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Benign neoplasm of sebaceous gland

MedGen UID:
195772
•Concept ID:
C0684358
•
Neoplastic Process
Synonyms: Benign Neoplasm of Sebaceous Gland; benign neoplasm of sebaceous gland; Benign Neoplasm of the Sebaceous Gland; benign neoplasm of the sebaceous gland; Benign Sebaceous Gland Neoplasm; benign sebaceous gland neoplasm; Benign Sebaceous Gland Tumor; benign sebaceous gland tumor; benign sebaceous gland tumour; Benign Sebaceous Neoplasm; benign sebaceous neoplasm; Benign Sebaceous Skin Neoplasm; benign sebaceous skin neoplasm; Benign Sebaceous Skin Tumor; benign sebaceous skin tumor; benign sebaceous skin tumour; Benign Sebaceous Tumor; benign sebaceous tumor; benign sebaceous tumour; Benign Tumor of Sebaceous Gland; benign tumor of sebaceous gland; Benign Tumor of the Sebaceous Gland; benign tumor of the sebaceous gland; benign tumour of sebaceous gland; benign tumour of the sebaceous gland; sebaceous gland benign neoplasm
SNOMED CT: Benign neoplasm of sebaceous gland (92337009)
 
Monarch Initiative: MONDO:0021490

Definition

An epithelial neoplasm that arises from the sebaceous gland and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of sebaceous gland

Professional guidelines

PubMed

Sebaceous carcinoma: an updated review of pathogenesis, diagnosis, and treatment options.
Dowell-Esquivel C, Lee R, DiCaprio RC 3rd, Nouri K
Arch Dermatol Res 2023 Dec 19;316(1):55. doi: 10.1007/s00403-023-02747-7. PMID: 38112896
S2k guideline: Laser therapy of the skin.
Paasch U, Zidane M, Baron JM, Bund T, Cappius HJ, Drosner M, Feise K, Fischer T, Gauglitz G, Gerber PA, Grunewald S, Herberger K, Jung A, Karsai S, Kautz G, Philipp C, Schädel D, Seitz AT, Nast A
J Dtsch Dermatol Ges 2022 Sep;20(9):1248-1267. Epub 2022 Sep 13 doi: 10.1111/ddg.14879. PMID: 36098675
Sebaceous carcinoma: evidence-based clinical practice guidelines.
Owen JL, Kibbi N, Worley B, Kelm RC, Wang JV, Barker CA, Behshad R, Bichakjian CK, Bolotin D, Bordeaux JS, Bradshaw SH, Cartee TV, Chandra S, Cho NL, Choi JN, Council ML, Demirci H, Eisen DB, Esmaeli B, Golda N, Huang CC, Ibrahim SF, Jiang SB, Kim J, Kuzel TM, Lai SY, Lawrence N, Lee EH, Leitenberger JJ, Maher IA, Mann MW, Minkis K, Mittal BB, Nehal KS, Neuhaus IM, Ozog DM, Petersen B, Rotemberg V, Samant S, Samie FH, Servaes S, Shields CL, Shin TM, Sobanko JF, Somani AK, Stebbins WG, Thomas JR, Thomas VD, Tse DT, Waldman AH, Wong MK, Xu YG, Yu SS, Zeitouni NC, Ramsay T, Reynolds KA, Poon E, Alam M
Lancet Oncol 2019 Dec;20(12):e699-e714. doi: 10.1016/S1470-2045(19)30673-4. PMID: 31797796

Recent clinical studies

Etiology

Tumors of the conjunctiva and cornea.
Shields CL, Shields JA
Indian J Ophthalmol 2019 Dec;67(12):1930-1948. doi: 10.4103/ijo.IJO_2040_19. PMID: 31755426Free PMC Article
Sebaceous Neoplasms.
Flux K
Surg Pathol Clin 2017 Jun;10(2):367-382. doi: 10.1016/j.path.2017.01.009. PMID: 28477886
Sebaceous Carcinomas of the Skin: 24 Cases and a Literature Review.
Haber R, Battistella M, Pages C, Bagot M, Lebbe C, Basset-Seguin N
Acta Derm Venereol 2017 Aug 31;97(8):959-961. doi: 10.2340/00015555-2685. PMID: 28448096
Expanded extracolonic tumor spectrum in MUTYH-associated polyposis.
Vogt S, Jones N, Christian D, Engel C, Nielsen M, Kaufmann A, Steinke V, Vasen HF, Propping P, Sampson JR, Hes FJ, Aretz S
Gastroenterology 2009 Dec;137(6):1976-85.e1-10. Epub 2009 Sep 2 doi: 10.1053/j.gastro.2009.08.052. PMID: 19732775
Virus-induced chalazion.
Mansour AM, Chan CC, Crawford MA, Tabbarah ZA, Shen D, Haddad WF, Salti I, Ghazi NG
Eye (Lond) 2006 Feb;20(2):242-6. doi: 10.1038/sj.eye.6701816. PMID: 15746955

