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Impaired renal tubular reabsorption of magnesium

MedGen UID:
1778245
•Concept ID:
C5539797
•
Finding
HPO: HP:0033759

Definition

Decreased renal tubular reabsorption of magnesium. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImpaired renal tubular reabsorption of magnesium

Conditions with this feature

Renal hypomagnesemia 6
MedGen UID:
462645
•Concept ID:
C3151295
•
Disease or Syndrome
See: Condition Record
Renal hypomagnesemia 6

Professional guidelines

PubMed

Evaluation and Management of Hyponatremia in Heart Failure.
Mondellini GM, Verbrugge FH
Curr Heart Fail Rep 2024 Jun;21(3):252-261. Epub 2024 Feb 27 doi: 10.1007/s11897-024-00651-3. PMID: 38411885
Early and late adverse renal effects after potentially nephrotoxic treatment for childhood cancer.
Kooijmans EC, Bökenkamp A, Tjahjadi NS, Tettero JM, van Dulmen-den Broeder E, van der Pal HJ, Veening MA
Cochrane Database Syst Rev 2019 Mar 11;3(3):CD008944. doi: 10.1002/14651858.CD008944.pub3. PMID: 30855726Free PMC Article
Early and late renal adverse effects after potentially nephrotoxic treatment for childhood cancer.
Knijnenburg SL, Mulder RL, Schouten-Van Meeteren AY, Bökenkamp A, Blufpand H, van Dulmen-den Broeder E, Veening MA, Kremer LC, Jaspers MW
Cochrane Database Syst Rev 2013 Oct 8;(10):CD008944. doi: 10.1002/14651858.CD008944.pub2. PMID: 24101439

Recent clinical studies

Etiology

The emerging role of magnesium in CKD.
Sakaguchi Y
Clin Exp Nephrol 2022 May;26(5):379-384. Epub 2022 Jan 25 doi: 10.1007/s10157-022-02182-4. PMID: 35076791Free PMC Article
Clinical and genetic approach to renal hypomagnesemia.
Tseng MH, Konrad M, Ding JJ, Lin SH
Biomed J 2022 Feb;45(1):74-87. Epub 2021 Nov 10 doi: 10.1016/j.bj.2021.11.002. PMID: 34767995Free PMC Article
Inherited and acquired disorders of magnesium homeostasis.
Wolf MT
Curr Opin Pediatr 2017 Apr;29(2):187-198. doi: 10.1097/MOP.0000000000000450. PMID: 27906866Free PMC Article
Early and late renal adverse effects after potentially nephrotoxic treatment for childhood cancer.
Knijnenburg SL, Mulder RL, Schouten-Van Meeteren AY, Bökenkamp A, Blufpand H, van Dulmen-den Broeder E, Veening MA, Kremer LC, Jaspers MW
Cochrane Database Syst Rev 2013 Oct 8;(10):CD008944. doi: 10.1002/14651858.CD008944.pub2. PMID: 24101439
The calcium-sensing receptor: a window into the physiology and pathophysiology of mineral ion metabolism.
Chattopadhyay N, Mithal A, Brown EM
Endocr Rev 1996 Aug;17(4):289-307. doi: 10.1210/edrv-17-4-289. PMID: 8854047

Diagnosis

Clinical and genetic approach to renal hypomagnesemia.
Tseng MH, Konrad M, Ding JJ, Lin SH
Biomed J 2022 Feb;45(1):74-87. Epub 2021 Nov 10 doi: 10.1016/j.bj.2021.11.002. PMID: 34767995Free PMC Article
Long-term renal function and hypertension in adult survivors of childhood sarcoma: Single center experience.
Schiavetti A, Pedetti V, Varrasso G, Marrucci O, Celani C, Andreoli G, Bonci E
Pediatr Hematol Oncol 2018 Apr;35(3):167-176. Epub 2018 Sep 19 doi: 10.1080/08880018.2018.1476941. PMID: 30230941
Inherited and acquired disorders of magnesium homeostasis.
Wolf MT
Curr Opin Pediatr 2017 Apr;29(2):187-198. doi: 10.1097/MOP.0000000000000450. PMID: 27906866Free PMC Article
Prevalence and clinical impact of magnesium disorders in end-stage renal disease: a protocol for a systematic review.
Floridis J, Abeyaratne A, Majoni SW
Syst Rev 2015 May 26;4:76. doi: 10.1186/s13643-015-0063-x. PMID: 26007218Free PMC Article
Early and late renal adverse effects after potentially nephrotoxic treatment for childhood cancer.
Knijnenburg SL, Mulder RL, Schouten-Van Meeteren AY, Bökenkamp A, Blufpand H, van Dulmen-den Broeder E, Veening MA, Kremer LC, Jaspers MW
Cochrane Database Syst Rev 2013 Oct 8;(10):CD008944. doi: 10.1002/14651858.CD008944.pub2. PMID: 24101439

