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Abnormal urine metabolite level

MedGen UID:
1785188
•Concept ID:
C5539535
•
Finding
HPO: HP:0033354

Definition

Any deviation from the normal amount of a metabolite in urine. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal urine metabolite level

Professional guidelines

PubMed

Preconception exposure to environmental antibiotics among childbearing couples in Anhui and health risk assessment: A multicenter population-based representative study.
Wang B, Geng M, Li M, Wang X, Gan H, Tang Y, Yang Q, Liu Y, Yang X, Wang S, Liu K, Wei Z, Shao S, Zhu P, Cao Y, Tao F
Ecotoxicol Environ Saf 2023 Oct 15;265:115514. Epub 2023 Sep 30 doi: 10.1016/j.ecoenv.2023.115514. PMID: 37783111
Cerebral creatine deficiency syndromes: clinical aspects, treatment and pathophysiology.
Stockler S, Schutz PW, Salomons GS
Subcell Biochem 2007;46:149-66. doi: 10.1007/978-1-4020-6486-9_8. PMID: 18652076
Catecholamine phenotyping: clues to the diagnosis, treatment, and pathophysiology of neurogenetic disorders.
Goldstein DS, Lenders JW, Kaler SG, Eisenhofer G
J Neurochem 1996 Nov;67(5):1781-90. doi: 10.1046/j.1471-4159.1996.67051781.x. PMID: 8863481

Recent clinical studies

Etiology

Association between nocturnal light exposure and melatonin in humans: a meta-analysis.
Lu J, Zou R, Yang Y, Bai X, Wei W, Ding R, Hua X
Environ Sci Pollut Res Int 2024 Jan;31(3):3425-3434. Epub 2023 Dec 20 doi: 10.1007/s11356-023-31502-8. PMID: 38123771
Organophosphate Flame Retardants in Pregnant Women: Sources, Occurrence, and Potential Risks to Pregnancy Outcomes.
Li Y, Wang X, Zhu Q, Xu Y, Fu Q, Wang T, Liao C, Jiang G
Environ Sci Technol 2023 May 9;57(18):7109-7128. Epub 2023 Apr 20 doi: 10.1021/acs.est.2c06503. PMID: 37079500
Sex Hormone Metabolism and Threatened Abortion.
Xu Q, Chen J, Wei Z, Brandon TR, Zava DT, Shi YE, Cao Y
Med Sci Monit 2017 Oct 23;23:5041-5048. doi: 10.12659/msm.904500. PMID: 29056745Free PMC Article
Cryptorchidism and pesticides: Is there a connection?
Fratrić I, Varga J, Vukmirović S, Sudji J, Živković D
J Pediatr Surg 2017 Jul;52(7):1166-1168. Epub 2016 Dec 7 doi: 10.1016/j.jpedsurg.2016.11.048. PMID: 27956069
Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children.
Zhang C, Yin A, Li H, Wang R, Wu G, Shen J, Zhang M, Wang L, Hou Y, Ouyang H, Zhang Y, Zheng Y, Wang J, Lv X, Wang Y, Zhang F, Zeng B, Li W, Yan F, Zhao Y, Pang X, Zhang X, Fu H, Chen F, Zhao N, Hamaker BR, Bridgewater LC, Weinkove D, Clement K, Dore J, Holmes E, Xiao H, Zhao G, Yang S, Bork P, Nicholson JK, Wei H, Tang H, Zhang X, Zhao L
EBioMedicine 2015 Aug;2(8):968-84. Epub 2015 Jul 10 doi: 10.1016/j.ebiom.2015.07.007. PMID: 26425705Free PMC Article

