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Pseudorabies

MedGen UID:
18730
•Concept ID:
C0033839
•
Disease or Syndrome
Synonyms: Aujeszky Disease; Aujeszky's Disease; Aujeszkys Disease
 
Monarch Initiative: MONDO:0005932

Definition

A highly contagious herpesvirus infection affecting the central nervous system of swine, cattle, dogs, cats, rats, and other animals. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPseudorabies

Professional guidelines

PubMed

Detection of virus or virus specific nucleic acid in foodstuff or bioproducts--hazards and risk assessment.
Büttner M, Oehmig A, Weiland F, Rziha HJ, Pfaff E
Arch Virol Suppl 1997;13:57-66. doi: 10.1007/978-3-7091-6534-8_6. PMID: 9413526
Quantitative risk assessment of the risks associated with the importation of pigs to abattoirs.
Morley RS
Rev Sci Tech 1993 Dec;12(4):1235-63. doi: 10.20506/rst.12.4.747. PMID: 8312623

Recent clinical studies

Etiology

The Epidemiology and Variation in Pseudorabies Virus: A Continuing Challenge to Pigs and Humans.
Liu Q, Kuang Y, Li Y, Guo H, Zhou C, Guo S, Tan C, Wu B, Chen H, Wang X
Viruses 2022 Jul 1;14(7) doi: 10.3390/v14071463. PMID: 35891443Free PMC Article
Pseudorabies Virus UL24 Abrogates Tumor Necrosis Factor Alpha-Induced NF-κB Activation by Degrading P65.
Wang TY, Yang YL, Feng C, Sun MX, Peng JM, Tian ZJ, Tang YD, Cai XH
Viruses 2020 Jan 2;12(1) doi: 10.3390/v12010051. PMID: 31906441Free PMC Article
Antiviral Effect of Resveratrol in Piglets Infected with Virulent Pseudorabies Virus.
Zhao X, Tong W, Song X, Jia R, Li L, Zou Y, He C, Liang X, Lv C, Jing B, Lin J, Yin L, Ye G, Yue G, Wang Y, Yin Z
Viruses 2018 Aug 27;10(9) doi: 10.3390/v10090457. PMID: 30150559Free PMC Article
Central autonomic control of the heart, angina, and pathogenic mechanisms of post-myocardial infarction depression.
Ter Horst GJ
Eur J Morphol 1999 Oct;37(4-5):257-66. doi: 10.1076/ejom.37.4.257.4722. PMID: 10477471
Transmission, species specificity, and pathogenicity of Aujeszky's disease virus.
Sawitzky D
Arch Virol Suppl 1997;13:201-6. doi: 10.1007/978-3-7091-6534-8_19. PMID: 9413539

Diagnosis

Pseudorabies Virus: From Pathogenesis to Prevention Strategies.
Zheng HH, Fu PF, Chen HY, Wang ZY
Viruses 2022 Jul 27;14(8) doi: 10.3390/v14081638. PMID: 36016260Free PMC Article
The Epidemiology and Variation in Pseudorabies Virus: A Continuing Challenge to Pigs and Humans.
Liu Q, Kuang Y, Li Y, Guo H, Zhou C, Guo S, Tan C, Wu B, Chen H, Wang X
Viruses 2022 Jul 1;14(7) doi: 10.3390/v14071463. PMID: 35891443Free PMC Article
Vitritis and retinal vasculitis caused by pseudorabies virus.
Ying M, Hu X, Wang M, Cheng X, Zhao B, Tao Y
J Int Med Res 2021 Nov;49(11):3000605211058990. doi: 10.1177/03000605211058990. PMID: 34851760Free PMC Article
Magnetic beads-based chemiluminescent assay for ultrasensitive detection of pseudorabies virus.
Yang H, Guo Y, Li S, Lan G, Jiang Q, Yang X, Fan J, Ali Z, Tang Y, Mou X, Liu H, Shah MA, Jin S, Jiang H, Li Z
J Nanosci Nanotechnol 2014 May;14(5):3337-42. doi: 10.1166/jnn.2014.8254. PMID: 24734549
Infectious skin diseases of cattle.
Hunt E
Vet Clin North Am Large Anim Pract 1984 Mar;6(1):155-74. doi: 10.1016/s0196-9846(17)30045-9. PMID: 6330955

