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Renal Pelvis Urothelial Carcinoma, High Grade

MedGen UID:
1792938
•Concept ID:
C5556497
•
Neoplastic Process
Synonyms: High Grade Renal Pelvis Urothelial Carcinoma; High-Grade Renal Pelvis Urothelial Carcinoma; Renal Pelvis Urothelial Carcinoma, High-Grade

Definition

Renal pelvis urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRenal Pelvis Urothelial Carcinoma, High Grade

Professional guidelines

PubMed

Optimal Management of Upper Tract Urothelial Carcinoma: an Unmet Need.
Azizi M, Cheriyan SK, Peyton CC, Foerster B, Shariat SF, Spiess PE
Curr Treat Options Oncol 2019 Apr 1;20(5):40. doi: 10.1007/s11864-019-0637-2. PMID: 30937554
Endoscopic Treatment of Upper Tract Urothelial Carcinoma.
Verges DP, Lallas CD, Hubosky SG, Bagley DH Jr
Curr Urol Rep 2017 Apr;18(4):31. doi: 10.1007/s11934-017-0675-x. PMID: 28251485
Management of ureteral and renal pelvic recurrence after cystectomy.
Braslis KG, Soloway MS
Urol Clin North Am 1994 Nov;21(4):653-9. PMID: 7974897

Recent clinical studies

Etiology

Upper urothelial tract high-grade carcinoma: comparison of urine cytology and DNA methylation analysis in urinary samples.
Pierconti F, Martini M, Fiorentino V, Cenci T, Racioppi M, Foschi N, Di Gianfrancesco L, Sacco E, Rossi E, Larocca LM, Bassi PF
Hum Pathol 2021 Dec;118:42-48. Epub 2021 Sep 25 doi: 10.1016/j.humpath.2021.09.007. PMID: 34582934
Contrast-Enhanced Ultrasound Characteristics of Renal Pelvis Urothelial Carcinoma and Its Relationship with Microvessel Density.
Zhang B, Li J, Wu Z, Li C, Sun T, Zhuo N, Liang J, Duan Q, Hu H, Tian J
Ultrasound Med Biol 2021 Feb;47(2):236-243. Epub 2020 Nov 4 doi: 10.1016/j.ultrasmedbio.2020.09.006. PMID: 33158635
Optimal Management of Upper Tract Urothelial Carcinoma: an Unmet Need.
Azizi M, Cheriyan SK, Peyton CC, Foerster B, Shariat SF, Spiess PE
Curr Treat Options Oncol 2019 Apr 1;20(5):40. doi: 10.1007/s11864-019-0637-2. PMID: 30937554
Adjuvant Sandwich Chemotherapy Plus Radiotherapy vs Adjuvant Chemotherapy Alone for Locally Advanced Bladder Cancer After Radical Cystectomy: A Randomized Phase 2 Trial.
Zaghloul MS, Christodouleas JP, Smith A, Abdallah A, William H, Khaled HM, Hwang WT, Baumann BC
JAMA Surg 2018 Jan 17;153(1):e174591. doi: 10.1001/jamasurg.2017.4591. PMID: 29188298Free PMC Article
Endoscopic Treatment of Upper Tract Urothelial Carcinoma.
Verges DP, Lallas CD, Hubosky SG, Bagley DH Jr
Curr Urol Rep 2017 Apr;18(4):31. doi: 10.1007/s11934-017-0675-x. PMID: 28251485

