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Lyme neuroborreliosis

MedGen UID:
199846
•Concept ID:
C0752235
•
Disease or Syndrome
Synonyms: Borrelia burgdorferi Neuroborreliosis; Lyme Borreliosis, Nervous System; Lyme Disease, Nervous System; Lyme Neuroborreliosis; Nervous System Lyme Borreliosis; Nervous System Lyme Disease; Neuroborrelioses, Borrelia burgdorferi; Neuroborreliosis, Borrelia burgdorferi; Neuroborreliosis, Lyme
SNOMED CT: Infection of central nervous system caused by Borrelia burgdorferi (715507005); Infection of central nervous system caused by Borrelia burgdorferi sensu lato (1269516003); Lyme neuroborreliosis (1269516003)

Definition

Nervous system infections caused by tick-borne spirochetes of the BORRELIA BURGDORFERI GROUP. The disease may affect elements of the central or peripheral nervous system in isolation or in combination. Common clinical manifestations include a lymphocytic meningitis, cranial neuropathy (most often a facial neuropathy), POLYRADICULOPATHY, and a mild loss of memory and other cognitive functions. Less often more extensive inflammation involving the central nervous system (encephalomyelitis) may occur. In the peripheral nervous system, B. burgdorferi infection is associated with mononeuritis multiplex and polyradiculoneuritis. (From J Neurol Sci 1998 Jan 8;153(2):182-91) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLyme neuroborreliosis

Professional guidelines

PubMed

Guidelines for diagnosis and treatment in neurology - Lyme neuroborreliosis.
Rauer S, Kastenbauer S, Hofmann H, Fingerle V, Huppertz HI, Hunfeld KP, Krause A, Ruf B, Dersch R; Consensus group
Ger Med Sci 2020;18:Doc03. Epub 2020 Feb 27 doi: 10.3205/000279. PMID: 32341686Free PMC Article
Diagnosis and management of Lyme neuroborreliosis.
Halperin JJ
Expert Rev Anti Infect Ther 2018 Jan;16(1):5-11. Epub 2017 Dec 26 doi: 10.1080/14787210.2018.1417836. PMID: 29278020
EFNS guidelines on the diagnosis and management of European Lyme neuroborreliosis.
Mygland A, Ljøstad U, Fingerle V, Rupprecht T, Schmutzhard E, Steiner I; European Federation of Neurological Societies
Eur J Neurol 2010 Jan;17(1):8-16, e1-4. Epub 2009 Nov 23 doi: 10.1111/j.1468-1331.2009.02862.x. PMID: 19930447

Recent clinical studies

Etiology

Guidelines for diagnosis and treatment in neurology - Lyme neuroborreliosis.
Rauer S, Kastenbauer S, Hofmann H, Fingerle V, Huppertz HI, Hunfeld KP, Krause A, Ruf B, Dersch R; Consensus group
Ger Med Sci 2020;18:Doc03. Epub 2020 Feb 27 doi: 10.3205/000279. PMID: 32341686Free PMC Article
Clinical spectrum of Lyme disease.
Cardenas-de la Garza JA, De la Cruz-Valadez E, Ocampo-Candiani J, Welsh O
Eur J Clin Microbiol Infect Dis 2019 Feb;38(2):201-208. Epub 2018 Nov 19 doi: 10.1007/s10096-018-3417-1. PMID: 30456435
Lyme Neuroborreliosis.
Rauer S, Kastenbauer S, Fingerle V, Hunfeld KP, Huppertz HI, Dersch R
Dtsch Arztebl Int 2018 Nov 9;115(45):751-756. doi: 10.3238/arztebl.2018.0751. PMID: 30573008Free PMC Article
Lyme borreliosis.
Steere AC, Strle F, Wormser GP, Hu LT, Branda JA, Hovius JW, Li X, Mead PS
Nat Rev Dis Primers 2016 Dec 15;2:16090. doi: 10.1038/nrdp.2016.90. PMID: 27976670Free PMC Article
Neuroborreliosis.
Halperin JJ
Am J Med 1995 Apr 24;98(4A):52S-56S; discussion 56S-59S. doi: 10.1016/s0002-9343(99)80044-8. PMID: 7726192

Diagnosis

Neurologic Complications of Lyme Disease.
Roos KL
Continuum (Minneap Minn) 2021 Aug 1;27(4):1040-1050. doi: 10.1212/CON.0000000000001015. PMID: 34623103
Guidelines for diagnosis and treatment in neurology - Lyme neuroborreliosis.
Rauer S, Kastenbauer S, Hofmann H, Fingerle V, Huppertz HI, Hunfeld KP, Krause A, Ruf B, Dersch R; Consensus group
Ger Med Sci 2020;18:Doc03. Epub 2020 Feb 27 doi: 10.3205/000279. PMID: 32341686Free PMC Article
Lyme neuroborreliosis.
Halperin JJ
Curr Opin Infect Dis 2019 Jun;32(3):259-264. doi: 10.1097/QCO.0000000000000545. PMID: 30921086
Lyme neuroborreliosis.
Koedel U, Pfister HW
Curr Opin Infect Dis 2017 Feb;30(1):101-107. doi: 10.1097/QCO.0000000000000332. PMID: 27820708
Lyme borreliosis.
Steere AC, Strle F, Wormser GP, Hu LT, Branda JA, Hovius JW, Li X, Mead PS
Nat Rev Dis Primers 2016 Dec 15;2:16090. doi: 10.1038/nrdp.2016.90. PMID: 27976670Free PMC Article

