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Rheumatic nodule

MedGen UID:
19780
•Concept ID:
C0035441
•
Pathologic Function
Synonyms: Nodule, Rheumatic; Nodules, Rheumatic; Rheumatic Nodule; Rheumatic Nodules
SNOMED CT: Rheumatic nodule (89050001)

Definition

A small round or oval, mostly subcutaneous nodule made up chiefly of a mass of Aschoff bodies and seen in cases of rheumatic fever. It is differentiated from the RHEUMATOID NODULE which appears in rheumatoid arthritis, most frequently over bony prominences. (From Dorland, 27th ed) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRheumatic nodule

Professional guidelines

PubMed

Recent advances in nonsurgical treatment of pulmonary ground-glass nodules.
Kong Y, Xu H, Huang Y, Lv X, Ye X
J Cancer Res Ther 2022 Apr;18(2):323-328. doi: 10.4103/jcrt.jcrt_2030_21. PMID: 35645096
Diagnosis of rheumatic fever: current status of Jones Criteria and role of echocardiography.
Saxena A
Indian J Pediatr 2000 Mar;67(3 Suppl):S11-4. PMID: 11129913
Diagnosis of rheumatic fever. A guide to the criteria and manifestations.
Tadzynski LA, Ryan ME
Postgrad Med 1986 Mar;79(4):295-300. doi: 10.1080/00325481.1986.11699333. PMID: 3952047

Recent clinical studies

Etiology

Disease activity and subcutaneous nodules are associated to severe periodontitis in patients with rheumatoid arthritis.
González DA, Bianchi ML, Salgado PA, Armada M, Seni S, Isnardi CA, Citera G, Ferrary T, Orman B
Rheumatol Int 2022 Aug;42(8):1331-1339. Epub 2021 Aug 22 doi: 10.1007/s00296-021-04974-5. PMID: 34420067
Low Prevalence of Nodules in Rheumatoid Arthritis Patients in Kuwait: A Description and a Comparison of Patients from the Kuwait Registry for Rheumatic Diseases.
Al-Herz A, Al-Awadhi A, Saleh K, Al-Kandari W, Hasan E, Ghanem A, Abutiban F, Alenizi A, Hussain M, Ali Y, Khadrawy A, Fazal A, Mokaddem K, Zaman A, Mazloum G, Aftab B, Haider N, Bartella Y, Hamed S, Al-Saber A
Med Princ Pract 2017;26(2):152-156. Epub 2016 Nov 23 doi: 10.1159/000454679. PMID: 27883999Free PMC Article
CHANGING CLINICAL PROFILE OF ACUTE RHEUMATIC FEVER AND RHEUMATIC RECURRENCE.
Sheikh AM, Sadiq M, Rehman AU
J Ayub Med Coll Abbottabad 2016 Jan-Mar;28(1):141-5. PMID: 27323580
Conjunctival nodule in rheumatoid arthritis.
Kheirkhah A, Amoli FA, Azari AA, Molaei S, Roozbahani M
Int Ophthalmol 2012 Feb;32(1):81-3. Epub 2012 Jan 24 doi: 10.1007/s10792-012-9514-8. PMID: 22271069
Diagnosis of rheumatic fever: current status of Jones Criteria and role of echocardiography.
Saxena A
Indian J Pediatr 2000 Mar;67(3 Suppl):S11-4. PMID: 11129913

Diagnosis

Nodules on the Knuckles.
Pippin M
Am Fam Physician 2020 Jan 1;101(1):47-48. PMID: 31894943
CHANGING CLINICAL PROFILE OF ACUTE RHEUMATIC FEVER AND RHEUMATIC RECURRENCE.
Sheikh AM, Sadiq M, Rehman AU
J Ayub Med Coll Abbottabad 2016 Jan-Mar;28(1):141-5. PMID: 27323580
What is that nodule? A diagnostic approach to evaluating subcutaneous and cutaneous nodules.
Evangelisto A, Werth V, Schumacher HR
J Clin Rheumatol 2006 Oct;12(5):230-40. doi: 10.1097/01.rhu.0000240034.72958.2f. PMID: 17023809
Diagnosis of rheumatic fever: current status of Jones Criteria and role of echocardiography.
Saxena A
Indian J Pediatr 2000 Mar;67(3 Suppl):S11-4. PMID: 11129913
Rheumatoid arthritis.
JAMA 1973 Apr 30;224(5 Suppl):687-70. PMID: 4573028

