Warts affecting the skin in the genital area (penile shaft, scrotum, vagina, or labia majora). Warts can be small, beginning as a pinhead-size swelling that may become larger and take on a pedunculated appearance. Warts can spread and coalesce into large masses in the genital or anal area. Their color is variable but tends to be skin colored or darker, and they may occasionally bleed. Warts may cause itching, redness, or discomfort. An outbreak of genital warts may also cause psychological distress.

Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia.

Impaired egress of mature neutrophils from bone marrow causing neutropenia.

A recurrent form of sinusitis.

An increased susceptibility to bronchitis as manifested by a history of recurrent bronchitis.

A reduced number of lymphocytes in the blood.

Inflammation of any part of the lung parenchyma.

Increased susceptibility to otitis media, as manifested by recurrent episodes of otitis media.

An abnormally low number of neutrophils in the peripheral blood.

Recurrent episodes of oral herpes, typically characterized by blisters or ulcers on the gums, lips and/or tongue caused by herpes virus.

The presence of autoantibodies in the serum that react against neutrophils.

A group of phenotypically heterogeneous genetic disorders characterized by profound deficiencies of T- and B-cell function, which predispose the patients to both infectious and noninfectious complications.

An abnormally decreased level of immunoglobulin in blood.

A reduction in the normal proportion of class-switched memory B cells (CD19+/CD27+/IgM+/IgD+) relative to the total number of B cells. Marginal zone B cells undergo limited somatic hypermutation and produce high-affinity IgM and some IgG, whereas class-switched memory B cells synthetize IgG, IgM, and IgA.

A type of inflammation of the lips involving one or both of the corners of the mouth.