U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cervical Stratified Mucin-Producing Intraepithelial Lesion

MedGen UID:
1790817
•Concept ID:
C5552983
•
Neoplastic Process
Synonym: Stratified Mucin-Producing Intraepithelial Lesion

Definition

A rare, human papillomavirus-associated premalignant glandular intraepithelial neoplasm that arises from the cervix. It is characterized by the presence of strati?ed, immature epithelial cells containing varying quantities of intracytoplasmic mucin. There is no evidence of stromal invasion. It is distinct from conventional cervical squamous or glandular intraepithelial neoplasias. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Stratified Mucin-Producing Intraepithelial Lesion

Professional guidelines

PubMed

Cervical Stratified Mucin-Producing Intraepithelial Lesion: A Systematic Review of Diagnosis and Management.
Wolf JL, Billingsley CC, Kendler A, Jackson AL
J Low Genit Tract Dis 2020 Jul;24(3):259-264. doi: 10.1097/LGT.0000000000000536. PMID: 32332219

Recent clinical studies

Etiology

Stratified Mucin-Producing Intraepithelial Lesion (SMILE) of the Uterine Cervix: High-Risk HPV Genotype Predominance and p40 Immunophenotype.
Strojan Fležar M, Nedelko N, Poljak M, Oštrbenk Valenčak A, Gutnik H
Cells 2021 Aug 10;10(8) doi: 10.3390/cells10082039. PMID: 34440808Free PMC Article
Cervical Stratified Mucin-Producing Intraepithelial Lesion: A Systematic Review of Diagnosis and Management.
Wolf JL, Billingsley CC, Kendler A, Jackson AL
J Low Genit Tract Dis 2020 Jul;24(3):259-264. doi: 10.1097/LGT.0000000000000536. PMID: 32332219
Stratified Mucin-Producing Intraepithelial Lesion of the Cervix: Subtle Features Not to Be Missed.
Schwock J, Ko HM, Dubé V, Rouzbahman M, Cesari M, Ghorab Z, Geddie WR
Acta Cytol 2016;60(3):225-31. Epub 2016 Jul 22 doi: 10.1159/000447940. PMID: 27442040
Stratified mucin-producing intraepithelial lesion with invasive carcinoma: 12 cases with immunohistochemical and ultrastructural findings.
Onishi J, Sato Y, Sawaguchi A, Yamashita A, Maekawa K, Sameshima H, Asada Y
Hum Pathol 2016 Sep;55:174-81. Epub 2016 May 27 doi: 10.1016/j.humpath.2016.05.007. PMID: 27237368
Stratified mucin-producing intraepithelial lesion (SMILE): report of a case series with associated pathological findings.
Boyle DP, McCluggage WG
Histopathology 2015 Apr;66(5):658-63. Epub 2015 Jan 15 doi: 10.1111/his.12498. PMID: 25039487

Diagnosis

Stratified Mucin-producing Intraepithelial Lesions of the Cervix: Clinical Diversity of Cases and Literature Review.
Delrue C, Vanwalleghem L, Paepe P, Van Trappen P
Anticancer Res 2022 Feb;42(2):1175-1180. doi: 10.21873/anticanres.15583. PMID: 35093923
Stratified Mucin-Producing Intraepithelial Lesion (SMILE) of the Uterine Cervix: High-Risk HPV Genotype Predominance and p40 Immunophenotype.
Strojan Fležar M, Nedelko N, Poljak M, Oštrbenk Valenčak A, Gutnik H
Cells 2021 Aug 10;10(8) doi: 10.3390/cells10082039. PMID: 34440808Free PMC Article
The Evolving Spectrum of Precursor Lesions of Cervical Adenocarcinomas.
Stolnicu S, Talia KL, McCluggage WG
Adv Anat Pathol 2020 Sep;27(5):278-293. doi: 10.1097/PAP.0000000000000266. PMID: 32482967
Cervical Stratified Mucin-Producing Intraepithelial Lesion: A Systematic Review of Diagnosis and Management.
Wolf JL, Billingsley CC, Kendler A, Jackson AL
J Low Genit Tract Dis 2020 Jul;24(3):259-264. doi: 10.1097/LGT.0000000000000536. PMID: 32332219
Invasive Stratified Mucin-producing Carcinoma (ISMC) of the Cervix: A Study on Morphologic Diversity.
Stolnicu S, Segura S, Parra-Herran C, Horn LC, Hoang L, Terinte C, Pesci A, Aviel-Ronen S, Kyokawa T, Alvarado-Cabrero I, Oliva E, Soslow RA, Park KJ
Am J Surg Pathol 2020 Jul;44(7):873-880. doi: 10.1097/PAS.0000000000001480. PMID: 32235154Free PMC Article

