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Primary vesicoureteral reflux

MedGen UID:
1788979
•Concept ID:
C5539786
•
Disease or Syndrome
Synonyms: Primary Vesicoureteral Reflux; Reflux, Primary Vesicoureteral; Vesicoureteral Reflux, Primary
 
HPO: HP:0033738

Definition

Vesicoureteral reflux due to abnormalities in ureterovesical junction, e.g. ectopic insertion of the ureter or short intravesical tunnel at the ureterovesical junction. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary vesicoureteral reflux

Professional guidelines

PubMed

Commentary to "The correlation between ureteric orifice morphology and primary vesicoureteral reflux grade and the impact on the effectiveness of endoscopic reflux correction".
Weinstein C, Kirsch A
J Pediatr Urol 2024 Apr;20(2):303-304. Epub 2023 Nov 28 doi: 10.1016/j.jpurol.2023.11.050. PMID: 38065758
Endoscopic treatment of primary vesicoureteral reflux.
Diamond DA, Mattoo TK
N Engl J Med 2012 Mar 29;366(13):1218-26. doi: 10.1056/NEJMct1108922. PMID: 22455416
Medical versus surgical treatment of primary vesicoureteral reflux: report of the International Reflux Study Committee.
Pediatrics 1981 Mar;67(3):392-400. PMID: 7017578

Recent clinical studies

Etiology

Primary vesicoureteral reflux.
Puri P, Friedmacher F, Farrugia MK, Sharma S, Esposito C, Mattoo TK
Nat Rev Dis Primers 2024 Oct 10;10(1):75. doi: 10.1038/s41572-024-00560-8. PMID: 39389958
Primary Vesicoureteral Reflux and Renal Scarring.
Mattoo TK, Mohammad D
Pediatr Clin North Am 2022 Dec;69(6):1115-1129. Epub 2022 Oct 29 doi: 10.1016/j.pcl.2022.07.007. PMID: 36880925
Armamentarium to treat primary vesicoureteral reflux in children.
Arlen AM, Kirsch AJ
Semin Pediatr Surg 2021 Aug;30(4):151086. Epub 2021 Jul 15 doi: 10.1016/j.sempedsurg.2021.151086. PMID: 34412883
Incidence of primary vesicoureteral reflux in patients with febrile convulsions.
Elmacı AM, Dönmez Mİ, Emiroğlu M
Neurol Sci 2020 Mar;41(3):687-689. Epub 2019 Nov 11 doi: 10.1007/s10072-019-04132-7. PMID: 31713190
Medical versus surgical treatment of primary vesicoureteral reflux: report of the International Reflux Study Committee.
Pediatrics 1981 Mar;67(3):392-400. PMID: 7017578

Diagnosis

Primary vesicoureteral reflux.
Puri P, Friedmacher F, Farrugia MK, Sharma S, Esposito C, Mattoo TK
Nat Rev Dis Primers 2024 Oct 10;10(1):75. doi: 10.1038/s41572-024-00560-8. PMID: 39389958
Primary Vesicoureteral Reflux and Renal Scarring.
Mattoo TK, Mohammad D
Pediatr Clin North Am 2022 Dec;69(6):1115-1129. Epub 2022 Oct 29 doi: 10.1016/j.pcl.2022.07.007. PMID: 36880925
Armamentarium to treat primary vesicoureteral reflux in children.
Arlen AM, Kirsch AJ
Semin Pediatr Surg 2021 Aug;30(4):151086. Epub 2021 Jul 15 doi: 10.1016/j.sempedsurg.2021.151086. PMID: 34412883
Primary Vesicoureteral reflux and chronic kidney disease in pediatric population. What we have learnt?
Andrioli V, Regacini R, Aguiar W
Int Braz J Urol 2020 Mar-Apr;46(2):262-268. doi: 10.1590/S1677-5538.IBJU.2020.02.02. PMID: 32022517Free PMC Article
Primary vesicoureteral reflux and end-stage renal disease.
Salvatierra O Jr, Kountz SL, Belzer FO
JAMA 1973 Dec 17;226(12):1454-6. PMID: 4800812

Therapy

Asymmetrical primary vesicoureteral reflux: Which is the best surgical strategy?
Montanaro B, Botto N, Broch A, Vinit N, Blanc T, Lottmann H
J Pediatr Urol 2024 Dec;20(6):1213-1218. Epub 2024 Sep 19 doi: 10.1016/j.jpurol.2024.09.011. PMID: 39358124
Comparison and clinical analysis of antibiotics and endoscopic injection for vesicoureteral reflux in children.
Yang Z, Dai K, Sun X, Tian C, Yuan L, Liu J, Li B, Chung PHY, Wong KKY
Pediatr Surg Int 2024 Jul 12;40(1):184. doi: 10.1007/s00383-024-05780-3. PMID: 38995440Free PMC Article
Primary vesicoureteral reflux; what have we learnt from the recently published randomized, controlled trials?
Garin EH
Pediatr Nephrol 2019 Sep;34(9):1513-1519. Epub 2018 Aug 21 doi: 10.1007/s00467-018-4045-9. PMID: 30132079
Probiotics prophylaxis in infants with primary vesicoureteral reflux.
Lee SJ, Lee JW
Pediatr Nephrol 2015 Apr;30(4):609-13. Epub 2014 Oct 30 doi: 10.1007/s00467-014-2988-z. PMID: 25354903
Medical versus surgical treatment of primary vesicoureteral reflux: a prospective international reflux study in children.
J Urol 1981 Mar;125(3):277-83. doi: 10.1016/s0022-5347(17)55009-0. PMID: 7206072

