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Anti-phosphatidyl serine antibody positivity

MedGen UID:
1814266
•Concept ID:
C5676696
•
Finding
HPO: HP:0034100

Definition

The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidyl serine. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-phosphatidyl serine antibody positivity

Recent clinical studies

Etiology

Anti-phosphatidyl-serine/prothrombin (aPS/PT) antibodies are superior predictors of LAC presence and APS diagnoses: A single center study.
Saadalla A, Nandakumar V
Clin Chim Acta 2024 Feb 1;554:117761. Epub 2024 Jan 7 doi: 10.1016/j.cca.2024.117761. PMID: 38195020
Anti-phosphatidyl-serine/prothrombin antibodies (aPS/PT) in isolated lupus anticoagulant (LA): is their presence linked to dual test positivity?
Tonello M, Bison E, Cattini MG, Pontara E, Iaccarino L, Denas G, Cheng C, Pengo V
Clin Chem Lab Med 2021 Nov 25;59(12):1950-1953. Epub 2021 Aug 16 doi: 10.1515/cclm-2021-0692. PMID: 34390635
Tetra positive thrombotic antiphospholipid syndrome: Major contribution of anti-phosphatidyl-serine/prothrombin antibodies to lupus anticoagulant activity.
Cattini MG, Bison E, Pontara E, Cheng C, Denas G, Pengo V
J Thromb Haemost 2020 May;18(5):1124-1132. Epub 2020 Mar 17 doi: 10.1111/jth.14765. PMID: 32052568
Relation of antiphospholipid antibodies to postmortem brain infarcts in older people.
Arvanitakis Z, Brey RL, Rand JH, Schneider JA, Capuano AW, Yu L, Leurgans SE, Bennett DA, Levine SR
Circulation 2015 Jan 13;131(2):182-9. Epub 2014 Oct 9 doi: 10.1161/CIRCULATIONAHA.114.012479. PMID: 25301832Free PMC Article
Risk of venous and arterial thrombosis according to type of antiphospholipid antibodies in adults without systemic lupus erythematosus: a systematic review and meta-analysis.
Reynaud Q, Lega JC, Mismetti P, Chapelle C, Wahl D, Cathébras P, Laporte S
Autoimmun Rev 2014 Jun;13(6):595-608. Epub 2014 Jan 11 doi: 10.1016/j.autrev.2013.11.004. PMID: 24418303

Diagnosis

Anti-phosphatidyl-serine/prothrombin (aPS/PT) antibodies are superior predictors of LAC presence and APS diagnoses: A single center study.
Saadalla A, Nandakumar V
Clin Chim Acta 2024 Feb 1;554:117761. Epub 2024 Jan 7 doi: 10.1016/j.cca.2024.117761. PMID: 38195020
Anti-phosphatidyl-serine/prothrombin antibodies (aPS/PT) in isolated lupus anticoagulant (LA): is their presence linked to dual test positivity?
Tonello M, Bison E, Cattini MG, Pontara E, Iaccarino L, Denas G, Cheng C, Pengo V
Clin Chem Lab Med 2021 Nov 25;59(12):1950-1953. Epub 2021 Aug 16 doi: 10.1515/cclm-2021-0692. PMID: 34390635
Cerebrovascular events in patients with isolated anti-phosphatidyl-serine/prothrombin antibodies.
Radin M, Barinotti A, Foddai SG, Cecchi I, Rubini E, Roccatello D, Menegatti E, Sciascia S
Immunol Res 2021 Aug;69(4):372-377. Epub 2021 Jul 10 doi: 10.1007/s12026-021-09208-1. PMID: 34245429Free PMC Article
Risk of venous and arterial thrombosis according to type of antiphospholipid antibodies in adults without systemic lupus erythematosus: a systematic review and meta-analysis.
Reynaud Q, Lega JC, Mismetti P, Chapelle C, Wahl D, Cathébras P, Laporte S
Autoimmun Rev 2014 Jun;13(6):595-608. Epub 2014 Jan 11 doi: 10.1016/j.autrev.2013.11.004. PMID: 24418303
Antiphospholipid antibodies associated with implantation failure after IVF/ET.
Coulam CB, Kaider BD, Kaider AS, Janowicz P, Roussev RG
J Assist Reprod Genet 1997 Nov;14(10):603-8. doi: 10.1023/a:1022588903620. PMID: 9447463Free PMC Article

Prognosis

Anti-phosphatidyl-serine/prothrombin (aPS/PT) antibodies are superior predictors of LAC presence and APS diagnoses: A single center study.
Saadalla A, Nandakumar V
Clin Chim Acta 2024 Feb 1;554:117761. Epub 2024 Jan 7 doi: 10.1016/j.cca.2024.117761. PMID: 38195020

Clinical prediction guides

Anti-phosphatidyl-serine/prothrombin (aPS/PT) antibodies are superior predictors of LAC presence and APS diagnoses: A single center study.
Saadalla A, Nandakumar V
Clin Chim Acta 2024 Feb 1;554:117761. Epub 2024 Jan 7 doi: 10.1016/j.cca.2024.117761. PMID: 38195020
Cerebrovascular events in patients with isolated anti-phosphatidyl-serine/prothrombin antibodies.
Radin M, Barinotti A, Foddai SG, Cecchi I, Rubini E, Roccatello D, Menegatti E, Sciascia S
Immunol Res 2021 Aug;69(4):372-377. Epub 2021 Jul 10 doi: 10.1007/s12026-021-09208-1. PMID: 34245429Free PMC Article
Antiphospholipid antibodies in patients with COVID-19: A relevant observation?
Devreese KMJ, Linskens EA, Benoit D, Peperstraete H
J Thromb Haemost 2020 Sep;18(9):2191-2201. Epub 2020 Jul 23 doi: 10.1111/jth.14994. PMID: 32619328Free PMC Article
Anti-beta(2)-glycoprotein I autoantibody expression as a potential biomarker for strokes in patients with anti-phospholipid syndrome.
Ali HY, Abdullah ZA
J Immunotoxicol 2008 Apr;5(2):173-7. doi: 10.1080/15476910802129638. PMID: 18569388

Recent systematic reviews

Risk of venous and arterial thrombosis according to type of antiphospholipid antibodies in adults without systemic lupus erythematosus: a systematic review and meta-analysis.
Reynaud Q, Lega JC, Mismetti P, Chapelle C, Wahl D, Cathébras P, Laporte S
Autoimmun Rev 2014 Jun;13(6):595-608. Epub 2014 Jan 11 doi: 10.1016/j.autrev.2013.11.004. PMID: 24418303

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