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Upper extremity hypokinesia

MedGen UID:
1783260
•Concept ID:
C5539574
•
Finding
Synonym: Hypokinesia of the upper extremities
 
HPO: HP:0033413

Definition

Abnormally diminished movement of the upper extremities. In contrast to paralysis, hypokinesia is not characterized by a lack of motor strength, but rather by a poverty of movement. The typical habitual movements (e.g., folding the arms, crossing the legs) are reduced in frequency. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUpper extremity hypokinesia

Recent clinical studies

Etiology

Ultrasound-based motion analysis demonstrates bilateral arm hypokinesia during gait in heterozygous PINK1 mutation carriers.
Nürnberger L, Klein C, Baudrexel S, Roggendorf J, Hildner M, Chen S, Kang JS, Hilker R, Hagenah J
Mov Disord 2015 Mar;30(3):386-92. Epub 2014 Dec 27 doi: 10.1002/mds.26127. PMID: 25545816
Effects of deep brain stimulation frequency on bradykinesia of Parkinson's disease.
Huang H, Watts RL, Montgomery EB Jr
Mov Disord 2014 Feb;29(2):203-6. Epub 2014 Jan 2 doi: 10.1002/mds.25773. PMID: 24395752
Motor control in complex regional pain syndrome: a kinematic analysis.
Schilder JCM, Schouten AC, Perez RSGM, Huygen FJPM, Dahan A, Noldus LPJJ, van Hilten JJ, Marinus J
Pain 2012 Apr;153(4):805-812. Epub 2012 Feb 14 doi: 10.1016/j.pain.2011.12.018. PMID: 22336720
Bradykinesia in patients with essential tremor.
Duval C, Sadikot AF, Panisset M
Brain Res 2006 Oct 18;1115(1):213-6. Epub 2006 Aug 22 doi: 10.1016/j.brainres.2006.07.066. PMID: 16920079
Control of movement distance in Parkinson's disease.
Pfann KD, Buchman AS, Comella CL, Corcos DM
Mov Disord 2001 Nov;16(6):1048-65. doi: 10.1002/mds.1220. PMID: 11748736

Diagnosis

Quantitative Assessment of Motor Neglect.
Toba MN, Pagliari C, Rabuffetti M, Nighoghossian N, Rode G, Cotton F, Spinazzola L, Baglio F, Migliaccio R, Bartolomeo P
Stroke 2021 May;52(5):1618-1627. Epub 2021 Mar 4 doi: 10.1161/STROKEAHA.120.031949. PMID: 33657852
Ultrasound-based motion analysis demonstrates bilateral arm hypokinesia during gait in heterozygous PINK1 mutation carriers.
Nürnberger L, Klein C, Baudrexel S, Roggendorf J, Hildner M, Chen S, Kang JS, Hilker R, Hagenah J
Mov Disord 2015 Mar;30(3):386-92. Epub 2014 Dec 27 doi: 10.1002/mds.26127. PMID: 25545816
Parkinson's disease is associated with greater regularity of repetitive voluntary movements.
Powell DW, Muthumani A, Xia R
Motor Control 2014 Jul;18(3):263-77. Epub 2014 Jan 21 doi: 10.1123/mc.2013-0025. PMID: 24457290
Parkinsonism mimicking rheumatoid arthritis.
Padhan P, Danda D
J Rheumatol 2010 Jun;37(6):1266. doi: 10.3899/jrheum.091473. PMID: 20516037
Bradykinesia in patients with essential tremor.
Duval C, Sadikot AF, Panisset M
Brain Res 2006 Oct 18;1115(1):213-6. Epub 2006 Aug 22 doi: 10.1016/j.brainres.2006.07.066. PMID: 16920079

Therapy

Quantitative Assessment of Motor Neglect.
Toba MN, Pagliari C, Rabuffetti M, Nighoghossian N, Rode G, Cotton F, Spinazzola L, Baglio F, Migliaccio R, Bartolomeo P
Stroke 2021 May;52(5):1618-1627. Epub 2021 Mar 4 doi: 10.1161/STROKEAHA.120.031949. PMID: 33657852
High-frequency peripheral vibration decreases completion time on a number of motor tasks.
Macerollo A, Palmer C, Foltynie T, Korlipara P, Limousin P, Edwards M, Kilner JM
Eur J Neurosci 2018 Jul;48(2):1789-1802. doi: 10.1111/ejn.14050. PMID: 29923362Free PMC Article
Parkinson's disease is associated with greater regularity of repetitive voluntary movements.
Powell DW, Muthumani A, Xia R
Motor Control 2014 Jul;18(3):263-77. Epub 2014 Jan 21 doi: 10.1123/mc.2013-0025. PMID: 24457290
Impact of subthalamic stimulation and medication on proximal and distal bradykinesia in Parkinson's disease.
Potter-Nerger M, Wenzelburger R, Deuschl G, Volkmann J
Eur Neurol 2009;62(2):114-9. Epub 2009 Jun 12 doi: 10.1159/000222783. PMID: 19521088
Congruent unilateral impairments for real and imagined hand movements.
Sirigu A, Cohen L, Duhamel JR, Pillon B, Dubois B, Agid Y, Pierrot-Deseilligny C
Neuroreport 1995 May 9;6(7):997-1001. doi: 10.1097/00001756-199505090-00012. PMID: 7632907