Diagnosis

Contemporary Issues in Urothelial Carcinoma of Upper Urinary Tract.
Zhao J, Guo CC, Rao P
Adv Anat Pathol 2024 Mar 1;31(2):80-87. Epub 2023 Nov 27 doi: 10.1097/PAP.0000000000000421. PMID: 38009077Free PMC Article
Upper urothelial tract high-grade carcinoma: comparison of urine cytology and DNA methylation analysis in urinary samples.
Pierconti F, Martini M, Fiorentino V, Cenci T, Racioppi M, Foschi N, Di Gianfrancesco L, Sacco E, Rossi E, Larocca LM, Bassi PF
Hum Pathol 2021 Dec;118:42-48. Epub 2021 Sep 25 doi: 10.1016/j.humpath.2021.09.007. PMID: 34582934
High-grade urothelial carcinoma in urine cytology: different spaces - different faces, highlighting morphologic variance.
McIntire PJ, Elsoukkary SS, Robinson BD, Siddiqui MT
J Am Soc Cytopathol 2021 Jan-Feb;10(1):36-40. Epub 2020 Aug 7 doi: 10.1016/j.jasc.2020.08.001. PMID: 32958411
Optimal Management of Upper Tract Urothelial Carcinoma: an Unmet Need.
Azizi M, Cheriyan SK, Peyton CC, Foerster B, Shariat SF, Spiess PE
Curr Treat Options Oncol 2019 Apr 1;20(5):40. doi: 10.1007/s11864-019-0637-2. PMID: 30937554
Recent advances in upper tract urothelial carcinomas: From bench to clinics.
Shao IH, Chang YH, Pang ST
Int J Urol 2019 Feb;26(2):148-159. Epub 2018 Oct 29 doi: 10.1111/iju.13826. PMID: 30372791

Therapy

Adverse Events of Immune Checkpoint Inhibitors Therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-analysis.
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Optimal Management of Upper Tract Urothelial Carcinoma: an Unmet Need.
Azizi M, Cheriyan SK, Peyton CC, Foerster B, Shariat SF, Spiess PE
Curr Treat Options Oncol 2019 Apr 1;20(5):40. doi: 10.1007/s11864-019-0637-2. PMID: 30937554
Recent advances in upper tract urothelial carcinomas: From bench to clinics.
Shao IH, Chang YH, Pang ST
Int J Urol 2019 Feb;26(2):148-159. Epub 2018 Oct 29 doi: 10.1111/iju.13826. PMID: 30372791
Adjuvant Sandwich Chemotherapy Plus Radiotherapy vs Adjuvant Chemotherapy Alone for Locally Advanced Bladder Cancer After Radical Cystectomy: A Randomized Phase 2 Trial.
Zaghloul MS, Christodouleas JP, Smith A, Abdallah A, William H, Khaled HM, Hwang WT, Baumann BC
JAMA Surg 2018 Jan 17;153(1):e174591. doi: 10.1001/jamasurg.2017.4591. PMID: 29188298Free PMC Article
Update of the ICUD-SIU consultation on upper tract urothelial carcinoma 2016: treatment of low-risk upper tract urothelial carcinoma.
Mandalapu RS, Remzi M, de Reijke TM, Margulis V, Palou J, Kapoor A, Yossepowitch O, Coleman J, Traxer O, Anderson JK, Catto J, de la Rosette J, O'Brien T, Zlotta A, Matin SF
World J Urol 2017 Mar;35(3):355-365. Epub 2016 May 27 doi: 10.1007/s00345-016-1859-6. PMID: 27233780Free PMC Article

