U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lacrimal Gland Oncocytic Adenocarcinoma

MedGen UID:
1782239
•Concept ID:
C5446388
•
Neoplastic Process

Definition

An adenocarcinoma that arises from the lacrimal gland. It is characterized by the presence of large malignant epithelial cells with abundant granular eosinophilic cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLacrimal Gland Oncocytic Adenocarcinoma

Professional guidelines

PubMed

Reply Re: "Does Multimodal Treatment Improve Eye and Life Salvage in Adenoid Cystic Carcinoma of the Lacrimal Gland?".
Manjandavida FP, Honavar SG, Murthy R, Das S, Vemuganti GK, Mulay K, Reddy VAP
Ophthalmic Plast Reconstr Surg 2022 Jul-Aug 01;38(4):407-408. Epub 2022 Jul 5 doi: 10.1097/IOP.0000000000002212. PMID: 35797666
Re: "Does Multimodal Treatment Improve Eye and Life Salvage in Adenoid Cystic Carcinoma of the Lacrimal Gland?".
Rose GE
Ophthalmic Plast Reconstr Surg 2022 Jul-Aug 01;38(4):406. Epub 2022 Jul 5 doi: 10.1097/IOP.0000000000002211. PMID: 35797665
Successful Treatment of Erlotinib on Metastatic Adenoid Cystic Carcinoma of the Lacrimal Gland.
Nie KK, Xu J, Gao C, Zhang ZF, Lan KT, Ji YX
Chin Med J (Engl) 2018 Jul 20;131(14):1746-1747. doi: 10.4103/0366-6999.235887. PMID: 29998897Free PMC Article

Recent clinical studies

Etiology

Clinical characteristics, radiologic features, and histopathology of biopsied lacrimal gland tumors.
Aryasit O, Amornthatree P, Tsutsumi WD, Sittivarakul W, Geater AF, Tengtrisorn S, Prapakornkovit V
Sci Rep 2023 Oct 3;13(1):16615. doi: 10.1038/s41598-023-43817-0. PMID: 37789105Free PMC Article
Lacrimal Sac Sebaceous Carcinoma.
Vahdani K, Coupland SE, Ashdown ME, Garrott H, Ford R
Ophthalmic Plast Reconstr Surg 2019 Jul/Aug;35(4):e89-e91. doi: 10.1097/IOP.0000000000001386. PMID: 30921057
Current treatment of lacrimal gland carcinoma.
Woo KI, Kim YD, Sa HS, Esmaeli B
Curr Opin Ophthalmol 2016 Sep;27(5):449-56. doi: 10.1097/ICU.0000000000000301. PMID: 27273588
Lacrimal sac mucus-secreting adenocarcinoma.
Bansal S, Khan AL, Hsuan J
Orbit 2008;27(3):199-201. doi: 10.1080/01676830701804180. PMID: 18569829
Primary orbital tumors.
Adam YG, Farr HW
Am J Surg 1971 Dec;122(6):726-31. doi: 10.1016/0002-9610(71)90435-1. PMID: 4331407

Diagnosis

Ultrasonic Aspiration for Debulking Infiltrative Masses of the Orbit.
Sun SY, Stewart K, Lyford-Pike S, Garrity JA, Harrison AR, Mokhtarzadeh A
Ophthalmic Plast Reconstr Surg 2020 Mar/Apr;36(2):198-201. doi: 10.1097/IOP.0000000000001537. PMID: 31868794
Lacrimal Sac Sebaceous Carcinoma.
Vahdani K, Coupland SE, Ashdown ME, Garrott H, Ford R
Ophthalmic Plast Reconstr Surg 2019 Jul/Aug;35(4):e89-e91. doi: 10.1097/IOP.0000000000001386. PMID: 30921057
Avoiding the major complication of ophthalmic pathology: misdiagnosis. A review of three common diagnostic challenges.
Rashid A, Jakobiec FA
Semin Ophthalmol 2014 Sep-Nov;29(5-6):468-74. doi: 10.3109/08820538.2014.959196. PMID: 25325875
Lacrimal fossa lesions: pictorial review of CT and MRI features.
Vaidhyanath R, Kirke R, Brown L, Sampath R
Orbit 2008;27(6):410-8. doi: 10.1080/01676830802333667. PMID: 19085295
Tumors of the lacrimal gland and lacrimal sac.
Jakobiec FA
Trans New Orleans Acad Ophthalmol 1982;30:190-202. PMID: 6289496

