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Angiofibroma of Soft Tissue

MedGen UID:
1780020
Concept ID:
C5447695
Neoplastic Process
Synonym: Angiofibroma of soft tissue
SNOMED CT: Angiofibroma of soft tissue (1290952009); Angiofibroma of soft tissue (1290955006)

Definition

A benign fibroblastic neoplasm composed of uniform spindle cells with abundant fibromyxoid stroma and a prominent network of innumerable branching, thin-walled blood vessels. It typically arises in the extremities, mainly the legs, frequently involving or adjacent to large joints such as the knee. Unusual anatomical locations include the back, abdominal wall, pelvic cavity, and breast. The tumors are often subcutaneous but may be intramuscular and deep. The lesion presents most often as a slow-growing painless mass. (WHO 2020) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAngiofibroma of Soft Tissue

Professional guidelines

PubMed

Williams MD, El-Naggar AK
Adv Otorhinolaryngol 2020;84:13-27. Epub 2020 Jul 30 doi: 10.1159/000457922. PMID: 32731232
Anschuetz L, Buchwalder M, Dettmer M, Caversaccio MD, Wagner F
ORL J Otorhinolaryngol Relat Spec 2017;79(3):131-146. Epub 2017 Apr 8 doi: 10.1159/000468945. PMID: 28391267
Margalit N, Wasserzug O, De-Row A, Abergel A, Fliss DM, Gil Z
J Neurosurg Pediatr 2009 Aug;4(2):113-7. doi: 10.3171/2009.4.PEDS08321. PMID: 19645542

Recent clinical studies

Etiology

Oda Y, Yamamoto H, Kohashi K, Yamada Y, Iura K, Ishii T, Maekawa A, Bekki H
Pathol Int 2017 Sep;67(9):435-446. Epub 2017 Jul 31 doi: 10.1111/pin.12565. PMID: 28759137
Fukuda Y, Motoi T, Kato I, Ikegami M, Funata N, Ohtomo R, Horiguchi S, Goto T, Hishima T
Pathol Int 2014 May;64(5):237-42. doi: 10.1111/pin.12163. PMID: 24888778

Diagnosis

Nakayama S, Nishio J, Aoki M, Koga K, Nabeshima K, Yamamoto T
Histol Histopathol 2022 Aug;37(8):717-722. Epub 2022 Feb 25 doi: 10.14670/HH-18-444. PMID: 35211945
Kallen ME, Hornick JL
Am J Surg Pathol 2021 Jan;45(1):e1-e23. doi: 10.1097/PAS.0000000000001552. PMID: 32796172
Mindiola-Romero AE, Maloney N, Bridge JA, Korkolopoulou P, Sakellariou S, Linos K
J Cutan Pathol 2020 Feb;47(2):179-185. Epub 2019 Oct 13 doi: 10.1111/cup.13580. PMID: 31568567
Yamada Y, Yamamoto H, Kohashi K, Ishii T, Iura K, Maekawa A, Bekki H, Otsuka H, Yamashita K, Tanaka H, Hiraki T, Mukai M, Shirakawa A, Shinnou Y, Jinno M, Yanai H, Taguchi K, Maehara Y, Iwamoto Y, Oda Y
Histopathology 2016 Sep;69(3):459-69. Epub 2016 Apr 1 doi: 10.1111/his.12943. PMID: 26845637
Riddle NN, Gardner JM
Surg Pathol Clin 2015 Sep;8(3):467-91. doi: 10.1016/j.path.2015.05.003. PMID: 26297066

Prognosis

Nakayama S, Nishio J, Aoki M, Koga K, Nabeshima K, Yamamoto T
Histol Histopathol 2022 Aug;37(8):717-722. Epub 2022 Feb 25 doi: 10.14670/HH-18-444. PMID: 35211945
Kallen ME, Hornick JL
Am J Surg Pathol 2021 Jan;45(1):e1-e23. doi: 10.1097/PAS.0000000000001552. PMID: 32796172
Mindiola-Romero AE, Maloney N, Bridge JA, Korkolopoulou P, Sakellariou S, Linos K
J Cutan Pathol 2020 Feb;47(2):179-185. Epub 2019 Oct 13 doi: 10.1111/cup.13580. PMID: 31568567
Oda Y, Yamamoto H, Kohashi K, Yamada Y, Iura K, Ishii T, Maekawa A, Bekki H
Pathol Int 2017 Sep;67(9):435-446. Epub 2017 Jul 31 doi: 10.1111/pin.12565. PMID: 28759137

Clinical prediction guides

Fukuda Y, Motoi T, Kato I, Ikegami M, Funata N, Ohtomo R, Horiguchi S, Goto T, Hishima T
Pathol Int 2014 May;64(5):237-42. doi: 10.1111/pin.12163. PMID: 24888778
Mariño-Enríquez A, Fletcher CD
Am J Surg Pathol 2012 Apr;36(4):500-8. doi: 10.1097/PAS.0b013e31823defbe. PMID: 22301504

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