Therapy

Evaluation and Management of Hyponatremia in Heart Failure.
Mondellini GM, Verbrugge FH
Curr Heart Fail Rep 2024 Jun;21(3):252-261. Epub 2024 Feb 27 doi: 10.1007/s11897-024-00651-3. PMID: 38411885
The emerging role of magnesium in CKD.
Sakaguchi Y
Clin Exp Nephrol 2022 May;26(5):379-384. Epub 2022 Jan 25 doi: 10.1007/s10157-022-02182-4. PMID: 35076791Free PMC Article
Early and late adverse renal effects after potentially nephrotoxic treatment for childhood cancer.
Kooijmans EC, Bökenkamp A, Tjahjadi NS, Tettero JM, van Dulmen-den Broeder E, van der Pal HJ, Veening MA
Cochrane Database Syst Rev 2019 Mar 11;3(3):CD008944. doi: 10.1002/14651858.CD008944.pub3. PMID: 30855726Free PMC Article
Long-term renal function and hypertension in adult survivors of childhood sarcoma: Single center experience.
Schiavetti A, Pedetti V, Varrasso G, Marrucci O, Celani C, Andreoli G, Bonci E
Pediatr Hematol Oncol 2018 Apr;35(3):167-176. Epub 2018 Sep 19 doi: 10.1080/08880018.2018.1476941. PMID: 30230941
Early and late renal adverse effects after potentially nephrotoxic treatment for childhood cancer.
Knijnenburg SL, Mulder RL, Schouten-Van Meeteren AY, Bökenkamp A, Blufpand H, van Dulmen-den Broeder E, Veening MA, Kremer LC, Jaspers MW
Cochrane Database Syst Rev 2013 Oct 8;(10):CD008944. doi: 10.1002/14651858.CD008944.pub2. PMID: 24101439

Prognosis

The emerging role of magnesium in CKD.
Sakaguchi Y
Clin Exp Nephrol 2022 May;26(5):379-384. Epub 2022 Jan 25 doi: 10.1007/s10157-022-02182-4. PMID: 35076791Free PMC Article
Clinical and genetic approach to renal hypomagnesemia.
Tseng MH, Konrad M, Ding JJ, Lin SH
Biomed J 2022 Feb;45(1):74-87. Epub 2021 Nov 10 doi: 10.1016/j.bj.2021.11.002. PMID: 34767995Free PMC Article
Long-term renal function and hypertension in adult survivors of childhood sarcoma: Single center experience.
Schiavetti A, Pedetti V, Varrasso G, Marrucci O, Celani C, Andreoli G, Bonci E
Pediatr Hematol Oncol 2018 Apr;35(3):167-176. Epub 2018 Sep 19 doi: 10.1080/08880018.2018.1476941. PMID: 30230941
Inherited and acquired disorders of magnesium homeostasis.
Wolf MT
Curr Opin Pediatr 2017 Apr;29(2):187-198. doi: 10.1097/MOP.0000000000000450. PMID: 27906866Free PMC Article
New TRPM6 missense mutations linked to hypomagnesemia with secondary hypocalcemia.
Lainez S, Schlingmann KP, van der Wijst J, Dworniczak B, van Zeeland F, Konrad M, Bindels RJ, Hoenderop JG
Eur J Hum Genet 2014 Apr;22(4):497-504. Epub 2013 Aug 14 doi: 10.1038/ejhg.2013.178. PMID: 23942199Free PMC Article

Clinical prediction guides

Clinical and genetic approach to renal hypomagnesemia.
Tseng MH, Konrad M, Ding JJ, Lin SH
Biomed J 2022 Feb;45(1):74-87. Epub 2021 Nov 10 doi: 10.1016/j.bj.2021.11.002. PMID: 34767995Free PMC Article
Prevalence and clinical impact of magnesium disorders in end-stage renal disease: a protocol for a systematic review.
Floridis J, Abeyaratne A, Majoni SW
Syst Rev 2015 May 26;4:76. doi: 10.1186/s13643-015-0063-x. PMID: 26007218Free PMC Article
New TRPM6 missense mutations linked to hypomagnesemia with secondary hypocalcemia.
Lainez S, Schlingmann KP, van der Wijst J, Dworniczak B, van Zeeland F, Konrad M, Bindels RJ, Hoenderop JG
Eur J Hum Genet 2014 Apr;22(4):497-504. Epub 2013 Aug 14 doi: 10.1038/ejhg.2013.178. PMID: 23942199Free PMC Article
Novel TRPM6 mutations in familial hypomagnesemia with secondary hypocalcemia.
Zhao Z, Pei Y, Huang X, Liu Y, Yang W, Sun J, Si N, Xing X, Li M, Wang O, Jiang Y, Zhang X, Xia W
Am J Nephrol 2013;37(6):541-8. Epub 2013 May 16 doi: 10.1159/000350886. PMID: 23689795
Claudin-19 mutations and clinical phenotype in Spanish patients with familial hypomagnesemia with hypercalciuria and nephrocalcinosis.
Claverie-Martín F, García-Nieto V, Loris C, Ariceta G, Nadal I, Espinosa L, Fernández-Maseda Á, Antón-Gamero M, Avila A, Madrid Á, González-Acosta H, Córdoba-Lanus E, Santos F, Gil-Calvo M, Espino M, García-Martinez E, Sanchez A, Muley R; RenalTube Group
PLoS One 2013;8(1):e53151. Epub 2013 Jan 3 doi: 10.1371/journal.pone.0053151. PMID: 23301036Free PMC Article

Recent systematic reviews

Early and late adverse renal effects after potentially nephrotoxic treatment for childhood cancer.
Kooijmans EC, Bökenkamp A, Tjahjadi NS, Tettero JM, van Dulmen-den Broeder E, van der Pal HJ, Veening MA
Cochrane Database Syst Rev 2019 Mar 11;3(3):CD008944. doi: 10.1002/14651858.CD008944.pub3. PMID: 30855726Free PMC Article
Early and late renal adverse effects after potentially nephrotoxic treatment for childhood cancer.
Knijnenburg SL, Mulder RL, Schouten-Van Meeteren AY, Bökenkamp A, Blufpand H, van Dulmen-den Broeder E, Veening MA, Kremer LC, Jaspers MW
Cochrane Database Syst Rev 2013 Oct 8;(10):CD008944. doi: 10.1002/14651858.CD008944.pub2. PMID: 24101439

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