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Impaired renal tubular reabsorption of sodium

MedGen UID:
1815095
•Concept ID:
C5706189
•
Pathologic Function
HPO: HP:0034358

Definition

Increased fractional excretion (FE) of sodium in the urine. The FE of sodium is the percentage of the sodium filtered by the kidney which is excreted in the urine. It is measured in terms of plasma and urine sodium, rather than by the interpretation of urinary glucose concentration alone, as urinary glucose concentrations can vary with water reabsorption. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImpaired renal tubular reabsorption of sodium

Professional guidelines

PubMed

Repurposing SGLT2 inhibitors: Treatment of renal proximal tubulopathy in Fanconi-Bickel syndrome with empagliflozin.
Overduin RJ, Grünert SC, Besouw MTP, Bolhuis MS, Groen J, Schreuder AB, Woidy M, Murko S, Santer R, Derks TGJ
J Inherit Metab Dis 2024 Sep;47(5):1018-1027. Epub 2024 May 27 doi: 10.1002/jimd.12752. PMID: 38802119
Evaluation and Management of Hyponatremia in Heart Failure.
Mondellini GM, Verbrugge FH
Curr Heart Fail Rep 2024 Jun;21(3):252-261. Epub 2024 Feb 27 doi: 10.1007/s11897-024-00651-3. PMID: 38411885
Congestive nephropathy: a neglected entity? Proposal for diagnostic criteria and future perspectives.
Husain-Syed F, Gröne HJ, Assmus B, Bauer P, Gall H, Seeger W, Ghofrani A, Ronco C, Birk HW
ESC Heart Fail 2021 Feb;8(1):183-203. Epub 2020 Nov 30 doi: 10.1002/ehf2.13118. PMID: 33258308Free PMC Article

Recent clinical studies

Etiology

Repurposing SGLT2 inhibitors: Treatment of renal proximal tubulopathy in Fanconi-Bickel syndrome with empagliflozin.
Overduin RJ, Grünert SC, Besouw MTP, Bolhuis MS, Groen J, Schreuder AB, Woidy M, Murko S, Santer R, Derks TGJ
J Inherit Metab Dis 2024 Sep;47(5):1018-1027. Epub 2024 May 27 doi: 10.1002/jimd.12752. PMID: 38802119
Mechanisms of enhanced renal and hepatic erythropoietin synthesis by sodium-glucose cotransporter 2 inhibitors.
Packer M
Eur Heart J 2023 Dec 21;44(48):5027-5035. doi: 10.1093/eurheartj/ehad235. PMID: 37086098Free PMC Article
Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms.
Hall JE, do Carmo JM, da Silva AA, Wang Z, Hall ME
Circ Res 2015 Mar 13;116(6):991-1006. doi: 10.1161/CIRCRESAHA.116.305697. PMID: 25767285Free PMC Article
Renal consequences of obesity.
Naumnik B, Myśliwiec M
Med Sci Monit 2010 Aug;16(8):RA163-70. PMID: 20671624
Leptospiral nephropathy.
Andrade L, de Francesco Daher E, Seguro AC
Semin Nephrol 2008 Jul;28(4):383-394. doi: 10.1016/j.semnephrol.2008.04.008. PMID: 18620961

Diagnosis

The physiology of growth hormone (GH) in adults: translational journey to GH replacement therapy.
Ho KK, O'Sullivan AJ, Burt MG
J Endocrinol 2023 May 1;257(2) Epub 2023 Mar 30 doi: 10.1530/JOE-22-0197. PMID: 36524723
Congestive nephropathy: a neglected entity? Proposal for diagnostic criteria and future perspectives.
Husain-Syed F, Gröne HJ, Assmus B, Bauer P, Gall H, Seeger W, Ghofrani A, Ronco C, Birk HW
ESC Heart Fail 2021 Feb;8(1):183-203. Epub 2020 Nov 30 doi: 10.1002/ehf2.13118. PMID: 33258308Free PMC Article
Pathophysiology of antenatal Bartter's syndrome.
Kömhoff M, Laghmani K
Curr Opin Nephrol Hypertens 2017 Sep;26(5):419-425. doi: 10.1097/MNH.0000000000000346. PMID: 28598867
Activation of mineralocorticoid receptor in salt-sensitive hypertension.
Ayuzawa N, Fujita T
Curr Hypertens Rep 2015 Jun;17(6):552. doi: 10.1007/s11906-015-0552-2. PMID: 25903070
Mechanism of salt-sensitive hypertension: focus on adrenal and sympathetic nervous systems.
Fujita T
J Am Soc Nephrol 2014 Jun;25(6):1148-55. Epub 2014 Feb 27 doi: 10.1681/ASN.2013121258. PMID: 24578129Free PMC Article

