studies

Etiology

Implications of intestinal microecology and immune function alterations for immunotherapy outcomes in advanced unresectable lung adenocarcinoma.
He S, Tian J, Zang J, Long L, Liu P, Zhang Y, Xiao J
Clin Respir J 2024 May;18(5):e13762. doi: 10.1111/crj.13762. PMID: 38685799Free PMC Article
Survival outcomes of targeted and immune consolidation therapies in locally advanced unresectable lung adenocarcinoma.
Wang X, Meng X, Cai G, Jin P, Bai M, Fu Y, Wang Z, Guo J, Han X
Int Immunopharmacol 2024 Mar 10;129:111684. Epub 2024 Feb 16 doi: 10.1016/j.intimp.2024.111684. PMID: 38364745
Effect of hyperthermia on intestinal microecology, immune function, and progression-free survival in patients with advanced unresectable lung adenocarcinoma.
Tian J, Long L, Zang J, Liu W, Liu P, Zhao L, Liang X, Xiao J
Sci Rep 2023 Oct 11;13(1):17223. doi: 10.1038/s41598-023-44350-w. PMID: 37821661Free PMC Article
Impact of cigarette smoking on response to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors in lung adenocarcinoma with activating EGFR mutations.
Kim MH, Kim HR, Cho BC, Bae MK, Kim EY, Lee CY, Lee JS, Kang DR, Kim JH
Lung Cancer 2014 May;84(2):196-202. Epub 2014 Feb 3 doi: 10.1016/j.lungcan.2014.01.022. PMID: 24629638
Whole-tumor perfusion CT in patients with advanced lung adenocarcinoma treated with conventional and antiangiogenetic chemotherapy: initial experience.
Fraioli F, Anzidei M, Zaccagna F, Mennini ML, Serra G, Gori B, Longo F, Catalano C, Passariello R
Radiology 2011 May;259(2):574-82. Epub 2011 Feb 25 doi: 10.1148/radiol.11100600. PMID: 21357523

Diagnosis

Implications of intestinal microecology and immune function alterations for immunotherapy outcomes in advanced unresectable lung adenocarcinoma.
He S, Tian J, Zang J, Long L, Liu P, Zhang Y, Xiao J
Clin Respir J 2024 May;18(5):e13762. doi: 10.1111/crj.13762. PMID: 38685799Free PMC Article
Dendritic cell vaccination in combination with erlotinib in a patient with inoperable lung adenocarcinoma: a case report.
Kosumi T, Kobayashi M, Shimodaira S, Sugiyama H, Koido S
J Med Case Rep 2024 Feb 10;18(1):88. doi: 10.1186/s13256-024-04363-z. PMID: 38336778Free PMC Article
Targeted Therapy Followed by Cytotoxic Chemotherapy in Preoperative Patients With Locally Advanced Lung Adenocarcinoma.
Aoki M, Ueda K, Umehara T, Kamimura GO, Tokunaga T, Harada-Takeda A, Maeda K, Nagata T, Yokomakura N, Kariatsumari K, Nonaka Y, Imamura N, Morizono S, Sato M
Anticancer Res 2020 May;40(5):2911-2916. doi: 10.21873/anticanres.14268. PMID: 32366442
Reduced doses of dabrafenib and trametinib combination therapy for BRAF V600E-mutant non-small cell lung cancer prevent rhabdomyolysis and maintain tumor shrinkage: a case report.
Adachi Y, Yanagimura N, Suzuki C, Ootani S, Tanimoto A, Nishiyama A, Yamashita K, Ohtsubo K, Takeuchi S, Yano S
BMC Cancer 2020 Feb 24;20(1):156. doi: 10.1186/s12885-020-6626-9. PMID: 32093631Free PMC Article
Impact of cigarette smoking on response to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors in lung adenocarcinoma with activating EGFR mutations.
Kim MH, Kim HR, Cho BC, Bae MK, Kim EY, Lee CY, Lee JS, Kang DR, Kim JH
Lung Cancer 2014 May;84(2):196-202. Epub 2014 Feb 3 doi: 10.1016/j.lungcan.2014.01.022. PMID: 24629638