Therapy

Phosphoproteomic landscape of pseudorabies virus infection reveals multiple potential antiviral targets.
Bo Z, Li X, Zhang C, Guo M, Cao Y, Zhang X, Wu Y
Microbiol Spectr 2024 Jan 11;12(1):e0301023. Epub 2023 Nov 22 doi: 10.1128/spectrum.03010-23. PMID: 37991362Free PMC Article
Membrane fusion, potential threats, and natural antiviral drugs of pseudorabies virus.
Ye N, Feng W, Fu T, Tang D, Zeng Z, Wang B
Vet Res 2023 May 2;54(1):39. doi: 10.1186/s13567-023-01171-z. PMID: 37131259Free PMC Article
A bivalent β-carboline derivative inhibits macropinocytosis-dependent entry of pseudorabies virus by targeting the kinase DYRK1A.
Wang C, Hu R, Wang T, Duan L, Hou Q, Wang J, Yang Z
J Biol Chem 2023 Apr;299(4):104605. Epub 2023 Mar 12 doi: 10.1016/j.jbc.2023.104605. PMID: 36918100Free PMC Article
The broad spectrum host-directed agent ivermectin as an antiviral for SARS-CoV-2 ?
Jans DA, Wagstaff KM
Biochem Biophys Res Commun 2021 Jan 29;538:163-172. Epub 2020 Oct 21 doi: 10.1016/j.bbrc.2020.10.042. PMID: 33341233Free PMC Article
Antiviral Effect of Resveratrol in Piglets Infected with Virulent Pseudorabies Virus.
Zhao X, Tong W, Song X, Jia R, Li L, Zou Y, He C, Liang X, Lv C, Jing B, Lin J, Yin L, Ye G, Yue G, Wang Y, Yin Z
Viruses 2018 Aug 27;10(9) doi: 10.3390/v10090457. PMID: 30150559Free PMC Article

Prognosis

A bivalent β-carboline derivative inhibits macropinocytosis-dependent entry of pseudorabies virus by targeting the kinase DYRK1A.
Wang C, Hu R, Wang T, Duan L, Hou Q, Wang J, Yang Z
J Biol Chem 2023 Apr;299(4):104605. Epub 2023 Mar 12 doi: 10.1016/j.jbc.2023.104605. PMID: 36918100Free PMC Article
Vitritis and retinal vasculitis caused by pseudorabies virus.
Ying M, Hu X, Wang M, Cheng X, Zhao B, Tao Y
J Int Med Res 2021 Nov;49(11):3000605211058990. doi: 10.1177/03000605211058990. PMID: 34851760Free PMC Article
The UL20 gene product of pseudorabies virus functions in virus egress.
Fuchs W, Klupp BG, Granzow H, Mettenleiter TC
J Virol 1997 Jul;71(7):5639-46. doi: 10.1128/JVI.71.7.5639-5646.1997. PMID: 9188641Free PMC Article
Identification and characterization of pseudorabies virus dUTPase.
Jöns A, Mettenleiter TC
J Virol 1996 Feb;70(2):1242-5. doi: 10.1128/JVI.70.2.1242-1245.1996. PMID: 8551588Free PMC Article
Tyrosine sulfation of varicella-zoster virus envelope glycoprotein gpl.
Edson CM
Virology 1993 Nov;197(1):159-65. doi: 10.1006/viro.1993.1576. PMID: 8212550

Clinical prediction guides

Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity.
Zhou Q, Shi D, Tang YD, Zhang L, Hu B, Zheng C, Huang L, Weng C
PLoS Pathog 2024 Apr;20(4):e1012146. Epub 2024 Apr 26 doi: 10.1371/journal.ppat.1012146. PMID: 38669242Free PMC Article
The Epidemiology and Variation in Pseudorabies Virus: A Continuing Challenge to Pigs and Humans.
Liu Q, Kuang Y, Li Y, Guo H, Zhou C, Guo S, Tan C, Wu B, Chen H, Wang X
Viruses 2022 Jul 1;14(7) doi: 10.3390/v14071463. PMID: 35891443Free PMC Article
Expression of the immediate early IE180 protein under the control of the hTERT and CEA tumor-specific promoters in recombinant pseudorabies viruses: Effects of IE180 protein on promoter activity and apoptosis induction.
Lerma L, Alcalá S, Piñero C, Torres M, Martin B, Lim F, Sainz B Jr, Tabarés E
Virology 2016 Jan 15;488:9-19. Epub 2015 Nov 17 doi: 10.1016/j.virol.2015.10.028. PMID: 26590793
A common neuronal response to alphaherpesvirus infection.
Szpara ML, Kobiler O, Enquist LW
J Neuroimmune Pharmacol 2010 Sep;5(3):418-27. Epub 2010 Apr 17 doi: 10.1007/s11481-010-9212-0. PMID: 20401540Free PMC Article
Recent findings on the organization of central nervous system structures involved in the innervation of endocrine glands and other organs; observations obtained by the transneuronal viral double-labeling technique.
Gerendai I, Tóth IE, Boldogkoi Z, Halász B
Endocrine 2009 Oct;36(2):179-88. Epub 2009 May 6 doi: 10.1007/s12020-009-9189-8. PMID: 19418269

Recent systematic reviews

Human Encephalitis Caused by Pseudorabies Virus in China: A Case Report and Systematic Review.
Hou Y, Wang Y, Zhang Y, Yu H, Zhao Y, Yi A
Vector Borne Zoonotic Dis 2022 Jul;22(7):391-396. Epub 2022 Jun 23 doi: 10.1089/vbz.2022.0002. PMID: 35736787
Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen.
Heidary F, Gharebaghi R
J Antibiot (Tokyo) 2020 Sep;73(9):593-602. Epub 2020 Jun 12 doi: 10.1038/s41429-020-0336-z. PMID: 32533071Free PMC Article

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