Diagnosis

Sebaceous carcinoma: an updated review of pathogenesis, diagnosis, and treatment options.
Dowell-Esquivel C, Lee R, DiCaprio RC 3rd, Nouri K
Arch Dermatol Res 2023 Dec 19;316(1):55. doi: 10.1007/s00403-023-02747-7. PMID: 38112896
Sebaceous Carcinoma.
Erickson LA
Mayo Clin Proc 2021 Aug;96(8):2285-2287. doi: 10.1016/j.mayocp.2021.06.009. PMID: 34353478
Androgens in women: Androgen-mediated skin disease and patient evaluation.
Bienenfeld A, Azarchi S, Lo Sicco K, Marchbein S, Shapiro J, Nagler AR
J Am Acad Dermatol 2019 Jun;80(6):1497-1506. Epub 2018 Oct 10 doi: 10.1016/j.jaad.2018.08.062. PMID: 30312644
Sebaceous Neoplasms.
Flux K
Surg Pathol Clin 2017 Jun;10(2):367-382. doi: 10.1016/j.path.2017.01.009. PMID: 28477886
Inverted follicular keratosis.
Azzopardi JG, Laurini R
J Clin Pathol 1975 Jun;28(6):465-71. doi: 10.1136/jcp.28.6.465. PMID: 1141446Free PMC Article

Therapy

Sebaceous carcinoma: an updated review of pathogenesis, diagnosis, and treatment options.
Dowell-Esquivel C, Lee R, DiCaprio RC 3rd, Nouri K
Arch Dermatol Res 2023 Dec 19;316(1):55. doi: 10.1007/s00403-023-02747-7. PMID: 38112896
Eruptions of Sebaceous Adenomas and Carcinomas Induced by Tacrolimus.
Navarro-Navarro I, Jiménez-Gallo D, Tello-Collantes K, Linares-Barrios M
Actas Dermosifiliogr (Engl Ed) 2021 Apr;112(4):379-381. Epub 2020 Oct 28 doi: 10.1016/j.ad.2019.11.008. PMID: 33129778
The Role of Pembrolizumab in the Treatment of Sebaceous Carcinoma.
Lin AC, Shriver EM
Int Ophthalmol Clin 2020 Spring;60(2):39-46. doi: 10.1097/IIO.0000000000000309. PMID: 32205651
Uncommon cutaneous neoplasms of the head and neck.
Reinstadler DR, Sinha UK
Facial Plast Surg Clin North Am 2012 Nov;20(4):483-91. doi: 10.1016/j.fsc.2012.08.002. PMID: 23084300
The aging skin.
Rapaport M
J Am Geriatr Soc 1973 May;21(5):206-7. doi: 10.1111/j.1532-5415.1973.tb01671.x. PMID: 4708836

