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Brain xanthomatosis

MedGen UID:
1842114
Concept ID:
C5826536
Disease or Syndrome
Synonyms: Brain xanthomas; Brain xanthomata
 
HPO: HP:0034625

Definition

Lipid deposits localized within the brain. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia. [from HPO]

Term Hierarchy

Professional guidelines

Recent clinical studies

Etiology

Ashrafi MR, Amanat M, Garshasbi M, Kameli R, Nilipour Y, Heidari M, Rezaei Z, Tavasoli AR
Expert Rev Neurother 2020 Jan;20(1):65-84. Epub 2019 Dec 12 doi: 10.1080/14737175.2020.1699060. PMID: 31829048
Stelten BML, van de Warrenburg BPC, Wevers RA, Verrips A
Parkinsonism Relat Disord 2019 Jan;58:12-16. Epub 2018 Jul 19 doi: 10.1016/j.parkreldis.2018.07.006. PMID: 30054180
Pearson HJ, Mosser JL, Jacks SK
Pediatr Dermatol 2017 Nov;34(6):e305-e308. doi: 10.1111/pde.13306. PMID: 29144045
Caparros-Lefebvre D, Pruvo JP, Rémy M, Wallaert B, Petit H
AJNR Am J Neuroradiol 1995 Apr;16(4):735-40. PMID: 7611030Free PMC Article
Dotti MT, Salen G, Federico A
Dev Neurosci 1991;13(4-5):371-6. doi: 10.1159/000112187. PMID: 1817044

Diagnosis

de Vries F, van Furth WR, Biermasz NR, Pereira AM
Presse Med 2021 Dec;50(4):104076. Epub 2021 Oct 21 doi: 10.1016/j.lpm.2021.104076. PMID: 34687912
Ashrafi MR, Amanat M, Garshasbi M, Kameli R, Nilipour Y, Heidari M, Rezaei Z, Tavasoli AR
Expert Rev Neurother 2020 Jan;20(1):65-84. Epub 2019 Dec 12 doi: 10.1080/14737175.2020.1699060. PMID: 31829048
Schöls L, Nägele T, Schüle R, Berg D
Neurology 2006 Dec 12;67(11):E20. doi: 10.1212/01.wnl.0000247673.08554.0f. PMID: 17159091
Castelnovo G, Jomir L, Bouly S
J Neurol Neurosurg Psychiatry 2003 Sep;74(9):1335. doi: 10.1136/jnnp.74.9.1335. PMID: 12933951Free PMC Article
Guazzi GC, Martin JJ, Philippart M, Roels H, van der Eecken H, Vrints L, Delbeke MJ, Hooft C
Eur Neurol 1968;1(6):334-62. doi: 10.1159/000113673. PMID: 5711398

Therapy

de Vries F, van Furth WR, Biermasz NR, Pereira AM
Presse Med 2021 Dec;50(4):104076. Epub 2021 Oct 21 doi: 10.1016/j.lpm.2021.104076. PMID: 34687912
Hanna B, Li YM, Beutler T, Goyal P, Hall WA
J Clin Neurosci 2015 Jul;22(7):1091-7. Epub 2015 May 6 doi: 10.1016/j.jocn.2015.01.019. PMID: 25957783
Dotti MT, Salen G, Federico A
Dev Neurosci 1991;13(4-5):371-6. doi: 10.1159/000112187. PMID: 1817044
Salen G, Shefer S, Berginer V
Dev Neurosci 1991;13(4-5):363-70. doi: 10.1159/000112186. PMID: 1817043
Stawiski MA, Voorhees JJ
Cutis 1976 Sep;18(3):415-21. PMID: 797552

Prognosis

Jain S, Ng ZX, Mantoo S, Yang EWR
World Neurosurg 2020 Aug;140:56-59. Epub 2020 May 11 doi: 10.1016/j.wneu.2020.05.015. PMID: 32437994
Caranci F, Leone G, Ponsiglione A, Muto M, Tortora F, Muto M, Cirillo S, Brunese L, Cerase A
Radiol Med 2020 Mar;125(3):319-328. Epub 2019 Dec 20 doi: 10.1007/s11547-019-01120-x. PMID: 31863360
Salen G, Steiner RD
J Inherit Metab Dis 2017 Nov;40(6):771-781. Epub 2017 Oct 4 doi: 10.1007/s10545-017-0093-8. PMID: 28980151
Palau F, Espinós C
Orphanet J Rare Dis 2006 Nov 17;1:47. doi: 10.1186/1750-1172-1-47. PMID: 17112370Free PMC Article
Dotti MT, Salen G, Federico A
Dev Neurosci 1991;13(4-5):371-6. doi: 10.1159/000112187. PMID: 1817044

Clinical prediction guides

Zubarioglu T, Kıykım E, Köse E, Eminoğlu FT, Teke Kısa P, Balcı MC, Özer I, İnci A, Çilesiz K, Canda E, Yazıcı H, Öztürk-Hişmi B, Bulut FD, Dorum S, Akgun A, Yalçın-Çakmaklı G, Kılıç-Yıldırım G, Soyuçen E, Akçalı A, Güneş D, Durmuş A, Gündüz A, Kasapkara ÇS, Göksoy E, Akar HT, Ersoy M, Erdöl Ş, Yıldız Y, Hanağası HA, Arslan N, Aktuğlu-Zeybek Ç
Mol Genet Metab 2024 Jun;142(2):108493. Epub 2024 May 13 doi: 10.1016/j.ymgme.2024.108493. PMID: 38772327
Roeben B, Just J, Hengel H, Bender F, Pöschl P, Synofzik M, Schöls L, Grimm A
Clin Neurophysiol 2020 Aug;131(8):1798-1803. Epub 2020 May 21 doi: 10.1016/j.clinph.2020.04.162. PMID: 32531740
Caranci F, Leone G, Ponsiglione A, Muto M, Tortora F, Muto M, Cirillo S, Brunese L, Cerase A
Radiol Med 2020 Mar;125(3):319-328. Epub 2019 Dec 20 doi: 10.1007/s11547-019-01120-x. PMID: 31863360
Sedel F, Tourbah A, Fontaine B, Lubetzki C, Baumann N, Saudubray JM, Lyon-Caen O
J Inherit Metab Dis 2008 Jun;31(3):295-307. Epub 2008 Feb 25 doi: 10.1007/s10545-008-0778-0. PMID: 18344012
Beard W, Foster DB, Kepes JJ, Guillan RA
Neurology 1970 Apr;20(4):305-14. doi: 10.1212/wnl.20.4.305. PMID: 5534963

Recent systematic reviews

de Vries F, van Furth WR, Biermasz NR, Pereira AM
Presse Med 2021 Dec;50(4):104076. Epub 2021 Oct 21 doi: 10.1016/j.lpm.2021.104076. PMID: 34687912
Zhu J, Wang Z, Wang W, Fan J, Zhang Y, Li X, Liu J, Jiang S, Deng K, Duan L, Yao Y, Zhu H
Front Endocrinol (Lausanne) 2021;12:735655. Epub 2021 Oct 1 doi: 10.3389/fendo.2021.735655. PMID: 34659121Free PMC Article
Mathkour M, Michael A, Scullen T, Carsky K, Hage M, Werner C, Carr C, Keen JR, Ware ML
Clin Neurol Neurosurg 2020 Nov;198:106143. Epub 2020 Aug 11 doi: 10.1016/j.clineuro.2020.106143. PMID: 32810760

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