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Complete cleft of the upper lip

MedGen UID:
1842011
•Concept ID:
C5827007
•
Congenital Abnormality
HPO: HP:5201009

Definition

Cleft of the upper lip that starts from the bottom of the upper lip and reaches the nasal cavity. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVComplete cleft of the upper lip

Professional guidelines

PubMed

Orthodontic treatment for prominent upper front teeth (Class II malocclusion) in children and adolescents.
Batista KB, Thiruvenkatachari B, Harrison JE, O'Brien KD
Cochrane Database Syst Rev 2018 Mar 13;3(3):CD003452. doi: 10.1002/14651858.CD003452.pub4. PMID: 29534303Free PMC Article
Best Practices for the Diagnosis and Evaluation of Infants With Robin Sequence: A Clinical Consensus Report.
Breugem CC, Evans KN, Poets CF, Suri S, Picard A, Filip C, Paes EC, Mehendale FV, Saal HM, Basart H, Murthy J, Joosten KF, Speleman L, Collares MV, van den Boogaard MJ, Muradin M, Andersson ME, Kogo M, Farlie PG, Don Griot P, Mossey PA, Slator R, Abadie V, Hong P
JAMA Pediatr 2016 Sep 1;170(9):894-902. doi: 10.1001/jamapediatrics.2016.0796. PMID: 27429161
Presurgical orthopaedic treatment of newborns with clefts--functional treatment with long-term effects.
Grabowski R, Kopp H, Stahl F, Gundlach KK
J Craniomaxillofac Surg 2006 Sep;34 Suppl 2:34-44. doi: 10.1016/S1010-5182(06)60009-7. PMID: 17071389

Recent clinical studies

Etiology

The effect of maternal smoking and alcohol consumption on lip morphology.
Davies KJM, Richmond S, Medeiros-Mirra RJ, Abbas HH, Wilson-Nagrani CE, Davis MG, Zhurov A
J Orthod 2022 Dec;49(4):403-411. Epub 2022 Jun 19 doi: 10.1177/14653125221094337. PMID: 35723071Free PMC Article
The unilateral cleft lip repair.
Grewal JS, Yanik SC, Strohl-Bryan AM, Tatum SA
Am J Otolaryngol 2021 May-Jun;42(3):102908. Epub 2021 Jan 13 doi: 10.1016/j.amjoto.2021.102908. PMID: 33508593
Orthodontic treatment for prominent upper front teeth (Class II malocclusion) in children and adolescents.
Batista KB, Thiruvenkatachari B, Harrison JE, O'Brien KD
Cochrane Database Syst Rev 2018 Mar 13;3(3):CD003452. doi: 10.1002/14651858.CD003452.pub4. PMID: 29534303Free PMC Article
Median cleft of the upper lip: A new classification to guide treatment decisions.
de Boutray M, Beziat JL, Yachouh J, Bigorre M, Gleizal A, Captier G
J Craniomaxillofac Surg 2016 Jun;44(6):664-71. Epub 2016 Mar 2 doi: 10.1016/j.jcms.2016.02.012. PMID: 27075944
The branchio-oculo-facial syndrome.
Lin AE, Losken HW, Jaffe R, Biglan AW
Cleft Palate Craniofac J 1991 Jan;28(1):96-102. doi: 10.1597/1545-1569_1991_028_0096_tbofs_2.3.co_2. PMID: 2004100

Diagnosis

Median Cleft Lip.
Menderes A, Ateşşahin FB, Babahan T, Terzi M, Atalmiş SE, Çağli HB
J Craniofac Surg 2023 Nov-Dec 01;34(8):e780-e781. Epub 2023 Aug 21 doi: 10.1097/SCS.0000000000009647. PMID: 37603894
Nasolabial Revisions in Unilateral Incomplete Cleft Lip: One Surgeon's 28-Year Experience.
Tan SPK, Ganske IM, Mulliken JB
Plast Reconstr Surg 2020 Jun;145(6):1477-1485. doi: 10.1097/PRS.0000000000006831. PMID: 32195854
Orthodontic burden of care for patients with a cleft lip and/or palate.
Hameed O, Amin N, Haria P, Patel B, Hay N
J Orthod 2019 Mar;46(1):63-67. Epub 2019 Jan 23 doi: 10.1177/1465312518823010. PMID: 31056071
The use and reliability of SymNose for quantitative measurement of the nose and lip in unilateral cleft lip and palate patients.
Mosmuller D, Tan R, Mulder F, Bachour Y, de Vet H, Don Griot P
J Craniomaxillofac Surg 2016 Oct;44(10):1515-1521. Epub 2016 Jul 28 doi: 10.1016/j.jcms.2016.07.022. PMID: 27562104
Best Practices for the Diagnosis and Evaluation of Infants With Robin Sequence: A Clinical Consensus Report.
Breugem CC, Evans KN, Poets CF, Suri S, Picard A, Filip C, Paes EC, Mehendale FV, Saal HM, Basart H, Murthy J, Joosten KF, Speleman L, Collares MV, van den Boogaard MJ, Muradin M, Andersson ME, Kogo M, Farlie PG, Don Griot P, Mossey PA, Slator R, Abadie V, Hong P
JAMA Pediatr 2016 Sep 1;170(9):894-902. doi: 10.1001/jamapediatrics.2016.0796. PMID: 27429161

