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Reduced circulating erythropoietin concentration

MedGen UID:
1841857
•Concept ID:
C5826396
•
Finding
Synonym: Erythropoietin low in blood
 
HPO: HP:0034443

Definition

Decreased concentration of erythropoietin in the blood circulation. Erythropoietin is a glycoprotein hormone produced by the peritubular cells of the kidney that stimulates red blood cell production. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced circulating erythropoietin concentration

Professional guidelines

PubMed

Predicting the hematopoietic response to recombinant human erythropoietin (Epoetin alfa) in the treatment of the anemia of cancer.
Adamson JW, Ludwig H
Oncology 1999;56(1):46-53. doi: 10.1159/000011929. PMID: 9885377
Epoetin alfa. A bloodless approach for the treatment of perioperative anemia.
Faris PM, Ritter MA
Clin Orthop Relat Res 1998 Dec;(357):60-7. PMID: 9917701

Recent clinical studies

Etiology

Association of High-Dose Erythropoietin With Circulating Biomarkers and Neurodevelopmental Outcomes Among Neonates With Hypoxic Ischemic Encephalopathy: A Secondary Analysis of the HEAL Randomized Clinical Trial.
Juul SE, Voldal E, Comstock BA, Massaro AN, Bammler TK, Mayock DE, Heagerty PJ, Wu YW, Numis AL; HEAL consortium
JAMA Netw Open 2023 Jul 3;6(7):e2322131. doi: 10.1001/jamanetworkopen.2023.22131. PMID: 37418263Free PMC Article
Dapagliflozin Suppresses Hepcidin And Increases Erythropoiesis.
Ghanim H, Abuaysheh S, Hejna J, Green K, Batra M, Makdissi A, Chaudhuri A, Dandona P
J Clin Endocrinol Metab 2020 Apr 1;105(4) doi: 10.1210/clinem/dgaa057. PMID: 32044999
Hypovolemia and reduced hemoglobin mass in patients with heart failure and preserved ejection fraction.
Montero D, Haider T, Barthelmes J, Goetze JP, Cantatore S, Sudano I, Ruschitzka F, Flammer AJ
Physiol Rep 2019 Nov;7(21):e14222. doi: 10.14814/phy2.14222. PMID: 31724335Free PMC Article
Erythropoietin response to anaemia in heart failure.
Montero D, Haider T, Flammer AJ
Eur J Prev Cardiol 2019 Jan;26(1):7-17. Epub 2018 Aug 2 doi: 10.1177/2047487318790823. PMID: 30068234
Blood boosting and sport.
Ekblom BT
Baillieres Best Pract Res Clin Endocrinol Metab 2000 Mar;14(1):89-98. doi: 10.1053/beem.2000.0056. PMID: 10932813

Diagnosis

Association of High-Dose Erythropoietin With Circulating Biomarkers and Neurodevelopmental Outcomes Among Neonates With Hypoxic Ischemic Encephalopathy: A Secondary Analysis of the HEAL Randomized Clinical Trial.
Juul SE, Voldal E, Comstock BA, Massaro AN, Bammler TK, Mayock DE, Heagerty PJ, Wu YW, Numis AL; HEAL consortium
JAMA Netw Open 2023 Jul 3;6(7):e2322131. doi: 10.1001/jamanetworkopen.2023.22131. PMID: 37418263Free PMC Article
Erythropoietin response to anaemia in heart failure.
Montero D, Haider T, Flammer AJ
Eur J Prev Cardiol 2019 Jan;26(1):7-17. Epub 2018 Aug 2 doi: 10.1177/2047487318790823. PMID: 30068234
Anemia and erythropoietin in space flights.
De Santo NG, Cirillo M, Kirsch KA, Correale G, Drummer C, Frassl W, Perna AF, Di Stazio E, Bellini L, Gunga HC
Semin Nephrol 2005 Nov;25(6):379-87. doi: 10.1016/j.semnephrol.2005.05.006. PMID: 16298259
Predicting the hematopoietic response to recombinant human erythropoietin (Epoetin alfa) in the treatment of the anemia of cancer.
Adamson JW, Ludwig H
Oncology 1999;56(1):46-53. doi: 10.1159/000011929. PMID: 9885377
The oxygen sensor that controls EPO production: facts and fancies.
Bauer C
J Perinat Med 1995;23(1-2):7-12. doi: 10.1515/jpme.1995.23.1-2.7. PMID: 7658323

