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Mosaic pulmonary attenuation pattern

MedGen UID:
1783252
•Concept ID:
C5539665
•
Finding
HPO: HP:0033537

Definition

Mosaic attenuation refers to heterogeneous areas of differing pulmonary attenuation on CT imaging. [from HPO]

Professional guidelines

PubMed

Clinical features of chronic summer-type hypersensitivity pneumonitis and proposition of diagnostic criteria.
Onishi Y, Kawamura T, Higashino T, Kagami R, Hirata N, Miyake K
Respir Investig 2020 Jan;58(1):59-67. Epub 2019 Oct 12 doi: 10.1016/j.resinv.2019.09.003. PMID: 31615746
Differential diagnosis of pulmonary infections in immunocompromised patients using high-resolution computed tomography.
Kunihiro Y, Tanaka N, Kawano R, Yujiri T, Kubo M, Ueda K, Gondo T, Kobayashi T, Matsumoto T
Eur Radiol 2019 Nov;29(11):6089-6099. Epub 2019 May 6 doi: 10.1007/s00330-019-06235-3. PMID: 31062135
HRCT findings in the lungs of primary care patients with lower respiratory tract infection.
Lähde S, Jartti A, Broas M, Koivisto M, Syrjälä H
Acta Radiol 2002 Mar;43(2):159-63. doi: 10.1080/028418502127347673. PMID: 12010295

Recent clinical studies

Etiology

HRCT findings in secondhand smokers with respiratory symptoms.
Detorakis EE, Lasithiotaki I, Dailiani K, Raissaki M
Jpn J Radiol 2023 Feb;41(2):153-163. Epub 2022 Sep 19 doi: 10.1007/s11604-022-01336-4. PMID: 36121625
Hypersensitivity pneumonitis: Airway-centered pulmonary fibrosis on chest CT.
Capaccione KM, Austin JHM, Saqi A, Patel N, Padilla M, Salvatore MM
Respir Investig 2021 Nov;59(6):845-848. Epub 2021 Aug 6 doi: 10.1016/j.resinv.2021.06.011. PMID: 34373236
Pulmonary interstitial glycogenosis - A systematic analysis of new cases.
Seidl E, Carlens J, Reu S, Wetzke M, Ley-Zaporozhan J, Brasch F, Wesselak T, Schams A, Rauch D, Schuch L, Kappler M, Schelstraete P, Wolf M, Stehling F, Haarmann E, Borensztajn D, van de Loo M, Rubak S, Lex C, Hinrichs B, Reiter K, Schwerk N, Griese M
Respir Med 2018 Jul;140:11-20. Epub 2018 May 17 doi: 10.1016/j.rmed.2018.05.009. PMID: 29957271
Mosaic Attenuation: Etiology, Methods of Differentiation, and Pitfalls.
Kligerman SJ, Henry T, Lin CT, Franks TJ, Galvin JR
Radiographics 2015 Sep-Oct;35(5):1360-80. Epub 2015 Aug 14 doi: 10.1148/rg.2015140308. PMID: 26274445
Parenchymal and pleural abnormalities in children with and without pulmonary embolism at MDCT pulmonary angiography.
Lee EY, Zurakowski D, Diperna S, d'Almeida Bastos M, Strauss KJ, Boiselle PM
Pediatr Radiol 2010 Feb;40(2):173-81. Epub 2009 Oct 22 doi: 10.1007/s00247-009-1418-z. PMID: 19847415

Diagnosis

Mosaic Attenuation Pattern: A Guide to Analysis with HRCT.
Lee GM, Carroll MB, Galvin JR, Walker CM
Radiol Clin North Am 2022 Nov;60(6):963-978. Epub 2022 Sep 3 doi: 10.1016/j.rcl.2022.06.009. PMID: 36202482
Overview and Challenges of Bronchiolar Disorders.
Swaminathan AC, Carney JM, Tailor TD, Palmer SM
Ann Am Thorac Soc 2020 Mar;17(3):253-263. doi: 10.1513/AnnalsATS.201907-569CME. PMID: 31860801
Mosaic Attenuation: Etiology, Methods of Differentiation, and Pitfalls.
Kligerman SJ, Henry T, Lin CT, Franks TJ, Galvin JR
Radiographics 2015 Sep-Oct;35(5):1360-80. Epub 2015 Aug 14 doi: 10.1148/rg.2015140308. PMID: 26274445
Radiologic and pathologic features of bronchiolitis.
Pipavath SJ, Lynch DA, Cool C, Brown KK, Newell JD
AJR Am J Roentgenol 2005 Aug;185(2):354-63. doi: 10.2214/ajr.185.2.01850354. PMID: 16037505
The radiological spectrum of small-airway diseases.
Sharma V, Shaaban AM, Berges G, Gosselin M
Semin Ultrasound CT MR 2002 Aug;23(4):339-51. doi: 10.1016/s0887-2171(02)90021-1. PMID: 12465689

