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Phosphorus metabolism disease

MedGen UID:
19276
•Concept ID:
C0031707
•
Disease or Syndrome
Synonyms: Disorder, Phosphorus Metabolism; Disorders, Phosphorus Metabolism; Metabolism Disorder, Phosphorus; Metabolism Disorders, Phosphorus; Phosphorus Metabolism Disorder; Phosphorus Metabolism Disorders
SNOMED CT: Disorder of phosphorus metabolism (87049008); Phosphorus metabolism disorder (87049008)
 
Monarch Initiative: MONDO:0002319

Definition

A metabolic disorder that affects the phosphate homeostasis. [from NCI]

Professional guidelines

PubMed

Osteoporosis - risk factors, pharmaceutical and non-pharmaceutical treatment.
Tański W, Kosiorowska J, Szymańska-Chabowska A
Eur Rev Med Pharmacol Sci 2021 May;25(9):3557-3566. doi: 10.26355/eurrev_202105_25838. PMID: 34002830
Secondary Hyperparathyroidism: Pathogenesis and Latest Treatment.
Mizobuchi M, Ogata H, Koiwa F
Ther Apher Dial 2019 Aug;23(4):309-318. Epub 2018 Dec 18 doi: 10.1111/1744-9987.12772. PMID: 30411503
Prevention and treatment of hyperphosphatemia in chronic kidney disease.
Vervloet MG, van Ballegooijen AJ
Kidney Int 2018 May;93(5):1060-1072. Epub 2018 Mar 23 doi: 10.1016/j.kint.2017.11.036. PMID: 29580635

Recent clinical studies

Etiology

Screening for Metabolic Bone Disease of prematurity.
Rayannavar A, Calabria AC
Semin Fetal Neonatal Med 2020 Feb;25(1):101086. Epub 2020 Jan 16 doi: 10.1016/j.siny.2020.101086. PMID: 32081592
ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Calcium, phosphorus and magnesium.
Mihatsch W, Fewtrell M, Goulet O, Molgaard C, Picaud JC, Senterre T; ESPGHAN/ESPEN/ESPR/CSPEN working group on pediatric parenteral nutrition
Clin Nutr 2018 Dec;37(6 Pt B):2360-2365. Epub 2018 Jun 18 doi: 10.1016/j.clnu.2018.06.950. PMID: 30097365
The refeeding syndrome. Importance of phosphorus.
Araujo Castro M, Vázquez Martínez C
Med Clin (Barc) 2018 Jun 22;150(12):472-478. Epub 2018 Feb 12 doi: 10.1016/j.medcli.2017.12.008. PMID: 29448987
Pathophysiology of Calcium, Phosphorus, and Magnesium Dysregulation in Chronic Kidney Disease.
Felsenfeld AJ, Levine BS, Rodriguez M
Semin Dial 2015 Nov-Dec;28(6):564-77. Epub 2015 Aug 25 doi: 10.1111/sdi.12411. PMID: 26303319
Calcium metabolism in health and disease.
Peacock M
Clin J Am Soc Nephrol 2010 Jan;5 Suppl 1:S23-30. doi: 10.2215/CJN.05910809. PMID: 20089499

Diagnosis

Screening for Metabolic Bone Disease of prematurity.
Rayannavar A, Calabria AC
Semin Fetal Neonatal Med 2020 Feb;25(1):101086. Epub 2020 Jan 16 doi: 10.1016/j.siny.2020.101086. PMID: 32081592
Secondary Hyperparathyroidism: Pathogenesis and Latest Treatment.
Mizobuchi M, Ogata H, Koiwa F
Ther Apher Dial 2019 Aug;23(4):309-318. Epub 2018 Dec 18 doi: 10.1111/1744-9987.12772. PMID: 30411503
The refeeding syndrome. Importance of phosphorus.
Araujo Castro M, Vázquez Martínez C
Med Clin (Barc) 2018 Jun 22;150(12):472-478. Epub 2018 Feb 12 doi: 10.1016/j.medcli.2017.12.008. PMID: 29448987
Rickets.
Carpenter TO, Shaw NJ, Portale AA, Ward LM, Abrams SA, Pettifor JM
Nat Rev Dis Primers 2017 Dec 21;3:17101. doi: 10.1038/nrdp.2017.101. PMID: 29265106
Endemic skeletal fluorosis.
Teotia M, Teotia SP, Kunwar KB
Arch Dis Child 1971 Oct;46(249):686-91. doi: 10.1136/adc.46.249.686. PMID: 5118057Free PMC Article

Therapy

Secondary Hyperparathyroidism: Pathogenesis and Latest Treatment.
Mizobuchi M, Ogata H, Koiwa F
Ther Apher Dial 2019 Aug;23(4):309-318. Epub 2018 Dec 18 doi: 10.1111/1744-9987.12772. PMID: 30411503
ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Calcium, phosphorus and magnesium.
Mihatsch W, Fewtrell M, Goulet O, Molgaard C, Picaud JC, Senterre T; ESPGHAN/ESPEN/ESPR/CSPEN working group on pediatric parenteral nutrition
Clin Nutr 2018 Dec;37(6 Pt B):2360-2365. Epub 2018 Jun 18 doi: 10.1016/j.clnu.2018.06.950. PMID: 30097365
The refeeding syndrome. Importance of phosphorus.
Araujo Castro M, Vázquez Martínez C
Med Clin (Barc) 2018 Jun 22;150(12):472-478. Epub 2018 Feb 12 doi: 10.1016/j.medcli.2017.12.008. PMID: 29448987
Calcium metabolism in health and disease.
Peacock M
Clin J Am Soc Nephrol 2010 Jan;5 Suppl 1:S23-30. doi: 10.2215/CJN.05910809. PMID: 20089499
The effects of calcium and phosphorus in hemodialysis.
Goldsmith RS
Annu Rev Med 1976;27:181-90. doi: 10.1146/annurev.me.27.020176.001145. PMID: 180871