Therapy

Association of High-Dose Erythropoietin With Circulating Biomarkers and Neurodevelopmental Outcomes Among Neonates With Hypoxic Ischemic Encephalopathy: A Secondary Analysis of the HEAL Randomized Clinical Trial.
Juul SE, Voldal E, Comstock BA, Massaro AN, Bammler TK, Mayock DE, Heagerty PJ, Wu YW, Numis AL; HEAL consortium
JAMA Netw Open 2023 Jul 3;6(7):e2322131. doi: 10.1001/jamanetworkopen.2023.22131. PMID: 37418263Free PMC Article
Dapagliflozin Suppresses Hepcidin And Increases Erythropoiesis.
Ghanim H, Abuaysheh S, Hejna J, Green K, Batra M, Makdissi A, Chaudhuri A, Dandona P
J Clin Endocrinol Metab 2020 Apr 1;105(4) doi: 10.1210/clinem/dgaa057. PMID: 32044999
Erythropoiesis and iron.
Cavill I
Best Pract Res Clin Haematol 2002 Jun;15(2):399-409. doi: 10.1016/s1521-6926(02)90004-6. PMID: 12401314
Blood boosting and sport.
Ekblom BT
Baillieres Best Pract Res Clin Endocrinol Metab 2000 Mar;14(1):89-98. doi: 10.1053/beem.2000.0056. PMID: 10932813
Worsening of anemia by angiotensin converting enzyme inhibitors and its prevention by antiestrogenic steroid in chronic hemodialysis patients.
Onoyama K, Sanai T, Motomura K, Fujishima M
J Cardiovasc Pharmacol 1989;13 Suppl 3:S27-30. doi: 10.1097/00005344-198900133-00007. PMID: 2474097

Prognosis

Association of High-Dose Erythropoietin With Circulating Biomarkers and Neurodevelopmental Outcomes Among Neonates With Hypoxic Ischemic Encephalopathy: A Secondary Analysis of the HEAL Randomized Clinical Trial.
Juul SE, Voldal E, Comstock BA, Massaro AN, Bammler TK, Mayock DE, Heagerty PJ, Wu YW, Numis AL; HEAL consortium
JAMA Netw Open 2023 Jul 3;6(7):e2322131. doi: 10.1001/jamanetworkopen.2023.22131. PMID: 37418263Free PMC Article
Dapagliflozin Suppresses Hepcidin And Increases Erythropoiesis.
Ghanim H, Abuaysheh S, Hejna J, Green K, Batra M, Makdissi A, Chaudhuri A, Dandona P
J Clin Endocrinol Metab 2020 Apr 1;105(4) doi: 10.1210/clinem/dgaa057. PMID: 32044999
Erythropoietin response to anaemia in heart failure.
Montero D, Haider T, Flammer AJ
Eur J Prev Cardiol 2019 Jan;26(1):7-17. Epub 2018 Aug 2 doi: 10.1177/2047487318790823. PMID: 30068234
The concentrations of bile acids and erythropoietin in pregnant women with intrahepatic cholestasis and the state of the fetus and newborn.
Kowalska-Kańka A, Maciejewski T, Niemiec KT
Med Wieku Rozwoj 2013 Jul-Sep;17(3):232-45. PMID: 24296447
Anemia and erythropoietin in space flights.
De Santo NG, Cirillo M, Kirsch KA, Correale G, Drummer C, Frassl W, Perna AF, Di Stazio E, Bellini L, Gunga HC
Semin Nephrol 2005 Nov;25(6):379-87. doi: 10.1016/j.semnephrol.2005.05.006. PMID: 16298259

Clinical prediction guides

Marked hemoglobin mass expansion and plasma volume contraction in Sherpas acclimatizing to 5,400 m altitude.
Roche J, Baniya S, Bhatta S, Subedi S, Gatterer H, Rasmussen P, Hilty MP, Sigg AA, Timalsina S, Siebenmann C
J Appl Physiol (1985) 2024 Dec 1;137(6):1632-1641. Epub 2024 Nov 7 doi: 10.1152/japplphysiol.00247.2024. PMID: 39508897Free PMC Article
Association of High-Dose Erythropoietin With Circulating Biomarkers and Neurodevelopmental Outcomes Among Neonates With Hypoxic Ischemic Encephalopathy: A Secondary Analysis of the HEAL Randomized Clinical Trial.
Juul SE, Voldal E, Comstock BA, Massaro AN, Bammler TK, Mayock DE, Heagerty PJ, Wu YW, Numis AL; HEAL consortium
JAMA Netw Open 2023 Jul 3;6(7):e2322131. doi: 10.1001/jamanetworkopen.2023.22131. PMID: 37418263Free PMC Article
Erythropoietin response to anaemia in heart failure.
Montero D, Haider T, Flammer AJ
Eur J Prev Cardiol 2019 Jan;26(1):7-17. Epub 2018 Aug 2 doi: 10.1177/2047487318790823. PMID: 30068234
The concentrations of bile acids and erythropoietin in pregnant women with intrahepatic cholestasis and the state of the fetus and newborn.
Kowalska-Kańka A, Maciejewski T, Niemiec KT
Med Wieku Rozwoj 2013 Jul-Sep;17(3):232-45. PMID: 24296447
What evidence supports use of erythropoietin as a novel neurotherapeutic?
Brines M
Oncology (Williston Park) 2002 Sep;16(9 Suppl 10):79-89. PMID: 12380958

Recent systematic reviews

Erythropoietin response to anaemia in heart failure.
Montero D, Haider T, Flammer AJ
Eur J Prev Cardiol 2019 Jan;26(1):7-17. Epub 2018 Aug 2 doi: 10.1177/2047487318790823. PMID: 30068234

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