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Elevated circulating fibroblast growth factor 23 concentration

MedGen UID:
1863638
•Concept ID:
C5937193
•
Finding
HPO: HP:6000407

Definition

The concentration of fibroblast growth factor 23 in the blood circulation is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating fibroblast growth factor 23 concentration

Professional guidelines

PubMed

Mechanisms Underlying Iron Deficiency-Induced Cardiac Disorders: Implications for Treatment.
Cirovic A, Starcevic A, Ivanovski A, Bogicevic D, Orisakwe OE, Cirovic A
Discov Med 2025 Jan;37(192):31-41. doi: 10.24976/Discov.Med.202537192.3. PMID: 39851221

Recent clinical studies

Etiology

FGF23 as a Potential Pathophysiological Factor in Peripheral Arterial Disease Associated with Chronic Kidney Disease.
Donate-Correa J, Martín-Núñez E, Hernández-Carballo C, González-Luis A, Mora-Fernández C, Martín-Olivera A, Rodríguez-Ramos S, Cerro-López P, López-Castillo Á, Delgado-Molinos A, López-Tarruella VC, Navarro-González JF
Int J Mol Sci 2024 May 17;25(10) doi: 10.3390/ijms25105457. PMID: 38791495Free PMC Article
Role of Chronic Kidney Disease (CKD)-Mineral and Bone Disorder (MBD) in the Pathogenesis of Cardiovascular Disease in CKD.
Yamada S, Nakano T
J Atheroscler Thromb 2023 Aug 1;30(8):835-850. Epub 2023 May 30 doi: 10.5551/jat.RV22006. PMID: 37258233Free PMC Article
Fibroblast Growth Factor-23-A Potential Uremic Toxin.
Kuczera P, Adamczak M, Wiecek A
Toxins (Basel) 2016 Dec 8;8(12) doi: 10.3390/toxins8120369. PMID: 27941640Free PMC Article
The use of fibroblast growth factor 23 testing in patients with kidney disease.
Smith ER
Clin J Am Soc Nephrol 2014 Jul;9(7):1283-303. Epub 2014 Feb 27 doi: 10.2215/CJN.10941013. PMID: 24578336Free PMC Article
Fibroblast growth factor-23: what we know, what we don't know, and what we need to know.
Kovesdy CP, Quarles LD
Nephrol Dial Transplant 2013 Sep;28(9):2228-36. Epub 2013 Apr 25 doi: 10.1093/ndt/gft065. PMID: 23625971Free PMC Article

Diagnosis

Intact Fibroblast Growth Factor 23 Concentrations in Hypophosphatemic Disorders.
Ramos P, Larson B, Ashrafzadeh-Kian S, Ito N, Kato H, Bornhorst JA, Algeciras-Schimnich A
Endocr Pract 2023 Mar;29(3):193-198. Epub 2023 Jan 7 doi: 10.1016/j.eprac.2023.01.003. PMID: 36627024
Inappropriate secretion of fibroblast growth factor 23 despite hypophosphataemia with changes in bone turnover markers in a girl with systemic lupus erythematosus: Case report and review of the literature.
Kawaguchi T, Inamo Y
Mod Rheumatol Case Rep 2023 Jan 3;7(1):60-64. doi: 10.1093/mrcr/rxac055. PMID: 35792508
Fibroblast growth factor 23 as novel biomarker for early risk stratification after ST-elevation myocardial infarction.
Reindl M, Reinstadler SJ, Feistritzer HJ, Mueller L, Koch C, Mayr A, Theurl M, Kirchmair R, Klug G, Metzler B
Heart 2017 Jun;103(11):856-862. Epub 2016 Dec 15 doi: 10.1136/heartjnl-2016-310520. PMID: 27979879
Phosphate, fibroblast growth factor 23 and retinopathy in chronic kidney disease: the Chronic Renal Insufficiency Cohort Study.
Mehta R, Ying GS, Houston S, Isakova T, Nessel L, Ojo A, Go A, Lash J, Kusek J, Grunwald J, Wolf M; CRIC Study Investigators
Nephrol Dial Transplant 2015 Sep;30(9):1534-41. Epub 2015 Apr 24 doi: 10.1093/ndt/gfv123. PMID: 25910495Free PMC Article
The use of fibroblast growth factor 23 testing in patients with kidney disease.
Smith ER
Clin J Am Soc Nephrol 2014 Jul;9(7):1283-303. Epub 2014 Feb 27 doi: 10.2215/CJN.10941013. PMID: 24578336Free PMC Article