Prognosis

Adverse Events of Immune Checkpoint Inhibitors Therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-analysis.
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
High-grade urothelial carcinoma in urine cytology: different spaces - different faces, highlighting morphologic variance.
McIntire PJ, Elsoukkary SS, Robinson BD, Siddiqui MT
J Am Soc Cytopathol 2021 Jan-Feb;10(1):36-40. Epub 2020 Aug 7 doi: 10.1016/j.jasc.2020.08.001. PMID: 32958411
Optimal Management of Upper Tract Urothelial Carcinoma: an Unmet Need.
Azizi M, Cheriyan SK, Peyton CC, Foerster B, Shariat SF, Spiess PE
Curr Treat Options Oncol 2019 Apr 1;20(5):40. doi: 10.1007/s11864-019-0637-2. PMID: 30937554
Recent advances in upper tract urothelial carcinomas: From bench to clinics.
Shao IH, Chang YH, Pang ST
Int J Urol 2019 Feb;26(2):148-159. Epub 2018 Oct 29 doi: 10.1111/iju.13826. PMID: 30372791
Update of the ICUD-SIU consultation on upper tract urothelial carcinoma 2016: treatment of localized high-risk disease.
Gakis G, Schubert T, Alemozaffar M, Bellmunt J, Bochner BH, Boorjian SA, Daneshmand S, Huang WC, Kondo T, Konety BR, Laguna MP, Matin SF, Siefker-Radtke AO, Shariat SF, Stenzl A
World J Urol 2017 Mar;35(3):327-335. Epub 2016 Apr 4 doi: 10.1007/s00345-016-1819-1. PMID: 27043218

Clinical prediction guides

Upper urothelial tract high-grade carcinoma: comparison of urine cytology and DNA methylation analysis in urinary samples.
Pierconti F, Martini M, Fiorentino V, Cenci T, Racioppi M, Foschi N, Di Gianfrancesco L, Sacco E, Rossi E, Larocca LM, Bassi PF
Hum Pathol 2021 Dec;118:42-48. Epub 2021 Sep 25 doi: 10.1016/j.humpath.2021.09.007. PMID: 34582934
Contrast-Enhanced Ultrasound Characteristics of Renal Pelvis Urothelial Carcinoma and Its Relationship with Microvessel Density.
Zhang B, Li J, Wu Z, Li C, Sun T, Zhuo N, Liang J, Duan Q, Hu H, Tian J
Ultrasound Med Biol 2021 Feb;47(2):236-243. Epub 2020 Nov 4 doi: 10.1016/j.ultrasmedbio.2020.09.006. PMID: 33158635
High-grade urothelial carcinoma in urine cytology: different spaces - different faces, highlighting morphologic variance.
McIntire PJ, Elsoukkary SS, Robinson BD, Siddiqui MT
J Am Soc Cytopathol 2021 Jan-Feb;10(1):36-40. Epub 2020 Aug 7 doi: 10.1016/j.jasc.2020.08.001. PMID: 32958411
Case 258: Granulomatous Prostatitis.
Diaz de Leon A, Costa DN, Francis F, Pedrosa I
Radiology 2018 Oct;289(1):267-271. doi: 10.1148/radiol.2018161272. PMID: 30230997
Endoscopic Treatment of Upper Tract Urothelial Carcinoma.
Verges DP, Lallas CD, Hubosky SG, Bagley DH Jr
Curr Urol Rep 2017 Apr;18(4):31. doi: 10.1007/s11934-017-0675-x. PMID: 28251485

Recent systematic reviews

Adverse Events of Immune Checkpoint Inhibitors Therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-analysis.
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Oncologic Outcomes of Kidney-sparing Surgery Versus Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Systematic Review by the EAU Non-muscle Invasive Bladder Cancer Guidelines Panel.
Seisen T, Peyronnet B, Dominguez-Escrig JL, Bruins HM, Yuan CY, Babjuk M, Böhle A, Burger M, Compérat EM, Cowan NC, Kaasinen E, Palou J, van Rhijn BW, Sylvester RJ, Zigeuner R, Shariat SF, Rouprêt M
Eur Urol 2016 Dec;70(6):1052-1068. Epub 2016 Jul 28 doi: 10.1016/j.eururo.2016.07.014. PMID: 27477528
Results and outcomes after endoscopic treatment of upper urinary tract carcinoma: the Austrian experience.
Fajkovic H, Klatte T, Nagele U, Dunzinger M, Zigeuner R, Hübner W, Remzi M
World J Urol 2013 Feb;31(1):37-44. Epub 2012 Sep 27 doi: 10.1007/s00345-012-0948-4. PMID: 23014836

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