Prognosis

Etiology of hypophosphatemia in adults.
Puente Ruiz N, Valero Díaz de Lamadrid MC, Riancho JA
Med Clin (Barc) 2025 Jan 10;164(1):30-37. Epub 2024 Jul 17 doi: 10.1016/j.medcli.2024.05.017. PMID: 39025772
Genetically predicted circulating concentrations of micronutrients and risk of breast cancer: A Mendelian randomization study.
Papadimitriou N, Dimou N, Gill D, Tzoulaki I, Murphy N, Riboli E, Lewis SJ, Martin RM, Gunter MJ, Tsilidis KK
Int J Cancer 2021 Feb 1;148(3):646-653. Epub 2020 Aug 25 doi: 10.1002/ijc.33246. PMID: 32761610Free PMC Article
The refeeding syndrome. Importance of phosphorus.
Araujo Castro M, Vázquez Martínez C
Med Clin (Barc) 2018 Jun 22;150(12):472-478. Epub 2018 Feb 12 doi: 10.1016/j.medcli.2017.12.008. PMID: 29448987
Magnesium and phosphorus.
Weisinger JR, Bellorín-Font E
Lancet 1998 Aug 1;352(9125):391-6. doi: 10.1016/S0140-6736(97)10535-9. PMID: 9717944
Home parenteral nutrition (HPN).
Howard L, Michalek AV
Annu Rev Nutr 1984;4:69-99. doi: 10.1146/annurev.nu.04.070184.000441. PMID: 6432013

Clinical prediction guides

Black Phosphorus Nanosheets Protect Neurons by Degrading Aggregative α-syn and Clearing ROS in Parkinson's Disease.
He M, Zhang X, Ran X, Zhang Y, Nie X, Xiao B, Lei L, Zhai S, Zhu J, Zhang J, Li R, Liu Z, Zhu Y, Dai Z, He Z, Feng J, Zhang C
Adv Mater 2024 Jul;36(30):e2404576. Epub 2024 May 9 doi: 10.1002/adma.202404576. PMID: 38696266
Mineral Bone Abnormalities and Vascular Calcifications.
Ray M, Jovanovich A
Adv Chronic Kidney Dis 2019 Nov;26(6):409-416. doi: 10.1053/j.ackd.2019.09.004. PMID: 31831119
Chronic kidney disease: Levels of phosphorus and patient outcomes.
Foley RN
Nat Rev Nephrol 2011 Jun 28;7(8):428-30. doi: 10.1038/nrneph.2011.87. PMID: 21712850
Magnesium and phosphorus.
Weisinger JR, Bellorín-Font E
Lancet 1998 Aug 1;352(9125):391-6. doi: 10.1016/S0140-6736(97)10535-9. PMID: 9717944
Frontal lobe phosphorus metabolism and neuropsychological function in aging and in Alzheimer's disease.
Smith CD, Pettigrew LC, Avison MJ, Kirsch JE, Tinkhtman AJ, Schmitt FA, Wermeling DP, Wekstein DR, Markesberry WR
Ann Neurol 1995 Aug;38(2):194-201. doi: 10.1002/ana.410380211. PMID: 7654066

Recent systematic reviews

Phosphorus Magnetic Resonance Spectroscopy ((31)P MRS) and Cardiovascular Disease: The Importance of Energy.
Tsampasian V, Cameron D, Sobhan R, Bazoukis G, Vassiliou VS
Medicina (Kaunas) 2023 Jan 15;59(1) doi: 10.3390/medicina59010174. PMID: 36676798Free PMC Article
Management of Hyperphosphatemia in End-Stage Renal Disease: A New Paradigm.
Rastogi A, Bhatt N, Rossetti S, Beto J
J Ren Nutr 2021 Jan;31(1):21-34. Epub 2020 May 5 doi: 10.1053/j.jrn.2020.02.003. PMID: 32386937
Osteoporosis in Patients with Chronic Kidney Diseases: A Systemic Review.
Hsu CY, Chen LR, Chen KH
Int J Mol Sci 2020 Sep 18;21(18) doi: 10.3390/ijms21186846. PMID: 32961953Free PMC Article
Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD).
Ruospo M, Palmer SC, Natale P, Craig JC, Vecchio M, Elder GJ, Strippoli GF
Cochrane Database Syst Rev 2018 Aug 22;8(8):CD006023. doi: 10.1002/14651858.CD006023.pub3. PMID: 30132304Free PMC Article
Serum Phosphorus and Progression of CKD and Mortality: A Meta-analysis of Cohort Studies.
Da J, Xie X, Wolf M, Disthabanchong S, Wang J, Zha Y, Lv J, Zhang L, Wang H
Am J Kidney Dis 2015 Aug;66(2):258-65. Epub 2015 Mar 21 doi: 10.1053/j.ajkd.2015.01.009. PMID: 25804679

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