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Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck

MedGen UID:
1793136
Concept ID:
C5556695
Neoplastic Process

Definition

Cutaneous squamous cell carcinoma of the head and neck that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck

Professional guidelines

PubMed

Yan F, Schmalbach CE
Surg Oncol Clin N Am 2024 Oct;33(4):723-733. Epub 2024 Jun 5 doi: 10.1016/j.soc.2024.04.006. PMID: 39244290
Wilmas KM, Nguyen QB, Patel J, Silapunt S, Migden MR
Future Oncol 2021 Dec;17(35):4971-4982. Epub 2021 Oct 5 doi: 10.2217/fon-2021-0901. PMID: 34608809
Work Group; Invited Reviewers, Kim JYS, Kozlow JH, Mittal B, Moyer J, Olenecki T, Rodgers P
J Am Acad Dermatol 2018 Mar;78(3):560-578. Epub 2018 Jan 10 doi: 10.1016/j.jaad.2017.10.007. PMID: 29331386Free PMC Article

Recent clinical studies

Etiology

Hanna GJ, Dharanesswaran H, Giobbie-Hurder A, Harran JJ, Liao Z, Pai L, Tchekmedyian V, Ruiz ES, Waldman AH, Schmults CD, Riella LV, Lizotte P, Paweletz CP, Chandraker AK, Murakami N, Silk AW
J Clin Oncol 2024 Mar 20;42(9):1021-1030. Epub 2024 Jan 22 doi: 10.1200/JCO.23.01498. PMID: 38252908Free PMC Article
Baggi A, Quaglino P, Rubatto M, Depenni R, Guida M, Ascierto PA, Trojaniello C, Queirolo P, Saponara M, Peris K, Spagnolo F, Bianchi L, De Galitiis F, Potenza MC, Proietti I, Marconcini R, Botticelli A, Barbieri V, Licitra L, Alfieri S, Ficorella C, Cortellini A, Fargnoli MC, Troiani T, Tondulli L, Bossi P
Eur J Cancer 2021 Nov;157:250-258. Epub 2021 Sep 15 doi: 10.1016/j.ejca.2021.08.018. PMID: 34536948
Migden MR, Khushalani NI, Chang ALS, Lewis KD, Schmults CD, Hernandez-Aya L, Meier F, Schadendorf D, Guminski A, Hauschild A, Wong DJ, Daniels GA, Berking C, Jankovic V, Stankevich E, Booth J, Li S, Weinreich DM, Yancopoulos GD, Lowy I, Fury MG, Rischin D
Lancet Oncol 2020 Feb;21(2):294-305. Epub 2020 Jan 14 doi: 10.1016/S1470-2045(19)30728-4. PMID: 31952975Free PMC Article
Migden MR, Rischin D, Schmults CD, Guminski A, Hauschild A, Lewis KD, Chung CH, Hernandez-Aya L, Lim AM, Chang ALS, Rabinowits G, Thai AA, Dunn LA, Hughes BGM, Khushalani NI, Modi B, Schadendorf D, Gao B, Seebach F, Li S, Li J, Mathias M, Booth J, Mohan K, Stankevich E, Babiker HM, Brana I, Gil-Martin M, Homsi J, Johnson ML, Moreno V, Niu J, Owonikoko TK, Papadopoulos KP, Yancopoulos GD, Lowy I, Fury MG
N Engl J Med 2018 Jul 26;379(4):341-351. Epub 2018 Jun 4 doi: 10.1056/NEJMoa1805131. PMID: 29863979
Work Group; Invited Reviewers, Kim JYS, Kozlow JH, Mittal B, Moyer J, Olenecki T, Rodgers P
J Am Acad Dermatol 2018 Mar;78(3):560-578. Epub 2018 Jan 10 doi: 10.1016/j.jaad.2017.10.007. PMID: 29331386Free PMC Article

