U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Elevated urinary creatine level

MedGen UID:
1841728
•Concept ID:
C5826510
•
Finding
Synonym: Creatine high in urine
 
HPO: HP:0034598

Definition

An increased amount of creatine in the urine. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated urinary creatine level

Professional guidelines

PubMed

Baricitinib for the Treatment of Alopecia Areata.
Freitas E, Guttman-Yassky E, Torres T
Drugs 2023 Jun;83(9):761-770. Epub 2023 May 17 doi: 10.1007/s40265-023-01873-w. PMID: 37195491Free PMC Article
Fenofibrate-induced hyperhomocysteinaemia: clinical implications and management.
Dierkes J, Westphal S, Luley C
Drug Saf 2003;26(2):81-91. doi: 10.2165/00002018-200326020-00002. PMID: 12534325

Recent clinical studies

Etiology

Efficacy and safety assessment of mineralocorticoid receptor antagonists in patients with chronic kidney disease.
Ding K, Li Z, Lu Y, Sun L
Eur J Intern Med 2023 Sep;115:114-127. Epub 2023 Jun 14 doi: 10.1016/j.ejim.2023.05.038. PMID: 37328398
The Effect of Years-Long Exposure to Low-Dose Colchicine on Renal and Liver Function and Blood Creatine Kinase Levels: Safety Insights from the Low-Dose Colchicine 2 (LoDoCo2) Trial.
van Broekhoven A, Mohammadnia N, Silvis MJM, Los J, Fiolet ATL, Opstal TSJ, Mosterd A, Eikelboom JW, Nidorf SM, Budgeon CA, Byrnes E, Bax WA, Tijssen JGP, de Kleijn DPV, Thompson PL, El Messaoudi S, Cornel JH
Clin Drug Investig 2022 Nov;42(11):977-985. Epub 2022 Oct 8 doi: 10.1007/s40261-022-01209-8. PMID: 36208364Free PMC Article
Clinical features of Guillain-Barré syndrome patients with elevated serum creatine kinase levels.
Hosokawa T, Nakajima H, Sawai T, Nakamura Y, Sano E, Tsukahara A, Unoda K, Ishida S, Sakane S, Kimura F, Arawaka S
BMC Neurol 2020 May 27;20(1):214. doi: 10.1186/s12883-020-01796-z. PMID: 32460711Free PMC Article
Urinary Metabolites Diagnostic and Prognostic of Intrahepatic Cholangiocarcinoma.
Haznadar M, Diehl CM, Parker AL, Krausz KW, Bowman ED, Rabibhadana S, Forgues M, Bhudhisawasdi V, Gonzalez FJ, Mahidol C, Budhu A, Wang XW, Ruchirawat M, Harris CC
Cancer Epidemiol Biomarkers Prev 2019 Oct;28(10):1704-1711. Epub 2019 Jul 29 doi: 10.1158/1055-9965.EPI-19-0453. PMID: 31358519Free PMC Article
The Renal Safety of L-Carnitine, L-Arginine, and Glutamine in Athletes and Bodybuilders.
Davani-Davari D, Karimzadeh I, Sagheb MM, Khalili H
J Ren Nutr 2019 May;29(3):221-234. Epub 2018 Oct 16 doi: 10.1053/j.jrn.2018.08.014. PMID: 30341034

Diagnosis

Laboratory and metabolic investigations.
Morava E, Oglesbee D
Handb Clin Neurol 2023;194:167-172. doi: 10.1016/B978-0-12-821751-1.00012-9. PMID: 36813311
Urinary titin as a biomarker in Fukuyama congenital muscular dystrophy.
Sato T, Awano H, Ishiguro K, Shichiji M, Murakami T, Shirakawa T, Matsuo M, Nagata S, Ishigaki K
Neuromuscul Disord 2021 Mar;31(3):194-197. Epub 2021 Jan 13 doi: 10.1016/j.nmd.2021.01.005. PMID: 33563515
Biomarkers, Creatine Kinase, and Kidney Function of Special Operation Candidates During Intense Physiological Training.
Shumway J, Irvin A, Shia R, Goodyear CD
Mil Med 2020 Aug 14;185(7-8):e982-e987. doi: 10.1093/milmed/usaa079. PMID: 32601703
Urinary Metabolites Diagnostic and Prognostic of Intrahepatic Cholangiocarcinoma.
Haznadar M, Diehl CM, Parker AL, Krausz KW, Bowman ED, Rabibhadana S, Forgues M, Bhudhisawasdi V, Gonzalez FJ, Mahidol C, Budhu A, Wang XW, Ruchirawat M, Harris CC
Cancer Epidemiol Biomarkers Prev 2019 Oct;28(10):1704-1711. Epub 2019 Jul 29 doi: 10.1158/1055-9965.EPI-19-0453. PMID: 31358519Free PMC Article
Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity.
Ward A, Chaffman MO, Sorkin EM
Drugs 1986 Aug;32(2):130-68. doi: 10.2165/00003495-198632020-00003. PMID: 3527659

