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Low-grade vesicoureteral reflux

MedGen UID:
1784267
•Concept ID:
C5539784
•
Disease or Syndrome
HPO: HP:0033733

Definition

Vesicoureteral reflux without dilation of the renal calyces (Grade I-II). [from HPO]

Professional guidelines

PubMed

Prospective study using a new bulking agent for the treatment of vesicoureteral reflux: polyacrylamide hydrogel.
Cloutier J, Blais AS, Moore K, Bolduc S
J Urol 2013 Sep;190(3):1034-7. Epub 2013 Mar 26 doi: 10.1016/j.juro.2013.03.071. PMID: 23538241
Endoscopic management of adult orthotopic ureterocele and associated calculi with holmium laser: experience with 16 patients over 4 years and review of literature.
Shah HN, Sodha H, Khandkar AA, Kharodawala S, Hegde SS, Bansal M
J Endourol 2008 Mar;22(3):489-96. doi: 10.1089/end.2007.0312. PMID: 18271717
Vesicoureteral reflux in children with myelodysplasia: natural history and results of treatment.
Sidi AA, Peng W, Gonzalez R
J Urol 1986 Jul;136(1 Pt 2):329-31. doi: 10.1016/s0022-5347(17)44856-7. PMID: 3723683

Recent clinical studies

Etiology

Comparative study of open, laparoscopic and endoscopic treatments of intermediate grade vesicoureteral reflux in children.
Tessier B, Scalabre A, Harper L, Garnier S, Vermesch S, Lopez C, Cazals A, Fila M, Morin D, Varlet F, Kalfa N
Surg Endosc 2023 Apr;37(4):2682-2687. Epub 2022 Nov 22 doi: 10.1007/s00464-021-08985-y. PMID: 36414870
Pediatric renal abscesses: A contemporary series.
Linder BJ, Granberg CF
J Pediatr Urol 2016 Apr;12(2):99.e1-5. Epub 2015 Sep 16 doi: 10.1016/j.jpurol.2015.05.037. PMID: 26522771
Unilateral ureteral reimplantation and management of contralateral low grade or resolved vesicoureteral reflux.
DeFoor W, Hazelwood L
J Urol 2014 Nov;192(5):1508-12. Epub 2014 May 14 doi: 10.1016/j.juro.2014.05.025. PMID: 24835056
Postoperative cystography and endoscopic treatment of low-grade vesicoureteral reflux.
Harper L, Boutchkova S, Lavrand F, Vergnes P, Semjen F, Dobremez E
J Laparoendosc Adv Surg Tech A 2008 Jun;18(3):461-3. doi: 10.1089/lap.2007.0256. PMID: 18503385
Low-grade vesicoureteral reflux. Variability in grade on sequential radiographic and nuclear cystograms.
Gelfand MJ, Strife JL, Hertzberg VS
Clin Nucl Med 1991 Apr;16(4):243-6. doi: 10.1097/00003072-199104000-00007. PMID: 2044317

Diagnosis

Pediatric renal abscesses: A contemporary series.
Linder BJ, Granberg CF
J Pediatr Urol 2016 Apr;12(2):99.e1-5. Epub 2015 Sep 16 doi: 10.1016/j.jpurol.2015.05.037. PMID: 26522771
Abnormal renal scans and decreased early resolution of low grade vesicoureteral reflux.
Nepple KG, Knudson MJ, Austin JC, Cooper CS
J Urol 2008 Oct;180(4 Suppl):1643-7; discussion 1647. Epub 2008 Aug 20 doi: 10.1016/j.juro.2008.03.102. PMID: 18715588
Postoperative cystography and endoscopic treatment of low-grade vesicoureteral reflux.
Harper L, Boutchkova S, Lavrand F, Vergnes P, Semjen F, Dobremez E
J Laparoendosc Adv Surg Tech A 2008 Jun;18(3):461-3. doi: 10.1089/lap.2007.0256. PMID: 18503385
Detection of low-grade vesicoureteral reflux in children by color Doppler imaging mode.
Haberlik A
Pediatr Surg Int 1997;12(1):38-43. doi: 10.1007/BF01194800. PMID: 9035208
Followup of conservatively treated children with high and low grade vesicoureteral reflux: a prospective study.
Goldraich NP, Goldraich IH
J Urol 1992 Nov;148(5 Pt 2):1688-92. doi: 10.1016/s0022-5347(17)37003-9. PMID: 1433589