Diagnosis

Ezzibdeh R, Diop M, Divi V
Curr Treat Options Oncol 2024 Jul;25(7):885-896. Epub 2024 Jun 25 doi: 10.1007/s11864-024-01197-1. PMID: 38916713
Dessinioti C, Pitoulias M, Stratigos AJ
J Eur Acad Dermatol Venereol 2022 Jan;36(1):39-50. Epub 2021 Oct 11 doi: 10.1111/jdv.17709. PMID: 34592000
Wilmas KM, Nguyen QB, Patel J, Silapunt S, Migden MR
Future Oncol 2021 Dec;17(35):4971-4982. Epub 2021 Oct 5 doi: 10.2217/fon-2021-0901. PMID: 34608809
Varra V, Smile TD, Geiger JL, Koyfman SA
Curr Treat Options Oncol 2020 Apr 23;21(5):37. doi: 10.1007/s11864-020-00739-7. PMID: 32328817
Work Group; Invited Reviewers, Kim JYS, Kozlow JH, Mittal B, Moyer J, Olenecki T, Rodgers P
J Am Acad Dermatol 2018 Mar;78(3):560-578. Epub 2018 Jan 10 doi: 10.1016/j.jaad.2017.10.007. PMID: 29331386Free PMC Article

Therapy

Baggi A, Quaglino P, Rubatto M, Depenni R, Guida M, Ascierto PA, Trojaniello C, Queirolo P, Saponara M, Peris K, Spagnolo F, Bianchi L, De Galitiis F, Potenza MC, Proietti I, Marconcini R, Botticelli A, Barbieri V, Licitra L, Alfieri S, Ficorella C, Cortellini A, Fargnoli MC, Troiani T, Tondulli L, Bossi P
Eur J Cancer 2021 Nov;157:250-258. Epub 2021 Sep 15 doi: 10.1016/j.ejca.2021.08.018. PMID: 34536948
Hughes BGM, Munoz-Couselo E, Mortier L, Bratland Å, Gutzmer R, Roshdy O, González Mendoza R, Schachter J, Arance A, Grange F, Meyer N, Joshi A, Billan S, Zhang P, Gumuscu B, Swaby RF, Grob JJ
Ann Oncol 2021 Oct;32(10):1276-1285. Epub 2021 Jul 20 doi: 10.1016/j.annonc.2021.07.008. PMID: 34293460
Migden MR, Khushalani NI, Chang ALS, Lewis KD, Schmults CD, Hernandez-Aya L, Meier F, Schadendorf D, Guminski A, Hauschild A, Wong DJ, Daniels GA, Berking C, Jankovic V, Stankevich E, Booth J, Li S, Weinreich DM, Yancopoulos GD, Lowy I, Fury MG, Rischin D
Lancet Oncol 2020 Feb;21(2):294-305. Epub 2020 Jan 14 doi: 10.1016/S1470-2045(19)30728-4. PMID: 31952975Free PMC Article
Migden MR, Rischin D, Schmults CD, Guminski A, Hauschild A, Lewis KD, Chung CH, Hernandez-Aya L, Lim AM, Chang ALS, Rabinowits G, Thai AA, Dunn LA, Hughes BGM, Khushalani NI, Modi B, Schadendorf D, Gao B, Seebach F, Li S, Li J, Mathias M, Booth J, Mohan K, Stankevich E, Babiker HM, Brana I, Gil-Martin M, Homsi J, Johnson ML, Moreno V, Niu J, Owonikoko TK, Papadopoulos KP, Yancopoulos GD, Lowy I, Fury MG
N Engl J Med 2018 Jul 26;379(4):341-351. Epub 2018 Jun 4 doi: 10.1056/NEJMoa1805131. PMID: 29863979
Work Group; Invited Reviewers, Kim JYS, Kozlow JH, Mittal B, Moyer J, Olenecki T, Rodgers P
J Am Acad Dermatol 2018 Mar;78(3):560-578. Epub 2018 Jan 10 doi: 10.1016/j.jaad.2017.10.007. PMID: 29331386Free PMC Article