Therapy

Neurologic Complications of Lyme Disease.
Roos KL
Continuum (Minneap Minn) 2021 Aug 1;27(4):1040-1050. doi: 10.1212/CON.0000000000001015. PMID: 34623103
Clinical spectrum of Lyme disease.
Cardenas-de la Garza JA, De la Cruz-Valadez E, Ocampo-Candiani J, Welsh O
Eur J Clin Microbiol Infect Dis 2019 Feb;38(2):201-208. Epub 2018 Nov 19 doi: 10.1007/s10096-018-3417-1. PMID: 30456435
Lyme neuroborreliosis.
Koedel U, Pfister HW
Curr Opin Infect Dis 2017 Feb;30(1):101-107. doi: 10.1097/QCO.0000000000000332. PMID: 27820708
Lyme borreliosis.
Steere AC, Strle F, Wormser GP, Hu LT, Branda JA, Hovius JW, Li X, Mead PS
Nat Rev Dis Primers 2016 Dec 15;2:16090. doi: 10.1038/nrdp.2016.90. PMID: 27976670Free PMC Article
Clinical management of infectious cerebral vasculitides.
Carod Artal FJ
Expert Rev Neurother 2016;16(2):205-21. Epub 2016 Jan 19 doi: 10.1586/14737175.2015.1134321. PMID: 26689107

Prognosis

Clinical spectrum of Lyme disease.
Cardenas-de la Garza JA, De la Cruz-Valadez E, Ocampo-Candiani J, Welsh O
Eur J Clin Microbiol Infect Dis 2019 Feb;38(2):201-208. Epub 2018 Nov 19 doi: 10.1007/s10096-018-3417-1. PMID: 30456435
Lyme Neuroborreliosis.
Rauer S, Kastenbauer S, Fingerle V, Hunfeld KP, Huppertz HI, Dersch R
Dtsch Arztebl Int 2018 Nov 9;115(45):751-756. doi: 10.3238/arztebl.2018.0751. PMID: 30573008Free PMC Article
Neuroborreliosis.
Halperin JJ
Neurol Clin 2018 Nov;36(4):821-830. doi: 10.1016/j.ncl.2018.06.006. PMID: 30366557
Lyme neuroborreliosis.
Koedel U, Pfister HW
Curr Opin Infect Dis 2017 Feb;30(1):101-107. doi: 10.1097/QCO.0000000000000332. PMID: 27820708
Lyme neuroborreliosis.
Haass A
Curr Opin Neurol 1998 Jun;11(3):253-8. doi: 10.1097/00019052-199806000-00011. PMID: 9642545

Clinical prediction guides

Doxycycline for the Treatment of Lyme Disease in Young Children.
Brown K, Corin S, Handel AS
Pediatr Infect Dis J 2023 Dec 1;42(12):e470-e472. Epub 2023 Oct 5 doi: 10.1097/INF.0000000000004128. PMID: 37820258
Neuroborreliosis.
Halperin JJ
Neurol Clin 2018 Nov;36(4):821-830. doi: 10.1016/j.ncl.2018.06.006. PMID: 30366557
Secondary dementia due to Lyme neuroborreliosis.
Kristoferitsch W, Aboulenein-Djamshidian F, Jecel J, Rauschka H, Rainer M, Stanek G, Fischer P
Wien Klin Wochenschr 2018 Aug;130(15-16):468-478. Epub 2018 Jul 25 doi: 10.1007/s00508-018-1361-9. PMID: 30046879Free PMC Article
Lyme neuroborreliosis and dementia.
Blanc F, Philippi N, Cretin B, Kleitz C, Berly L, Jung B, Kremer S, Namer IJ, Sellal F, Jaulhac B, de Seze J
J Alzheimers Dis 2014;41(4):1087-93. doi: 10.3233/JAD-130446. PMID: 24762944
Lyme neuroborreliosis.
Haass A
Curr Opin Neurol 1998 Jun;11(3):253-8. doi: 10.1097/00019052-199806000-00011. PMID: 9642545

Recent systematic reviews

Efficacy and safety of pharmacological treatments for Lyme neuroborreliosis: An updated systematic review.
Dersch R, Rauer S
Eur J Neurol 2023 Dec;30(12):3780-3788. Epub 2023 Sep 10 doi: 10.1111/ene.16034. PMID: 37565386
Lyme neuroborreliosis with encephalitis; a systematic literature review and a Scandinavian cohort study.
Knudtzen FC, Eikeland R, Bremell D, Quist-Paulsen E, Johansen IS, Solheim AM, Skarphédinsson S
Clin Microbiol Infect 2022 May;28(5):649-656. Epub 2021 Nov 10 doi: 10.1016/j.cmi.2021.11.001. PMID: 34768019
Neurosyphilis and Lyme neuroborreliosis.
Dersch R, Singh AE
Curr Opin Neurol 2021 Jun 1;34(3):403-409. doi: 10.1097/WCO.0000000000000923. PMID: 33709978
Lyme Neuroborreliosis.
Rauer S, Kastenbauer S, Fingerle V, Hunfeld KP, Huppertz HI, Dersch R
Dtsch Arztebl Int 2018 Nov 9;115(45):751-756. doi: 10.3238/arztebl.2018.0751. PMID: 30573008Free PMC Article
Prevalence and spectrum of residual symptoms in Lyme neuroborreliosis after pharmacological treatment: a systematic review.
Dersch R, Sommer H, Rauer S, Meerpohl JJ
J Neurol 2016 Jan;263(1):17-24. Epub 2015 Oct 12 doi: 10.1007/s00415-015-7923-0. PMID: 26459093

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