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Recurrent Appendix Adenocarcinoma

MedGen UID:
1793983
•Concept ID:
C5557542
•
Neoplastic Process

Definition

The reemergence of appendix adenocarcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Appendix Adenocarcinoma

Professional guidelines

PubMed

Mucinous appendiceal neoplasms and pseudomyxoma peritonei: Morphological and clinical findings, differential diagnosis, and prognosis.
Akay E, Arslan A, Eren SK, Özhan N, Karaman H
Indian J Pathol Microbiol 2022 Jul-Sep;65(3):565-571. doi: 10.4103/ijpm.ijpm_827_21. PMID: 35900483
Guideline No. 408: Management of Gestational Trophoblastic Diseases.
Eiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, Bouchard-Fortier G, Osborne R, Sauthier P
J Obstet Gynaecol Can 2021 Jan;43(1):91-105.e1. doi: 10.1016/j.jogc.2020.03.001. PMID: 33384141
Goblet cell appendiceal tumors--management dilemmas and long-term outcomes.
Rossi RE, Luong TV, Caplin ME, Thirlwell C, Meyer T, Garcia-Hernandez J, Baneke A, Conte D, Toumpanakis C
Surg Oncol 2015 Mar;24(1):47-53. Epub 2015 Jan 28 doi: 10.1016/j.suronc.2015.01.001. PMID: 25686643

Recent clinical studies

Etiology

Does a Positive Appendiceal Resection Margin in Low-Grade Appendiceal Mucinous Neoplasms, Warrant Additional Surgery? Our Institution Experience and Literature Review.
Ibrahim E, Akrmah M, Ligato S
Ann Surg Oncol 2023 Nov;30(12):7189-7195. Epub 2023 Jul 21 doi: 10.1245/s10434-023-13930-5. PMID: 37477747
Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Guideline No. 408: Management of Gestational Trophoblastic Diseases.
Eiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, Bouchard-Fortier G, Osborne R, Sauthier P
J Obstet Gynaecol Can 2021 Jan;43(1):91-105.e1. doi: 10.1016/j.jogc.2020.03.001. PMID: 33384141
Pseudomyxoma peritonei.
Hinson FL, Ambrose NS
Br J Surg 1998 Oct;85(10):1332-9. doi: 10.1046/j.1365-2168.1998.00882.x. PMID: 9782010
Appendiceal mucoceles and pseudomyxoma peritonei.
Landen S, Bertrand C, Maddern GJ, Herman D, Pourbaix A, de Neve A, Schmitz A
Surg Gynecol Obstet 1992 Nov;175(5):401-4. PMID: 1440166

Diagnosis

Confined Low Grade Appendiceal Mucinous Neoplasm With Coexisting Distant Metastasis.
Arshi J, Peter AD, Liang Y, Hao Y
In Vivo 2024 Jan-Feb;38(1):295-298. doi: 10.21873/invivo.13438. PMID: 38148061Free PMC Article
Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Guideline No. 408: Management of Gestational Trophoblastic Diseases.
Eiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, Bouchard-Fortier G, Osborne R, Sauthier P
J Obstet Gynaecol Can 2021 Jan;43(1):91-105.e1. doi: 10.1016/j.jogc.2020.03.001. PMID: 33384141
Pseudomyxoma peritonei.
Hinson FL, Ambrose NS
Br J Surg 1998 Oct;85(10):1332-9. doi: 10.1046/j.1365-2168.1998.00882.x. PMID: 9782010
Appendiceal mucoceles and pseudomyxoma peritonei.
Landen S, Bertrand C, Maddern GJ, Herman D, Pourbaix A, de Neve A, Schmitz A
Surg Gynecol Obstet 1992 Nov;175(5):401-4. PMID: 1440166

Therapy

Guideline No. 408: Management of Gestational Trophoblastic Diseases.
Eiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, Bouchard-Fortier G, Osborne R, Sauthier P
J Obstet Gynaecol Can 2021 Jan;43(1):91-105.e1. doi: 10.1016/j.jogc.2020.03.001. PMID: 33384141
Duodenal Obstruction Caused by the Long-term Recurrence of Appendiceal Goblet Cell Carcinoid.
Saito M, Asanuma K, Hatta W, Koike T, Hata T, Fujishima F, Furukawa T, Unno M, Masamune A
Intern Med 2020 Dec 1;59(23):3001-3007. Epub 2020 Aug 4 doi: 10.2169/internalmedicine.4548-20. PMID: 32759580Free PMC Article
Low-Grade Appendiceal Mucinous Neoplasms: A Single Institution Experience of 64 Cases With Clinical Follow-up and Correlation With the Current (Eighth Edition) AJCC Staging.
Wong M, Barrows B, Gangi A, Kim S, Mertens RB, Dhall D
Int J Surg Pathol 2020 May;28(3):252-258. Epub 2019 Oct 24 doi: 10.1177/1066896919883679. PMID: 31645160
Nivolumab plus ipilimumab as first-line treatment for advanced non-small-cell lung cancer (CheckMate 012): results of an open-label, phase 1, multicohort study.
Hellmann MD, Rizvi NA, Goldman JW, Gettinger SN, Borghaei H, Brahmer JR, Ready NE, Gerber DE, Chow LQ, Juergens RA, Shepherd FA, Laurie SA, Geese WJ, Agrawal S, Young TC, Li X, Antonia SJ
Lancet Oncol 2017 Jan;18(1):31-41. Epub 2016 Dec 5 doi: 10.1016/S1470-2045(16)30624-6. PMID: 27932067Free PMC Article
Pseudomyxoma peritonei.
Hinson FL, Ambrose NS
Br J Surg 1998 Oct;85(10):1332-9. doi: 10.1046/j.1365-2168.1998.00882.x. PMID: 9782010