Therapy

Pediatric renal abscesses: A contemporary series.
Linder BJ, Granberg CF
J Pediatr Urol 2016 Apr;12(2):99.e1-5. Epub 2015 Sep 16 doi: 10.1016/j.jpurol.2015.05.037. PMID: 26522771
Unilateral ureteral reimplantation and management of contralateral low grade or resolved vesicoureteral reflux.
DeFoor W, Hazelwood L
J Urol 2014 Nov;192(5):1508-12. Epub 2014 May 14 doi: 10.1016/j.juro.2014.05.025. PMID: 24835056
Postoperative cystography and endoscopic treatment of low-grade vesicoureteral reflux.
Harper L, Boutchkova S, Lavrand F, Vergnes P, Semjen F, Dobremez E
J Laparoendosc Adv Surg Tech A 2008 Jun;18(3):461-3. doi: 10.1089/lap.2007.0256. PMID: 18503385
Endoscopic management of adult orthotopic ureterocele and associated calculi with holmium laser: experience with 16 patients over 4 years and review of literature.
Shah HN, Sodha H, Khandkar AA, Kharodawala S, Hegde SS, Bansal M
J Endourol 2008 Mar;22(3):489-96. doi: 10.1089/end.2007.0312. PMID: 18271717
Vesicoureteral reflux in children with myelodysplasia: natural history and results of treatment.
Sidi AA, Peng W, Gonzalez R
J Urol 1986 Jul;136(1 Pt 2):329-31. doi: 10.1016/s0022-5347(17)44856-7. PMID: 3723683

Prognosis

Unilateral ureteral reimplantation and management of contralateral low grade or resolved vesicoureteral reflux.
DeFoor W, Hazelwood L
J Urol 2014 Nov;192(5):1508-12. Epub 2014 May 14 doi: 10.1016/j.juro.2014.05.025. PMID: 24835056
Abnormal renal scans and decreased early resolution of low grade vesicoureteral reflux.
Nepple KG, Knudson MJ, Austin JC, Cooper CS
J Urol 2008 Oct;180(4 Suppl):1643-7; discussion 1647. Epub 2008 Aug 20 doi: 10.1016/j.juro.2008.03.102. PMID: 18715588
Detection of low-grade vesicoureteral reflux in children by color Doppler imaging mode.
Haberlik A
Pediatr Surg Int 1997;12(1):38-43. doi: 10.1007/BF01194800. PMID: 9035208
Followup of conservatively treated children with high and low grade vesicoureteral reflux: a prospective study.
Goldraich NP, Goldraich IH
J Urol 1992 Nov;148(5 Pt 2):1688-92. doi: 10.1016/s0022-5347(17)37003-9. PMID: 1433589
Low-grade vesicoureteral reflux. Variability in grade on sequential radiographic and nuclear cystograms.
Gelfand MJ, Strife JL, Hertzberg VS
Clin Nucl Med 1991 Apr;16(4):243-6. doi: 10.1097/00003072-199104000-00007. PMID: 2044317

Clinical prediction guides

Long-term Outcomes of Endoscopic Anti-reflux Surgery in Pediatric Patients with Vesicoureteral Reflux: Urinary Tract Infection, Renal Scarring, and Predictive Factors for Success.
Choi W, Nam W, Lee C, Han JH, Shin JH, Kim KS, Song SH
J Korean Med Sci 2018 Sep 17;33(38):e240. Epub 2018 Aug 8 doi: 10.3346/jkms.2018.33.e240. PMID: 30224908Free PMC Article
Unilateral ureteral reimplantation and management of contralateral low grade or resolved vesicoureteral reflux.
DeFoor W, Hazelwood L
J Urol 2014 Nov;192(5):1508-12. Epub 2014 May 14 doi: 10.1016/j.juro.2014.05.025. PMID: 24835056
Abnormal renal scans and decreased early resolution of low grade vesicoureteral reflux.
Nepple KG, Knudson MJ, Austin JC, Cooper CS
J Urol 2008 Oct;180(4 Suppl):1643-7; discussion 1647. Epub 2008 Aug 20 doi: 10.1016/j.juro.2008.03.102. PMID: 18715588
Detection of low-grade vesicoureteral reflux in children by color Doppler imaging mode.
Haberlik A
Pediatr Surg Int 1997;12(1):38-43. doi: 10.1007/BF01194800. PMID: 9035208
Antibody to Tamm-Horsfall protein in patients with urinary tract obstruction and vesicoureteral reflux.
Marier R, Fong E, Jansen M, Hodson CJ, Richards F, Andriole VT
J Infect Dis 1978 Dec;138(6):781-90. doi: 10.1093/infdis/138.6.781. PMID: 739157

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