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Pineocytoma

MedGen UID:
183004
•Concept ID:
C0917890
•
Neoplastic Process
Synonyms: Pinealocytoma; Pineocytoma (disease)
SNOMED CT: Pineocytoma (89096009); Pineocytoma (1156473003)
 
HPO: HP:0030407
Monarch Initiative: MONDO:0016723
Orphanet: ORPHA251912

Definition

A type of pineal parenchymal cell neoplasm that is a mature well-differentiated tumor (WHO grade I). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPineocytoma
Follow this link to review classifications for Pineocytoma in Orphanet.

Professional guidelines

PubMed

SNO-EANO-EURACAN consensus on management of pineal parenchymal tumors.
Liu APY, Li BK, Vasiljevic A, Dewan MC, Tamrazi B, Ertl-Wagner B, Hansford JR, Pfaff E, Mynarek M, Ng HK, Tsang DS, Gottardo NG, Gajjar A, Bouffet E, Dufour C, Pizer B, Schiff D, Jenkinson MD, Lombardi G, Wen PY, van den Bent MJ, Huang A
Neuro Oncol 2024 Dec 5;26(12):2159-2173. doi: 10.1093/neuonc/noae128. PMID: 39073785Free PMC Article
Role of radiosurgery in the management of pineal region tumours: indications, method, outcome.
Balossier A, Blond S, Touzet G, Sarrazin T, Lartigau E, Reyns N
Neurochirurgie 2015 Apr-Jun;61(2-3):216-22. Epub 2014 May 27 doi: 10.1016/j.neuchi.2013.11.007. PMID: 24874722
The role of radiosurgery for the treatment of pineal parenchymal tumors.
Hasegawa T, Kondziolka D, Hadjipanayis CG, Flickinger JC, Lunsford LD
Neurosurgery 2002 Oct;51(4):880-9. doi: 10.1097/00006123-200210000-00006. PMID: 12234394

Recent clinical studies

Etiology

SNO-EANO-EURACAN consensus on management of pineal parenchymal tumors.
Liu APY, Li BK, Vasiljevic A, Dewan MC, Tamrazi B, Ertl-Wagner B, Hansford JR, Pfaff E, Mynarek M, Ng HK, Tsang DS, Gottardo NG, Gajjar A, Bouffet E, Dufour C, Pizer B, Schiff D, Jenkinson MD, Lombardi G, Wen PY, van den Bent MJ, Huang A
Neuro Oncol 2024 Dec 5;26(12):2159-2173. doi: 10.1093/neuonc/noae128. PMID: 39073785Free PMC Article
Devascularization of a Hemorrhagic Pineocytoma by Laser Thermal Ablation Followed by Endoscopic Resection: A Proof-of-Principle Case Report.
Freeman D, Guillaume D, Bell WR, Chen CC
World Neurosurg 2020 Jul;139:583-587. Epub 2020 Apr 28 doi: 10.1016/j.wneu.2020.04.125. PMID: 32360672
Third ventricular meningiomas.
Li P, Diao X, Bi Z, Hao S, Ren X, Zhang J, Xing J
J Clin Neurosci 2015 Nov;22(11):1776-84. Epub 2015 Aug 29 doi: 10.1016/j.jocn.2015.05.025. PMID: 26455422
Contemporary management of pineocytoma.
Clark AJ, Sughrue ME, Aranda D, Parsa AT
Neurosurg Clin N Am 2011 Jul;22(3):403-7, ix. Epub 2011 Jun 16 doi: 10.1016/j.nec.2011.05.004. PMID: 21801989
Pathology of pineal parenchymal tumors.
Han SJ, Clark AJ, Ivan ME, Parsa AT, Perry A
Neurosurg Clin N Am 2011 Jul;22(3):335-40, vii. Epub 2011 Jun 16 doi: 10.1016/j.nec.2011.05.006. PMID: 21801981