Diagnosis

Laboratory and metabolic investigations.
Morava E, Oglesbee D
Handb Clin Neurol 2023;194:167-172. doi: 10.1016/B978-0-12-821751-1.00012-9. PMID: 36813311
Apparent mineralocorticoid excess.
Funder JW
J Steroid Biochem Mol Biol 2017 Jan;165(Pt A):151-153. Epub 2016 Mar 5 doi: 10.1016/j.jsbmb.2016.03.010. PMID: 26956190
The important role of biochemical and functional studies in the diagnostics of peroxisomal disorders.
Ferdinandusse S, Ebberink MS, Vaz FM, Waterham HR, Wanders RJ
J Inherit Metab Dis 2016 Jul;39(4):531-43. Epub 2016 Mar 4 doi: 10.1007/s10545-016-9922-4. PMID: 26943801Free PMC Article
Chromatographic techniques coupled with mass spectrometry for the determination of organic acids in the study of autism.
Kałużna-Czaplińska J, Zurawicz E, Jóźwik J
J Chromatogr B Analyt Technol Biomed Life Sci 2014 Aug 1;964:128-35. Epub 2013 Oct 22 doi: 10.1016/j.jchromb.2013.10.026. PMID: 24210941
Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma.
Chen T, Xie G, Wang X, Fan J, Qiu Y, Zheng X, Qi X, Cao Y, Su M, Wang X, Xu LX, Yen Y, Liu P, Jia W
Mol Cell Proteomics 2011 Jul;10(7):M110.004945. Epub 2011 Apr 25 doi: 10.1074/mcp.M110.004945. PMID: 21518826Free PMC Article

Therapy

Fibroblast Growth Factor 23 and Klotho in AKI.
Christov M, Neyra JA, Gupta S, Leaf DE
Semin Nephrol 2019 Jan;39(1):57-75. doi: 10.1016/j.semnephrol.2018.10.005. PMID: 30606408
Cryptorchidism and pesticides: Is there a connection?
Fratrić I, Varga J, Vukmirović S, Sudji J, Živković D
J Pediatr Surg 2017 Jul;52(7):1166-1168. Epub 2016 Dec 7 doi: 10.1016/j.jpedsurg.2016.11.048. PMID: 27956069
Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children.
Zhang C, Yin A, Li H, Wang R, Wu G, Shen J, Zhang M, Wang L, Hou Y, Ouyang H, Zhang Y, Zheng Y, Wang J, Lv X, Wang Y, Zhang F, Zeng B, Li W, Yan F, Zhao Y, Pang X, Zhang X, Fu H, Chen F, Zhao N, Hamaker BR, Bridgewater LC, Weinkove D, Clement K, Dore J, Holmes E, Xiao H, Zhao G, Yang S, Bork P, Nicholson JK, Wei H, Tang H, Zhang X, Zhao L
EBioMedicine 2015 Aug;2(8):968-84. Epub 2015 Jul 10 doi: 10.1016/j.ebiom.2015.07.007. PMID: 26425705Free PMC Article
The physiology and pharmacology of melatonin in humans.
Geoffriau M, Brun J, Chazot G, Claustrat B
Horm Res 1998;49(3-4):136-41. doi: 10.1159/000023160. PMID: 9550114
Biogenic amines and affective disorders. A critical analysis.
Luchins D
Int Pharmacopsychiatry 1976;11(3):135-49. doi: 10.1159/000468223. PMID: 136425

