U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

African Swine Fever

MedGen UID:
1779
•Concept ID:
C0001752
•
Disease or Syndrome
Synonyms: African Swine Fever Virus Infection; Asfivirus Infection; Asfivirus Infections; Infection, Asfivirus; Infections, Asfivirus; Swine Fever, African; Wart Hog Disease; Wart-Hog Disease; Wart-Hog Diseases

Definition

A sometimes fatal ASFIVIRUS infection of pigs, characterized by fever, cough, diarrhea, hemorrhagic lymph nodes, and edema of the gallbladder. It is transmitted between domestic swine by direct contact, ingestion of infected meat, or fomites, or mechanically by biting flies or soft ticks (genus Ornithodoros). [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAfrican Swine Fever

Professional guidelines

PubMed

Quantitative risk assessment of African swine fever introduction into Spain by legal import of swine products.
Muñoz-Pérez C, Martínez-López B, Gómez-Vázquez JP, Aguilar-Vega C, Bosch J, Ito S, Martínez-Avilés M, Sánchez-Vizcaíno JM
Res Vet Sci 2023 Oct;163:104990. Epub 2023 Aug 23 doi: 10.1016/j.rvsc.2023.104990. PMID: 37639803
Quantitative risk assessment of African swine fever virus introduction to Japan via pork products brought in air passengers' luggage.
Ito S, Jurado C, Sánchez-Vizcaíno JM, Isoda N
Transbound Emerg Dis 2020 Mar;67(2):894-905. Epub 2019 Nov 17 doi: 10.1111/tbed.13414. PMID: 31692238
Quantitative risk assessment case study: smuggled meats as disease vectors.
Wooldridge M, Hartnett E, Cox A, Seaman M
Rev Sci Tech 2006 Apr;25(1):105-17. doi: 10.20506/rst.25.1.1651. PMID: 16796040

Recent clinical studies

Etiology

A CRISPR/Cas9 eraser strategy for contamination-free PCR end-point detection.
Lin W, Tian T, Jiang Y, Xiong E, Zhu D, Zhou X
Biotechnol Bioeng 2021 May;118(5):2053-2066. Epub 2021 Mar 1 doi: 10.1002/bit.27718. PMID: 33615437Free PMC Article
The risk from African swine fever.
Jarvis S
Vet Rec 2018 Nov 3;183(17):515. doi: 10.1136/vr.k4609. PMID: 30389859
Tick-borne viruses.
Bartíková P, Holíková V, Kazimírová M, Štibrániová I
Acta Virol 2017;61(4):413-427. doi: 10.4149/av_2017_403. PMID: 29186958
Structural models of DYNLL1 with interacting partners: African swine fever virus protein p54 and postsynaptic scaffolding protein gephyrin.
García-Mayoral MF, Rodríguez-Crespo I, Bruix M
FEBS Lett 2011 Jan 3;585(1):53-7. Epub 2010 Nov 19 doi: 10.1016/j.febslet.2010.11.027. PMID: 21094642
Speculations on the viral etiology of acquired immune deficiency syndrome and Kaposi's sarcoma.
Conant MA
J Invest Dermatol 1984 Jul;83(1 Suppl):57s-62s. doi: 10.1111/1523-1747.ep12281181. PMID: 6330223

Diagnosis

ELISpot Assay for the Detection of ASFV-Specific Interferon-Gamma (IFN-γ)-Producing Cells.
Portugal R
Methods Mol Biol 2022;2503:169-178. doi: 10.1007/978-1-0716-2333-6_12. PMID: 35575894
A one-pot CRISPR/Cas13a-based contamination-free biosensor for low-cost and rapid nucleic acid diagnostics.
Hu F, Liu Y, Zhao S, Zhang Z, Li X, Peng N, Jiang Z
Biosens Bioelectron 2022 Apr 15;202:113994. Epub 2022 Jan 13 doi: 10.1016/j.bios.2022.113994. PMID: 35042129Free PMC Article
Exploiting the orthogonal CRISPR-Cas12a/Cas13a trans-cleavage for dual-gene virus detection using a handheld device.
Tian T, Qiu Z, Jiang Y, Zhu D, Zhou X
Biosens Bioelectron 2022 Jan 15;196:113701. Epub 2021 Oct 10 doi: 10.1016/j.bios.2021.113701. PMID: 34653714
CRISPR-Cas systems for diagnosing infectious diseases.
Kostyusheva A, Brezgin S, Babin Y, Vasilyeva I, Glebe D, Kostyushev D, Chulanov V
Methods 2022 Jul;203:431-446. Epub 2021 Apr 9 doi: 10.1016/j.ymeth.2021.04.007. PMID: 33839288Free PMC Article
A CRISPR/Cas9 eraser strategy for contamination-free PCR end-point detection.
Lin W, Tian T, Jiang Y, Xiong E, Zhu D, Zhou X
Biotechnol Bioeng 2021 May;118(5):2053-2066. Epub 2021 Mar 1 doi: 10.1002/bit.27718. PMID: 33615437Free PMC Article

