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Corneal decompensation

MedGen UID:
184923
•Concept ID:
C0948284
•
Disease or Syndrome
Synonyms: Corneal Decompensation; Corneal Endothelial Decompensation
SNOMED CT: Corneal decompensation (425540008)

Definition

Endothelial decompensation that is manifested by opacity of the cornea. The condition often occurs as a nonspecific response to mechanical injury from incidental corneal contact by intraocular instruments during surgery; chemical injury from the improper use of intraocular drugs, drugs containing preservatives, or from residues from inadequate rinsing of detergents or other residues from surgical instruments. The most common causes of corneal endothelial decompensation in the adult population are cataract removal/IOL-related endothelial loss and Fuchs dystrophy. When severe, corneal endothelial decompensation requires corneal transplantation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCorneal decompensation

Professional guidelines

PubMed

Adult retinopathy of prematurity: treatment implications, long term sequelae, and management.
Chang E, Rao P
Curr Opin Ophthalmol 2021 Sep 1;32(5):489-493. doi: 10.1097/ICU.0000000000000787. PMID: 34231528
Ocular manifestations of isolated corneal bee sting injury, management strategies, and clinical outcomes.
Gudiseva H, Uddaraju M, Pradhan S, Das M, Mascarenhas J, Srinivasan M, Prajna NV
Indian J Ophthalmol 2018 Feb;66(2):262-268. doi: 10.4103/ijo.IJO_600_17. PMID: 29380771Free PMC Article
Iris cysts: A comprehensive review on diagnosis and treatment.
Georgalas I, Petrou P, Papaconstantinou D, Brouzas D, Koutsandrea C, Kanakis M
Surv Ophthalmol 2018 May-Jun;63(3):347-364. Epub 2017 Sep 5 doi: 10.1016/j.survophthal.2017.08.009. PMID: 28882598

Recent clinical studies

Etiology

Analysis of perioperative problems related to intraocular Implantable Collamer Lens (ICL) implantation.
Zhang H, Gong R, Zhang X, Deng Y
Int Ophthalmol 2022 Nov;42(11):3625-3641. Epub 2022 Jun 22 doi: 10.1007/s10792-022-02355-w. PMID: 35731355Free PMC Article
Cell therapy in corneal endothelial disease.
Wong EN, Mehta JS
Curr Opin Ophthalmol 2022 Jul 1;33(4):275-281. Epub 2022 Jun 16 doi: 10.1097/ICU.0000000000000853. PMID: 35708056
Corneal Decompensation in Uveitis Patients: Incidence, Etiology, and Outcome.
Wong SW, Carley F, Jones NP
Ocul Immunol Inflamm 2021 May 19;29(4):771-775. Epub 2020 Jan 6 doi: 10.1080/09273948.2019.1698747. PMID: 31906778
Descemet membrane detachment.
Singhal D, Sahay P, Goel S, Asif MI, Maharana PK, Sharma N
Surv Ophthalmol 2020 May-Jun;65(3):279-293. Epub 2020 Jan 8 doi: 10.1016/j.survophthal.2019.12.006. PMID: 31923476
Determinants of visual quality after endothelial keratoplasty.
Turnbull AM, Tsatsos M, Hossain PN, Anderson DF
Surv Ophthalmol 2016 May-Jun;61(3):257-71. Epub 2015 Dec 19 doi: 10.1016/j.survophthal.2015.12.006. PMID: 26708363

Diagnosis

Toxic anterior segment syndrome (TASS): A review and update.
Verma L, Malik A, Maharana PK, Dada T, Sharma N
Indian J Ophthalmol 2024 Jan 1;72(1):11-18. Epub 2023 Dec 22 doi: 10.4103/IJO.IJO_1796_23. PMID: 38131565Free PMC Article
Analysis of perioperative problems related to intraocular Implantable Collamer Lens (ICL) implantation.
Zhang H, Gong R, Zhang X, Deng Y
Int Ophthalmol 2022 Nov;42(11):3625-3641. Epub 2022 Jun 22 doi: 10.1007/s10792-022-02355-w. PMID: 35731355Free PMC Article
Phakic intraocular lenses: An overview.
Jonker SMR, Berendschot TTJM, Saelens IEY, Bauer NJC, Nuijts RMMA
Indian J Ophthalmol 2020 Dec;68(12):2779-2796. doi: 10.4103/ijo.IJO_2995_20. PMID: 33229653Free PMC Article
Descemet membrane detachment.
Singhal D, Sahay P, Goel S, Asif MI, Maharana PK, Sharma N
Surv Ophthalmol 2020 May-Jun;65(3):279-293. Epub 2020 Jan 8 doi: 10.1016/j.survophthal.2019.12.006. PMID: 31923476
Hypotony Keratopathy Following Trabeculectomy.
Camp AS, Weinreb RN
J Glaucoma 2020 Feb;29(2):77-80. doi: 10.1097/IJG.0000000000001425. PMID: 31876870

