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Metastatic Malignant Nongerminomatous Germ Cell Tumor

MedGen UID:
1791049
•Concept ID:
C5554608
•
Neoplastic Process

Definition

A malignant nongerminomatous germ cell tumor that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Nongerminomatous Germ Cell Tumor

Professional guidelines

PubMed

Pattern of treatment failures in patients with central nervous system non-germinomatous germ cell tumors (CNS-NGGCT): A pooled analysis of clinical trials.
Fonseca A, Faure-Conter C, Murray MJ, Fangusaro J, Bailey S, Goldman S, Khatua S, Frappaz D, Calaminus G, Dhall G, Nicholson JC, Bouffet E, Bartels U
Neuro Oncol 2022 Nov 2;24(11):1950-1961. doi: 10.1093/neuonc/noac057. PMID: 35218656Free PMC Article
EANO, SNO and Euracan consensus review on the current management and future development of intracranial germ cell tumors in adolescents and young adults.
Frappaz D, Dhall G, Murray MJ, Goldman S, Faure Conter C, Allen J, Kortmann RD, Haas-Kogen D, Morana G, Finlay J, Nicholson JC, Bartels U, Souweidane M, Schönberger S, Vasiljevic A, Robertson P, Albanese A, Alapetite C, Czech T, Lau CC, Wen P, Schiff D, Shaw D, Calaminus G, Bouffet E
Neuro Oncol 2022 Apr 1;24(4):516-527. doi: 10.1093/neuonc/noab252. PMID: 34724065Free PMC Article
Symptom interval and treatment burden for patients with malignant central nervous system germ cell tumours.
Hayden J, Murray MJ, Bartels U, Ajithkumar T, Muthusamy B, Penn A, Calaminus G, Nicholson J
Arch Dis Child 2020 Mar;105(3):247-252. Epub 2019 Oct 8 doi: 10.1136/archdischild-2019-317245. PMID: 31594777

Recent clinical studies

Etiology

Intracranial Germ Cell Tumors.
Yeoh TDYY, Nga V, Kimpo M, Lo SS, Vellayappan B
Semin Neurol 2023 Dec;43(6):897-908. Epub 2023 Nov 14 doi: 10.1055/s-0043-1776763. PMID: 37963583
KRAS Mutation in Pediatric Intracranial Germ Cell Tumors.
Khaiman C, Techavichit P, Poparn H, Chiangthong K, Lauhasurayotin S, Sosothikul D, Shotelersuk K, Nantavithya C, Jakchairoongruang K, Amornfa J, Khongkhaduead E, Santisukwongchote S, Teerapakpinyo C, Shuangshot S
Asian Pac J Cancer Prev 2022 Sep 1;23(9):3179-3185. doi: 10.31557/APJCP.2022.23.9.3179. PMID: 36172682Free PMC Article
EANO, SNO and Euracan consensus review on the current management and future development of intracranial germ cell tumors in adolescents and young adults.
Frappaz D, Dhall G, Murray MJ, Goldman S, Faure Conter C, Allen J, Kortmann RD, Haas-Kogen D, Morana G, Finlay J, Nicholson JC, Bartels U, Souweidane M, Schönberger S, Vasiljevic A, Robertson P, Albanese A, Alapetite C, Czech T, Lau CC, Wen P, Schiff D, Shaw D, Calaminus G, Bouffet E
Neuro Oncol 2022 Apr 1;24(4):516-527. doi: 10.1093/neuonc/noab252. PMID: 34724065Free PMC Article
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Intracranial Germ Cell Tumors in Adolescents and Young Adults: A 40-Year Multi-Institutional Review of Outcomes.
Lo AC, Hodgson D, Dang J, Tyldesley S, Bouffet E, Bartels U, Cheng S, Hukin J, Bedard PL, Goddard K, Laperriere N
Int J Radiat Oncol Biol Phys 2020 Feb 1;106(2):269-278. Epub 2019 Oct 22 doi: 10.1016/j.ijrobp.2019.10.020. PMID: 31654785

Diagnosis

Intracranial Germ Cell Tumors.
Yeoh TDYY, Nga V, Kimpo M, Lo SS, Vellayappan B
Semin Neurol 2023 Dec;43(6):897-908. Epub 2023 Nov 14 doi: 10.1055/s-0043-1776763. PMID: 37963583
KRAS Mutation in Pediatric Intracranial Germ Cell Tumors.
Khaiman C, Techavichit P, Poparn H, Chiangthong K, Lauhasurayotin S, Sosothikul D, Shotelersuk K, Nantavithya C, Jakchairoongruang K, Amornfa J, Khongkhaduead E, Santisukwongchote S, Teerapakpinyo C, Shuangshot S
Asian Pac J Cancer Prev 2022 Sep 1;23(9):3179-3185. doi: 10.31557/APJCP.2022.23.9.3179. PMID: 36172682Free PMC Article
EANO, SNO and Euracan consensus review on the current management and future development of intracranial germ cell tumors in adolescents and young adults.
Frappaz D, Dhall G, Murray MJ, Goldman S, Faure Conter C, Allen J, Kortmann RD, Haas-Kogen D, Morana G, Finlay J, Nicholson JC, Bartels U, Souweidane M, Schönberger S, Vasiljevic A, Robertson P, Albanese A, Alapetite C, Czech T, Lau CC, Wen P, Schiff D, Shaw D, Calaminus G, Bouffet E
Neuro Oncol 2022 Apr 1;24(4):516-527. doi: 10.1093/neuonc/noab252. PMID: 34724065Free PMC Article
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Extraneural metastasis of a nongerminomatous germ cell tumor of the central nervous system in a pediatric patient with a ventriculoperitoneal shunt: a case report and review of the literature.
Belongia M, Jogal S
J Pediatr Hematol Oncol 2012 Jan;34(1):e12-6. doi: 10.1097/MPH.0b013e31823dd370. PMID: 22215101

