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Human Papillomavirus-Independent Cervical Adenocarcinoma

MedGen UID:
1793107
•Concept ID:
C5556666
•
Neoplastic Process
Synonyms: HPV-Independent Cervical Adenocarcinoma; NHPVA Cervical Adenocarcinoma

Definition

Cervical adenocarcinoma not associated with human papillomavirus infection. [from NCI]

Recent clinical studies

Etiology

Clinicopathological characteristics and survival outcomes in human papillomavirus independent cervical cancer: a propensity score matched analysis.
Li D, Huang S, Liu K, Qin Y, Zhang Y, Yang Y
Int J Gynecol Cancer 2022 May 3;32(5):599-605. doi: 10.1136/ijgc-2021-003159. PMID: 35331994
Clear Cell Carcinoma (CCC) of the Cervix Is a Human Papillomavirus (HPV)-independent Tumor Associated With Poor Outcome: A Comprehensive Analysis of 58 Cases.
Stolnicu S, Karpathiou G, Guerra E, Mateoiu C, Reques A, Garcia A, Bart J, Felix A, Fanni D, Gama J, Hardisson D, Bennett JA, Parra-Herran C, Oliva E, Abu-Rustum N, Soslow RA, Park KJ
Am J Surg Pathol 2022 Jun 1;46(6):765-773. Epub 2022 Jan 5 doi: 10.1097/PAS.0000000000001863. PMID: 34985047Free PMC Article
Programmed death-ligand 1 expression in human papillomavirus-independent cervical adenocarcinoma and its prognostic significance.
Chen L, Lucas E, Zhang X, Liu Q, Zhuang Y, Lin W, Chen H, Zhou F
Histopathology 2022 Jan;80(2):338-347. Epub 2021 Oct 13 doi: 10.1111/his.14552. PMID: 34455625
Grading of Endocervical Adenocarcinomas: Review of the Literature and Recommendations From the International Society of Gynecological Pathologists.
Talia KL, Oliva E, Rabban JT, Singh N, Stolnicu S, McCluggage WG
Int J Gynecol Pathol 2021 Mar 1;40(Suppl 1):S66-S74. doi: 10.1097/PGP.0000000000000741. PMID: 33570864Free PMC Article
Gastric-type endocervical adenocarcinoma and cervical cytology: Experience at a general hospital and review of the literature.
Greenland NY, Wolsky RJ, Darragh TM, Vohra P
Cytopathology 2021 Jan;32(1):75-83. Epub 2020 Oct 5 doi: 10.1111/cyt.12907. PMID: 32851700

Diagnosis

Comprehensive Clinicopathological and Immunohistochemical Analysis of Human Papillomavirus-independent Squamous Cell Carcinoma and Adenosquamous Carcinoma of the Uterine Cervix.
Na JM, Kim HS
Anticancer Res 2024 Nov;44(11):4969-4981. doi: 10.21873/anticanres.17322. PMID: 39477315
Invasive Squamous Cell Carcinoma of the Cervix: A Review of Morphological Appearances Encountered in Human Papillomavirus-associated and Papillomavirus-independent Tumors and Precursor Lesions.
Stolnicu S, Allison D, Patrichi A, Flynn J, Iasonos A, Soslow RA
Adv Anat Pathol 2024 Jan 1;31(1):1-14. Epub 2023 Aug 28 doi: 10.1097/PAP.0000000000000411. PMID: 37638549Free PMC Article
Clear Cell Carcinoma (CCC) of the Cervix Is a Human Papillomavirus (HPV)-independent Tumor Associated With Poor Outcome: A Comprehensive Analysis of 58 Cases.
Stolnicu S, Karpathiou G, Guerra E, Mateoiu C, Reques A, Garcia A, Bart J, Felix A, Fanni D, Gama J, Hardisson D, Bennett JA, Parra-Herran C, Oliva E, Abu-Rustum N, Soslow RA, Park KJ
Am J Surg Pathol 2022 Jun 1;46(6):765-773. Epub 2022 Jan 5 doi: 10.1097/PAS.0000000000001863. PMID: 34985047Free PMC Article
Human papillomavirus-independent cervical cancer.
Fernandes A, Viveros-Carreño D, Hoegl J, Ávila M, Pareja R
Int J Gynecol Cancer 2022 Jan;32(1):1-7. Epub 2021 Nov 1 doi: 10.1136/ijgc-2021-003014. PMID: 34725203
Gastric-type endocervical adenocarcinoma and cervical cytology: Experience at a general hospital and review of the literature.
Greenland NY, Wolsky RJ, Darragh TM, Vohra P
Cytopathology 2021 Jan;32(1):75-83. Epub 2020 Oct 5 doi: 10.1111/cyt.12907. PMID: 32851700

