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Ectopic pregnancy

MedGen UID:
18618
Concept ID:
C0032987
Pathologic Function
Synonyms: Ectopic Pregnancies; Ectopic Pregnancy; Extrauterine Pregnancies; Extrauterine Pregnancy; Pregnancies, Ectopic; Pregnancies, Extrauterine; Pregnancy, Ectopic; Pregnancy, Extrauterine
SNOMED CT: EP - Ectopic pregnancy (34801009); Ectopic pregnancy (34801009)
 
HPO: HP:0031456
Monarch Initiative: MONDO:0000755

Definition

A pregnancy in which the fertilized egg inserts in a location outside of the main cavity of the uterus (usually in the Fallopian tube). [from HPO]

Professional guidelines

PubMed

Mullany K, Minneci M, Monjazeb R, C Coiado O
Womens Health (Lond) 2023 Jan-Dec;19:17455057231160349. doi: 10.1177/17455057231160349. PMID: 36999281Free PMC Article
Hendriks E, Rosenberg R, Prine L
Am Fam Physician 2020 May 15;101(10):599-606. PMID: 32412215
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2018 Mar;131(3):e91-e103. doi: 10.1097/AOG.0000000000002560. PMID: 29470343

Curated

UK NICE Guideline NG126, Ectopic pregnancy and miscarriage: diagnosis and initial management, 2023

Recent clinical studies

Etiology

Ban Y, Shen J, Wang X, Zhang T, Lu X, Qu W, Hao Y, Mao Z, Li S, Tao G, Wang F, Zhao Y, Zhang X, Zhang Y, Zhang G, Cui B
Obstet Gynecol 2023 May 1;141(5):927-936. Epub 2023 Apr 5 doi: 10.1097/AOG.0000000000005113. PMID: 37023450Free PMC Article
Mullany K, Minneci M, Monjazeb R, C Coiado O
Womens Health (Lond) 2023 Jan-Dec;19:17455057231160349. doi: 10.1177/17455057231160349. PMID: 36999281Free PMC Article
Hendriks E, Rosenberg R, Prine L
Am Fam Physician 2020 May 15;101(10):599-606. PMID: 32412215
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2018 Mar;131(3):e91-e103. doi: 10.1097/AOG.0000000000002560. PMID: 29470343
Farquhar CM
Lancet 2005 Aug 13-19;366(9485):583-91. doi: 10.1016/S0140-6736(05)67103-6. PMID: 16099295

Diagnosis

Mullany K, Minneci M, Monjazeb R, C Coiado O
Womens Health (Lond) 2023 Jan-Dec;19:17455057231160349. doi: 10.1177/17455057231160349. PMID: 36999281Free PMC Article
Houser M, Kandalaft N, Khati NJ
Emerg Radiol 2022 Feb;29(1):161-172. Epub 2021 Oct 7 doi: 10.1007/s10140-021-01974-7. PMID: 34618256
Hendriks E, Rosenberg R, Prine L
Am Fam Physician 2020 May 15;101(10):599-606. PMID: 32412215
Farquhar CM
Lancet 2005 Aug 13-19;366(9485):583-91. doi: 10.1016/S0140-6736(05)67103-6. PMID: 16099295
Duchatel FC
Curr Opin Obstet Gynecol 1995 Dec;7(6):472-6. doi: 10.1097/00001703-199512000-00013. PMID: 8620082

Therapy

Mullany K, Minneci M, Monjazeb R, C Coiado O
Womens Health (Lond) 2023 Jan-Dec;19:17455057231160349. doi: 10.1177/17455057231160349. PMID: 36999281Free PMC Article
Tonick S, Conageski C
Obstet Gynecol Clin North Am 2022 Sep;49(3):537-549. doi: 10.1016/j.ogc.2022.02.018. PMID: 36122984
Bafort C, Beebeejaun Y, Tomassetti C, Bosteels J, Duffy JM
Cochrane Database Syst Rev 2020 Oct 23;10(10):CD011031. doi: 10.1002/14651858.CD011031.pub3. PMID: 33095458Free PMC Article
Showell MG, Mackenzie-Proctor R, Jordan V, Hart RJ
Cochrane Database Syst Rev 2020 Aug 27;8(8):CD007807. doi: 10.1002/14651858.CD007807.pub4. PMID: 32851663Free PMC Article
Gonzalez N, Tulandi T
J Minim Invasive Gynecol 2017 Jul-Aug;24(5):731-738. Epub 2017 Mar 6 doi: 10.1016/j.jmig.2017.02.020. PMID: 28268103