Diagnosis

SNO-EANO-EURACAN consensus on management of pineal parenchymal tumors.
Liu APY, Li BK, Vasiljevic A, Dewan MC, Tamrazi B, Ertl-Wagner B, Hansford JR, Pfaff E, Mynarek M, Ng HK, Tsang DS, Gottardo NG, Gajjar A, Bouffet E, Dufour C, Pizer B, Schiff D, Jenkinson MD, Lombardi G, Wen PY, van den Bent MJ, Huang A
Neuro Oncol 2024 Dec 5;26(12):2159-2173. doi: 10.1093/neuonc/noae128. PMID: 39073785Free PMC Article
Pineocytoma in a child with Pallister-Killian syndrome: a case report and review of the literature.
De Martino L, Russo C, Bifano D, Quaglietta L, Spennato P, Cinalli G
Childs Nerv Syst 2024 Aug;40(8):2619-2623. Epub 2024 Apr 30 doi: 10.1007/s00381-024-06426-4. PMID: 38689102
A Neoplastic Lesion in the Pineal Region.
Mansour MA, Khalil DF, Ayad AA
Curr Probl Cancer 2023 Jun;47(3):100954. Epub 2023 Feb 17 doi: 10.1016/j.currproblcancer.2023.100954. PMID: 36870166
Coincident pineocytoma and probable brainstem glioma in a child with 22q11.2 deletion syndrome.
Adams JW, Malicki D, Levy M, Crawford JR
BMJ Case Rep 2022 Mar 10;15(3) doi: 10.1136/bcr-2022-249232. PMID: 35272994Free PMC Article
Familial pineocytoma.
Gempt J, Ringel F, Oexle K, Delbridge C, Förschler A, Schlegel J, Meyer B, Schmidt-Graf F
Acta Neurochir (Wien) 2012 Aug;154(8):1413-6. Epub 2012 Jun 15 doi: 10.1007/s00701-012-1402-5. PMID: 22699425

Therapy

Supraorbital subfrontal trans-laminar endoscope-assisted approach for tumors of the posterior third ventricle.
Iacoangeli M, Colasanti R, Esposito D, Di Rienzo A, di Somma L, Dobran M, Gladi M, Scerrati M
Acta Neurochir (Wien) 2017 Apr;159(4):645-654. Epub 2017 Feb 24 doi: 10.1007/s00701-017-3117-0. PMID: 28236180
Adjuvant temozolomide chemotherapy for treatment of papillary tumor of the pineal region.
Lorenzetti M, Motta F, Campanella R, Bauer D, Assi A, Arienta C, Gaini SM, Caroli M
World Neurosurg 2011 Jul-Aug;76(1-2):160-3. doi: 10.1016/j.wneu.2010.10.039. PMID: 21839968
Successful treatment of neoadjuvant therapy for papillary tumor of the pineal region.
Nakamura H, Makino K, Kochi M, Nakazato Y, Kuratsu J
Brain Tumor Pathol 2009;26(2):73-7. Epub 2009 Oct 27 doi: 10.1007/s10014-009-0250-3. PMID: 19856218
Pineal parenchymal tumours: I. Pineocytoma: a tumour responsive to platinum-based chemotherapy.
Jackson AS, Plowman PN
Clin Oncol (R Coll Radiol) 2004 Jun;16(4):238-43. doi: 10.1016/j.clon.2003.11.016. PMID: 15214646
Brain stem necrosis after preradiation high-dose methotrexate.
Packer RJ, Grossman RI, Rorke LB, Sutton LN, Siegel KR, Littman P
Childs Nerv Syst 1985;1(6):355-8. doi: 10.1007/BF00270824. PMID: 3833337