Prognosis

Sebaceous carcinoma: an updated review of pathogenesis, diagnosis, and treatment options.
Dowell-Esquivel C, Lee R, DiCaprio RC 3rd, Nouri K
Arch Dermatol Res 2023 Dec 19;316(1):55. doi: 10.1007/s00403-023-02747-7. PMID: 38112896
Epithelial-Myoepithelial Carcinoma.
Nakaguro M, Nagao T
Surg Pathol Clin 2021 Mar;14(1):97-109. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.10.002. PMID: 33526226
Sebaceous carcinoma: evidence-based clinical practice guidelines.
Owen JL, Kibbi N, Worley B, Kelm RC, Wang JV, Barker CA, Behshad R, Bichakjian CK, Bolotin D, Bordeaux JS, Bradshaw SH, Cartee TV, Chandra S, Cho NL, Choi JN, Council ML, Demirci H, Eisen DB, Esmaeli B, Golda N, Huang CC, Ibrahim SF, Jiang SB, Kim J, Kuzel TM, Lai SY, Lawrence N, Lee EH, Leitenberger JJ, Maher IA, Mann MW, Minkis K, Mittal BB, Nehal KS, Neuhaus IM, Ozog DM, Petersen B, Rotemberg V, Samant S, Samie FH, Servaes S, Shields CL, Shin TM, Sobanko JF, Somani AK, Stebbins WG, Thomas JR, Thomas VD, Tse DT, Waldman AH, Wong MK, Xu YG, Yu SS, Zeitouni NC, Ramsay T, Reynolds KA, Poon E, Alam M
Lancet Oncol 2019 Dec;20(12):e699-e714. doi: 10.1016/S1470-2045(19)30673-4. PMID: 31797796
Sebaceous Carcinomas of the Skin: 24 Cases and a Literature Review.
Haber R, Battistella M, Pages C, Bagot M, Lebbe C, Basset-Seguin N
Acta Derm Venereol 2017 Aug 31;97(8):959-961. doi: 10.2340/00015555-2685. PMID: 28448096
Expanded extracolonic tumor spectrum in MUTYH-associated polyposis.
Vogt S, Jones N, Christian D, Engel C, Nielsen M, Kaufmann A, Steinke V, Vasen HF, Propping P, Sampson JR, Hes FJ, Aretz S
Gastroenterology 2009 Dec;137(6):1976-85.e1-10. Epub 2009 Sep 2 doi: 10.1053/j.gastro.2009.08.052. PMID: 19732775

Clinical prediction guides

Yield of sentinel lymph node biopsy in sebaceous carcinoma and predictors of advanced disease: A retrospective analysis of the National Cancer Database.
Maloney NJ, Nguyen KA, So NA, Zaba LC
J Am Acad Dermatol 2023 Feb;88(2):504-506. Epub 2022 Jul 14 doi: 10.1016/j.jaad.2022.07.015. PMID: 35843481
Sebaceous Carcinoma of the Eyelid: A Systematic Review and Meta-Analysis.
Desiato VM, Byun YJ, Nguyen SA, Thiers BH, Day TA
Dermatol Surg 2021 Jan 1;47(1):104-110. doi: 10.1097/DSS.0000000000002660. PMID: 33347004
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
A clinical scoring system to identify patients with sebaceous neoplasms at risk for the Muir-Torre variant of Lynch syndrome.
Roberts ME, Riegert-Johnson DL, Thomas BC, Rumilla KM, Thomas CS, Heckman MG, Purcell JU, Hanson NB, Leppig KA, Lim J, Cappel MA
Genet Med 2014 Sep;16(9):711-6. Epub 2014 Mar 6 doi: 10.1038/gim.2014.19. PMID: 24603434
Expanded extracolonic tumor spectrum in MUTYH-associated polyposis.
Vogt S, Jones N, Christian D, Engel C, Nielsen M, Kaufmann A, Steinke V, Vasen HF, Propping P, Sampson JR, Hes FJ, Aretz S
Gastroenterology 2009 Dec;137(6):1976-85.e1-10. Epub 2009 Sep 2 doi: 10.1053/j.gastro.2009.08.052. PMID: 19732775

Recent systematic reviews

Characterization of sebaceous and non-sebaceous cutaneous manifestations in patients with lynch syndrome: a systematic review.
Aziz S, O'Sullivan H, Heelan K, Alam A, McVeigh TP
Fam Cancer 2023 Apr;22(2):167-175. Epub 2022 Nov 23 doi: 10.1007/s10689-022-00319-8. PMID: 36418753Free PMC Article
Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.
Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546Free PMC Article
Emerging therapies for rare cutaneous cancers: A systematic review.
Garcia A, Nelson K, Patel V
Cancer Treat Rev 2021 Nov;100:102266. Epub 2021 Aug 16 doi: 10.1016/j.ctrv.2021.102266. PMID: 34418780
Sebaceous Carcinoma of the Eyelid: A Systematic Review and Meta-Analysis.
Desiato VM, Byun YJ, Nguyen SA, Thiers BH, Day TA
Dermatol Surg 2021 Jan 1;47(1):104-110. doi: 10.1097/DSS.0000000000002660. PMID: 33347004
Application of intense pulsed light in the treatment of dermatologic disease: a systematic review.
Wat H, Wu DC, Rao J, Goldman MP
Dermatol Surg 2014 Apr;40(4):359-77. Epub 2014 Feb 4 doi: 10.1111/dsu.12424. PMID: 24495252

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