Therapy

HRCT findings in secondhand smokers with respiratory symptoms.
Detorakis EE, Lasithiotaki I, Dailiani K, Raissaki M
Jpn J Radiol 2023 Feb;41(2):153-163. Epub 2022 Sep 19 doi: 10.1007/s11604-022-01336-4. PMID: 36121625
Pulmonary interstitial glycogenosis - A systematic analysis of new cases.
Seidl E, Carlens J, Reu S, Wetzke M, Ley-Zaporozhan J, Brasch F, Wesselak T, Schams A, Rauch D, Schuch L, Kappler M, Schelstraete P, Wolf M, Stehling F, Haarmann E, Borensztajn D, van de Loo M, Rubak S, Lex C, Hinrichs B, Reiter K, Schwerk N, Griese M
Respir Med 2018 Jul;140:11-20. Epub 2018 May 17 doi: 10.1016/j.rmed.2018.05.009. PMID: 29957271
The "Complex Restrictive" Pulmonary Function Pattern: Clinical and Radiologic Analysis of a Common but Previously Undescribed Restrictive Pattern.
Clay RD, Iyer VN, Reddy DR, Siontis B, Scanlon PD
Chest 2017 Dec;152(6):1258-1265. Epub 2017 Jul 17 doi: 10.1016/j.chest.2017.07.009. PMID: 28728932
Parenchymal and pleural abnormalities in children with and without pulmonary embolism at MDCT pulmonary angiography.
Lee EY, Zurakowski D, Diperna S, d'Almeida Bastos M, Strauss KJ, Boiselle PM
Pediatr Radiol 2010 Feb;40(2):173-81. Epub 2009 Oct 22 doi: 10.1007/s00247-009-1418-z. PMID: 19847415
Clinical spectrum of adult chronic bronchiolitis.
Poletti V, Zompatori M, Cancellieri A
Sarcoidosis Vasc Diffuse Lung Dis 1999 Sep;16(2):183-96. PMID: 10560122

Prognosis

Mosaic attenuation in non-fibrotic areas as a predictor of non-usual interstitial pneumonia pathologic diagnosis.
Gayá García-Manso I, Arenas-Jiménez J, García-Sevila R, Ruiz-Alcaraz S, Sirera-Matilla M, García-Garrigós E, Martínez-García MÁ, Hernández-Blasco L
Sci Rep 2022 May 4;12(1):7289. doi: 10.1038/s41598-022-10750-7. PMID: 35508493Free PMC Article
The "Complex Restrictive" Pulmonary Function Pattern: Clinical and Radiologic Analysis of a Common but Previously Undescribed Restrictive Pattern.
Clay RD, Iyer VN, Reddy DR, Siontis B, Scanlon PD
Chest 2017 Dec;152(6):1258-1265. Epub 2017 Jul 17 doi: 10.1016/j.chest.2017.07.009. PMID: 28728932
Presence of Air Trapping and Mosaic Attenuation on Chest Computed Tomography Predicts Survival in Chronic Hypersensitivity Pneumonitis.
Chung JH, Zhan X, Cao M, Koelsch TL, Manjarres DCG, Brown KK, Lynch DA, Russell G, Fernández Pérez ER
Ann Am Thorac Soc 2017 Oct;14(10):1533-1538. doi: 10.1513/AnnalsATS.201701-035OC. PMID: 28513215
Pulmonary sarcoidosis: typical and atypical manifestations at high-resolution CT with pathologic correlation.
Criado E, Sánchez M, Ramírez J, Arguis P, de Caralt TM, Perea RJ, Xaubet A
Radiographics 2010 Oct;30(6):1567-86. doi: 10.1148/rg.306105512. PMID: 21071376
Parenchymal and pleural abnormalities in children with and without pulmonary embolism at MDCT pulmonary angiography.
Lee EY, Zurakowski D, Diperna S, d'Almeida Bastos M, Strauss KJ, Boiselle PM
Pediatr Radiol 2010 Feb;40(2):173-81. Epub 2009 Oct 22 doi: 10.1007/s00247-009-1418-z. PMID: 19847415

Clinical prediction guides

Incidental pulmonary nodules in children: characteristic features and clinical course.
Başaran A, Başaran AE, Keven A, Elmalı A, Durmuş SY, Kazlı T, Kocacık-Uygun DF, Bingöl A
Turk J Pediatr 2022;64(3):466-473. doi: 10.24953/turkjped.2021.4858. PMID: 35899559
Mosaic attenuation in non-fibrotic areas as a predictor of non-usual interstitial pneumonia pathologic diagnosis.
Gayá García-Manso I, Arenas-Jiménez J, García-Sevila R, Ruiz-Alcaraz S, Sirera-Matilla M, García-Garrigós E, Martínez-García MÁ, Hernández-Blasco L
Sci Rep 2022 May 4;12(1):7289. doi: 10.1038/s41598-022-10750-7. PMID: 35508493Free PMC Article
Clinical impact of the radiological indeterminate for usual interstitial pneumonia pattern on the diagnosis of idiopathic pulmonary fibrosis.
Inomata M, Jo T, Kuse N, Awano N, Tone M, Yoshimura H, Moriya A, Bae Y, Terada Y, Furuhata Y, Kumasaka T, Ushiwata A, Harada A, Terasaki Y, Takeuchi M, Sugiura H, Takemura T, Izumo T
Respir Investig 2021 Jan;59(1):81-89. Epub 2020 Aug 28 doi: 10.1016/j.resinv.2020.07.001. PMID: 32868263
Parenchymal and pleural abnormalities in children with and without pulmonary embolism at MDCT pulmonary angiography.
Lee EY, Zurakowski D, Diperna S, d'Almeida Bastos M, Strauss KJ, Boiselle PM
Pediatr Radiol 2010 Feb;40(2):173-81. Epub 2009 Oct 22 doi: 10.1007/s00247-009-1418-z. PMID: 19847415
CT mosaic pattern of lung attenuation: distinguishing different causes.
Stern EJ, Swensen SJ, Hartman TE, Frank MS
AJR Am J Roentgenol 1995 Oct;165(4):813-6. doi: 10.2214/ajr.165.4.7676972. PMID: 7676972

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