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Rheumatic heart disease

MedGen UID:
20565
Concept ID:
C0035439
Disease or Syndrome
Synonyms: Disease, Rheumatic Heart; Diseases, Rheumatic Heart; Heart Disease, Rheumatic; Heart Diseases, Rheumatic; Rheumatic Heart Disease; Rheumatic Heart Diseases
SNOMED CT: Rheumatic heart disease (23685000); Chronic rheumatic heart disease (23685000); Chronic rheumatic fever (23685000)
 
Monarch Initiative: MONDO:0006955

Definition

An autoinflammatory condition following an infection with Group A Beta Hemolytic Streptococcus (GABHS), in which the heart is attacked by antibodies formed in reaction to a recent GABHS infection. Chief anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords, all of which can result in valvular dysfunction. [from NCI]

Professional guidelines

PubMed

Bejjani A, Khairani CD, Assi A, Piazza G, Sadeghipour P, Talasaz AH, Fanikos J, Connors JM, Siegal DM, Barnes GD, Martin KA, Angiolillo DJ, Kleindorfer D, Monreal M, Jimenez D, Middeldorp S, Elkind MSV, Ruff CT, Goldhaber SZ, Krumholz HM, Mehran R, Cushman M, Eikelboom JW, Lip GYH, Weitz JI, Lopes RD, Bikdeli B
J Am Coll Cardiol 2024 Jan 23;83(3):444-465. doi: 10.1016/j.jacc.2023.10.038. PMID: 38233019
Ralph AP, Noonan S, Wade V, Currie BJ
Med J Aust 2021 Mar;214(5):220-227. Epub 2020 Nov 15 doi: 10.5694/mja2.50851. PMID: 33190309
Wunderlich NC, Dalvi B, Ho SY, Küx H, Siegel RJ
Curr Cardiol Rep 2019 Feb 28;21(3):14. doi: 10.1007/s11886-019-1099-7. PMID: 30815750

Recent clinical studies

Etiology

Dougherty S, Okello E, Mwangi J, Kumar RK
J Am Coll Cardiol 2023 Jan 3;81(1):81-94. doi: 10.1016/j.jacc.2022.09.050. PMID: 36599614
Arvind B, Ramakrishnan S
Indian J Pediatr 2020 Apr;87(4):305-311. Epub 2020 Jan 11 doi: 10.1007/s12098-019-03128-7. PMID: 31925717
Karthikeyan G, Guilherme L
Lancet 2018 Jul 14;392(10142):161-174. Epub 2018 Jun 29 doi: 10.1016/S0140-6736(18)30999-1. PMID: 30025809
Marijon E, Mirabel M, Celermajer DS, Jouven X
Lancet 2012 Mar 10;379(9819):953-964. doi: 10.1016/S0140-6736(11)61171-9. PMID: 22405798
Brown A, Kritharides L
Heart Lung Circ 2010 May-Jun;19(5-6):263. Epub 2010 Apr 2 doi: 10.1016/j.hlc.2010.02.012. PMID: 20363188

Diagnosis

Dougherty S, Okello E, Mwangi J, Kumar RK
J Am Coll Cardiol 2023 Jan 3;81(1):81-94. doi: 10.1016/j.jacc.2022.09.050. PMID: 36599614
Arvind B, Ramakrishnan S
Indian J Pediatr 2020 Apr;87(4):305-311. Epub 2020 Jan 11 doi: 10.1007/s12098-019-03128-7. PMID: 31925717
Leal MTBC, Passos LSA, Guarçoni FV, Aguiar JMS, Silva RBRD, Paula TMN, Santos RFD, Nassif MCL, Gomes NFA, Tan TC, Nunes MCP
Rev Soc Bras Med Trop 2019 Mar 14;52:e20180041. doi: 10.1590/0037-8682-0041-2019. PMID: 30892546
Marijon E, Mirabel M, Celermajer DS, Jouven X
Lancet 2012 Mar 10;379(9819):953-964. doi: 10.1016/S0140-6736(11)61171-9. PMID: 22405798
Brown A, Kritharides L
Heart Lung Circ 2010 May-Jun;19(5-6):263. Epub 2010 Apr 2 doi: 10.1016/j.hlc.2010.02.012. PMID: 20363188

