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Hereditary kidney oncocytoma

MedGen UID:
209307
•Concept ID:
C0879606
•
Neoplastic Process
Synonyms: Familial Renal Oncocytoma; familial renal oncocytoma; Hereditary Kidney Oncocytoma; hereditary kidney oncocytoma; Hereditary Renal Oncocytoma; hereditary renal oncocytoma
 
Monarch Initiative: MONDO:0003824

Definition

An inherited condition characterized by the development of kidney oncocytomas which are often bilateral and multifocal. This condition may be connected to Birt-Hogg-Dube syndrome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHereditary kidney oncocytoma

Professional guidelines

PubMed

Assessment of Risk of Hereditary Predisposition in Patients With Melanoma and/or Mesothelioma and Renal Neoplasia.
Gupta S, Erickson LA, Lohse CM, Shen W, Pitel BA, Knight SM, Halling KC, Herrera-Hernandez L, Boorjian SA, Thompson RH, Leibovich BC, Jimenez RE, Cheville JC
JAMA Netw Open 2021 Nov 1;4(11):e2132615. doi: 10.1001/jamanetworkopen.2021.32615. PMID: 34767027Free PMC Article
New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia.
Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427

Recent clinical studies

Etiology

The 2022 revision of the World Health Organization classification of tumors of the urinary system and male genital organs: advances and challenges.
Mohanty SK, Lobo A, Cheng L
Hum Pathol 2023 Jun;136:123-143. Epub 2022 Sep 6 doi: 10.1016/j.humpath.2022.08.006. PMID: 36084769
Do we need an updated classification of oncocytic renal tumors? : Emergence of low-grade oncocytic tumor (LOT) and eosinophilic vacuolated tumor (EVT) as novel renal entities.
Hes O, Trpkov K
Mod Pathol 2022 Sep;35(9):1140-1150. Epub 2022 Mar 10 doi: 10.1038/s41379-022-01057-z. PMID: 35273336
Assessment of Risk of Hereditary Predisposition in Patients With Melanoma and/or Mesothelioma and Renal Neoplasia.
Gupta S, Erickson LA, Lohse CM, Shen W, Pitel BA, Knight SM, Halling KC, Herrera-Hernandez L, Boorjian SA, Thompson RH, Leibovich BC, Jimenez RE, Cheville JC
JAMA Netw Open 2021 Nov 1;4(11):e2132615. doi: 10.1001/jamanetworkopen.2021.32615. PMID: 34767027Free PMC Article
Origin of renal cell carcinomas.
Valladares Ayerbes M, Aparicio Gallego G, Díaz Prado S, Jiménez Fonseca P, García Campelo R, Antón Aparicio LM
Clin Transl Oncol 2008 Nov;10(11):697-712. doi: 10.1007/s12094-008-0276-8. PMID: 19015066
Localized renal cell carcinoma.
Russo P
Curr Treat Options Oncol 2001 Oct;2(5):447-55. doi: 10.1007/s11864-001-0050-4. PMID: 12057108

Diagnosis

Do we need an updated classification of oncocytic renal tumors? : Emergence of low-grade oncocytic tumor (LOT) and eosinophilic vacuolated tumor (EVT) as novel renal entities.
Hes O, Trpkov K
Mod Pathol 2022 Sep;35(9):1140-1150. Epub 2022 Mar 10 doi: 10.1038/s41379-022-01057-z. PMID: 35273336
New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia.
Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
Oncocytic renal neoplasms: diagnostic considerations.
Abrahams NA, Tamboli P
Clin Lab Med 2005 Jun;25(2):317-39, vi. doi: 10.1016/j.cll.2005.01.006. PMID: 15848739
Imaging of hereditary renal cancer.
Choyke PL
Radiol Clin North Am 2003 Sep;41(5):1037-51. doi: 10.1016/s0033-8389(03)00068-x. PMID: 14521208
Hereditary renal cancers.
Choyke PL, Glenn GM, Walther MM, Zbar B, Linehan WM
Radiology 2003 Jan;226(1):33-46. doi: 10.1148/radiol.2261011296. PMID: 12511666

Therapy

Birt-Hogg-Dubé syndrome: Clinical and molecular aspects of recently identified kidney cancer syndrome.
Hasumi H, Baba M, Hasumi Y, Furuya M, Yao M
Int J Urol 2016 Mar;23(3):204-10. Epub 2015 Nov 25 doi: 10.1111/iju.13015. PMID: 26608100

Prognosis

New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia.
Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
Use of (99m)Tc-sestamibi Single-photon Emission Computed Tomography / X-ray Computed Tomography in the Diagnosis of Hybrid Oncocytic / Chromophobe Tumor in a Pediatric Patient.
Almassi N, Gorin MA, Purysko AS, Rowe SP, Kaouk J, Allaf ME, Campbell SC, Rhee A
Urology 2018 Mar;113:206-208. Epub 2017 Nov 23 doi: 10.1016/j.urology.2017.11.015. PMID: 29174943
Genetic alterations and histopathologic findings in familial renal cell carcinoma.
Hansel DE
Histol Histopathol 2006 Apr;21(4):437-44. doi: 10.14670/HH-21.437. PMID: 16437389
The genetic basis of cancer of the kidney.
Linehan WM, Walther MM, Zbar B
J Urol 2003 Dec;170(6 Pt 1):2163-72. doi: 10.1097/01.ju.0000096060.92397.ed. PMID: 14634372
Localized renal cell carcinoma.
Russo P
Curr Treat Options Oncol 2001 Oct;2(5):447-55. doi: 10.1007/s11864-001-0050-4. PMID: 12057108

Clinical prediction guides

Immunoexpression of SDHB, FH, and CK20 among eosinophilic renal tumors: A tissue microarray study.
Karatay H, Ozluk Y, Dogan MA, Erdem S, Kilicaslan I
Ann Diagn Pathol 2021 Oct;54:151788. Epub 2021 Jul 2 doi: 10.1016/j.anndiagpath.2021.151788. PMID: 34246177
(18)Fluorodeoxyglucose-positron emission tomography/computed tomography for differentiation of renal tumors in hereditary kidney cancer syndromes.
Nikpanah M, Paschall AK, Ahlman MA, Civelek AC, Farhadi F, Mirmomen SM, Li X, Saboury B, Ball MW, Merino MJ, Srinivasan R, Jones EC, Linehan WM, Malayeri AA
Abdom Radiol (NY) 2021 Jul;46(7):3301-3308. Epub 2021 Mar 10 doi: 10.1007/s00261-021-02999-9. PMID: 33688985Free PMC Article
New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia.
Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
Origin of renal cell carcinomas.
Valladares Ayerbes M, Aparicio Gallego G, Díaz Prado S, Jiménez Fonseca P, García Campelo R, Antón Aparicio LM
Clin Transl Oncol 2008 Nov;10(11):697-712. doi: 10.1007/s12094-008-0276-8. PMID: 19015066
MET expression in sporadic renal cell carcinomas.
Choi JS, Kim MK, Seo JW, Choi YL, Kim DH, Chun YK, Ko YH
J Korean Med Sci 2006 Aug;21(4):672-7. doi: 10.3346/jkms.2006.21.4.672. PMID: 16891811Free PMC Article

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