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Cartilaginous tracheobronchomalacia

MedGen UID:
1814106
•Concept ID:
C5558369
•
Disease or Syndrome
Synonym: Cartilaginous malacia
 
HPO: HP:0033990

Definition

Softening of the tracheal and/or bronchial cartilage resulting in segmental tracheal and/or bronchial weakness. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCartilaginous tracheobronchomalacia

Professional guidelines

PubMed

Tracheobronchomalacia, Tracheobronchial Compression, and Tracheobronchial Malformations: Diagnostic and Treatment Strategies.
Kamran A, Baird CW, Jennings RW
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2020;23:53-61. doi: 10.1053/j.pcsu.2020.02.006. PMID: 32354548
Treatment of adult tracheobronchomalacia and excessive dynamic airway collapse : an update.
Murgu SD, Colt HG
Treat Respir Med 2006;5(2):103-15. doi: 10.2165/00151829-200605020-00004. PMID: 16512691
Treatment of severe tracheobronchomalacia with continuous positive airway pressure (CPAP).
Kanter RK, Pollack MM, Wright WW, Grundfast KM
Anesthesiology 1982 Jul;57(1):54-6. doi: 10.1097/00000542-198207000-00017. PMID: 7046516

Recent clinical studies

Etiology

Reoperation to correct unsuccessful vascular ring and vascular decompression surgery.
Labuz DF, Kamran A, Jennings RW, Baird CW
J Thorac Cardiovasc Surg 2022 Jul;164(1):199-207. Epub 2021 Nov 11 doi: 10.1016/j.jtcvs.2021.08.089. PMID: 34922756
Pediatric airway surgery.
Maeda K
Pediatr Surg Int 2017 Apr;33(4):435-443. Epub 2017 Jan 28 doi: 10.1007/s00383-016-4050-7. PMID: 28132084
Tracheobronchomalacia: current concepts and controversies.
Ridge CA, O'donnell CR, Lee EY, Majid A, Boiselle PM
J Thorac Imaging 2011 Nov;26(4):278-89. doi: 10.1097/RTI.0b013e3182203342. PMID: 22009081
Tracheomalacia after reoperation for an adenomatous goiter located in a unique position.
Nakadate Y, Fukuda T, Hara H, Tanaka M
J Anesth 2011 Oct;25(5):745-8. Epub 2011 Jun 16 doi: 10.1007/s00540-011-1181-9. PMID: 21674300
Pediatric and adult tracheobronchomalacia.
Masaoka A, Yamakawa Y, Niwa H, Hara F, Kondo S, Fukai I, Kiriyama M
Eur J Cardiothorac Surg 1996;10(2):87-92. doi: 10.1016/s1010-7940(96)80129-1. PMID: 8664011

Diagnosis

Pediatric airway surgery.
Maeda K
Pediatr Surg Int 2017 Apr;33(4):435-443. Epub 2017 Jan 28 doi: 10.1007/s00383-016-4050-7. PMID: 28132084
Pediatric tracheomalacia.
Fraga JC, Jennings RW, Kim PC
Semin Pediatr Surg 2016 Jun;25(3):156-64. Epub 2016 Feb 22 doi: 10.1053/j.sempedsurg.2016.02.008. PMID: 27301602
Paediatric Tracheomalacia.
Hysinger EB, Panitch HB
Paediatr Respir Rev 2016 Jan;17:9-15. Epub 2015 Mar 17 doi: 10.1016/j.prrv.2015.03.002. PMID: 25962857
Multidetector CT evaluation of tracheobronchomalacia.
Lee EY, Litmanovich D, Boiselle PM
Radiol Clin North Am 2009 Mar;47(2):261-9. doi: 10.1016/j.rcl.2008.11.007. PMID: 19249455
Tracheobronchomalacia: evolving role of dynamic multislice helical CT.
Boiselle PM, Feller-Kopman D, Ashiku S, Weeks D, Ernst A
Radiol Clin North Am 2003 May;41(3):627-36. doi: 10.1016/s0033-8389(03)00023-x. PMID: 12797610