Therapy

Diagnostic and prognostic potential of the intra-tumoral microbiota profile in HPV-independent endocervical adenocarcinoma.
Zhou X, Chen L, Lin W, Zheng W, Zhang H, Zhou F
Front Cell Infect Microbiol 2024;14:1440017. Epub 2024 Aug 16 doi: 10.3389/fcimb.2024.1440017. PMID: 39220287Free PMC Article

Prognosis

Invasive Squamous Cell Carcinoma of the Cervix: A Review of Morphological Appearances Encountered in Human Papillomavirus-associated and Papillomavirus-independent Tumors and Precursor Lesions.
Stolnicu S, Allison D, Patrichi A, Flynn J, Iasonos A, Soslow RA
Adv Anat Pathol 2024 Jan 1;31(1):1-14. Epub 2023 Aug 28 doi: 10.1097/PAP.0000000000000411. PMID: 37638549Free PMC Article
Clinicopathological characteristics and survival outcomes in human papillomavirus independent cervical cancer: a propensity score matched analysis.
Li D, Huang S, Liu K, Qin Y, Zhang Y, Yang Y
Int J Gynecol Cancer 2022 May 3;32(5):599-605. doi: 10.1136/ijgc-2021-003159. PMID: 35331994
Human papillomavirus-independent cervical cancer.
Fernandes A, Viveros-Carreño D, Hoegl J, Ávila M, Pareja R
Int J Gynecol Cancer 2022 Jan;32(1):1-7. Epub 2021 Nov 1 doi: 10.1136/ijgc-2021-003014. PMID: 34725203
Programmed death-ligand 1 expression in human papillomavirus-independent cervical adenocarcinoma and its prognostic significance.
Chen L, Lucas E, Zhang X, Liu Q, Zhuang Y, Lin W, Chen H, Zhou F
Histopathology 2022 Jan;80(2):338-347. Epub 2021 Oct 13 doi: 10.1111/his.14552. PMID: 34455625
Gastric-type endocervical adenocarcinoma and cervical cytology: Experience at a general hospital and review of the literature.
Greenland NY, Wolsky RJ, Darragh TM, Vohra P
Cytopathology 2021 Jan;32(1):75-83. Epub 2020 Oct 5 doi: 10.1111/cyt.12907. PMID: 32851700

Clinical prediction guides

Diagnostic and prognostic potential of the intra-tumoral microbiota profile in HPV-independent endocervical adenocarcinoma.
Zhou X, Chen L, Lin W, Zheng W, Zhang H, Zhou F
Front Cell Infect Microbiol 2024;14:1440017. Epub 2024 Aug 16 doi: 10.3389/fcimb.2024.1440017. PMID: 39220287Free PMC Article
The Updated World Health Organization Classification Better Predicts Survival in Patients With Endocervical Adenocarcinoma (KROG 20-07).
Cho WK, Kim HS, Park W, Kim YS, Kang J, Kim YB, Kim YS, Kim YJ, Kim KR, Kim JH, Kwon SY, Choi JH, Yoon M, Kim NI
Int J Radiat Oncol Biol Phys 2023 Sep 1;117(1):154-163. Epub 2023 Mar 18 doi: 10.1016/j.ijrobp.2023.03.048. PMID: 36935025
Assessment of HER2 in Gastric-Type Endocervical Adenocarcinoma and its Prognostic Significance.
Wang S, Zhou X, Niu S, Chen L, Zhang H, Chen H, Zhou F
Mod Pathol 2023 Jun;36(6):100148. Epub 2023 Feb 24 doi: 10.1016/j.modpat.2023.100148. PMID: 36841435
Clinicopathological characteristics and survival outcomes in human papillomavirus independent cervical cancer: a propensity score matched analysis.
Li D, Huang S, Liu K, Qin Y, Zhang Y, Yang Y
Int J Gynecol Cancer 2022 May 3;32(5):599-605. doi: 10.1136/ijgc-2021-003159. PMID: 35331994
Programmed death-ligand 1 expression in human papillomavirus-independent cervical adenocarcinoma and its prognostic significance.
Chen L, Lucas E, Zhang X, Liu Q, Zhuang Y, Lin W, Chen H, Zhou F
Histopathology 2022 Jan;80(2):338-347. Epub 2021 Oct 13 doi: 10.1111/his.14552. PMID: 34455625

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