Prognosis

Urinary Metabolite Profile Predicting the Progression of CKD.
Kim Y, Lee J, Kang MS, Song J, Kim SG, Cho S, Huh H, Lee S, Park S, Jo HA, Yang SH, Paek JH, Park WY, Han SS, Lee H, Lee JP, Joo KW, Lim CS, Hwang GS, Kim DK
Kidney360 2023 Aug 1;4(8):1048-1057. Epub 2023 Jun 9 doi: 10.34067/KID.0000000000000158. PMID: 37291728Free PMC Article
Organophosphate Flame Retardants in Pregnant Women: Sources, Occurrence, and Potential Risks to Pregnancy Outcomes.
Li Y, Wang X, Zhu Q, Xu Y, Fu Q, Wang T, Liao C, Jiang G
Environ Sci Technol 2023 May 9;57(18):7109-7128. Epub 2023 Apr 20 doi: 10.1021/acs.est.2c06503. PMID: 37079500
Fibroblast Growth Factor 23 and Klotho in AKI.
Christov M, Neyra JA, Gupta S, Leaf DE
Semin Nephrol 2019 Jan;39(1):57-75. doi: 10.1016/j.semnephrol.2018.10.005. PMID: 30606408
Cryptorchidism and pesticides: Is there a connection?
Fratrić I, Varga J, Vukmirović S, Sudji J, Živković D
J Pediatr Surg 2017 Jul;52(7):1166-1168. Epub 2016 Dec 7 doi: 10.1016/j.jpedsurg.2016.11.048. PMID: 27956069
Chromatographic techniques coupled with mass spectrometry for the determination of organic acids in the study of autism.
Kałużna-Czaplińska J, Zurawicz E, Jóźwik J
J Chromatogr B Analyt Technol Biomed Life Sci 2014 Aug 1;964:128-35. Epub 2013 Oct 22 doi: 10.1016/j.jchromb.2013.10.026. PMID: 24210941

Clinical prediction guides

Urinary Metabolite Profile Predicting the Progression of CKD.
Kim Y, Lee J, Kang MS, Song J, Kim SG, Cho S, Huh H, Lee S, Park S, Jo HA, Yang SH, Paek JH, Park WY, Han SS, Lee H, Lee JP, Joo KW, Lim CS, Hwang GS, Kim DK
Kidney360 2023 Aug 1;4(8):1048-1057. Epub 2023 Jun 9 doi: 10.34067/KID.0000000000000158. PMID: 37291728Free PMC Article
Organophosphate Flame Retardants in Pregnant Women: Sources, Occurrence, and Potential Risks to Pregnancy Outcomes.
Li Y, Wang X, Zhu Q, Xu Y, Fu Q, Wang T, Liao C, Jiang G
Environ Sci Technol 2023 May 9;57(18):7109-7128. Epub 2023 Apr 20 doi: 10.1021/acs.est.2c06503. PMID: 37079500
Laboratory and metabolic investigations.
Morava E, Oglesbee D
Handb Clin Neurol 2023;194:167-172. doi: 10.1016/B978-0-12-821751-1.00012-9. PMID: 36813311
Fibroblast Growth Factor 23 and Klotho in AKI.
Christov M, Neyra JA, Gupta S, Leaf DE
Semin Nephrol 2019 Jan;39(1):57-75. doi: 10.1016/j.semnephrol.2018.10.005. PMID: 30606408
Mitochondrial dysfunction in Autism Spectrum Disorder: clinical features and perspectives.
Hollis F, Kanellopoulos AK, Bagni C
Curr Opin Neurobiol 2017 Aug;45:178-187. Epub 2017 Jun 16 doi: 10.1016/j.conb.2017.05.018. PMID: 28628841

Recent systematic reviews

Paediatric obesity: a systematic review and pathway mapping of metabolic alterations underlying early disease processes.
De Spiegeleer M, De Paepe E, Van Meulebroek L, Gies I, De Schepper J, Vanhaecke L
Mol Med 2021 Nov 6;27(1):145. doi: 10.1186/s10020-021-00394-0. PMID: 34742239Free PMC Article
Association between prenatal phthalate exposure and gestational metabolic syndrome parameters: a systematic review of epidemiological studies.
Gao H, Zhang C, Tao FB
Environ Sci Pollut Res Int 2021 May;28(17):20921-20938. Epub 2021 Mar 5 doi: 10.1007/s11356-021-13120-4. PMID: 33674970
Metabolomic Analysis in Inflammatory Bowel Disease: A Systematic Review.
Gallagher K, Catesson A, Griffin JL, Holmes E, Williams HRT
J Crohns Colitis 2021 May 4;15(5):813-826. doi: 10.1093/ecco-jcc/jjaa227. PMID: 33175138

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