Therapy

Bejjani A, Khairani CD, Assi A, Piazza G, Sadeghipour P, Talasaz AH, Fanikos J, Connors JM, Siegal DM, Barnes GD, Martin KA, Angiolillo DJ, Kleindorfer D, Monreal M, Jimenez D, Middeldorp S, Elkind MSV, Ruff CT, Goldhaber SZ, Krumholz HM, Mehran R, Cushman M, Eikelboom JW, Lip GYH, Weitz JI, Lopes RD, Bikdeli B
J Am Coll Cardiol 2024 Jan 23;83(3):444-465. doi: 10.1016/j.jacc.2023.10.038. PMID: 38233019
Dougherty S, Okello E, Mwangi J, Kumar RK
J Am Coll Cardiol 2023 Jan 3;81(1):81-94. doi: 10.1016/j.jacc.2022.09.050. PMID: 36599614
Connolly SJ, Karthikeyan G, Ntsekhe M, Haileamlak A, El Sayed A, El Ghamrawy A, Damasceno A, Avezum A, Dans AML, Gitura B, Hu D, Kamanzi ER, Maklady F, Fana G, Gonzalez-Hermosillo JA, Musuku J, Kazmi K, Zühlke L, Gondwe L, Ma C, Paniagua M, Ogah OS, Molefe-Baikai OJ, Lwabi P, Chillo P, Sharma SK, Cabral TTJ, Tarhuni WM, Benz A, van Eikels M, Krol A, Pattath D, Balasubramanian K, Rangarajan S, Ramasundarahettige C, Mayosi B, Yusuf S; INVICTUS Investigators
N Engl J Med 2022 Sep 15;387(11):978-988. Epub 2022 Aug 28 doi: 10.1056/NEJMoa2209051. PMID: 36036525
Karthikeyan G, Guilherme L
Lancet 2018 Jul 14;392(10142):161-174. Epub 2018 Jun 29 doi: 10.1016/S0140-6736(18)30999-1. PMID: 30025809
Lancet 1967 Jul 1;2(7505):29. PMID: 4165444

Prognosis

Sun J, Qiao Y, Zhao M, Magnussen CG, Xi B
BMC Med 2023 Jun 26;21(1):222. doi: 10.1186/s12916-023-02925-4. PMID: 37365627Free PMC Article
Lahiri S, Sanyahumbi A
Pediatr Rev 2021 May;42(5):221-232. doi: 10.1542/pir.2019-0288. PMID: 33931507
Karthikeyan G
Heart 2021 May;107(9):694-696. Epub 2021 Jan 18 doi: 10.1136/heartjnl-2020-318756. PMID: 33462122
Branco CEB, Sampaio RO, Tarasoutchi F, Zachariah JP
Congenit Heart Dis 2018 Nov;13(6):1069-1071. Epub 2018 Oct 2 doi: 10.1111/chd.12676. PMID: 30280492
Watkins DA, Johnson CO, Colquhoun SM, Karthikeyan G, Beaton A, Bukhman G, Forouzanfar MH, Longenecker CT, Mayosi BM, Mensah GA, Nascimento BR, Ribeiro ALP, Sable CA, Steer AC, Naghavi M, Mokdad AH, Murray CJL, Vos T, Carapetis JR, Roth GA
N Engl J Med 2017 Aug 24;377(8):713-722. doi: 10.1056/NEJMoa1603693. PMID: 28834488

Clinical prediction guides

Ruan R, Liu X, Zhang Y, Tang M, He B, Zhang QW, Shu T
J Am Heart Assoc 2023 Jul 4;12(13):e028921. Epub 2023 Jun 27 doi: 10.1161/JAHA.122.028921. PMID: 37366108Free PMC Article
Watkins DA, Johnson CO, Colquhoun SM, Karthikeyan G, Beaton A, Bukhman G, Forouzanfar MH, Longenecker CT, Mayosi BM, Mensah GA, Nascimento BR, Ribeiro ALP, Sable CA, Steer AC, Naghavi M, Mokdad AH, Murray CJL, Vos T, Carapetis JR, Roth GA
N Engl J Med 2017 Aug 24;377(8):713-722. doi: 10.1056/NEJMoa1603693. PMID: 28834488
Krapf L, Dreyfus J, Cueff C, Lepage L, Brochet E, Vahanian A, Messika-Zeitoun D
Arch Cardiovasc Dis 2013 Feb;106(2):111-5. Epub 2013 Jan 23 doi: 10.1016/j.acvd.2012.11.004. PMID: 23527915
Que YA, Moreillon P
Nat Rev Cardiol 2011 Jun;8(6):322-36. Epub 2011 Apr 12 doi: 10.1038/nrcardio.2011.43. PMID: 21487430
Ansari A, Rigolin VH
Curr Cardiol Rep 2010 May;12(3):265-71. doi: 10.1007/s11886-010-0107-8. PMID: 20424971

Recent systematic reviews

Lamichhane P, Pokhrel KM, Pokharel P, Bhandari B, Lamichhane P, Regmi PR
Int J Cardiol 2022 Jul 1;358:110-119. Epub 2022 Apr 11 doi: 10.1016/j.ijcard.2022.04.010. PMID: 35504739
Liaw J, Walker B, Hall L, Gorton S, White AV, Heal C
PLoS One 2021;16(6):e0253581. Epub 2021 Jun 29 doi: 10.1371/journal.pone.0253581. PMID: 34185797Free PMC Article
Paige E, O'Donoghue Jenkins L, Agostino J, Pennings S, Wade V, Lovett R, Daluwatta A, McLoughlin K, Banks E
Public Health Res Pract 2020 Jun 30;30(2) doi: 10.17061/phrp29231910. PMID: 32601657
Russell EA, Walsh WF, Costello B, McLellan AJA, Brown A, Reid CM, Tran L, Maguire GP
Cardiol Rev 2018 Jul/Aug;26(4):187-195. doi: 10.1097/CRD.0000000000000185. PMID: 29608495
Galobardes B, Lynch JW, Davey Smith G
Epidemiol Rev 2004;26:7-21. doi: 10.1093/epirev/mxh008. PMID: 15234944

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