U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Non-gestational choriocarcinoma

MedGen UID:
211656
•Concept ID:
C1135873
•
Neoplastic Process
Synonyms: Choriocarcinoma, Non gestational; Choriocarcinoma, Non-gestational; Choriocarcinomas, Non-gestational; Non gestational Choriocarcinoma; Non-gestational Choriocarcinoma; Non-gestational Choriocarcinomas
 
Monarch Initiative: MONDO:0006871

Definition

A highly malignant choriocarcinoma derived from the non-placental origin such as the totipotent cells in the testis, the ovary, and the pineal gland. It produces high levels of chorionic gonadotropin and can metastasize widely through the bloodstream to the lungs, brain, liver, bone, and other viscera by the time of diagnosis. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-gestational choriocarcinoma

Professional guidelines

PubMed

Pulse actinomycin D as first-line treatment of low-risk post-molar non-choriocarcinoma gestational trophoblastic neoplasia.
Li L, Wan X, Feng F, Ren T, Yang J, Zhao J, Jiang F, Xiang Y
BMC Cancer 2018 May 23;18(1):585. doi: 10.1186/s12885-018-4512-5. PMID: 29792175Free PMC Article

Recent clinical studies

Etiology

Non-gestational choriocarcinoma: unraveling the similarities and distinctions from its gestational counterpart.
Mangla M, Palo S, Kanikaram P, Kaur H
Int J Gynecol Cancer 2024 Jun 3;34(6):926-934. doi: 10.1136/ijgc-2023-004906. PMID: 38123189
Identification of Glypican-3 (GPC3) Expression in a Lethal Subgroup of Refractory Cisplatin-Resistant Testicular Germ-Cell Tumors.
Chahoud J, Zhang M, Pisters LL, Lin SC, Lin SH, Tu SM
Clin Genitourin Cancer 2018 Oct;16(5):325-327. Epub 2018 May 26 doi: 10.1016/j.clgc.2018.05.004. PMID: 29807831
Choriocarcinoma in Women: Analysis of a Case Series With Genotyping.
Savage J, Adams E, Veras E, Murphy KM, Ronnett BM
Am J Surg Pathol 2017 Dec;41(12):1593-1606. doi: 10.1097/PAS.0000000000000937. PMID: 28877059
Genomic profile in gestational and non-gestational choriocarcinomas.
Mello JB, Ramos Cirilo PD, Michelin OC, Custódio Domingues MA, Cunha Rudge MV, Rogatto SR, Maestá I
Placenta 2017 Feb;50:8-15. Epub 2016 Dec 7 doi: 10.1016/j.placenta.2016.12.009. PMID: 28161066
Primary intracranial choriocarcinoma: MR imaging findings.
Lv XF, Qiu YW, Zhang XL, Han LJ, Qiu SJ, Xiong W, Wen G, Zhang YZ, Zhang J
AJNR Am J Neuroradiol 2010 Nov;31(10):1994-8. Epub 2010 Jul 8 doi: 10.3174/ajnr.A2194. PMID: 20616180Free PMC Article

Diagnosis

Non-gestational choriocarcinoma: unraveling the similarities and distinctions from its gestational counterpart.
Mangla M, Palo S, Kanikaram P, Kaur H
Int J Gynecol Cancer 2024 Jun 3;34(6):926-934. doi: 10.1136/ijgc-2023-004906. PMID: 38123189
Establishment and characterization of a non-gestational choriocarcinoma patient-derived xenograft model.
Oda Y, Niimi K, Yoshida K, Tamauchi S, Yokoi A, Yasui Y, Nishiko Y, Shibata M, Shimizu Y, Yoshihara M, Ikeda Y, Yoshikawa N, Nishino K, Yamamoto E, Kajiyama H
BMC Cancer 2023 Nov 13;23(1):1103. doi: 10.1186/s12885-023-11626-3. PMID: 37957624Free PMC Article
Primary Choriocarcinoma of the Bladder: A Case Report and Review of Literature.
Monn MF, Jaqua KR, Bihrle R, Cheng L
Clin Genitourin Cancer 2017 Apr;15(2):188-191. Epub 2016 Sep 7 doi: 10.1016/j.clgc.2016.08.027. PMID: 27793609
Primary pulmonary choriocarcinoma: a diagnostic dilemma.
Perwaiz M, Boujaoude Z, Ranasuriya G, Raja H, Gaspard D, Abouzgheib W
J Bronchology Interv Pulmonol 2015 Apr;22(2):183-5. doi: 10.1097/LBR.0000000000000144. PMID: 25887023
Pure nongestational choriocarcinoma of ovary.
Corakçi A, Ozeren S, Ozkan S, Gürbüz Y, Ustün H, Yücesoy I
Arch Gynecol Obstet 2005 Feb;271(2):176-7. Epub 2004 Feb 28 doi: 10.1007/s00404-004-0604-3. PMID: 14991382

