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Human Papillomavirus-Independent Vulvar Squamous Cell Carcinoma

MedGen UID:
1793789
•Concept ID:
C5557348
•
Neoplastic Process
Synonym: HPV-Independent Vulvar Squamous Cell Carcinoma

Definition

Vulvar squamous cell carcinoma not associated with human papillomavirus infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHuman Papillomavirus-Independent Vulvar Squamous Cell Carcinoma

Recent clinical studies

Etiology

Biopsy-verified vulvar lichen sclerosus and the risk of non-vulvar cancer: A nationwide cohort study.
Kaderly Rasmussen EL, Hannibal CG, Hertzum-Larsen R, Kjær SK, Baandrup L
Int J Cancer 2024 Nov 15;155(10):1714-1720. Epub 2024 Jul 17 doi: 10.1002/ijc.35101. PMID: 39016007
Differentiated vulvar intraepithelial neoplasia long-term follow up and prognostic factors: An analysis of a large historical cohort.
Gallio N, Preti M, Jones RW, Borella F, Woelber L, Bertero L, Urru S, Micheletti L, Zamagni F, Bevilacqua F, Tondo P, Pollano B, Cassoni P, Benedetto C
Acta Obstet Gynecol Scand 2024 Jun;103(6):1175-1182. Epub 2024 Feb 21 doi: 10.1111/aogs.14814. PMID: 38383115Free PMC Article
p53-Abnormal "Fields of Dysplasia" in Human Papillomavirus-Independent Vulvar Squamous Cell Carcinoma Impacts Margins and Recurrence Risk.
Thompson EF, Wong RWC, Trevisan G, Tessier-Cloutier B, Almadani N, Chen J, Cheng A, Karnezis A, McConechy MK, Lum A, Senz J, McAlpine JN, Huntsman DG, Gilks B, Jamieson A, Hoang LN
Mod Pathol 2023 Feb;36(2):100010. Epub 2023 Jan 9 doi: 10.1016/j.modpat.2022.100010. PMID: 36853783

Diagnosis

Biopsy-verified vulvar lichen sclerosus and the risk of non-vulvar cancer: A nationwide cohort study.
Kaderly Rasmussen EL, Hannibal CG, Hertzum-Larsen R, Kjær SK, Baandrup L
Int J Cancer 2024 Nov 15;155(10):1714-1720. Epub 2024 Jul 17 doi: 10.1002/ijc.35101. PMID: 39016007
Differentiated vulvar intraepithelial neoplasia long-term follow up and prognostic factors: An analysis of a large historical cohort.
Gallio N, Preti M, Jones RW, Borella F, Woelber L, Bertero L, Urru S, Micheletti L, Zamagni F, Bevilacqua F, Tondo P, Pollano B, Cassoni P, Benedetto C
Acta Obstet Gynecol Scand 2024 Jun;103(6):1175-1182. Epub 2024 Feb 21 doi: 10.1111/aogs.14814. PMID: 38383115Free PMC Article
Well-differentiated Squamous Cell Carcinoma With Sarcomatous Differentiation in Patient With a History of Recurrent Verrucous Carcinoma.
Ijaz K, Johannesen E, Nguyen T V
Int J Gynecol Pathol 2024 Mar 1;43(2):171-175. Epub 2023 Nov 13 doi: 10.1097/PGP.0000000000000999. PMID: 38329416
p53-Abnormal "Fields of Dysplasia" in Human Papillomavirus-Independent Vulvar Squamous Cell Carcinoma Impacts Margins and Recurrence Risk.
Thompson EF, Wong RWC, Trevisan G, Tessier-Cloutier B, Almadani N, Chen J, Cheng A, Karnezis A, McConechy MK, Lum A, Senz J, McAlpine JN, Huntsman DG, Gilks B, Jamieson A, Hoang LN
Mod Pathol 2023 Feb;36(2):100010. Epub 2023 Jan 9 doi: 10.1016/j.modpat.2022.100010. PMID: 36853783
Comparison of p53 immunohistochemical staining in differentiated vulvar intraepithelial neoplasia (dVIN) with that in inflammatory dermatoses and benign squamous lesions in the vulva.
Liu YA, Ji JX, Almadani N, Crawford RI, Gilks CB, Kinloch M, Hoang L
Histopathology 2021 Feb;78(3):424-433. Epub 2020 Oct 27 doi: 10.1111/his.14238. PMID: 32799363

Prognosis

Biopsy-verified vulvar lichen sclerosus and the risk of non-vulvar cancer: A nationwide cohort study.
Kaderly Rasmussen EL, Hannibal CG, Hertzum-Larsen R, Kjær SK, Baandrup L
Int J Cancer 2024 Nov 15;155(10):1714-1720. Epub 2024 Jul 17 doi: 10.1002/ijc.35101. PMID: 39016007
Differentiated vulvar intraepithelial neoplasia long-term follow up and prognostic factors: An analysis of a large historical cohort.
Gallio N, Preti M, Jones RW, Borella F, Woelber L, Bertero L, Urru S, Micheletti L, Zamagni F, Bevilacqua F, Tondo P, Pollano B, Cassoni P, Benedetto C
Acta Obstet Gynecol Scand 2024 Jun;103(6):1175-1182. Epub 2024 Feb 21 doi: 10.1111/aogs.14814. PMID: 38383115Free PMC Article

Clinical prediction guides

Comparison of p53 immunohistochemical staining in differentiated vulvar intraepithelial neoplasia (dVIN) with that in inflammatory dermatoses and benign squamous lesions in the vulva.
Liu YA, Ji JX, Almadani N, Crawford RI, Gilks CB, Kinloch M, Hoang L
Histopathology 2021 Feb;78(3):424-433. Epub 2020 Oct 27 doi: 10.1111/his.14238. PMID: 32799363

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