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Decreased circulating alpha-fetoprotein concentration

MedGen UID:
1841521
•Concept ID:
C5826839
•
Finding
HPO: HP:0045057

Definition

Concentration of alpha-fetoprotein in the blood circulation below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating alpha-fetoprotein concentration

Conditions with this feature

Alpha-fetoprotein deficiency
MedGen UID:
354899
•Concept ID:
C1863081
•
Disease or Syndrome
Alpha-fetoprotein deficiency appears to be a benign genetic trait (Greenberg et al., 1992; Sharony et al., 2004).
See: Condition Record
Alpha-fetoprotein deficiency

Recent clinical studies

Etiology

Biomarkers Associated With Response to Regorafenib in Patients With Hepatocellular Carcinoma.
Teufel M, Seidel H, Köchert K, Meinhardt G, Finn RS, Llovet JM, Bruix J
Gastroenterology 2019 May;156(6):1731-1741. Epub 2019 Feb 6 doi: 10.1053/j.gastro.2019.01.261. PMID: 30738047
Retaining mTeSR1 Medium during Hepatic Differentiation Facilitates Hepatocyte-Like Cell Survival by Decreasing Apoptosis.
Hou J, Long Y, Hu B, Huang S, Xu G, Gao T, Wu F, Li Y, Wu ZK
Cell Physiol Biochem 2018;51(4):1533-1543. Epub 2018 Nov 29 doi: 10.1159/000495644. PMID: 30497075
Human chorionic gonadotropin and alpha-fetoprotein concentrations in pregnancy and maternal risk of breast cancer: a nested case-control study.
Lukanova A, Andersson R, Wulff M, Zeleniuch-Jacquotte A, Grankvist K, Dossus L, Afanasyeva Y, Johansson R, Arslan AA, Lenner P, Wadell G, Hallmans G, Toniolo P, Lundin E
Am J Epidemiol 2008 Dec 1;168(11):1284-91. Epub 2008 Oct 20 doi: 10.1093/aje/kwn254. PMID: 18936438Free PMC Article
Relationship between protein concentrations in embryological fluids and maternal serum and yolk sac size during human early pregnancy.
Jauniaux E, Gulbis B, Jurkovic D, Campbell S, Collins WP, Ooms HA
Hum Reprod 1994 Jan;9(1):161-6. doi: 10.1093/oxfordjournals.humrep.a138308. PMID: 8195341
Placental proteins as tumor markers.
Braunstein GD
Immunol Ser 1990;53:673-701. PMID: 1713070

Diagnosis

Vitamin-H Channeled Self-Therapeutic P-gp Inhibitor Curcumin-Derived Nanomicelles for Targeting the Tumor Milieu by pH- and Enzyme-Triggered Hierarchical Disassembly.
Das M, Joshi A, Devkar R, Seshadri S, Thakore S
Bioconjug Chem 2022 Feb 16;33(2):369-385. Epub 2022 Jan 11 doi: 10.1021/acs.bioconjchem.1c00614. PMID: 35015523
Circulating transforming growth factor-β and epidermal growth factor receptor as related to virus infection in liver carcinogenesis.
Divella R, Daniele A, Gadaleta C, Tufaro A, Venneri MT, Paradiso A, Quaranta M
Anticancer Res 2012 Jan;32(1):141-5. PMID: 22213299
Human chorionic gonadotropin and alpha-fetoprotein concentrations in pregnancy and maternal risk of breast cancer: a nested case-control study.
Lukanova A, Andersson R, Wulff M, Zeleniuch-Jacquotte A, Grankvist K, Dossus L, Afanasyeva Y, Johansson R, Arslan AA, Lenner P, Wadell G, Hallmans G, Toniolo P, Lundin E
Am J Epidemiol 2008 Dec 1;168(11):1284-91. Epub 2008 Oct 20 doi: 10.1093/aje/kwn254. PMID: 18936438Free PMC Article
Fetuin-A induces cytokine expression and suppresses adiponectin production.
Hennige AM, Staiger H, Wicke C, Machicao F, Fritsche A, Häring HU, Stefan N
PLoS One 2008 Mar 12;3(3):e1765. doi: 10.1371/journal.pone.0001765. PMID: 18335040Free PMC Article
Placental proteins as tumor markers.
Braunstein GD
Immunol Ser 1990;53:673-701. PMID: 1713070