Prognosis

Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Guideline No. 408: Management of Gestational Trophoblastic Diseases.
Eiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, Bouchard-Fortier G, Osborne R, Sauthier P
J Obstet Gynaecol Can 2021 Jan;43(1):91-105.e1. doi: 10.1016/j.jogc.2020.03.001. PMID: 33384141
Pseudomyxoma peritonei.
Hinson FL, Ambrose NS
Br J Surg 1998 Oct;85(10):1332-9. doi: 10.1046/j.1365-2168.1998.00882.x. PMID: 9782010
Appendiceal mucoceles and pseudomyxoma peritonei.
Landen S, Bertrand C, Maddern GJ, Herman D, Pourbaix A, de Neve A, Schmitz A
Surg Gynecol Obstet 1992 Nov;175(5):401-4. PMID: 1440166
Adenocarcinoma of the appendix.
Lenriot JP, Huguier M
Am J Surg 1988 Mar;155(3):470-5. doi: 10.1016/s0002-9610(88)80115-6. PMID: 3344912

Clinical prediction guides

Mucinous appendiceal neoplasms and pseudomyxoma peritonei: Morphological and clinical findings, differential diagnosis, and prognosis.
Akay E, Arslan A, Eren SK, Özhan N, Karaman H
Indian J Pathol Microbiol 2022 Jul-Sep;65(3):565-571. doi: 10.4103/ijpm.ijpm_827_21. PMID: 35900483
Controversies in appendiceal pathology: mucinous and goblet cell neoplasms.
Orr CE, Yantiss RK
Pathology 2022 Mar;54(2):167-176. Epub 2021 Nov 23 doi: 10.1016/j.pathol.2021.09.003. PMID: 34836648
The Frontiers of Appendiceal Controversies: Mucinous Neoplasms and Pseudomyxoma Peritonei.
Hissong E, Yantiss RK
Am J Surg Pathol 2022 Jan 1;46(1):e27-e42. doi: 10.1097/PAS.0000000000001662. PMID: 33417324
Guideline No. 408: Management of Gestational Trophoblastic Diseases.
Eiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, Bouchard-Fortier G, Osborne R, Sauthier P
J Obstet Gynaecol Can 2021 Jan;43(1):91-105.e1. doi: 10.1016/j.jogc.2020.03.001. PMID: 33384141
Appendiceal mucoceles and pseudomyxoma peritonei.
Landen S, Bertrand C, Maddern GJ, Herman D, Pourbaix A, de Neve A, Schmitz A
Surg Gynecol Obstet 1992 Nov;175(5):401-4. PMID: 1440166

Recent systematic reviews

Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gallbladder: A Systematic Review of Outcomes Following Surgical Management.
Machairas N, Paspala A, Frountzas M, Tsilimigras DI, Moris D, Ntomi V, Tsapralis D, Schizas D
In Vivo 2019 Nov-Dec;33(6):1721-1726. doi: 10.21873/invivo.11662. PMID: 31662496Free PMC Article
Systematic review and meta-analysis of appendiceal carcinoid tumors in children.
Njere I, Smith LL, Thurairasa D, Malik R, Jeffrey I, Okoye B, Sinha C
Pediatr Blood Cancer 2018 Aug;65(8):e27069. Epub 2018 May 10 doi: 10.1002/pbc.27069. PMID: 29745005
Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer.
Vellayappan BA, Soon YY, Ku GY, Leong CN, Lu JJ, Tey JC
Cochrane Database Syst Rev 2017 Aug 22;8(8):CD010511. doi: 10.1002/14651858.CD010511.pub2. PMID: 28829911Free PMC Article
Perforation in appendiceal well-differentiated carcinoid and goblet cell tumors: impact on prognosis? A systematic review.
Madani A, van der Bilt JD, Consten EC, Vriens MR, Borel Rinkes IH
Ann Surg Oncol 2015 Mar;22(3):959-65. Epub 2014 Sep 5 doi: 10.1245/s10434-014-4023-9. PMID: 25190118

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