Prognosis

Invasive stratified mucin-producing carcinoma (ISMC) of uterine cervix: description of pathological findings and prognosis factors in a series of 15 Chinese patients.
Lin T, Wang W, Xu L, He Y
Arch Gynecol Obstet 2022 Nov;306(5):1703-1709. Epub 2022 Apr 8 doi: 10.1007/s00404-022-06544-x. PMID: 35394200
Invasive stratified mucin-producing carcinoma: a clinicopathological analysis of three cases.
Lei R
Cancer Biol Ther 2019;20(11):1403-1407. Epub 2019 Jul 30 doi: 10.1080/15384047.2019.1647054. PMID: 31362570Free PMC Article
Diagnostic Algorithmic Proposal Based on Comprehensive Immunohistochemical Evaluation of 297 Invasive Endocervical Adenocarcinomas.
Stolnicu S, Barsan I, Hoang L, Patel P, Chiriboga L, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Aug;42(8):989-1000. doi: 10.1097/PAS.0000000000001090. PMID: 29851704Free PMC Article
Stratified mucin-producing intraepithelial lesion with invasive carcinoma: 12 cases with immunohistochemical and ultrastructural findings.
Onishi J, Sato Y, Sawaguchi A, Yamashita A, Maekawa K, Sameshima H, Asada Y
Hum Pathol 2016 Sep;55:174-81. Epub 2016 May 27 doi: 10.1016/j.humpath.2016.05.007. PMID: 27237368
Invasive Stratified Mucin-producing Carcinoma and Stratified Mucin-producing Intraepithelial Lesion (SMILE): 15 Cases Presenting a Spectrum of Cervical Neoplasia With Description of a Distinctive Variant of Invasive Adenocarcinoma.
Lastra RR, Park KJ, Schoolmeester JK
Am J Surg Pathol 2016 Feb;40(2):262-9. doi: 10.1097/PAS.0000000000000543. PMID: 26523540

Clinical prediction guides

Invasive stratified mucin-producing carcinoma (ISMC) of uterine cervix: description of pathological findings and prognosis factors in a series of 15 Chinese patients.
Lin T, Wang W, Xu L, He Y
Arch Gynecol Obstet 2022 Nov;306(5):1703-1709. Epub 2022 Apr 8 doi: 10.1007/s00404-022-06544-x. PMID: 35394200
Is hysterectomy necessary for the treatment of preinvasive stratified mucin producing intraepithelial lesions of the cervix?
Kahn R, Zhou ZN, Goyal A, Gamble C, Nicholson N, Caputo TA, Holcomb K, Frey MK, Chapman-Davis E
Int J Gynecol Cancer 2020 Sep;30(9):1298-1302. Epub 2020 May 23 doi: 10.1136/ijgc-2020-001272. PMID: 32448806
Diagnostic Algorithmic Proposal Based on Comprehensive Immunohistochemical Evaluation of 297 Invasive Endocervical Adenocarcinomas.
Stolnicu S, Barsan I, Hoang L, Patel P, Chiriboga L, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Aug;42(8):989-1000. doi: 10.1097/PAS.0000000000001090. PMID: 29851704Free PMC Article
Stratified mucin-producing intraepithelial lesion with invasive carcinoma: 12 cases with immunohistochemical and ultrastructural findings.
Onishi J, Sato Y, Sawaguchi A, Yamashita A, Maekawa K, Sameshima H, Asada Y
Hum Pathol 2016 Sep;55:174-81. Epub 2016 May 27 doi: 10.1016/j.humpath.2016.05.007. PMID: 27237368
Invasive Stratified Mucin-producing Carcinoma and Stratified Mucin-producing Intraepithelial Lesion (SMILE): 15 Cases Presenting a Spectrum of Cervical Neoplasia With Description of a Distinctive Variant of Invasive Adenocarcinoma.
Lastra RR, Park KJ, Schoolmeester JK
Am J Surg Pathol 2016 Feb;40(2):262-9. doi: 10.1097/PAS.0000000000000543. PMID: 26523540

Recent systematic reviews

Cervical Stratified Mucin-Producing Intraepithelial Lesion: A Systematic Review of Diagnosis and Management.
Wolf JL, Billingsley CC, Kendler A, Jackson AL
J Low Genit Tract Dis 2020 Jul;24(3):259-264. doi: 10.1097/LGT.0000000000000536. PMID: 32332219

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...