Therapy

Repurposing SGLT2 inhibitors: Treatment of renal proximal tubulopathy in Fanconi-Bickel syndrome with empagliflozin.
Overduin RJ, Grünert SC, Besouw MTP, Bolhuis MS, Groen J, Schreuder AB, Woidy M, Murko S, Santer R, Derks TGJ
J Inherit Metab Dis 2024 Sep;47(5):1018-1027. Epub 2024 May 27 doi: 10.1002/jimd.12752. PMID: 38802119
Evaluation and Management of Hyponatremia in Heart Failure.
Mondellini GM, Verbrugge FH
Curr Heart Fail Rep 2024 Jun;21(3):252-261. Epub 2024 Feb 27 doi: 10.1007/s11897-024-00651-3. PMID: 38411885
The physiology of growth hormone (GH) in adults: translational journey to GH replacement therapy.
Ho KK, O'Sullivan AJ, Burt MG
J Endocrinol 2023 May 1;257(2) Epub 2023 Mar 30 doi: 10.1530/JOE-22-0197. PMID: 36524723
Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms.
Hall JE, do Carmo JM, da Silva AA, Wang Z, Hall ME
Circ Res 2015 Mar 13;116(6):991-1006. doi: 10.1161/CIRCRESAHA.116.305697. PMID: 25767285Free PMC Article
Mechanism of salt-sensitive hypertension: focus on adrenal and sympathetic nervous systems.
Fujita T
J Am Soc Nephrol 2014 Jun;25(6):1148-55. Epub 2014 Feb 27 doi: 10.1681/ASN.2013121258. PMID: 24578129Free PMC Article

Prognosis

A more tubulocentric view of diabetic kidney disease.
Zeni L, Norden AGW, Cancarini G, Unwin RJ
J Nephrol 2017 Dec;30(6):701-717. Epub 2017 Aug 24 doi: 10.1007/s40620-017-0423-9. PMID: 28840540Free PMC Article
The Potential Role of Catheter-Based Renal Sympathetic Denervation in Chronic and End-Stage Kidney Disease.
Sata Y, Schlaich MP
J Cardiovasc Pharmacol Ther 2016 Jul;21(4):344-52. Epub 2016 Jan 6 doi: 10.1177/1074248415624156. PMID: 26740184
Renal function in angiotensinogen gene-mutated renal tubular dysgenesis with glomerular cysts.
Hibino S, Sasaki H, Abe Y, Hojo A, Uematsu M, Sekine T, Itabashi K
Pediatr Nephrol 2015 Feb;30(2):357-60. Epub 2014 Nov 22 doi: 10.1007/s00467-014-3007-0. PMID: 25414114
Renal implications of the renin-angiotensin-aldosterone system blockade in heart failure.
Ruilope LM, Barrios V, Volpe M
J Hypertens 2000 Nov;18(11):1545-51. doi: 10.1097/00004872-200018110-00003. PMID: 11081765
Disorders of the serum electrolytes, acid-base balance, and renal function in alcoholism.
Pitts TO, Van Thiel DH
Recent Dev Alcohol 1986;4:311-39. doi: 10.1007/978-1-4899-1695-2_14. PMID: 3704221

Clinical prediction guides

Repurposing SGLT2 inhibitors: Treatment of renal proximal tubulopathy in Fanconi-Bickel syndrome with empagliflozin.
Overduin RJ, Grünert SC, Besouw MTP, Bolhuis MS, Groen J, Schreuder AB, Woidy M, Murko S, Santer R, Derks TGJ
J Inherit Metab Dis 2024 Sep;47(5):1018-1027. Epub 2024 May 27 doi: 10.1002/jimd.12752. PMID: 38802119
Mechanisms of enhanced renal and hepatic erythropoietin synthesis by sodium-glucose cotransporter 2 inhibitors.
Packer M
Eur Heart J 2023 Dec 21;44(48):5027-5035. doi: 10.1093/eurheartj/ehad235. PMID: 37086098Free PMC Article
A more tubulocentric view of diabetic kidney disease.
Zeni L, Norden AGW, Cancarini G, Unwin RJ
J Nephrol 2017 Dec;30(6):701-717. Epub 2017 Aug 24 doi: 10.1007/s40620-017-0423-9. PMID: 28840540Free PMC Article
Clinical pharmacokinetics and pharmacodynamics of the novel SGLT2 inhibitor ipragliflozin.
Kadokura T, Zhang W, Krauwinkel W, Leeflang S, Keirns J, Taniuchi Y, Nakajo I, Smulders R
Clin Pharmacokinet 2014 Nov;53(11):975-88. doi: 10.1007/s40262-014-0180-z. PMID: 25316572
Neural control of renal function in health and disease.
DiBona GF
Clin Auton Res 1994 Apr;4(1-2):69-74. doi: 10.1007/BF01828841. PMID: 8054840

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