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Refractory Ovarian Low Grade Serous Adenocarcinoma

MedGen UID:
1791622
•Concept ID:
C5555181
•
Neoplastic Process
Synonyms: Refractory Low Grade Ovarian Serous Adenocarcinoma; Refractory Ovarian-Low Grade Serous Adenocarcinoma

Definition

Ovarian low-grade serous adenocarcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Ovarian Low Grade Serous Adenocarcinoma

Recent clinical studies

Etiology

Salvage chemotherapy in recurrent platinum-resistant or refractory epithelial ovarian cancer with Carboplatin and distearoylphosphatidylcholine pegylated liposomal Doxorubicin (lipo-dox®).
Khemapech N, Oranratanaphan S, Termrungruanglert W, Lertkhachonsuk R, Vasurattana A
Asian Pac J Cancer Prev 2013;14(3):2131-5. doi: 10.7314/apjcp.2013.14.3.2131. PMID: 23679331

Therapy

Molecular Characterization of Non-responders to Chemotherapy in Serous Ovarian Cancer.
McDonald ME, Salinas EA, Devor EJ, Newtson AM, Thiel KW, Goodheart MJ, Bender DP, Smith BJ, Leslie KK, Gonzalez-Bosquet J
Int J Mol Sci 2019 Mar 7;20(5) doi: 10.3390/ijms20051175. PMID: 30866519Free PMC Article
Salvage chemotherapy in recurrent platinum-resistant or refractory epithelial ovarian cancer with Carboplatin and distearoylphosphatidylcholine pegylated liposomal Doxorubicin (lipo-dox®).
Khemapech N, Oranratanaphan S, Termrungruanglert W, Lertkhachonsuk R, Vasurattana A
Asian Pac J Cancer Prev 2013;14(3):2131-5. doi: 10.7314/apjcp.2013.14.3.2131. PMID: 23679331
Topotecan as a continuous infusion over 14 days in recurrent ovarian cancer patients.
Denschlag D, Watermann D, Hörig K, Kissel C, Tempfer C, Gitsch G
Anticancer Res 2004 Mar-Apr;24(2C):1267-9. PMID: 15154658

Prognosis

Salvage chemotherapy in recurrent platinum-resistant or refractory epithelial ovarian cancer with Carboplatin and distearoylphosphatidylcholine pegylated liposomal Doxorubicin (lipo-dox®).
Khemapech N, Oranratanaphan S, Termrungruanglert W, Lertkhachonsuk R, Vasurattana A
Asian Pac J Cancer Prev 2013;14(3):2131-5. doi: 10.7314/apjcp.2013.14.3.2131. PMID: 23679331
TGF-beta induces serous borderline ovarian tumor cell invasion by activating EMT but triggers apoptosis in low-grade serous ovarian carcinoma cells.
Cheng JC, Auersperg N, Leung PC
PLoS One 2012;7(8):e42436. Epub 2012 Aug 15 doi: 10.1371/journal.pone.0042436. PMID: 22905131Free PMC Article

Clinical prediction guides

Topotecan as a continuous infusion over 14 days in recurrent ovarian cancer patients.
Denschlag D, Watermann D, Hörig K, Kissel C, Tempfer C, Gitsch G
Anticancer Res 2004 Mar-Apr;24(2C):1267-9. PMID: 15154658

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