Prognosis

Skerlev M, Čulav-Košćak I
Clin Dermatol 2014 Mar-Apr;32(2):275-81. doi: 10.1016/j.clindermatol.2013.08.010. PMID: 24559563
Marion LL, Meeks GR
Clin Obstet Gynecol 2012 Jun;55(2):376-86. doi: 10.1097/GRF.0b013e3182516d7b. PMID: 22510618
De Los Ríos JF, Castañeda JD, Miryam A
J Minim Invasive Gynecol 2007 Jul-Aug;14(4):419-27. doi: 10.1016/j.jmig.2007.01.011. PMID: 17630158
Kriebs JM, Fahey JO
J Midwifery Womens Health 2006 Nov-Dec;51(6):431-9. doi: 10.1016/j.jmwh.2006.07.008. PMID: 17081933
Moore L
Nurs Stand 1998 Jun 10-16;12(38):48-53; quiz 54-5. doi: 10.7748/ns.12.38.48.s58. PMID: 9775912

Clinical prediction guides

Ban Y, Shen J, Wang X, Zhang T, Lu X, Qu W, Hao Y, Mao Z, Li S, Tao G, Wang F, Zhao Y, Zhang X, Zhang Y, Zhang G, Cui B
Obstet Gynecol 2023 May 1;141(5):927-936. Epub 2023 Apr 5 doi: 10.1097/AOG.0000000000005113. PMID: 37023450Free PMC Article
Yong PJ, Matwani S, Brace C, Quaiattini A, Bedaiwy MA, Albert A, Allaire C
J Minim Invasive Gynecol 2020 Feb;27(2):352-361.e2. Epub 2019 Sep 20 doi: 10.1016/j.jmig.2019.09.778. PMID: 31546066
Bourne T, Bottomley C
Fertil Steril 2012 Nov;98(5):1091-6. doi: 10.1016/j.fertnstert.2012.09.017. PMID: 23084011
Practice Committee of the American Society for Reproductive Medicine
Fertil Steril 2006 Nov;86(5 Suppl 1):S96-102. doi: 10.1016/j.fertnstert.2006.07.1481. PMID: 17055853
Gutman SJ, Lindsay K
Can Fam Physician 2000 Jun;46:1297-8. PMID: 10907568Free PMC Article

Recent systematic reviews

Silva B, Viana Pinto P, Costa MA
Eur J Obstet Gynecol Reprod Biol 2023 Sep;288:36-43. Epub 2023 Jul 1 doi: 10.1016/j.ejogrb.2023.06.030. PMID: 37421745
Xiao C, Shi Q, Cheng Q, Xu J
Medicine (Baltimore) 2021 Dec 17;100(50):e27851. doi: 10.1097/MD.0000000000027851. PMID: 34918633Free PMC Article
Bafort C, Beebeejaun Y, Tomassetti C, Bosteels J, Duffy JM
Cochrane Database Syst Rev 2020 Oct 23;10(10):CD011031. doi: 10.1002/14651858.CD011031.pub3. PMID: 33095458Free PMC Article
Showell MG, Mackenzie-Proctor R, Jordan V, Hart RJ
Cochrane Database Syst Rev 2020 Aug 27;8(8):CD007807. doi: 10.1002/14651858.CD007807.pub4. PMID: 32851663Free PMC Article
Gonzalez N, Tulandi T
J Minim Invasive Gynecol 2017 Jul-Aug;24(5):731-738. Epub 2017 Mar 6 doi: 10.1016/j.jmig.2017.02.020. PMID: 28268103

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Guideline NG126, Ectopic pregnancy and miscarriage: diagnosis and initial management, 2023

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