Therapy

Off-label prescribing of immune checkpoint inhibitor therapy at a single pediatric cancer center.
Gikandi A, Chi SN, Yeo KK, O'Neill AF, Shulman DS, DuBois SG, Collins NB
Cancer Med 2024 Apr;13(8):e7154. doi: 10.1002/cam4.7154. PMID: 38629258Free PMC Article
Feasibility of treating pediatric intracranial germ cell tumors in a middle-income country: The Jordanian experience.
Amayiri N, Sarhan N, Yousef Y, Ibrahimi AK, Abu-Shanab S, Al-Zebin Z, Al-Hussaini M, Musharbash A, Tawalbeh A, Bouffet E, Bartels U
Pediatr Blood Cancer 2022 Dec;69(12):e30011. Epub 2022 Sep 21 doi: 10.1002/pbc.30011. PMID: 36131594
Intracranial Germ Cell Tumors in Adolescents and Young Adults: A 40-Year Multi-Institutional Review of Outcomes.
Lo AC, Hodgson D, Dang J, Tyldesley S, Bouffet E, Bartels U, Cheng S, Hukin J, Bedard PL, Goddard K, Laperriere N
Int J Radiat Oncol Biol Phys 2020 Feb 1;106(2):269-278. Epub 2019 Oct 22 doi: 10.1016/j.ijrobp.2019.10.020. PMID: 31654785
Intracranial germ cell tumors: a single institution experience and review of the literature.
Smith AA, Weng E, Handler M, Foreman NK
J Neurooncol 2004 Jun;68(2):153-9. doi: 10.1023/b:neon.0000027670.96412.36. PMID: 15218952
The growing teratoma syndrome in a nongerminomatous germ cell tumor of the pineal gland: a case report and review.
O'Callaghan AM, Katapodis O, Ellison DW, Theaker JM, Mead GM
Cancer 1997 Sep 1;80(5):942-7. doi: 10.1002/(sici)1097-0142(19970901)80:5<942::aid-cncr16>3.0.co;2-w. PMID: 9307195

Prognosis

Treatment Outcome of Response-Based Radiation Therapy in Children and Adolescents With Central Nervous System Nongerminomatous Germ Cell Tumors: Results of a Prospective Study.
Zeng C, Yang Q, Li Z, Wei Z, Chen T, Deng M, Wang J, Wang J, Sun F, Huang J, Lu S, Zhu J, Sun X, Zhen Z
Int J Radiat Oncol Biol Phys 2024 Jul 1;119(3):858-868. Epub 2023 Dec 18 doi: 10.1016/j.ijrobp.2023.12.006. PMID: 38122991
Treatment outcome and long-term follow-up of central nervous system germ cell tumor using upfront chemotherapy with subsequent photon or proton radiation therapy: a single tertiary center experience of 127 patients.
Hong KT, Lee DH, Kim BK, An HY, Choi JY, Phi JH, Cheon JE, Kang HJ, Kim SK, Kim JY, Park SH, Kim IH, Shin HY
BMC Cancer 2020 Oct 9;20(1):979. doi: 10.1186/s12885-020-07484-y. PMID: 33036578Free PMC Article
Early outcomes and patterns of failure following proton therapy for nonmetastatic intracranial nongerminomatous germ cell tumors.
Mokhtech M, Rotondo RL, Bradley JA, Sandler ES, Nanda R, Logie N, Aldana PR, Morris CG, Indelicato DJ
Pediatr Blood Cancer 2018 Jun;65(6):e26997. Epub 2018 Jan 30 doi: 10.1002/pbc.26997. PMID: 29380526
Evaluation of neoadjuvant therapy in patients with nongerminomatous malignant germ cell tumors.
Nakamura H, Makino K, Kochi M, Ushio Y, Kuratsu J
J Neurosurg Pediatr 2011 Apr;7(4):431-8. doi: 10.3171/2011.1.PEDS10433. PMID: 21456918
Update on current standard treatments in central nervous system germ cell tumors.
Kamoshima Y, Sawamura Y
Curr Opin Neurol 2010 Dec;23(6):571-5. doi: 10.1097/WCO.0b013e32833ff522. PMID: 20885323

Clinical prediction guides

Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Symptom interval and treatment burden for patients with malignant central nervous system germ cell tumours.
Hayden J, Murray MJ, Bartels U, Ajithkumar T, Muthusamy B, Penn A, Calaminus G, Nicholson J
Arch Dis Child 2020 Mar;105(3):247-252. Epub 2019 Oct 8 doi: 10.1136/archdischild-2019-317245. PMID: 31594777
Intracranial teratomas in children: the role and timing of surgical removal.
Noudel R, Vinchon M, Dhellemmes P, Litré CF, Rousseaux P
J Neurosurg Pediatr 2008 Nov;2(5):331-8. doi: 10.3171/PED.2008.2.11.331. PMID: 18976103
Bifocal mixed germ-cell tumor with growing teratoma syndrome and metachronous mature metastases: case report.
Peltier J, Vinchon M, Baroncini M, Kerdraon O, Dhellemmes P
J Neurooncol 2008 Oct;90(1):111-5. Epub 2008 Jun 24 doi: 10.1007/s11060-008-9640-3. PMID: 18574668

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