Therapy

A 20-Year-Old-Man With New Onset of Melena.
Yang XY, Bégin LR, Tamaz R
Gastroenterology 2022 Jan;162(1):e14-e15. Epub 2021 Jun 17 doi: 10.1053/j.gastro.2021.05.065. PMID: 34146570
A Young Female With Metastatic Nongestational Choriocarcinoma.
Yadav BS, Rai B, Suri V, Mukherjee KK, Bal A, Morgan R, Shonka NA, Lele S, Morris GJ
Semin Oncol 2015 Dec;42(6):e109-15. Epub 2015 Sep 24 doi: 10.1053/j.seminoncol.2015.09.021. PMID: 26615138
Isolated bilateral adrenal choriocarcinoma.
Trastour C, Rahili A, Chevallier A, Bernard JL, Bongain A, Sadoul JL, Thyss A
Lancet Oncol 2005 Nov;6(11):905-7. doi: 10.1016/S1470-2045(05)70426-5. PMID: 16257799
Concurrent ovarian-type primary peritoneal adenocarcinoma and peritoneal choriocarcinoma. A case report and review of the literature.
Pentheroudakis G, White J, Davis J, Brown I, Vasey P
Gynecol Oncol 2004 Feb;92(2):697-700. doi: 10.1016/j.ygyno.2003.10.049. PMID: 14766269
Infantile choriocarcinoma treated with chemotherapy alone.
Johnson EJ, Crofton PM, O'Neill JM, Wilkinson AG, McKenzie KJ, Munro FD, Myles L, Seckl MJ, Wallace WH
Med Pediatr Oncol 2003 Dec;41(6):550-7. doi: 10.1002/mpo.10411. PMID: 14595713

Prognosis

Non-gestational choriocarcinoma: unraveling the similarities and distinctions from its gestational counterpart.
Mangla M, Palo S, Kanikaram P, Kaur H
Int J Gynecol Cancer 2024 Jun 3;34(6):926-934. doi: 10.1136/ijgc-2023-004906. PMID: 38123189
Establishment and characterization of a non-gestational choriocarcinoma patient-derived xenograft model.
Oda Y, Niimi K, Yoshida K, Tamauchi S, Yokoi A, Yasui Y, Nishiko Y, Shibata M, Shimizu Y, Yoshihara M, Ikeda Y, Yoshikawa N, Nishino K, Yamamoto E, Kajiyama H
BMC Cancer 2023 Nov 13;23(1):1103. doi: 10.1186/s12885-023-11626-3. PMID: 37957624Free PMC Article
65-Year-Old with Acute Cerebral Hemorrhage.
Gopal M, Gupta K, Preet Singh A, Salunke P
Brain Pathol 2020 Mar;30(2):429-430. doi: 10.1111/bpa.12825. PMID: 32100435Free PMC Article
Genomic profile in gestational and non-gestational choriocarcinomas.
Mello JB, Ramos Cirilo PD, Michelin OC, Custódio Domingues MA, Cunha Rudge MV, Rogatto SR, Maestá I
Placenta 2017 Feb;50:8-15. Epub 2016 Dec 7 doi: 10.1016/j.placenta.2016.12.009. PMID: 28161066
Concurrent ovarian-type primary peritoneal adenocarcinoma and peritoneal choriocarcinoma. A case report and review of the literature.
Pentheroudakis G, White J, Davis J, Brown I, Vasey P
Gynecol Oncol 2004 Feb;92(2):697-700. doi: 10.1016/j.ygyno.2003.10.049. PMID: 14766269

Clinical prediction guides

Establishment and characterization of a non-gestational choriocarcinoma patient-derived xenograft model.
Oda Y, Niimi K, Yoshida K, Tamauchi S, Yokoi A, Yasui Y, Nishiko Y, Shibata M, Shimizu Y, Yoshihara M, Ikeda Y, Yoshikawa N, Nishino K, Yamamoto E, Kajiyama H
BMC Cancer 2023 Nov 13;23(1):1103. doi: 10.1186/s12885-023-11626-3. PMID: 37957624Free PMC Article
A rare case of gestational ovarian choriocarcinoma coexistent with intrauterine pregnancy.
Sakurai S, Asano R, Furugori M, Shigeta H
Taiwan J Obstet Gynecol 2022 Jul;61(4):708-712. doi: 10.1016/j.tjog.2021.09.036. PMID: 35779927
Clinical Experience of Male Primary Choriocarcinoma at the Samsung Medical Center.
Ji YS, Park SH
Cancer Res Treat 2021 Jul;53(3):874-880. Epub 2020 Dec 7 doi: 10.4143/crt.2020.1066. PMID: 33285049Free PMC Article
Genomic profile in gestational and non-gestational choriocarcinomas.
Mello JB, Ramos Cirilo PD, Michelin OC, Custódio Domingues MA, Cunha Rudge MV, Rogatto SR, Maestá I
Placenta 2017 Feb;50:8-15. Epub 2016 Dec 7 doi: 10.1016/j.placenta.2016.12.009. PMID: 28161066
Pure nongestational uterine choriocarcinoma in a postmenopausal Chinese woman confirmed with short tandem repeat analysis.
Wang Y, Yang Y, Teng F, Zhang H, Xue F
Am J Obstet Gynecol 2014 Jul;211(1):e1-3. Epub 2014 Apr 13 doi: 10.1016/j.ajog.2014.04.013. PMID: 24732004

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...