Therapy

Efficacy and safety assessment of mineralocorticoid receptor antagonists in patients with chronic kidney disease.
Ding K, Li Z, Lu Y, Sun L
Eur J Intern Med 2023 Sep;115:114-127. Epub 2023 Jun 14 doi: 10.1016/j.ejim.2023.05.038. PMID: 37328398
Baricitinib for the Treatment of Alopecia Areata.
Freitas E, Guttman-Yassky E, Torres T
Drugs 2023 Jun;83(9):761-770. Epub 2023 May 17 doi: 10.1007/s40265-023-01873-w. PMID: 37195491Free PMC Article
The Renal Safety of L-Carnitine, L-Arginine, and Glutamine in Athletes and Bodybuilders.
Davani-Davari D, Karimzadeh I, Sagheb MM, Khalili H
J Ren Nutr 2019 May;29(3):221-234. Epub 2018 Oct 16 doi: 10.1053/j.jrn.2018.08.014. PMID: 30341034
Muscle creatine loading in men.
Hultman E, Söderlund K, Timmons JA, Cederblad G, Greenhaff PL
J Appl Physiol (1985) 1996 Jul;81(1):232-7. doi: 10.1152/jappl.1996.81.1.232. PMID: 8828669
Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity.
Ward A, Chaffman MO, Sorkin EM
Drugs 1986 Aug;32(2):130-68. doi: 10.2165/00003495-198632020-00003. PMID: 3527659

Prognosis

Rhabdomyolysis associated acute renal failure - Report of two fatal cases and a brief review of literature.
Das S, Hanuman SB, Mylapalli JL
J Forensic Leg Med 2020 Apr;71:101941. Epub 2020 Mar 12 doi: 10.1016/j.jflm.2020.101941. PMID: 32342911
Urinary Metabolites Diagnostic and Prognostic of Intrahepatic Cholangiocarcinoma.
Haznadar M, Diehl CM, Parker AL, Krausz KW, Bowman ED, Rabibhadana S, Forgues M, Bhudhisawasdi V, Gonzalez FJ, Mahidol C, Budhu A, Wang XW, Ruchirawat M, Harris CC
Cancer Epidemiol Biomarkers Prev 2019 Oct;28(10):1704-1711. Epub 2019 Jul 29 doi: 10.1158/1055-9965.EPI-19-0453. PMID: 31358519Free PMC Article
Urinary Mitochondrial DNA Levels Identify Acute Kidney Injury in Surgical Critical Illness Patients.
Hu Q, Ren J, Wu J, Li G, Wu X, Liu S, Wang G, Gu G, Ren H, Hong Z, Li J
Shock 2017 Jul;48(1):11-17. doi: 10.1097/SHK.0000000000000830. PMID: 28060212
The value of measuring urinary β2-microglobulin and serum creatinine for detecting tubulointerstitial nephritis and uveitis syndrome in young patients with uveitis.
Hettinga YM, Scheerlinck LM, Lilien MR, Rothova A, de Boer JH
JAMA Ophthalmol 2015 Feb;133(2):140-5. doi: 10.1001/jamaophthalmol.2014.4301. PMID: 25356569
Noninvasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer.
Mathé EA, Patterson AD, Haznadar M, Manna SK, Krausz KW, Bowman ED, Shields PG, Idle JR, Smith PB, Anami K, Kazandjian DG, Hatzakis E, Gonzalez FJ, Harris CC
Cancer Res 2014 Jun 15;74(12):3259-70. Epub 2014 Apr 15 doi: 10.1158/0008-5472.CAN-14-0109. PMID: 24736543Free PMC Article

Clinical prediction guides

The glycolytic enzyme PFKFB3 drives kidney fibrosis through promoting histone lactylation-mediated NF-κB family activation.
Wang Y, Li H, Jiang S, Fu D, Lu X, Lu M, Li Y, Luo D, Wu K, Xu Y, Li G, Zhou Y, Zhou Y, Chen W, Liu Q, Mao H
Kidney Int 2024 Aug;106(2):226-240. Epub 2024 May 22 doi: 10.1016/j.kint.2024.04.016. PMID: 38789037
Laboratory and metabolic investigations.
Morava E, Oglesbee D
Handb Clin Neurol 2023;194:167-172. doi: 10.1016/B978-0-12-821751-1.00012-9. PMID: 36813311
Urinary titin as a biomarker in Fukuyama congenital muscular dystrophy.
Sato T, Awano H, Ishiguro K, Shichiji M, Murakami T, Shirakawa T, Matsuo M, Nagata S, Ishigaki K
Neuromuscul Disord 2021 Mar;31(3):194-197. Epub 2021 Jan 13 doi: 10.1016/j.nmd.2021.01.005. PMID: 33563515
Clinical features of Guillain-Barré syndrome patients with elevated serum creatine kinase levels.
Hosokawa T, Nakajima H, Sawai T, Nakamura Y, Sano E, Tsukahara A, Unoda K, Ishida S, Sakane S, Kimura F, Arawaka S
BMC Neurol 2020 May 27;20(1):214. doi: 10.1186/s12883-020-01796-z. PMID: 32460711Free PMC Article
Muscle creatine loading in men.
Hultman E, Söderlund K, Timmons JA, Cederblad G, Greenhaff PL
J Appl Physiol (1985) 1996 Jul;81(1):232-7. doi: 10.1152/jappl.1996.81.1.232. PMID: 8828669

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...