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Elevated CSF proline concentration

MedGen UID:
1842022
•Concept ID:
C5826632
•
Finding
HPO: HP:0034743

Definition

Concentration of proline in the cerebrospinal fluid (CSF) above the upper limit of normal. [from HPO]

Recent clinical studies

Etiology

Thyrotropin-releasing hormone and cyclo (His-Pro)-like immunoreactivities in the cerebrospinal fluids of 'normal' infants and adults, and patients with various neuropsychiatric and neurologic disorders.
Iriuchijima T, Prasad C, Wilber JF, Jayaraman A, Rao JK, Robertson HJ, Rogers DJ
Life Sci 1987 Nov 30;41(22):2419-28. doi: 10.1016/0024-3205(87)90667-9. PMID: 2891013

Diagnosis

Elevated phospholipids and acylcarnitines C4 and C5 in cerebrospinal fluid distinguish viral CNS infections from autoimmune neuroinflammation.
Al-Mekhlafi A, Waqas FH, Krueger M, Klawonn F, Akmatov MK, Müller-Vahl K, Trebst C, Skripuletz T, Stangel M, Sühs KW, Pessler F
J Transl Med 2023 Nov 2;21(1):776. doi: 10.1186/s12967-023-04637-y. PMID: 37919735Free PMC Article

Therapy

Acute oral captopril inhibits angiotensin converting enzyme activity in human cerebrospinal fluid.
Geppetti P, Spillantini MG, Frilli S, Pietrini U, Fanciullacci M, Sicuteri F
J Hypertens 1987 Apr;5(2):151-4. doi: 10.1097/00004872-198704000-00004. PMID: 3038992

Clinical prediction guides

Elevated phospholipids and acylcarnitines C4 and C5 in cerebrospinal fluid distinguish viral CNS infections from autoimmune neuroinflammation.
Al-Mekhlafi A, Waqas FH, Krueger M, Klawonn F, Akmatov MK, Müller-Vahl K, Trebst C, Skripuletz T, Stangel M, Sühs KW, Pessler F
J Transl Med 2023 Nov 2;21(1):776. doi: 10.1186/s12967-023-04637-y. PMID: 37919735Free PMC Article
Acute oral captopril inhibits angiotensin converting enzyme activity in human cerebrospinal fluid.
Geppetti P, Spillantini MG, Frilli S, Pietrini U, Fanciullacci M, Sicuteri F
J Hypertens 1987 Apr;5(2):151-4. doi: 10.1097/00004872-198704000-00004. PMID: 3038992

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