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Blunted aldosterone response to aldosterone suppression test

MedGen UID:
1863824
•Concept ID:
C5937156
•
Finding
HPO: HP:6000362

Definition

A non-suppressible aldosterone excess, defined as an abnormal result of one of any four suppression tests. These tests use oral sodium loading, oral fludrocortisone, oral captopril, or saline infusion to suppress aldosterone secretion. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBlunted aldosterone response to aldosterone suppression test

Recent clinical studies

Etiology

Adrenal incidentaloma: an overview of hormonal data from the National Italian Study Group.
Mantero F, Masini AM, Opocher G, Giovagnetti M, Arnaldi G
Horm Res 1997;47(4-6):284-9. doi: 10.1159/000185478. PMID: 9167966
Blood pressure and endocrine responses to changes in dietary sodium intake in cardiac transplant recipients. Implications for the control of sodium balance.
Singer DR, Markandu ND, Buckley MG, Miller MA, Sagnella GA, Lachno DR, Cappuccio FP, Murday A, Yacoub MH, MacGregor GA
Circulation 1994 Mar;89(3):1153-9. doi: 10.1161/01.cir.89.3.1153. PMID: 8124802

Diagnosis

A patient with concurrent primary hyperaldosteronism and adrenal insufficiency.
Puentes F, Jackson TW, Isales CM
Am J Med Sci 2004 Dec;328(6):344-7. doi: 10.1016/s0002-9629(15)33944-6. PMID: 15599330
Blood pressure, sodium intake, insulin resistance, and urinary nitrate excretion.
Facchini FS, DoNascimento C, Reaven GM, Yip JW, Ni XP, Humphreys MH
Hypertension 1999 Apr;33(4):1008-12. doi: 10.1161/01.hyp.33.4.1008. PMID: 10205239
Adrenal incidentaloma: an overview of hormonal data from the National Italian Study Group.
Mantero F, Masini AM, Opocher G, Giovagnetti M, Arnaldi G
Horm Res 1997;47(4-6):284-9. doi: 10.1159/000185478. PMID: 9167966
Blood pressure and endocrine responses to changes in dietary sodium intake in cardiac transplant recipients. Implications for the control of sodium balance.
Singer DR, Markandu ND, Buckley MG, Miller MA, Sagnella GA, Lachno DR, Cappuccio FP, Murday A, Yacoub MH, MacGregor GA
Circulation 1994 Mar;89(3):1153-9. doi: 10.1161/01.cir.89.3.1153. PMID: 8124802

Therapy

Ingestion of sodium citrate suppresses aldosterone level in blood at rest and during exercise.
Oöpik V, Timpmann S, Hackney AC, Kadak K, Medijainen L, Karelson K
Appl Physiol Nutr Metab 2010 Jun;35(3):278-85. doi: 10.1139/H10-018. PMID: 20555371
Effects of salt supplementation on the albuminuric response to telmisartan with or without hydrochlorothiazide therapy in hypertensive patients with type 2 diabetes are modulated by habitual dietary salt intake.
Ekinci EI, Thomas G, Thomas D, Johnson C, Macisaac RJ, Houlihan CA, Finch S, Panagiotopoulos S, O'Callaghan C, Jerums G
Diabetes Care 2009 Aug;32(8):1398-403. Epub 2009 Jun 23 doi: 10.2337/dc08-2297. PMID: 19549737Free PMC Article
Blood pressure, sodium intake, insulin resistance, and urinary nitrate excretion.
Facchini FS, DoNascimento C, Reaven GM, Yip JW, Ni XP, Humphreys MH
Hypertension 1999 Apr;33(4):1008-12. doi: 10.1161/01.hyp.33.4.1008. PMID: 10205239
Neuroendocrine, fluid balance, and thirst responses to alcohol in alcoholics.
Collins GB, Brosnihan KB, Zuti RA, Messina M, Gupta MK
Alcohol Clin Exp Res 1992 Apr;16(2):228-33. doi: 10.1111/j.1530-0277.1992.tb01368.x. PMID: 1590544
The effects of fadrozole hydrochloride on aldosterone secretion in healthy male subjects.
Trunet PF, Mueller P, Girard F, Aupetit B, Bhatnagar AS, Zognbi F, Ezzet F, Menard J
J Clin Endocrinol Metab 1992 Mar;74(3):571-6. doi: 10.1210/jcem.74.3.1531483. PMID: 1531483

Clinical prediction guides

Ingestion of sodium citrate suppresses aldosterone level in blood at rest and during exercise.
Oöpik V, Timpmann S, Hackney AC, Kadak K, Medijainen L, Karelson K
Appl Physiol Nutr Metab 2010 Jun;35(3):278-85. doi: 10.1139/H10-018. PMID: 20555371
Neuroendocrine, fluid balance, and thirst responses to alcohol in alcoholics.
Collins GB, Brosnihan KB, Zuti RA, Messina M, Gupta MK
Alcohol Clin Exp Res 1992 Apr;16(2):228-33. doi: 10.1111/j.1530-0277.1992.tb01368.x. PMID: 1590544
The effects of fadrozole hydrochloride on aldosterone secretion in healthy male subjects.
Trunet PF, Mueller P, Girard F, Aupetit B, Bhatnagar AS, Zognbi F, Ezzet F, Menard J
J Clin Endocrinol Metab 1992 Mar;74(3):571-6. doi: 10.1210/jcem.74.3.1531483. PMID: 1531483
Blunted aldosterone response to dexamethasone in female patients with endogenous depression.
Holsboer F, Dörr HG, Sippell WG
Psychoneuroendocrinology 1982;7(2-3):155-62. doi: 10.1016/0306-4530(82)90008-7. PMID: 7178371

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