Prognosis

SNO-EANO-EURACAN consensus on management of pineal parenchymal tumors.
Liu APY, Li BK, Vasiljevic A, Dewan MC, Tamrazi B, Ertl-Wagner B, Hansford JR, Pfaff E, Mynarek M, Ng HK, Tsang DS, Gottardo NG, Gajjar A, Bouffet E, Dufour C, Pizer B, Schiff D, Jenkinson MD, Lombardi G, Wen PY, van den Bent MJ, Huang A
Neuro Oncol 2024 Dec 5;26(12):2159-2173. doi: 10.1093/neuonc/noae128. PMID: 39073785Free PMC Article
Contemporary management of pineocytoma.
Clark AJ, Sughrue ME, Aranda D, Parsa AT
Neurosurg Clin N Am 2011 Jul;22(3):403-7, ix. Epub 2011 Jun 16 doi: 10.1016/j.nec.2011.05.004. PMID: 21801989
Life without the vein of Galen: Clinical and radiographic sequelae.
Youssef AS, Downes AE, Agazzi S, Van Loveren HR
Clin Anat 2011 Sep;24(6):776-85. Epub 2011 Mar 24 doi: 10.1002/ca.21176. PMID: 21438020
Pineocytomas.
Disclafani A, Hudgins RJ, Edwards MS, Wara W, Wilson CB, Levin VA
Cancer 1989 Jan 15;63(2):302-4. doi: 10.1002/1097-0142(19890115)63:2<302::aid-cncr2820630216>3.0.co;2-d. PMID: 2910435
The separation of pineocytoma from pineoblastoma.
Borit A, Blackwood W, Mair WG
Cancer 1980 Mar 15;45(6):1408-18. doi: 10.1002/1097-0142(19800315)45:6<1408::aid-cncr2820450619>3.0.co;2-0. PMID: 6986979

Clinical prediction guides

Primary Gamma Knife Radiosurgery for pineal region tumors: A systematic review and pooled analysis of available literature with histological stratification.
Gagliardi F, De Domenico P, Garbin E, Snider S, Mortini P
J Pineal Res 2023 Dec;75(4):e12910. Epub 2023 Sep 13 doi: 10.1111/jpi.12910. PMID: 37705383
Third ventricular meningiomas.
Li P, Diao X, Bi Z, Hao S, Ren X, Zhang J, Xing J
J Clin Neurosci 2015 Nov;22(11):1776-84. Epub 2015 Aug 29 doi: 10.1016/j.jocn.2015.05.025. PMID: 26455422
Life without the vein of Galen: Clinical and radiographic sequelae.
Youssef AS, Downes AE, Agazzi S, Van Loveren HR
Clin Anat 2011 Sep;24(6):776-85. Epub 2011 Mar 24 doi: 10.1002/ca.21176. PMID: 21438020
Observed magnetic resonance imaging changes in pediatric patients treated with stereotactic radiosurgery for intracranial tumors.
Nath SK, Carmona R, Rose BS, Simpson DR, Russell M, Lawson JD, Mundt AJ, Murphy KT
Childs Nerv Syst 2011 Mar;27(3):399-406. Epub 2010 Oct 7 doi: 10.1007/s00381-010-1288-6. PMID: 20927529Free PMC Article
Pathology of pineal parenchymal tumors.
Sato K, Kubota T
Prog Neurol Surg 2009;23:12-25. Epub 2009 Mar 23 doi: 10.1159/000210050. PMID: 19329858

Recent systematic reviews

Primary Gamma Knife Radiosurgery for pineal region tumors: A systematic review and pooled analysis of available literature with histological stratification.
Gagliardi F, De Domenico P, Garbin E, Snider S, Mortini P
J Pineal Res 2023 Dec;75(4):e12910. Epub 2023 Sep 13 doi: 10.1111/jpi.12910. PMID: 37705383
Tumor control after surgery and radiotherapy for pineocytoma.
Clark AJ, Ivan ME, Sughrue ME, Yang I, Aranda D, Han SJ, Kane AJ, Parsa AT
J Neurosurg 2010 Aug;113(2):319-24. doi: 10.3171/2009.12.JNS091683. PMID: 20136388

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