Therapy

Nodules on the Knuckles.
Pippin M
Am Fam Physician 2020 Jan 1;101(1):47-48. PMID: 31894943
A review of methotrexate-induced accelerated nodulosis.
Patatanian E, Thompson DF
Pharmacotherapy 2002 Sep;22(9):1157-62. doi: 10.1592/phco.22.13.1157.33525. PMID: 12222551
Laryngeal involvement in systemic lupus erythematosus.
Teitel AD, MacKenzie CR, Stern R, Paget SA
Semin Arthritis Rheum 1992 Dec;22(3):203-14. doi: 10.1016/0049-0172(92)90020-e. PMID: 1295093
Rheumatoid arthritis.
JAMA 1973 Apr 30;224(5 Suppl):687-70. PMID: 4573028
Rheumatic fever.
JAMA 1973 Apr 30;224(5 Suppl):736-9. PMID: 4550028

Prognosis

Conjunctival nodule in rheumatoid arthritis.
Kheirkhah A, Amoli FA, Azari AA, Molaei S, Roozbahani M
Int Ophthalmol 2012 Feb;32(1):81-3. Epub 2012 Jan 24 doi: 10.1007/s10792-012-9514-8. PMID: 22271069
Calcaneal osteomyelitis due to fistulization of an ulcerated rheumatoid nodule.
Alcaraz P, Aubran C, Jaoua S, Roudier C, Mattei JP, Announ N, Chagnaud C, Roudier J, Guis S
Joint Bone Spine 2006 Jan;73(1):102-4. doi: 10.1016/j.jbspin.2005.01.006. PMID: 16226476
NERDS syndrome: an additional case report.
Zenarola P, Melillo L, Bisceglia M, Carotenuto M, Lomuto M
Dermatology 1995;191(2):133-8. doi: 10.1159/000246531. PMID: 8520060
Laryngeal involvement in systemic lupus erythematosus.
Teitel AD, MacKenzie CR, Stern R, Paget SA
Semin Arthritis Rheum 1992 Dec;22(3):203-14. doi: 10.1016/0049-0172(92)90020-e. PMID: 1295093
HLA DR antigens in rheumatoid arthritis.
Gran JT, Husby G, Thorsby E
Scand J Rheumatol 1983;12(3):241-5. doi: 10.3109/03009748309098541. PMID: 6604939

Clinical prediction guides

Disease activity and subcutaneous nodules are associated to severe periodontitis in patients with rheumatoid arthritis.
González DA, Bianchi ML, Salgado PA, Armada M, Seni S, Isnardi CA, Citera G, Ferrary T, Orman B
Rheumatol Int 2022 Aug;42(8):1331-1339. Epub 2021 Aug 22 doi: 10.1007/s00296-021-04974-5. PMID: 34420067
Potential role of Anitschkow cells in cardiovascular disease in human and veterinary medicine: A review of the literature.
Colombino E, Biasato I, Biasibetti E, Sereno A, Chiappino L, Evangelista R, Cenacchi G, Guarda F, Capucchio MT
Anat Histol Embryol 2019 May;48(3):201-206. Epub 2019 Feb 17 doi: 10.1111/ahe.12433. PMID: 30772944
Low Prevalence of Nodules in Rheumatoid Arthritis Patients in Kuwait: A Description and a Comparison of Patients from the Kuwait Registry for Rheumatic Diseases.
Al-Herz A, Al-Awadhi A, Saleh K, Al-Kandari W, Hasan E, Ghanem A, Abutiban F, Alenizi A, Hussain M, Ali Y, Khadrawy A, Fazal A, Mokaddem K, Zaman A, Mazloum G, Aftab B, Haider N, Bartella Y, Hamed S, Al-Saber A
Med Princ Pract 2017;26(2):152-156. Epub 2016 Nov 23 doi: 10.1159/000454679. PMID: 27883999Free PMC Article
Laryngeal assessment in rheumatic disease patients.
Ramos HV, Pillon J, Kosugi EM, Fujita R, Pontes P
Braz J Otorhinolaryngol 2005 Jul-Aug;71(4):499-503. Epub 2005 Dec 15 doi: 10.1016/s1808-8694(15)31206-4. PMID: 16446967Free PMC Article
HLA DR antigens in rheumatoid arthritis.
Gran JT, Husby G, Thorsby E
Scand J Rheumatol 1983;12(3):241-5. doi: 10.3109/03009748309098541. PMID: 6604939

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