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Recurrent respiratory papillomatosis(RRP)

MedGen UID:
216998
•Concept ID:
C1168198
•
Neoplastic Process
Synonyms: Adult-onset recurrent respiratory papillomatosis (type); AORRP (type); JORRP (type); Juvenile laryngeal papilloma; Juvenile-onset recurrent respiratory papillomatosis (type); Laryngeal papilloma, recurrent; RRP
SNOMED CT: Recurrent respiratory papillomatosis (472827002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018955
Orphanet: ORPHA60032

Definition

Recurrent respiratory papillomatosis is a rare respiratory disease characterized by the development of exophytic papillomas, affecting the mucosa of the upper aero-digestive tract (with a strong predilection for the larynx), caused by an infection with human papilloma virus. Symptoms at presentation may include hoarseness, chronic cough, dyspnea, recurrent upper respiratory tract infections, pneumonia, dysphagia, stridor, and/or failure to thrive. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent respiratory papillomatosis
Follow this link to review classifications for Recurrent respiratory papillomatosis in Orphanet.

Professional guidelines

PubMed

Biologics for the Treatment of Recurrent Respiratory Papillomatosis.
Allen CT
Otolaryngol Clin North Am 2021 Aug;54(4):769-777. Epub 2021 Jun 5 doi: 10.1016/j.otc.2021.05.002. PMID: 34099306Free PMC Article
Diagnosis and management of recurrent respiratory papillomatosis.
Wilcox LJ, Hull BP, Baldassari CM, Derkay CS
Pediatr Infect Dis J 2014 Dec;33(12):1283-4. doi: 10.1097/INF.0000000000000551. PMID: 25229272
Surgical treatment and adjuvant therapies of recurrent respiratory papillomatosis.
Avelino MA, Zaiden TC, Gomes RO
Braz J Otorhinolaryngol 2013 Sep-Oct;79(5):636-42. doi: 10.5935/1808-8694.20130114. PMID: 24141682Free PMC Article

Recent clinical studies

Etiology

HPV-related diseases in male patients: an underestimated conundrum.
Garolla A, Graziani A, Grande G, Ortolani C, Ferlin A
J Endocrinol Invest 2024 Feb;47(2):261-274. Epub 2023 Sep 28 doi: 10.1007/s40618-023-02192-3. PMID: 37770654Free PMC Article
Recurrent laryngeal papillomatosis: multimodal therapeutic strategies. Literature review and multicentre retrospective study.
Bertino G, Pedretti F, Mauramati S, Filauro M, Vallin A, Mora F, Crosetti E, Succo G, Peretti G, Benazzo M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl. 1):S111-S122. doi: 10.14639/0392-100X-suppl.1-43-2023-14. PMID: 37698108Free PMC Article
The role of human papilloma virus test in men: First exhaustive review of literature.
Vives A, Cosentino M, Palou J
Actas Urol Esp (Engl Ed) 2020 Mar;44(2):86-93. Epub 2019 Dec 23 doi: 10.1016/j.acuro.2019.08.010. PMID: 31874781
Epidemiology and burden of HPV-related disease.
Serrano B, Brotons M, Bosch FX, Bruni L
Best Pract Res Clin Obstet Gynaecol 2018 Feb;47:14-26. Epub 2017 Sep 2 doi: 10.1016/j.bpobgyn.2017.08.006. PMID: 29037457
Juvenile-onset recurrent respiratory papillomatosis.
Maturo SC, Hartnick CJ
Adv Otorhinolaryngol 2012;73:105-8. Epub 2012 Mar 29 doi: 10.1159/000334457. PMID: 22472239

Diagnosis

Recurrent Respiratory Papillomatosis.
Frazier AA
Radiographics 2018 Nov-Dec;38(7):2150. doi: 10.1148/rg.2018184010. PMID: 30422770
Recurrent respiratory papillomatosis: A state-of-the-art review.
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Recurrent respiratory papillomatosis.
Venkatesan NN, Pine HS, Underbrink MP
Otolaryngol Clin North Am 2012 Jun;45(3):671-94, viii-ix. doi: 10.1016/j.otc.2012.03.006. PMID: 22588043Free PMC Article
Recurrent respiratory papillomatosis.
Shykhon M, Kuo M, Pearman K
Clin Otolaryngol Allied Sci 2002 Aug;27(4):237-43. doi: 10.1046/j.1365-2273.2002.00555.x. PMID: 12169123
Recurrent respiratory papillomatosis.
Lancet 1988 Dec 17;2(8625):1406. PMID: 2904531

Therapy

HPV-related diseases in male patients: an underestimated conundrum.
Garolla A, Graziani A, Grande G, Ortolani C, Ferlin A
J Endocrinol Invest 2024 Feb;47(2):261-274. Epub 2023 Sep 28 doi: 10.1007/s40618-023-02192-3. PMID: 37770654Free PMC Article
The Efficacy of Human Papillomavirus Vaccination as an Adjuvant Therapy in Recurrent Respiratory Papillomatosis.
Ponduri A, Azmy MC, Axler E, Lin J, Schwartz R, Chirilă M, Dikkers FG, Yang CJ, Mehta V, Gangar M
Laryngoscope 2023 Sep;133(9):2046-2054. Epub 2023 Jan 18 doi: 10.1002/lary.30560. PMID: 36651338Free PMC Article
Update on Recurrent Respiratory Papillomatosis.
Derkay CS, Bluher AE
Otolaryngol Clin North Am 2019 Aug;52(4):669-679. Epub 2019 May 8 doi: 10.1016/j.otc.2019.03.011. PMID: 31078306
Recurrent respiratory papillomatosis.
Venkatesan NN, Pine HS, Underbrink MP
Otolaryngol Clin North Am 2012 Jun;45(3):671-94, viii-ix. doi: 10.1016/j.otc.2012.03.006. PMID: 22588043Free PMC Article
Recurrent respiratory papillomatosis.
Lancet 1988 Dec 17;2(8625):1406. PMID: 2904531