Therapy

A multi-state survey of farm-level preparedness towards African swine fever outbreak in Nigeria.
Ogundijo OA, Omotosho OO, Al-Mustapha AI, Abiola JO, Awosanya EJ, Odukoya A, Owoicho S, Oyewo M, Ibrahim A, Orum TG, Nanven MB, Bolajoko MB, Luka P, Adeyemo OK
Acta Trop 2023 Oct;246:106989. Epub 2023 Jul 27 doi: 10.1016/j.actatropica.2023.106989. PMID: 37507080
The recombinant pseudorabies virus expressing African swine fever virus CD2v protein is safe and effective in mice.
Feng Z, Chen J, Liang W, Chen W, Li Z, Chen Q, Cai S
Virol J 2020 Nov 16;17(1):180. doi: 10.1186/s12985-020-01450-7. PMID: 33198749Free PMC Article
New paths for sustainable solutions to tackle global and emerging infectious threats.
Holm A
Biologicals 2020 May;65:42-45. Epub 2020 Apr 20 doi: 10.1016/j.biologicals.2020.04.003. PMID: 32327306Free PMC Article
A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs.
Chen W, Zhao D, He X, Liu R, Wang Z, Zhang X, Li F, Shan D, Chen H, Zhang J, Wang L, Wen Z, Wang X, Guan Y, Liu J, Bu Z
Sci China Life Sci 2020 May;63(5):623-634. Epub 2020 Mar 1 doi: 10.1007/s11427-020-1657-9. PMID: 32124180Free PMC Article
Polyvalent 2D Entry Inhibitors for Pseudorabies and African Swine Fever Virus.
Ziem B, Rahn J, Donskyi I, Silberreis K, Cuellar L, Dernedde J, Keil G, Mettenleiter TC, Haag R
Macromol Biosci 2017 Jun;17(6) Epub 2017 Mar 15 doi: 10.1002/mabi.201600499. PMID: 28296132

Prognosis

Defining correlates of protection for mammalian livestock vaccines against high-priority viral diseases.
Davis SK, Jia F, Wright QG, Islam MT, Bean A, Layton D, Williams DT, Lynch SE
Front Immunol 2024;15:1397780. Epub 2024 Jul 19 doi: 10.3389/fimmu.2024.1397780. PMID: 39100679Free PMC Article
Crystal structure of African swine fever virus pE301R reveals a ring-shaped trimeric DNA sliding clamp.
Wu J, Zheng H, Gong P
J Biol Chem 2023 Jul;299(7):104872. Epub 2023 May 29 doi: 10.1016/j.jbc.2023.104872. PMID: 37257822Free PMC Article
Change in the ASF entry risk into Japan as a result of the COVID-19 pandemic.
Sugiura K, Kure K, Kato T, Kyutoku F, Haga T
Transbound Emerg Dis 2021 May;68(3):1700-1703. Epub 2020 Sep 28 doi: 10.1111/tbed.13836. PMID: 32969591
Better Epitope Discovery, Precision Immune Engineering, and Accelerated Vaccine Design Using Immunoinformatics Tools.
De Groot AS, Moise L, Terry F, Gutierrez AH, Hindocha P, Richard G, Hoft DF, Ross TM, Noe AR, Takahashi Y, Kotraiah V, Silk SE, Nielsen CM, Minassian AM, Ashfield R, Ardito M, Draper SJ, Martin WD
Front Immunol 2020;11:442. Epub 2020 Apr 7 doi: 10.3389/fimmu.2020.00442. PMID: 32318055Free PMC Article
The lesional changes and pathogenesis in the kidney in African swine fever.
Hervás J, Gómez-Villamandos JC, Méndez A, Carrasco L, Sierra MA
Vet Res Commun 1996;20(3):285-99. doi: 10.1007/BF00366926. PMID: 8739527

Clinical prediction guides

African swine fever virus MGF505-6R attenuates type I interferon production by targeting STING for degradation.
Yao M, Cao H, Li W, Hu Z, Rong Z, Yin M, Tian L, Hu D, Li X, Qian P
Front Immunol 2024;15:1380220. Epub 2024 May 10 doi: 10.3389/fimmu.2024.1380220. PMID: 38799458Free PMC Article
Infection of Human Macrophage-Like Cells by African Swine Fever Virus.
Karalyan ZA, Ghonyan SA, Poghosyan DA, Hakobyan LH, Avagyan HR, Avetisyan AS, Abroyan LO, Poghosyan AA, Hakobyan SA, Manukyan GP
Front Biosci (Landmark Ed) 2024 Apr 23;29(4):164. doi: 10.31083/j.fbl2904164. PMID: 38682190
Crystal structure of African swine fever virus pE301R reveals a ring-shaped trimeric DNA sliding clamp.
Wu J, Zheng H, Gong P
J Biol Chem 2023 Jul;299(7):104872. Epub 2023 May 29 doi: 10.1016/j.jbc.2023.104872. PMID: 37257822Free PMC Article
Change in the ASF entry risk into Japan as a result of the COVID-19 pandemic.
Sugiura K, Kure K, Kato T, Kyutoku F, Haga T
Transbound Emerg Dis 2021 May;68(3):1700-1703. Epub 2020 Sep 28 doi: 10.1111/tbed.13836. PMID: 32969591
Better Epitope Discovery, Precision Immune Engineering, and Accelerated Vaccine Design Using Immunoinformatics Tools.
De Groot AS, Moise L, Terry F, Gutierrez AH, Hindocha P, Richard G, Hoft DF, Ross TM, Noe AR, Takahashi Y, Kotraiah V, Silk SE, Nielsen CM, Minassian AM, Ashfield R, Ardito M, Draper SJ, Martin WD
Front Immunol 2020;11:442. Epub 2020 Apr 7 doi: 10.3389/fimmu.2020.00442. PMID: 32318055Free PMC Article

Recent systematic reviews

Arboviruses in Mammals in the Neotropics: A Systematic Review to Strengthen Epidemiological Monitoring Strategies and Conservation Medicine.
García-Romero C, Carrillo Bilbao GA, Navarro JC, Martin-Solano S, Saegerman C
Viruses 2023 Feb 1;15(2) doi: 10.3390/v15020417. PMID: 36851630Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...