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Syndrome with limb duplication, polydactyly, syndactyly, and/or hyperphalangy

MedGen UID:
1842981
Concept ID:
C5681001
Disease or Syndrome
Orphanet: ORPHA294959

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSyndrome with limb duplication, polydactyly, syndactyly, and/or hyperphalangy

Recent clinical studies

Etiology

Manzke H, Lehmann K, Klopocki E, Caliebe A
Eur J Med Genet 2008 Sep-Oct;51(5):452-65. Epub 2008 Apr 11 doi: 10.1016/j.ejmg.2008.03.005. PMID: 18501694
Upton J
Handchir Mikrochir Plast Chir 2004 Apr-Jun;36(2-3):152-60. doi: 10.1055/s-2004-817903. PMID: 15162314
Castilla EE, Lugarinho R, da Graça Dutra M, Salgado LJ
Am J Med Genet 1998 Dec 28;80(5):459-65. doi: 10.1002/(sici)1096-8628(19981228)80:5<459::aid-ajmg5>3.0.co;2-g. PMID: 9880209

Diagnosis

Xu J, Wu J, Teng X, Cai L, Yuan H, Chen X, Hu M, Wang X, Jiang N, Chen H
Am J Med Genet A 2020 Sep;182(9):2117-2123. Epub 2020 Jul 14 doi: 10.1002/ajmg.a.61757. PMID: 32662247
Miller DE, Chow P, Gallagher ER, Perkins JA, Wenger TL
Am J Med Genet A 2020 Mar;182(3):437-440. Epub 2019 Dec 12 doi: 10.1002/ajmg.a.61436. PMID: 31833187
Boschann F, Stuurman KE, de Bruin C, van Slegtenhorst M, van Duyvenvoorde HA, Kant SG, Ehmke N
Am J Med Genet A 2020 Mar;182(3):431-436. Epub 2019 Nov 25 doi: 10.1002/ajmg.a.61419. PMID: 31769200
Dai L, Guo H, Meng H, Zhang K, Hu H, Yao H, Bai Y
Eur J Pediatr 2013 Nov;172(11):1467-73. Epub 2013 Jun 22 doi: 10.1007/s00431-013-2071-y. PMID: 23793141
Aucourt J, Budzik JF, Manouvrier-Hanu S, Mézel A, Cotten A, Boutry N
Semin Musculoskelet Radiol 2012 Apr;16(2):146-58. Epub 2012 May 30 doi: 10.1055/s-0032-1311766. PMID: 22648430

Therapy

Upton J
Handchir Mikrochir Plast Chir 2004 Apr-Jun;36(2-3):152-60. doi: 10.1055/s-2004-817903. PMID: 15162314

Prognosis

Ehmke N, Caliebe A, Koenig R, Kant SG, Stark Z, Cormier-Daire V, Wieczorek D, Gillessen-Kaesbach G, Hoff K, Kawalia A, Thiele H, Altmüller J, Fischer-Zirnsak B, Knaus A, Zhu N, Heinrich V, Huber C, Harabula I, Spielmann M, Horn D, Kornak U, Hecht J, Krawitz PM, Nürnberg P, Siebert R, Manzke H, Mundlos S
Am J Hum Genet 2014 Dec 4;95(6):763-70. doi: 10.1016/j.ajhg.2014.11.004. PMID: 25480037Free PMC Article
Aucourt J, Budzik JF, Manouvrier-Hanu S, Mézel A, Cotten A, Boutry N
Semin Musculoskelet Radiol 2012 Apr;16(2):146-58. Epub 2012 May 30 doi: 10.1055/s-0032-1311766. PMID: 22648430
Upton J
Handchir Mikrochir Plast Chir 2004 Apr-Jun;36(2-3):152-60. doi: 10.1055/s-2004-817903. PMID: 15162314
Kantaputra PN, Sumitsawan Y, Schutte BC, Tochareontanaphol C
Am J Med Genet 2002 Apr 1;108(4):275-80. doi: 10.1002/ajmg.10276. PMID: 11920830

Clinical prediction guides

Ehmke N, Caliebe A, Koenig R, Kant SG, Stark Z, Cormier-Daire V, Wieczorek D, Gillessen-Kaesbach G, Hoff K, Kawalia A, Thiele H, Altmüller J, Fischer-Zirnsak B, Knaus A, Zhu N, Heinrich V, Huber C, Harabula I, Spielmann M, Horn D, Kornak U, Hecht J, Krawitz PM, Nürnberg P, Siebert R, Manzke H, Mundlos S
Am J Hum Genet 2014 Dec 4;95(6):763-70. doi: 10.1016/j.ajhg.2014.11.004. PMID: 25480037Free PMC Article
Yuksel-Apak M, Bögershausen N, Pawlik B, Li Y, Apak S, Uyguner O, Milz E, Nürnberg G, Karaman B, Gülgören A, Grzeschik KH, Nürnberg P, Kayserili H, Wollnik B
Eur J Hum Genet 2012 Jun;20(6):639-44. Epub 2012 Jan 11 doi: 10.1038/ejhg.2011.250. PMID: 22234151Free PMC Article
Fernandez C, Soulier M, Coulibaly B, Liprandi A, Benoit B, Giuliano F, Sigaudy S, Figarella-Branger D, Fallet-Bianco C
Acta Neuropathol 2008 Jan;115(1):151-6. Epub 2007 Jun 26 doi: 10.1007/s00401-007-0249-y. PMID: 17593378
Castilla EE, Lugarinho R, da Graça Dutra M, Salgado LJ
Am J Med Genet 1998 Dec 28;80(5):459-65. doi: 10.1002/(sici)1096-8628(19981228)80:5<459::aid-ajmg5>3.0.co;2-g. PMID: 9880209
Schinzel A
J Med Genet 1988 May;25(5):332-6. doi: 10.1136/jmg.25.5.332. PMID: 3385741Free PMC Article

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