Therapy

Randomized trial of intravenous iron-induced hypophosphatemia.
Wolf M, Chertow GM, Macdougall IC, Kaper R, Krop J, Strauss W
JCI Insight 2018 Dec 6;3(23) doi: 10.1172/jci.insight.124486. PMID: 30518682Free PMC Article
Identifying early pathogenic events during vascular calcification in uremic rats.
Hortells L, Sosa C, Guillén N, Lucea S, Millán Á, Sorribas V
Kidney Int 2017 Dec;92(6):1384-1394. Epub 2017 Aug 23 doi: 10.1016/j.kint.2017.06.019. PMID: 28844316
Fibroblast growth factor 23 and left ventricular hypertrophy in children on dialysis.
Seeherunvong W, Abitbol CL, Chandar J, Rusconi P, Zilleruelo GE, Freundlich M
Pediatr Nephrol 2012 Nov;27(11):2129-2136. Epub 2012 Jun 19 doi: 10.1007/s00467-012-2224-7. PMID: 22710695
Treatment of X-linked hypophosphatemia with calcitriol and phosphate increases circulating fibroblast growth factor 23 concentrations.
Imel EA, DiMeglio LA, Hui SL, Carpenter TO, Econs MJ
J Clin Endocrinol Metab 2010 Apr;95(4):1846-50. Epub 2010 Feb 15 doi: 10.1210/jc.2009-1671. PMID: 20157195Free PMC Article
Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers.
Larsson T, Nisbeth U, Ljunggren O, Jüppner H, Jonsson KB
Kidney Int 2003 Dec;64(6):2272-9. doi: 10.1046/j.1523-1755.2003.00328.x. PMID: 14633152

Prognosis

Role of Chronic Kidney Disease (CKD)-Mineral and Bone Disorder (MBD) in the Pathogenesis of Cardiovascular Disease in CKD.
Yamada S, Nakano T
J Atheroscler Thromb 2023 Aug 1;30(8):835-850. Epub 2023 May 30 doi: 10.5551/jat.RV22006. PMID: 37258233Free PMC Article
Fibroblast growth factor 23 as novel biomarker for early risk stratification after ST-elevation myocardial infarction.
Reindl M, Reinstadler SJ, Feistritzer HJ, Mueller L, Koch C, Mayr A, Theurl M, Kirchmair R, Klug G, Metzler B
Heart 2017 Jun;103(11):856-862. Epub 2016 Dec 15 doi: 10.1136/heartjnl-2016-310520. PMID: 27979879
Fibroblast Growth Factor-23-A Potential Uremic Toxin.
Kuczera P, Adamczak M, Wiecek A
Toxins (Basel) 2016 Dec 8;8(12) doi: 10.3390/toxins8120369. PMID: 27941640Free PMC Article
The use of fibroblast growth factor 23 testing in patients with kidney disease.
Smith ER
Clin J Am Soc Nephrol 2014 Jul;9(7):1283-303. Epub 2014 Feb 27 doi: 10.2215/CJN.10941013. PMID: 24578336Free PMC Article
Fibroblast growth factor-23: what we know, what we don't know, and what we need to know.
Kovesdy CP, Quarles LD
Nephrol Dial Transplant 2013 Sep;28(9):2228-36. Epub 2013 Apr 25 doi: 10.1093/ndt/gft065. PMID: 23625971Free PMC Article

Clinical prediction guides

Fibroblast growth factor 23 as novel biomarker for early risk stratification after ST-elevation myocardial infarction.
Reindl M, Reinstadler SJ, Feistritzer HJ, Mueller L, Koch C, Mayr A, Theurl M, Kirchmair R, Klug G, Metzler B
Heart 2017 Jun;103(11):856-862. Epub 2016 Dec 15 doi: 10.1136/heartjnl-2016-310520. PMID: 27979879
The use of fibroblast growth factor 23 testing in patients with kidney disease.
Smith ER
Clin J Am Soc Nephrol 2014 Jul;9(7):1283-303. Epub 2014 Feb 27 doi: 10.2215/CJN.10941013. PMID: 24578336Free PMC Article
Fibroblast growth factor-23: what we know, what we don't know, and what we need to know.
Kovesdy CP, Quarles LD
Nephrol Dial Transplant 2013 Sep;28(9):2228-36. Epub 2013 Apr 25 doi: 10.1093/ndt/gft065. PMID: 23625971Free PMC Article
Fibroblast growth factor 23 and left ventricular hypertrophy in children on dialysis.
Seeherunvong W, Abitbol CL, Chandar J, Rusconi P, Zilleruelo GE, Freundlich M
Pediatr Nephrol 2012 Nov;27(11):2129-2136. Epub 2012 Jun 19 doi: 10.1007/s00467-012-2224-7. PMID: 22710695
Fibroblast growth factor 23 and its receptors.
Yu X, White KE
Ther Apher Dial 2005 Aug;9(4):308-12. doi: 10.1111/j.1744-9987.2005.00287.x. PMID: 16076372

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