Therapy

Vitamin-H Channeled Self-Therapeutic P-gp Inhibitor Curcumin-Derived Nanomicelles for Targeting the Tumor Milieu by pH- and Enzyme-Triggered Hierarchical Disassembly.
Das M, Joshi A, Devkar R, Seshadri S, Thakore S
Bioconjug Chem 2022 Feb 16;33(2):369-385. Epub 2022 Jan 11 doi: 10.1021/acs.bioconjchem.1c00614. PMID: 35015523
Biomarkers Associated With Response to Regorafenib in Patients With Hepatocellular Carcinoma.
Teufel M, Seidel H, Köchert K, Meinhardt G, Finn RS, Llovet JM, Bruix J
Gastroenterology 2019 May;156(6):1731-1741. Epub 2019 Feb 6 doi: 10.1053/j.gastro.2019.01.261. PMID: 30738047
Aberrant hormone balance in fetal autoimmune NZB/W mice following prenatal exposure to testosterone excess or the androgen blocker flutamide.
Keisler LW, vom Saal FS, Keisler DH, Rudeen PK, Walker SE
Biol Reprod 1995 Nov;53(5):1190-7. doi: 10.1095/biolreprod53.5.1190. PMID: 8527525
Changes in serum hormone levels during labor induced by oral PGE2 or oxytocin infusion.
Bremme K, Eneroth P
Acta Obstet Gynecol Scand Suppl 1980;92:31-43. doi: 10.3109/00016348009156935. PMID: 6160719

Prognosis

Biomarkers Associated With Response to Regorafenib in Patients With Hepatocellular Carcinoma.
Teufel M, Seidel H, Köchert K, Meinhardt G, Finn RS, Llovet JM, Bruix J
Gastroenterology 2019 May;156(6):1731-1741. Epub 2019 Feb 6 doi: 10.1053/j.gastro.2019.01.261. PMID: 30738047
Circulating transforming growth factor-β and epidermal growth factor receptor as related to virus infection in liver carcinogenesis.
Divella R, Daniele A, Gadaleta C, Tufaro A, Venneri MT, Paradiso A, Quaranta M
Anticancer Res 2012 Jan;32(1):141-5. PMID: 22213299
Placental proteins as tumor markers.
Braunstein GD
Immunol Ser 1990;53:673-701. PMID: 1713070
Correlation of plasma hormone levels and peripheral circulating lymphocyte subpopulations during human pregnancy.
Canepa S, Horowitz R, Degenne D, Magnin G, Valat C, Bardos P
Immunol Lett 1984;8(4):159-63. doi: 10.1016/0165-2478(84)90070-1. PMID: 6209211
Changes in serum hormone levels during labor induced by oral PGE2 or oxytocin infusion.
Bremme K, Eneroth P
Acta Obstet Gynecol Scand Suppl 1980;92:31-43. doi: 10.3109/00016348009156935. PMID: 6160719

Clinical prediction guides

Vitamin-H Channeled Self-Therapeutic P-gp Inhibitor Curcumin-Derived Nanomicelles for Targeting the Tumor Milieu by pH- and Enzyme-Triggered Hierarchical Disassembly.
Das M, Joshi A, Devkar R, Seshadri S, Thakore S
Bioconjug Chem 2022 Feb 16;33(2):369-385. Epub 2022 Jan 11 doi: 10.1021/acs.bioconjchem.1c00614. PMID: 35015523
Biomarkers Associated With Response to Regorafenib in Patients With Hepatocellular Carcinoma.
Teufel M, Seidel H, Köchert K, Meinhardt G, Finn RS, Llovet JM, Bruix J
Gastroenterology 2019 May;156(6):1731-1741. Epub 2019 Feb 6 doi: 10.1053/j.gastro.2019.01.261. PMID: 30738047
Retaining mTeSR1 Medium during Hepatic Differentiation Facilitates Hepatocyte-Like Cell Survival by Decreasing Apoptosis.
Hou J, Long Y, Hu B, Huang S, Xu G, Gao T, Wu F, Li Y, Wu ZK
Cell Physiol Biochem 2018;51(4):1533-1543. Epub 2018 Nov 29 doi: 10.1159/000495644. PMID: 30497075
Human chorionic gonadotropin and alpha-fetoprotein concentrations in pregnancy and maternal risk of breast cancer: a nested case-control study.
Lukanova A, Andersson R, Wulff M, Zeleniuch-Jacquotte A, Grankvist K, Dossus L, Afanasyeva Y, Johansson R, Arslan AA, Lenner P, Wadell G, Hallmans G, Toniolo P, Lundin E
Am J Epidemiol 2008 Dec 1;168(11):1284-91. Epub 2008 Oct 20 doi: 10.1093/aje/kwn254. PMID: 18936438Free PMC Article
Hypercalcemia and parathyroid hormone-related protein in hepatocellular carcinoma.
Yen TC, Hwang SJ, Wang CC, Lee SD, Yeh SH
Liver 1993 Dec;13(6):311-5. doi: 10.1111/j.1600-0676.1993.tb00651.x. PMID: 8295494

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