Prognosis

Characterizing Disease Progression in Parkinson's Disease from Videos of the Finger Tapping Test.
Guarin DL, Wong JK, McFarland NR, Ramirez-Zamora A
IEEE Trans Neural Syst Rehabil Eng 2024;32:2293-2301. Epub 2024 Jun 26 doi: 10.1109/TNSRE.2024.3416446. PMID: 38905096Free PMC Article
Time-resolved quantification of fine hand movements as a proxy for evaluating bradykinesia-induced motor dysfunction.
Spooner RK, Bahners BH, Schnitzler A, Florin E
Sci Rep 2024 Mar 4;14(1):5340. doi: 10.1038/s41598-024-55862-4. PMID: 38438484Free PMC Article
High-frequency peripheral vibration decreases completion time on a number of motor tasks.
Macerollo A, Palmer C, Foltynie T, Korlipara P, Limousin P, Edwards M, Kilner JM
Eur J Neurosci 2018 Jul;48(2):1789-1802. doi: 10.1111/ejn.14050. PMID: 29923362Free PMC Article
Quantification assessment of bradykinesia in Parkinson's disease based on a wearable device.
Zhirong Lin, Houde Dai, Yongsheng Xiong, Xuke Xia, Shi-Jinn Horng
Annu Int Conf IEEE Eng Med Biol Soc 2017 Jul;2017:803-806. doi: 10.1109/EMBC.2017.8036946. PMID: 29059994
Bradykinesia in patients with essential tremor.
Duval C, Sadikot AF, Panisset M
Brain Res 2006 Oct 18;1115(1):213-6. Epub 2006 Aug 22 doi: 10.1016/j.brainres.2006.07.066. PMID: 16920079

Clinical prediction guides

Time-resolved quantification of fine hand movements as a proxy for evaluating bradykinesia-induced motor dysfunction.
Spooner RK, Bahners BH, Schnitzler A, Florin E
Sci Rep 2024 Mar 4;14(1):5340. doi: 10.1038/s41598-024-55862-4. PMID: 38438484Free PMC Article
Characterization and localization of upper and lower extremity motor improvements in STN DBS for Parkinson's disease.
Askari A, Zhu BJ, Lyu X, Chou KL, Patil PG
Parkinsonism Relat Disord 2022 Jan;94:84-88. Epub 2021 Dec 2 doi: 10.1016/j.parkreldis.2021.11.036. PMID: 34896928
Quantitative Assessment of Motor Neglect.
Toba MN, Pagliari C, Rabuffetti M, Nighoghossian N, Rode G, Cotton F, Spinazzola L, Baglio F, Migliaccio R, Bartolomeo P
Stroke 2021 May;52(5):1618-1627. Epub 2021 Mar 4 doi: 10.1161/STROKEAHA.120.031949. PMID: 33657852
Quantification assessment of bradykinesia in Parkinson's disease based on a wearable device.
Zhirong Lin, Houde Dai, Yongsheng Xiong, Xuke Xia, Shi-Jinn Horng
Annu Int Conf IEEE Eng Med Biol Soc 2017 Jul;2017:803-806. doi: 10.1109/EMBC.2017.8036946. PMID: 29059994
Bradykinesia in patients with essential tremor.
Duval C, Sadikot AF, Panisset M
Brain Res 2006 Oct 18;1115(1):213-6. Epub 2006 Aug 22 doi: 10.1016/j.brainres.2006.07.066. PMID: 16920079

Recent systematic reviews

Smartphone-Based Hand Function Assessment: Systematic Review.
Fu Y, Zhang Y, Ye B, Babineau J, Zhao Y, Gao Z, Mihailidis A
J Med Internet Res 2024 Sep 16;26:e51564. doi: 10.2196/51564. PMID: 39283676Free PMC Article
Clinical assessment of upper limb impairments and functional capacity in Parkinson's disease: a systematic review.
Capato TTC, Rodrigues R, Cury RG, Teixeira MJ, Barbosa ER
Arq Neuropsiquiatr 2023 Nov;81(11):1008-1015. Epub 2023 Oct 29 doi: 10.1055/s-0043-1772769. PMID: 37899049Free PMC Article

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