Prognosis

The Role of Urinary NGAL in the Management of Primary Vesicoureteral Reflux in Children.
Gavrilovici C, Dusa CP, Iliescu Halitchi C, Lupu VV, Spoiala EL, Bogos RA, Mocanu A, Gafencu M, Lupu A, Stoica C, Starcea IM
Int J Mol Sci 2023 Apr 26;24(9) doi: 10.3390/ijms24097904. PMID: 37175609Free PMC Article
Incidence of primary vesicoureteral reflux in patients with febrile convulsions.
Elmacı AM, Dönmez Mİ, Emiroğlu M
Neurol Sci 2020 Mar;41(3):687-689. Epub 2019 Nov 11 doi: 10.1007/s10072-019-04132-7. PMID: 31713190
Vesicoureteral Reflux Index: 2-Institution Analysis and Validation.
Arlen AM, Garcia-Roig M, Weiss AD, Leong T, Cooper CS, Kirsch AJ
J Urol 2016 Apr;195(4 Pt 2):1294-9. Epub 2015 Mar 23 doi: 10.1016/j.juro.2015.03.094. PMID: 25813448
Vesicoureteral reflux and reflux nephropathy.
Mattoo TK
Adv Chronic Kidney Dis 2011 Sep;18(5):348-54. doi: 10.1053/j.ackd.2011.07.006. PMID: 21896376Free PMC Article
Medical versus surgical treatment of primary vesicoureteral reflux: a prospective international reflux study in children.
J Urol 1981 Mar;125(3):277-83. doi: 10.1016/s0022-5347(17)55009-0. PMID: 7206072

Clinical prediction guides

The Role of Urinary NGAL in the Management of Primary Vesicoureteral Reflux in Children.
Gavrilovici C, Dusa CP, Iliescu Halitchi C, Lupu VV, Spoiala EL, Bogos RA, Mocanu A, Gafencu M, Lupu A, Stoica C, Starcea IM
Int J Mol Sci 2023 Apr 26;24(9) doi: 10.3390/ijms24097904. PMID: 37175609Free PMC Article
Armamentarium to treat primary vesicoureteral reflux in children.
Arlen AM, Kirsch AJ
Semin Pediatr Surg 2021 Aug;30(4):151086. Epub 2021 Jul 15 doi: 10.1016/j.sempedsurg.2021.151086. PMID: 34412883
Vesicoureteral Reflux Index: 2-Institution Analysis and Validation.
Arlen AM, Garcia-Roig M, Weiss AD, Leong T, Cooper CS, Kirsch AJ
J Urol 2016 Apr;195(4 Pt 2):1294-9. Epub 2015 Mar 23 doi: 10.1016/j.juro.2015.03.094. PMID: 25813448
Vesicoureteral reflux and reflux nephropathy.
Mattoo TK
Adv Chronic Kidney Dis 2011 Sep;18(5):348-54. doi: 10.1053/j.ackd.2011.07.006. PMID: 21896376Free PMC Article
A recessive gene for primary vesicoureteral reflux maps to chromosome 12p11-q13.
Weng PL, Sanna-Cherchi S, Hensle T, Shapiro E, Werzberger A, Caridi G, Izzi C, Konka A, Reese AC, Cheng R, Werzberger S, Schlussel RN, Burk RD, Lee JH, Ravazzolo R, Scolari F, Ghiggeri GM, Glassberg K, Gharavi AG
J Am Soc Nephrol 2009 Jul;20(7):1633-40. Epub 2009 May 14 doi: 10.1681/ASN.2008111199. PMID: 19443636Free PMC Article

Recent systematic reviews

What are the Effective Factors in Spontaneous Resolution Rate of Primary Vesicoureteral Reflux: A Meta-Analysis and Systematic Review.
Basiri A, Ziaeefar P, Khoshdel A, Fattahi P, Mafi Balani M, Tofighi Zavareh MA
Urol J 2023 Dec 26;20(6):385-396. doi: 10.22037/uj.v20i06.8095. PMID: 38158632
Effectiveness and risks of endoscopic management compared to vesicoureteral reimplantation in patients with high-grade vesicoureteral reflux: systematic review and network meta-analysis.
Mina-Riascos SH, Fernández N, García-Perdomo HA
Eur J Pediatr 2021 May;180(5):1383-1391. Epub 2021 Jan 20 doi: 10.1007/s00431-021-03948-w. PMID: 33474581

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