Prognosis

Bellamkonda N, Kull A, Monroe MM
Otolaryngol Head Neck Surg 2024 Oct;171(4):1092-1096. Epub 2024 Jun 21 doi: 10.1002/ohn.851. PMID: 39031592
Dessinioti C, Pitoulias M, Stratigos AJ
J Eur Acad Dermatol Venereol 2022 Jan;36(1):39-50. Epub 2021 Oct 11 doi: 10.1111/jdv.17709. PMID: 34592000
Migden MR, Khushalani NI, Chang ALS, Lewis KD, Schmults CD, Hernandez-Aya L, Meier F, Schadendorf D, Guminski A, Hauschild A, Wong DJ, Daniels GA, Berking C, Jankovic V, Stankevich E, Booth J, Li S, Weinreich DM, Yancopoulos GD, Lowy I, Fury MG, Rischin D
Lancet Oncol 2020 Feb;21(2):294-305. Epub 2020 Jan 14 doi: 10.1016/S1470-2045(19)30728-4. PMID: 31952975Free PMC Article
Phillips TJ, Harris BN, Moore MG, Farwell DG, Bewley AF
J Otolaryngol Head Neck Surg 2019 Oct 25;48(1):55. doi: 10.1186/s40463-019-0374-3. PMID: 31653276Free PMC Article
Mydlarz WK, Weber RS, Kupferman ME
Surg Oncol Clin N Am 2015 Jul;24(3):593-613. Epub 2015 Apr 8 doi: 10.1016/j.soc.2015.03.010. PMID: 25979402

Clinical prediction guides

Hanna GJ, Dharanesswaran H, Giobbie-Hurder A, Harran JJ, Liao Z, Pai L, Tchekmedyian V, Ruiz ES, Waldman AH, Schmults CD, Riella LV, Lizotte P, Paweletz CP, Chandraker AK, Murakami N, Silk AW
J Clin Oncol 2024 Mar 20;42(9):1021-1030. Epub 2024 Jan 22 doi: 10.1200/JCO.23.01498. PMID: 38252908Free PMC Article
Hasmat S, Howle JR, Carlino MS, Sundaresan P, Veness MJ
ANZ J Surg 2023 Jan;93(1-2):235-241. Epub 2022 Dec 25 doi: 10.1111/ans.18219. PMID: 36567642
Baggi A, Quaglino P, Rubatto M, Depenni R, Guida M, Ascierto PA, Trojaniello C, Queirolo P, Saponara M, Peris K, Spagnolo F, Bianchi L, De Galitiis F, Potenza MC, Proietti I, Marconcini R, Botticelli A, Barbieri V, Licitra L, Alfieri S, Ficorella C, Cortellini A, Fargnoli MC, Troiani T, Tondulli L, Bossi P
Eur J Cancer 2021 Nov;157:250-258. Epub 2021 Sep 15 doi: 10.1016/j.ejca.2021.08.018. PMID: 34536948
Migden MR, Khushalani NI, Chang ALS, Lewis KD, Schmults CD, Hernandez-Aya L, Meier F, Schadendorf D, Guminski A, Hauschild A, Wong DJ, Daniels GA, Berking C, Jankovic V, Stankevich E, Booth J, Li S, Weinreich DM, Yancopoulos GD, Lowy I, Fury MG, Rischin D
Lancet Oncol 2020 Feb;21(2):294-305. Epub 2020 Jan 14 doi: 10.1016/S1470-2045(19)30728-4. PMID: 31952975Free PMC Article
Migden MR, Rischin D, Schmults CD, Guminski A, Hauschild A, Lewis KD, Chung CH, Hernandez-Aya L, Lim AM, Chang ALS, Rabinowits G, Thai AA, Dunn LA, Hughes BGM, Khushalani NI, Modi B, Schadendorf D, Gao B, Seebach F, Li S, Li J, Mathias M, Booth J, Mohan K, Stankevich E, Babiker HM, Brana I, Gil-Martin M, Homsi J, Johnson ML, Moreno V, Niu J, Owonikoko TK, Papadopoulos KP, Yancopoulos GD, Lowy I, Fury MG
N Engl J Med 2018 Jul 26;379(4):341-351. Epub 2018 Jun 4 doi: 10.1056/NEJMoa1805131. PMID: 29863979

Recent systematic reviews

Mehta NK, Li AR, Nguyen SA, Kaczmar JM, Neskey DM, Day TA
Target Oncol 2021 Nov;16(6):743-752. Epub 2021 Oct 22 doi: 10.1007/s11523-021-00844-z. PMID: 34677815
Lenzi R, Muscatello L, Saibene AM, Felisati G, Pipolo C
Eur Arch Otorhinolaryngol 2017 Jun;274(6):2389-2394. Epub 2017 Feb 24 doi: 10.1007/s00405-017-4490-2. PMID: 28236011

Supplemental Content

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