Therapy

Analysis of perioperative problems related to intraocular Implantable Collamer Lens (ICL) implantation.
Zhang H, Gong R, Zhang X, Deng Y
Int Ophthalmol 2022 Nov;42(11):3625-3641. Epub 2022 Jun 22 doi: 10.1007/s10792-022-02355-w. PMID: 35731355Free PMC Article
Descemet membrane detachment.
Singhal D, Sahay P, Goel S, Asif MI, Maharana PK, Sharma N
Surv Ophthalmol 2020 May-Jun;65(3):279-293. Epub 2020 Jan 8 doi: 10.1016/j.survophthal.2019.12.006. PMID: 31923476
Hypotony Keratopathy Following Trabeculectomy.
Camp AS, Weinreb RN
J Glaucoma 2020 Feb;29(2):77-80. doi: 10.1097/IJG.0000000000001425. PMID: 31876870
Glaucoma Drainage Implant Surgery.
Aref AA, Gedde SJ, Budenz DL
Dev Ophthalmol 2017;59:43-52. Epub 2017 Apr 25 doi: 10.1159/000458485. PMID: 28442686
Glaucoma drainage implant surgery.
Aref AA, Gedde SJ, Budenz DL
Dev Ophthalmol 2012;50:37-47. Epub 2012 Apr 17 doi: 10.1159/000334777. PMID: 22517172

Prognosis

Toxic anterior segment syndrome (TASS): A review and update.
Verma L, Malik A, Maharana PK, Dada T, Sharma N
Indian J Ophthalmol 2024 Jan 1;72(1):11-18. Epub 2023 Dec 22 doi: 10.4103/IJO.IJO_1796_23. PMID: 38131565Free PMC Article
Analysis of perioperative problems related to intraocular Implantable Collamer Lens (ICL) implantation.
Zhang H, Gong R, Zhang X, Deng Y
Int Ophthalmol 2022 Nov;42(11):3625-3641. Epub 2022 Jun 22 doi: 10.1007/s10792-022-02355-w. PMID: 35731355Free PMC Article
Corneal Decompensation in Uveitis Patients: Incidence, Etiology, and Outcome.
Wong SW, Carley F, Jones NP
Ocul Immunol Inflamm 2021 May 19;29(4):771-775. Epub 2020 Jan 6 doi: 10.1080/09273948.2019.1698747. PMID: 31906778
Descemet membrane endothelial keratoplasty and refractive surgery.
Tong CM, Baydoun L, Melles GRJ
Curr Opin Ophthalmol 2017 Jul;28(4):316-325. doi: 10.1097/ICU.0000000000000380. PMID: 28399068
Pathology of ocular melanomas.
McCartney AC
Br Med Bull 1995 Jul;51(3):678-93. doi: 10.1093/oxfordjournals.bmb.a072986. PMID: 7552088

Clinical prediction guides

Analysis of perioperative problems related to intraocular Implantable Collamer Lens (ICL) implantation.
Zhang H, Gong R, Zhang X, Deng Y
Int Ophthalmol 2022 Nov;42(11):3625-3641. Epub 2022 Jun 22 doi: 10.1007/s10792-022-02355-w. PMID: 35731355Free PMC Article
Iris cysts: A comprehensive review on diagnosis and treatment.
Georgalas I, Petrou P, Papaconstantinou D, Brouzas D, Koutsandrea C, Kanakis M
Surv Ophthalmol 2018 May-Jun;63(3):347-364. Epub 2017 Sep 5 doi: 10.1016/j.survophthal.2017.08.009. PMID: 28882598
Descemet membrane endothelial keratoplasty and refractive surgery.
Tong CM, Baydoun L, Melles GRJ
Curr Opin Ophthalmol 2017 Jul;28(4):316-325. doi: 10.1097/ICU.0000000000000380. PMID: 28399068
Evolution of Endothelial Keratoplasty: Where Are We Headed?
Price FW Jr, Feng MT, Price MO
Cornea 2015 Oct;34 Suppl 10:S41-7. doi: 10.1097/ICO.0000000000000505. PMID: 26114828
Phacopower modulation and the risk for postoperative corneal decompensation: a randomized clinical trial.
Doors M, Berendschot TT, Touwslager W, Webers CA, Nuijts RM
JAMA Ophthalmol 2013 Nov;131(11):1443-50. doi: 10.1001/jamaophthalmol.2013.5009. PMID: 24030086

Recent systematic reviews

Acute corneal allograft rejection following SARS-CoV-2 vaccination-A systematic review.
Moura-Coelho N, Cunha JP, Papa-Vettorazzi R, Gris Ó, Güell JL
Acta Ophthalmol 2023 Feb;101(1):e1-e13. Epub 2022 Jul 4 doi: 10.1111/aos.15211. PMID: 35781792Free PMC Article
Corneal Endothelial Cell Density Loss after Glaucoma Surgery Alone or in Combination with Cataract Surgery: A Systematic Review and Meta-analysis.
Fang CEH, Mathew RG, Khaw PT, Henein C
Ophthalmology 2022 Aug;129(8):841-855. Epub 2022 Mar 22 doi: 10.1016/j.ophtha.2022.03.015. PMID: 35331751
Postoperative results of cosmetic iris implants.
Galvis V, Tello A, Corrales MI
J Cataract Refract Surg 2016 Oct;42(10):1518-1526. doi: 10.1016/j.jcrs.2016.08.013. PMID: 27839608
Beneficial effects of adjuvant intravitreal bevacizumab injection on outcomes of Ahmed glaucoma valve implantation in patients with neovascular glaucoma: systematic literature review.
Hwang HB, Han JW, Yim HB, Lee NY
J Ocul Pharmacol Ther 2015 May;31(4):198-203. Epub 2015 Feb 25 doi: 10.1089/jop.2014.0108. PMID: 25714761
Laser iridotomy and the corneal endothelium: a systemic review.
Wang PX, Koh VT, Loon SC
Acta Ophthalmol 2014 Nov;92(7):604-16. Epub 2014 Feb 16 doi: 10.1111/aos.12367. PMID: 24528451

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