Therapy

Dendritic cell vaccination in combination with erlotinib in a patient with inoperable lung adenocarcinoma: a case report.
Kosumi T, Kobayashi M, Shimodaira S, Sugiyama H, Koido S
J Med Case Rep 2024 Feb 10;18(1):88. doi: 10.1186/s13256-024-04363-z. PMID: 38336778Free PMC Article
Effect of hyperthermia on intestinal microecology, immune function, and progression-free survival in patients with advanced unresectable lung adenocarcinoma.
Tian J, Long L, Zang J, Liu W, Liu P, Zhao L, Liang X, Xiao J
Sci Rep 2023 Oct 11;13(1):17223. doi: 10.1038/s41598-023-44350-w. PMID: 37821661Free PMC Article
Reduced doses of dabrafenib and trametinib combination therapy for BRAF V600E-mutant non-small cell lung cancer prevent rhabdomyolysis and maintain tumor shrinkage: a case report.
Adachi Y, Yanagimura N, Suzuki C, Ootani S, Tanimoto A, Nishiyama A, Yamashita K, Ohtsubo K, Takeuchi S, Yano S
BMC Cancer 2020 Feb 24;20(1):156. doi: 10.1186/s12885-020-6626-9. PMID: 32093631Free PMC Article
Impact of cigarette smoking on response to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors in lung adenocarcinoma with activating EGFR mutations.
Kim MH, Kim HR, Cho BC, Bae MK, Kim EY, Lee CY, Lee JS, Kang DR, Kim JH
Lung Cancer 2014 May;84(2):196-202. Epub 2014 Feb 3 doi: 10.1016/j.lungcan.2014.01.022. PMID: 24629638
Whole-tumor perfusion CT in patients with advanced lung adenocarcinoma treated with conventional and antiangiogenetic chemotherapy: initial experience.
Fraioli F, Anzidei M, Zaccagna F, Mennini ML, Serra G, Gori B, Longo F, Catalano C, Passariello R
Radiology 2011 May;259(2):574-82. Epub 2011 Feb 25 doi: 10.1148/radiol.11100600. PMID: 21357523

Prognosis

Predictive factors for treatment response using dual-energy computed tomography in patients with advanced lung adenocarcinoma.
Hong SR, Hur J, Moon YW, Han K, Chang S, Kim JY, Im DJ, Suh YJ, Hong YJ, Lee HJ, Kim YJ, Choi BW
Eur J Radiol 2018 Apr;101:118-123. Epub 2018 Feb 17 doi: 10.1016/j.ejrad.2018.02.019. PMID: 29571784
Impact of cigarette smoking on response to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors in lung adenocarcinoma with activating EGFR mutations.
Kim MH, Kim HR, Cho BC, Bae MK, Kim EY, Lee CY, Lee JS, Kang DR, Kim JH
Lung Cancer 2014 May;84(2):196-202. Epub 2014 Feb 3 doi: 10.1016/j.lungcan.2014.01.022. PMID: 24629638

Clinical prediction guides

Implications of intestinal microecology and immune function alterations for immunotherapy outcomes in advanced unresectable lung adenocarcinoma.
He S, Tian J, Zang J, Long L, Liu P, Zhang Y, Xiao J
Clin Respir J 2024 May;18(5):e13762. doi: 10.1111/crj.13762. PMID: 38685799Free PMC Article
Effect of hyperthermia on intestinal microecology, immune function, and progression-free survival in patients with advanced unresectable lung adenocarcinoma.
Tian J, Long L, Zang J, Liu W, Liu P, Zhao L, Liang X, Xiao J
Sci Rep 2023 Oct 11;13(1):17223. doi: 10.1038/s41598-023-44350-w. PMID: 37821661Free PMC Article
Predictive factors for treatment response using dual-energy computed tomography in patients with advanced lung adenocarcinoma.
Hong SR, Hur J, Moon YW, Han K, Chang S, Kim JY, Im DJ, Suh YJ, Hong YJ, Lee HJ, Kim YJ, Choi BW
Eur J Radiol 2018 Apr;101:118-123. Epub 2018 Feb 17 doi: 10.1016/j.ejrad.2018.02.019. PMID: 29571784
Impact of cigarette smoking on response to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors in lung adenocarcinoma with activating EGFR mutations.
Kim MH, Kim HR, Cho BC, Bae MK, Kim EY, Lee CY, Lee JS, Kang DR, Kim JH
Lung Cancer 2014 May;84(2):196-202. Epub 2014 Feb 3 doi: 10.1016/j.lungcan.2014.01.022. PMID: 24629638
Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer.
Rosenberg SA, Lotze MT, Muul LM, Leitman S, Chang AE, Ettinghausen SE, Matory YL, Skibber JM, Shiloni E, Vetto JT
N Engl J Med 1985 Dec 5;313(23):1485-92. doi: 10.1056/NEJM198512053132327. PMID: 3903508

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