Therapy

Accumulation of 131Iodine in the nasolacrimal sac/duct after radioiodine therapy for papillary thyroid cancer.
Usmani S, Jain A, Al-Riyami K, Abubakar S
J Pak Med Assoc 2023 Mar;73(3):713-714. doi: 10.47391/JPMA.23-22. PMID: 36932793
Nasolacrimal duct obstruction secondary to lacrimal sac involvement by sebaceous carcinoma.
Wu A, Curragh DS, Morrow R, Selva D, Davis G
Orbit 2020 Dec;39(6):433-436. Epub 2019 Dec 6 doi: 10.1080/01676830.2019.1700282. PMID: 31809621
Intra-arterial Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma.
Zhang M, Fathy C, Breazzano MP, Hollar M, Barahimi B
Int Ophthalmol Clin 2017 Winter;57(1):143-152. doi: 10.1097/IIO.0000000000000158. PMID: 27898620
Cavitary mucoepidermoid carcinoma of lung with metastases in skeletal muscles as presenting features: a case report and review of the literature.
Singh A, Pandey KC, Pant NK
J Cancer Res Ther 2010 Jul-Sep;6(3):350-2. doi: 10.4103/0973-1482.73363. PMID: 21119274
Sebaceous carcinoma of the ocular region: a review.
Shields JA, Demirci H, Marr BP, Eagle RC Jr, Shields CL
Surv Ophthalmol 2005 Mar-Apr;50(2):103-22. doi: 10.1016/j.survophthal.2004.12.008. PMID: 15749305

Prognosis

A Red and Swollen Eyelid. Breast carcinoma metastasis to left lacrimal gland.
Rao RC, Elner VM, Demirci H
JAMA Oncol 2015 Jul;1(4):537-8. doi: 10.1001/jamaoncol.2015.0461. PMID: 26181264Free PMC Article
Avoiding the major complication of ophthalmic pathology: misdiagnosis. A review of three common diagnostic challenges.
Rashid A, Jakobiec FA
Semin Ophthalmol 2014 Sep-Nov;29(5-6):468-74. doi: 10.3109/08820538.2014.959196. PMID: 25325875
Lacrimal sac mucus-secreting adenocarcinoma.
Bansal S, Khan AL, Hsuan J
Orbit 2008;27(3):199-201. doi: 10.1080/01676830701804180. PMID: 18569829
Sebaceous carcinoma of the ocular region: a review.
Shields JA, Demirci H, Marr BP, Eagle RC Jr, Shields CL
Surv Ophthalmol 2005 Mar-Apr;50(2):103-22. doi: 10.1016/j.survophthal.2004.12.008. PMID: 15749305
Unilateral proptosis.
Parsons GA
P N G Med J 1975 Jun;18(2):90-3. PMID: 1061465

Clinical prediction guides

The poor prognosis of lacrimal gland adenocarcinoma: a clinical study and literature review.
Liu R, Ren T, Li J, Wang N, Xu L, Guo Q, Zhang H, Ma J
J Cancer Res Clin Oncol 2024 Jan 23;150(1):26. doi: 10.1007/s00432-023-05510-7. PMID: 38263473Free PMC Article
Adenoid Cystic Carcinoma from the salivary and lacrimal glands and the breast: Different clinical outcomes to the same tumor.
Emerick C, Mariano FV, Vargas PA, Nör JE, Squarize CH, Castilho RM
Crit Rev Oncol Hematol 2022 Nov;179:103792. Epub 2022 Aug 13 doi: 10.1016/j.critrevonc.2022.103792. PMID: 35973662
Metabolic alterations in carcinoma ex pleomorphic adenoma development of lacrimal glands.
de Lima-Souza RA, Rodrigues NM, Scarini JF, Silva MFS, Tincani AJ, Egal ESA, Altemani A, Mariano FV
Int Ophthalmol 2022 Apr;42(4):1101-1109. Epub 2021 Nov 10 doi: 10.1007/s10792-021-02096-2. PMID: 34757565
Whole Exome Sequencing of Lacrimal Gland Adenoid Cystic Carcinoma.
Sant DW, Tao W, Field MG, Pelaez D, Jin K, Capobianco A, Dubovy SR, Tse DT, Wang G
Invest Ophthalmol Vis Sci 2017 May 1;58(6):BIO240-BIO246. doi: 10.1167/iovs.16-21097. PMID: 28820917Free PMC Article
Mucoepidermoid carcinoma of the lacrimal sac: a report of two cases, with observations on the histogenesis.
Fliss DM, Freeman JL, Hurwitz JJ, Heathcote JG
Can J Ophthalmol 1993 Aug;28(5):228-35. PMID: 8221372

Recent systematic reviews

Ectopic Lacrimal Gland Tissue: A Systematic Review.
Nagendran S, Alsamnan M, Strianese D, Malhotra R
Ophthalmic Plast Reconstr Surg 2020 Nov/Dec;36(6):540-544. doi: 10.1097/IOP.0000000000001621. PMID: 32205779
Intraductal carcinomas of the salivary glands: systematic review and classification of 93 published cases.
Palicelli A
APMIS 2020 Mar;128(3):191-200. Epub 2020 Jan 3 doi: 10.1111/apm.13009. PMID: 31697865

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...