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Abnormal scleral thickness

MedGen UID:
1863491
•Concept ID:
C5937560
•
Anatomical Abnormality
HPO: HP:6000841

Definition

Any deviation from the normal height of the sclera, the white part of the eye that forms the tough, fibrous outer layer of the exterior of the eyeball. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal scleral thickness

Professional guidelines

PubMed

Scleral Contact Lens as Initial Management in a Neonate With a Large Upper Eyelid Coloboma.
Mortensen ZQ, Simmons BA, Shriver EM, Carter KD, Downes SJ
Ophthalmic Plast Reconstr Surg 2022 Jan-Feb 01;38(1):e10-e13. doi: 10.1097/IOP.0000000000002057. PMID: 34570047

Recent clinical studies

Etiology

CURRENT VIEW OF THE SPECTRUM OF PACHYCHOROID DISEASES. A REVIEW.
Stepanov A
Cesk Slov Oftalmol 2023 Winter;3(Ahead of Print):1001-1005. PMID: 38016808
SCLERAL AND CHOROIDAL THICKNESS IN SECONDARY HIGH AXIAL MYOPIA.
Shen L, You QS, Xu X, Gao F, Zhang Z, Li B, Jonas JB
Retina 2016 Aug;36(8):1579-85. doi: 10.1097/IAE.0000000000000947. PMID: 26735565
Hypotony maculopathy.
Costa VP, Arcieri ES
Acta Ophthalmol Scand 2007 Sep;85(6):586-97. Epub 2007 Jun 2 doi: 10.1111/j.1600-0420.2007.00910.x. PMID: 17542978
Surgical management of the idiopathic uveal effusion syndrome.
Johnson MW, Gass JD
Ophthalmology 1990 Jun;97(6):778-85. doi: 10.1016/s0161-6420(90)32511-3. PMID: 2374682
Vortex vein decompression for nanophthalmic uveal effusion.
Brockhurst RJ
Arch Ophthalmol 1980 Nov;98(11):1987-90. doi: 10.1001/archopht.1980.01020040839008. PMID: 7436831

Diagnosis

CURRENT VIEW OF THE SPECTRUM OF PACHYCHOROID DISEASES. A REVIEW.
Stepanov A
Cesk Slov Oftalmol 2023 Winter;3(Ahead of Print):1001-1005. PMID: 38016808
Scleral Contact Lens as Initial Management in a Neonate With a Large Upper Eyelid Coloboma.
Mortensen ZQ, Simmons BA, Shriver EM, Carter KD, Downes SJ
Ophthalmic Plast Reconstr Surg 2022 Jan-Feb 01;38(1):e10-e13. doi: 10.1097/IOP.0000000000002057. PMID: 34570047
Management of double optic disc pit complicated by maculopathy.
Babu N, Baliga G, Kohli P, Ramasamy K
Indian J Ophthalmol 2020 Apr;68(4):663-665. doi: 10.4103/ijo.IJO_1114_19. PMID: 32174600Free PMC Article
Choroidal biomarkers.
Pichi F, Aggarwal K, Neri P, Salvetti P, Lembo A, Nucci P, Gemmy Cheung CM, Gupta V
Indian J Ophthalmol 2018 Dec;66(12):1716-1726. doi: 10.4103/ijo.IJO_893_18. PMID: 30451172Free PMC Article
Hypotony maculopathy.
Costa VP, Arcieri ES
Acta Ophthalmol Scand 2007 Sep;85(6):586-97. Epub 2007 Jun 2 doi: 10.1111/j.1600-0420.2007.00910.x. PMID: 17542978