Therapy

Maxillary Protraction Therapy in Class III Patients With and Without Cleft Lip and Palate: An Interim Report of a Prospective Comparative Study.
Lin Y, Fu Z, Guo R, Ma L, Li W
Cleft Palate Craniofac J 2021 Apr;58(4):429-437. Epub 2020 Sep 28 doi: 10.1177/1055665620954058. PMID: 32985240
Orthodontic treatment for prominent upper front teeth (Class II malocclusion) in children and adolescents.
Batista KB, Thiruvenkatachari B, Harrison JE, O'Brien KD
Cochrane Database Syst Rev 2018 Mar 13;3(3):CD003452. doi: 10.1002/14651858.CD003452.pub4. PMID: 29534303Free PMC Article
Three-Dimensional Upper Lip and Nostril Sill Changes After Cleft Alveolus Reconstruction Using Autologous Bone Grafting Versus Recombinant Human Bone Morphogenetic Protein-2.
Raposo-Amaral CE, Denadai R, Alonso N
J Craniofac Surg 2016 Jun;27(4):913-8. doi: 10.1097/SCS.0000000000002652. PMID: 27244210
Transverse effect of Haas and Hyrax appliances on the upper dental arch in patients with unilateral complete cleft lip and palate: a comparative study.
Façanha AJ, Lara TS, Garib DG, da Silva Filho OG
Dental Press J Orthod 2014 Mar-Apr;19(2):39-45. doi: 10.1590/2176-9451.19.2.039-045.oar. PMID: 24945513Free PMC Article
Position, shape, and dimension of the maxilla in unoperated cleft lip and palate patients: review of the literature.
Lambrecht JT, Kreusch T, Schulz L
Clin Anat 2000;13(2):121-33. doi: 10.1002/(SICI)1098-2353(2000)13:2<121::AID-CA6>3.0.CO;2-K. PMID: 10679856

Prognosis

Median Cleft Lip.
Menderes A, Ateşşahin FB, Babahan T, Terzi M, Atalmiş SE, Çağli HB
J Craniofac Surg 2023 Nov-Dec 01;34(8):e780-e781. Epub 2023 Aug 21 doi: 10.1097/SCS.0000000000009647. PMID: 37603894
Novel Reconstruction of Orbicularis Oris in Unilateral Complete Cleft Lip Repair.
Liu Y, Yao M, Tsauo C, Chen Y, Shi B, Li C
Facial Plast Surg Aesthet Med 2023 Jan-Feb;25(1):49-53. Epub 2022 Nov 10 doi: 10.1089/fpsam.2022.0058. PMID: 36355049
Long-Term Results of the Murawski Unilateral Cleft Lip Repair.
Murawski EL, Gawrych EH, Cutting CB, Sifakis ED, Wang Q, Tao Y
Plast Reconstr Surg 2022 Feb 1;149(2):254e-260e. doi: 10.1097/PRS.0000000000008788. PMID: 35077424
Orthodontic treatment for prominent upper front teeth (Class II malocclusion) in children and adolescents.
Batista KB, Thiruvenkatachari B, Harrison JE, O'Brien KD
Cochrane Database Syst Rev 2018 Mar 13;3(3):CD003452. doi: 10.1002/14651858.CD003452.pub4. PMID: 29534303Free PMC Article
Median cleft of the upper lip: A new classification to guide treatment decisions.
de Boutray M, Beziat JL, Yachouh J, Bigorre M, Gleizal A, Captier G
J Craniomaxillofac Surg 2016 Jun;44(6):664-71. Epub 2016 Mar 2 doi: 10.1016/j.jcms.2016.02.012. PMID: 27075944

Clinical prediction guides

Results of Lip Adhesion in Wide Unilateral Complete Cleft Lip Patients.
Lee HS, Bae YC, Seo HJ
J Craniofac Surg 2021 Nov-Dec 01;32(8):2671-2676. doi: 10.1097/SCS.0000000000007946. PMID: 34727469
Aesthetic and psychosocial impact of dentofacial appearance after primary rhinoplasty for cleft lip and palate.
Dissaux C, Diop V, Wagner D, Talmant JC, Morand B, Bruant-Rodier C, Ruffenach L, Grollemund B
J Craniomaxillofac Surg 2021 Oct;49(10):914-922. Epub 2021 Jun 23 doi: 10.1016/j.jcms.2021.06.004. PMID: 34187731
The unilateral cleft lip repair.
Grewal JS, Yanik SC, Strohl-Bryan AM, Tatum SA
Am J Otolaryngol 2021 May-Jun;42(3):102908. Epub 2021 Jan 13 doi: 10.1016/j.amjoto.2021.102908. PMID: 33508593
Effectiveness of Nasoalveolar Molding in the Unilateral Cleft Lip and Cleft Palate.
Mariqueo GEC, Arriagada EEA, Bustos TDPI, Navarro SM, Espinoza GEE
J Craniofac Surg 2018 Sep;29(6):1522-1525. doi: 10.1097/SCS.0000000000004724. PMID: 29944571
Tooth agenesis code (TAC) in complete unilateral and bilateral cleft lip and palate patients.
López-Giménez A, Silvestre-Rangil J, Silvestre FJ, Paredes-Gallardo V
Odontology 2018 Jul;106(3):257-265. Epub 2017 Dec 14 doi: 10.1007/s10266-017-0332-3. PMID: 29243181

Recent systematic reviews

Orthodontic treatment for prominent upper front teeth (Class II malocclusion) in children and adolescents.
Batista KB, Thiruvenkatachari B, Harrison JE, O'Brien KD
Cochrane Database Syst Rev 2018 Mar 13;3(3):CD003452. doi: 10.1002/14651858.CD003452.pub4. PMID: 29534303Free PMC Article
Median cleft of the upper lip: A new classification to guide treatment decisions.
de Boutray M, Beziat JL, Yachouh J, Bigorre M, Gleizal A, Captier G
J Craniomaxillofac Surg 2016 Jun;44(6):664-71. Epub 2016 Mar 2 doi: 10.1016/j.jcms.2016.02.012. PMID: 27075944

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