Prognosis

Recurrent laryngeal papillomatosis: multimodal therapeutic strategies. Literature review and multicentre retrospective study.
Bertino G, Pedretti F, Mauramati S, Filauro M, Vallin A, Mora F, Crosetti E, Succo G, Peretti G, Benazzo M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl. 1):S111-S122. doi: 10.14639/0392-100X-suppl.1-43-2023-14. PMID: 37698108Free PMC Article
Epidemiology and burden of HPV-related disease.
Serrano B, Brotons M, Bosch FX, Bruni L
Best Pract Res Clin Obstet Gynaecol 2018 Feb;47:14-26. Epub 2017 Sep 2 doi: 10.1016/j.bpobgyn.2017.08.006. PMID: 29037457
Recurrent respiratory papillomatosis: A state-of-the-art review.
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Recurrent respiratory papillomatosis.
Venkatesan NN, Pine HS, Underbrink MP
Otolaryngol Clin North Am 2012 Jun;45(3):671-94, viii-ix. doi: 10.1016/j.otc.2012.03.006. PMID: 22588043Free PMC Article
Juvenile-onset recurrent respiratory papillomatosis.
Maturo SC, Hartnick CJ
Adv Otorhinolaryngol 2012;73:105-8. Epub 2012 Mar 29 doi: 10.1159/000334457. PMID: 22472239

Clinical prediction guides

HPV-related diseases in male patients: an underestimated conundrum.
Garolla A, Graziani A, Grande G, Ortolani C, Ferlin A
J Endocrinol Invest 2024 Feb;47(2):261-274. Epub 2023 Sep 28 doi: 10.1007/s40618-023-02192-3. PMID: 37770654Free PMC Article
The tumor microenvironment state associates with response to HPV therapeutic vaccination in patients with respiratory papillomatosis.
Norberg SM, Bai K, Sievers C, Robbins Y, Friedman J, Yang X, Kenyon M, Ward E, Schlom J, Gulley J, Lankford A, Semnani R, Sabzevari H, Brough DE, Allen CT
Sci Transl Med 2023 Oct 25;15(719):eadj0740. doi: 10.1126/scitranslmed.adj0740. PMID: 37878675Free PMC Article
Recurrent laryngeal papillomatosis: multimodal therapeutic strategies. Literature review and multicentre retrospective study.
Bertino G, Pedretti F, Mauramati S, Filauro M, Vallin A, Mora F, Crosetti E, Succo G, Peretti G, Benazzo M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl. 1):S111-S122. doi: 10.14639/0392-100X-suppl.1-43-2023-14. PMID: 37698108Free PMC Article
Recurrent respiratory papillomatosis: clinical characteristics and viral genotyping in a Brazilian population.
Carvalho AMAS, Brito DS, Cunha APA, Monteiro PM, Ferreira MB, Assis DSFR, Bentivi JO, Andrade MS, Vidal FCB, Salgado Filho N
Rev Inst Med Trop Sao Paulo 2021;63:e63. Epub 2021 Aug 16 doi: 10.1590/S1678-9946202163063. PMID: 34406288Free PMC Article
A Systematic Review.
Drejet S, Halum S, Brigger M, Skopelja E, Parker NP
Otolaryngol Head Neck Surg 2017 Mar;156(3):435-441. Epub 2017 Jan 10 doi: 10.1177/0194599816683384. PMID: 28072562

Recent systematic reviews

Systemic Bevacizumab (Avastin) for Juvenile-Onset Recurrent Respiratory Papillomatosis: A Systematic Review.
Ryan MA, Leu GR, Upchurch PA, Tunkel DE, Walsh JM, Boss EF
Laryngoscope 2021 May;131(5):1138-1146. Epub 2020 Sep 22 doi: 10.1002/lary.29084. PMID: 32959914
Recurrent Respiratory Papillomatosis Office versus Operating Room: Systematic Review and Meta-Analysis.
Chen S, Connors J, Zhang Y, Wang B, Vieira D, Shapira-Galitz Y, Garber D, Amin MR
Ann Otol Rhinol Laryngol 2021 Mar;130(3):234-244. Epub 2020 Aug 12 doi: 10.1177/0003489420949586. PMID: 32781827
A Systematic Review.
Drejet S, Halum S, Brigger M, Skopelja E, Parker NP
Otolaryngol Head Neck Surg 2017 Mar;156(3):435-441. Epub 2017 Jan 10 doi: 10.1177/0194599816683384. PMID: 28072562
The association between gastroesophageal reflux disease and recurrent respiratory papillomatosis: A systematic review.
San Giorgi MR, Helder HM, Lindeman RJ, de Bock GH, Dikkers FG
Laryngoscope 2016 Oct;126(10):2330-9. Epub 2016 Apr 26 doi: 10.1002/lary.25898. PMID: 27113025
Photodynamic therapy for recurrent respiratory papillomatosis.
Lieder A, Khan MK, Lippert BM
Cochrane Database Syst Rev 2014 Jun 5;2014(6):CD009810. doi: 10.1002/14651858.CD009810.pub2. PMID: 24898010Free PMC Article

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