Therapy

Association of macular outward scleral height with axial length, macular choroidal thickness and morphologic characteristics of the optic disc in Chinese adults.
Li M, Xu H, Ye L, Zhou S, Xie J, Liu C, Zhu J, He J, Fan Y, Xu X
Eye (Lond) 2024 Apr;38(5):923-929. Epub 2023 Oct 28 doi: 10.1038/s41433-023-02804-5. PMID: 37898715Free PMC Article
Observation of the effect of posterior scleral reinforcement combined with orthokeratology and 0.01% atropine in the treatment of congenital myopia: a case report.
Yan C, Zhao F, Gao S, Liu X, Yu T, Mu Y, Zhang L, Xu J
BMC Ophthalmol 2023 Nov 28;23(1):486. doi: 10.1186/s12886-023-03211-w. PMID: 38012561Free PMC Article
A report on a series of nanophthalmos with histopathology and immunohistochemistry analyses using light microscopy.
Rajendrababu S, Shroff S, More S, Radhakrishnan S, Chidambaranathan G, Senthilkumar VA, Sithiq UM, Kannan NB
Indian J Ophthalmol 2022 Jul;70(7):2597-2602. doi: 10.4103/ijo.IJO_2973_21. PMID: 35791166Free PMC Article
Scleral window surgery and topical mitomycin C for nanophthalmic uveal effusion complicated by renal failure: case report.
Suzuki Y, Nishina S, Azuma N
Graefes Arch Clin Exp Ophthalmol 2007 May;245(5):755-7. Epub 2006 Oct 6 doi: 10.1007/s00417-006-0403-6. PMID: 17024441
Management of a partial-thickness scleral-flap buttonhole during trabeculectomy.
Brown SV
Ophthalmic Surg 1994 Nov-Dec;25(10):732-3. PMID: 7898871

Prognosis

Primary congenital glaucoma: An iridotrabeculodysgenesis?
Sihota R, Mahalingam K, Maurya AK, Sharma A, Bukke AN, Dada T
Indian J Ophthalmol 2024 Mar 1;72(3):328-334. Epub 2023 Dec 15 doi: 10.4103/IJO.IJO_370_23. PMID: 38099353Free PMC Article
Uveal effusion syndrome.
Elagouz M, Stanescu-Segall D, Jackson TL
Surv Ophthalmol 2010 Mar-Apr;55(2):134-45. doi: 10.1016/j.survophthal.2009.05.003. PMID: 20159229
Hypotony maculopathy.
Costa VP, Arcieri ES
Acta Ophthalmol Scand 2007 Sep;85(6):586-97. Epub 2007 Jun 2 doi: 10.1111/j.1600-0420.2007.00910.x. PMID: 17542978
Surgical management of the idiopathic uveal effusion syndrome.
Johnson MW, Gass JD
Ophthalmology 1990 Jun;97(6):778-85. doi: 10.1016/s0161-6420(90)32511-3. PMID: 2374682
Vortex vein decompression for nanophthalmic uveal effusion.
Brockhurst RJ
Arch Ophthalmol 1980 Nov;98(11):1987-90. doi: 10.1001/archopht.1980.01020040839008. PMID: 7436831

Clinical prediction guides

Primary congenital glaucoma: An iridotrabeculodysgenesis?
Sihota R, Mahalingam K, Maurya AK, Sharma A, Bukke AN, Dada T
Indian J Ophthalmol 2024 Mar 1;72(3):328-334. Epub 2023 Dec 15 doi: 10.4103/IJO.IJO_370_23. PMID: 38099353Free PMC Article
Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner.
Zhou W, Jiang Z, Yi Z, Ouyang J, Li X, Zhang Q, Wang P
Int J Mol Sci 2023 Nov 29;24(23) doi: 10.3390/ijms242316928. PMID: 38069250Free PMC Article
CURRENT VIEW OF THE SPECTRUM OF PACHYCHOROID DISEASES. A REVIEW.
Stepanov A
Cesk Slov Oftalmol 2023 Winter;3(Ahead of Print):1001-1005. PMID: 38016808
CURRENT VIEW OF THE SPECTRUM OF PACHYCHOROID DISEASES. A REVIEW.
Stepanov A
Cesk Slov Oftalmol 2023 Spring;79(4):163-166. doi: 10.31348/2023/9. PMID: 37567771
Exudative retinal detachment in nanophthalmos.
Krohn J, Seland JH
Acta Ophthalmol Scand 1998 Aug;76(4):499-502. doi: 10.1034/j.1600-0420.1998.760421.x. PMID: 9716342

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