Therapy

Williams-Campbell syndrome complicated with pulmonary hypertension and Type 2 respiratory failure: An adult case report.
Liu M, Yuan Q, Zhao H, Wang Y
Clin Respir J 2019 Dec;13(12):795-799. Epub 2019 Oct 10 doi: 10.1111/crj.13090. PMID: 31559694
Sudden Airway Collapse After Pneumoperitoneum With Undiagnosed Tracheomalacia in a Morbidly Obese 12-Year-Old Boy Undergoing Laparoscopic Cholecystectomy: A Case Report.
Kojima T, Kandil AI, Previte JP
A A Pract 2019 Jun 15;12(11):421-423. doi: 10.1213/XAA.0000000000000950. PMID: 30575611
Paediatric Tracheomalacia.
Hysinger EB, Panitch HB
Paediatr Respir Rev 2016 Jan;17:9-15. Epub 2015 Mar 17 doi: 10.1016/j.prrv.2015.03.002. PMID: 25962857
Difficult to control asthma in the patient with pseudoachondroplasia.
Wilczynska M, Ching T
BMJ Case Rep 2011 Oct 11;2011 doi: 10.1136/bcr.08.2011.4667. PMID: 22675014Free PMC Article
Tracheomalacia after reoperation for an adenomatous goiter located in a unique position.
Nakadate Y, Fukuda T, Hara H, Tanaka M
J Anesth 2011 Oct;25(5):745-8. Epub 2011 Jun 16 doi: 10.1007/s00540-011-1181-9. PMID: 21674300

Prognosis

Thoracoscopic posterior tracheopexy during primary esophageal atresia repair: a new approach to prevent tracheomalacia complications.
Tytgat SHAJ, van Herwaarden-Lindeboom MYA, van Tuyll van Serooskerken ES, van der Zee DC
J Pediatr Surg 2018 Jul;53(7):1420-1423. Epub 2018 Apr 27 doi: 10.1016/j.jpedsurg.2018.04.024. PMID: 29804792
Pediatric airway surgery.
Maeda K
Pediatr Surg Int 2017 Apr;33(4):435-443. Epub 2017 Jan 28 doi: 10.1007/s00383-016-4050-7. PMID: 28132084
What's in a name? Expiratory tracheal narrowing in adults explained.
Leong P, Bardin PG, Lau KK
Clin Radiol 2013 Dec;68(12):1268-75. Epub 2013 Aug 13 doi: 10.1016/j.crad.2013.06.017. PMID: 23953005
Tracheomalacia after reoperation for an adenomatous goiter located in a unique position.
Nakadate Y, Fukuda T, Hara H, Tanaka M
J Anesth 2011 Oct;25(5):745-8. Epub 2011 Jun 16 doi: 10.1007/s00540-011-1181-9. PMID: 21674300
Pediatric and adult tracheobronchomalacia.
Masaoka A, Yamakawa Y, Niwa H, Hara F, Kondo S, Fukai I, Kiriyama M
Eur J Cardiothorac Surg 1996;10(2):87-92. doi: 10.1016/s1010-7940(96)80129-1. PMID: 8664011

Clinical prediction guides

Management of bronchomalacia in infants post-cardiac surgery using synchronized nasal DuoPAP: A novel technology.
Kumar A, Praveen M, Tiwari N, Ramamoorthy HR, Joshi A, Parikh B
Ann Card Anaesth 2022 Oct-Dec;25(4):531-535. doi: 10.4103/aca.aca_112_21. PMID: 36254924Free PMC Article
BMP4 and Wnt signaling interact to promote mouse tracheal mesenchyme morphogenesis.
Bottasso-Arias N, Leesman L, Burra K, Snowball J, Shah R, Mohanakrishnan M, Xu Y, Sinner D
Am J Physiol Lung Cell Mol Physiol 2022 Feb 1;322(2):L224-L242. Epub 2021 Dec 1 doi: 10.1152/ajplung.00255.2021. PMID: 34851738Free PMC Article
Tracheal suspension with autogenous rib cartilage in a patient with severe tracheomalacia.
Xu S, Zhu J, Zhao G, Li S
J Cardiothorac Surg 2019 Jan 25;14(1):21. doi: 10.1186/s13019-019-0840-z. PMID: 30683123Free PMC Article
Tracheomalacia after reoperation for an adenomatous goiter located in a unique position.
Nakadate Y, Fukuda T, Hara H, Tanaka M
J Anesth 2011 Oct;25(5):745-8. Epub 2011 Jun 16 doi: 10.1007/s00540-011-1181-9. PMID: 21674300
Lung disease associated with periventricular nodular heterotopia and an FLNA mutation.
Masurel-Paulet A, Haan E, Thompson EM, Goizet C, Thauvin-Robinet C, Tai A, Kennedy D, Smith G, Khong TY, Solé G, Guerineau E, Coupry I, Huet F, Robertson S, Faivre L
Eur J Med Genet 2011 Jan-Feb;54(1):25-8. Epub 2010 Oct 1 doi: 10.1016/j.ejmg.2010.09.010. PMID: 20888935

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