U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Miliary tuberculosis

MedGen UID:
21726
Concept ID:
C0041321
Disease or Syndrome
Synonyms: Miliary Tuberculoses; Miliary Tuberculosis; Tuberculoses, Miliary; Tuberculosis, Miliary
SNOMED CT: MTB - Miliary tuberculosis (47604008); Miliary tuberculosis (47604008)
 
Monarch Initiative: MONDO:0005848

Definition

Clinical disease resulting from hematogenous dissemination of Mycobacterium tuberculosis bacilli. Originally described by the appearance of millet seed-like granulomas in the lungs, its progression from sustained bacteremia to extrapulmonary involvement is suggestive of a poor prognosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMiliary tuberculosis

Professional guidelines

PubMed

Garg RK, Rizvi I, Malhotra HS, Uniyal R, Kumar N
Expert Rev Anti Infect Ther 2018 Nov;16(11):813-831. doi: 10.1080/14787210.2018.1540930. PMID: 30359140
Nachiappan AC, Rahbar K, Shi X, Guy ES, Mortani Barbosa EJ Jr, Shroff GS, Ocazionez D, Schlesinger AE, Katz SI, Hammer MM
Radiographics 2017 Jan-Feb;37(1):52-72. doi: 10.1148/rg.2017160032. PMID: 28076011
Barbagallo J, Tager P, Ingleton R, Hirsch RJ, Weinberg JM
Am J Clin Dermatol 2002;3(5):319-28. doi: 10.2165/00128071-200203050-00004. PMID: 12069638

Recent clinical studies

Etiology

Nachiappan AC, Rahbar K, Shi X, Guy ES, Mortani Barbosa EJ Jr, Shroff GS, Ocazionez D, Schlesinger AE, Katz SI, Hammer MM
Radiographics 2017 Jan-Feb;37(1):52-72. doi: 10.1148/rg.2017160032. PMID: 28076011
Pérez-Jacoiste Asín MA, Fernández-Ruiz M, López-Medrano F, Lumbreras C, Tejido Á, San Juan R, Arrebola-Pajares A, Lizasoain M, Prieto S, Aguado JM
Medicine (Baltimore) 2014 Oct;93(17):236-254. doi: 10.1097/MD.0000000000000119. PMID: 25398060Free PMC Article
Golden MP, Vikram HR
Am Fam Physician 2005 Nov 1;72(9):1761-8. PMID: 16300038
Carrol ED, Clark JE, Cant AJ
Paediatr Respir Rev 2001 Jun;2(2):113-9. doi: 10.1053/prrv.2000.0118. PMID: 12531057
Snider D
Chest 1984 Sep;86(3 Suppl):10S-13S. doi: 10.1378/chest.86.3.10s. PMID: 6380977

Diagnosis

Vélez-Tirado N, Cote-Orozco JE
Pediatr Neurol 2018 Apr;81:51. Epub 2017 Dec 11 doi: 10.1016/j.pediatrneurol.2017.12.004. PMID: 29398165
Sharma SK, Mohan A
Microbiol Spectr 2017 Mar;5(2) doi: 10.1128/microbiolspec.TNMI7-0013-2016. PMID: 28281441
Restrepo CS, Katre R, Mumbower A
Radiol Clin North Am 2016 May;54(3):453-73. doi: 10.1016/j.rcl.2015.12.007. PMID: 27153783
Knowles KF, Saltman D, Robson HG, Lalonde R
Tubercle 1990 Mar;71(1):65-8. doi: 10.1016/0041-3879(90)90064-f. PMID: 2371763
Sahn SA, Neff TA
Am J Med 1974 Apr;56(4):494-505. doi: 10.1016/0002-9343(74)90482-3. PMID: 4206484

Therapy

Sharma SK, Mohan A
Microbiol Spectr 2017 Mar;5(2) doi: 10.1128/microbiolspec.TNMI7-0013-2016. PMID: 28281441
Tsai FF, Shiao CC, Lin SY, Tai HM
QJM 2014 May;107(5):391-2. Epub 2013 Jul 30 doi: 10.1093/qjmed/hct158. PMID: 23904516
Andreu J, Mauleón S, Pallisa E, Majó J, Martinez-Rodriguez M, Cáceres J
Curr Probl Diagn Radiol 2002 Sep-Oct;31(5):189-97. PMID: 12419999
Carrol ED, Clark JE, Cant AJ
Paediatr Respir Rev 2001 Jun;2(2):113-9. doi: 10.1053/prrv.2000.0118. PMID: 12531057
Sahn SA, Neff TA
Am J Med 1974 Apr;56(4):494-505. doi: 10.1016/0002-9343(74)90482-3. PMID: 4206484

Prognosis

Chakaya J, Petersen E, Nantanda R, Mungai BN, Migliori GB, Amanullah F, Lungu P, Ntoumi F, Kumarasamy N, Maeurer M, Zumla A
Int J Infect Dis 2022 Nov;124 Suppl 1:S26-S29. Epub 2022 Mar 20 doi: 10.1016/j.ijid.2022.03.011. PMID: 35321845Free PMC Article
Pérez-Jacoiste Asín MA, Fernández-Ruiz M, López-Medrano F, Lumbreras C, Tejido Á, San Juan R, Arrebola-Pajares A, Lizasoain M, Prieto S, Aguado JM
Medicine (Baltimore) 2014 Oct;93(17):236-254. doi: 10.1097/MD.0000000000000119. PMID: 25398060Free PMC Article
Liu A, Nicol E, Hu Y, Coates A
Int J Cardiol 2013 Aug 10;167(3):640-5. Epub 2012 Sep 26 doi: 10.1016/j.ijcard.2012.08.009. PMID: 23021600
Golden MP, Vikram HR
Am Fam Physician 2005 Nov 1;72(9):1761-8. PMID: 16300038
Carrol ED, Clark JE, Cant AJ
Paediatr Respir Rev 2001 Jun;2(2):113-9. doi: 10.1053/prrv.2000.0118. PMID: 12531057

Clinical prediction guides

Wei X, Xie M, Wu S, Bao Y
Ann Med 2024 Dec;56(1):2356647. Epub 2024 Jun 7 doi: 10.1080/07853890.2024.2356647. PMID: 38848041Free PMC Article
Global Tuberculosis Network and TB/COVID-19 Global Study Group, Casco N, Jorge AL, Palmero DJ, Alffenaar JW, Fox GJ, Ezz W, Cho JG, Denholm J, Skrahina A, Solodovnikova V, Arbex MA, Alves T, Rabahi MF, Pereira GR, Sales R, Silva DR, Saffie MM, Salinas NE, Miranda RC, Cisterna C, Concha C, Fernandez I, Villalón C, Vera CG, Tapia PG, Cancino V, Carbonell M, Cruz A, Muñoz E, Muñoz C, Navarro I, Pizarro R, Cristina Sánchez GP, Vergara Riquelme MS, Vilca E, Soto A, Flores X, Garavagno A, Bahamondes MH, Merino LM, Pradenas AM, Revillot ME, Rodriguez P, Salinas AS, Taiba C, Valdés JF, Subiabre JN, Ortega C, Palma S, Castillo PP, Pinto M, Bidegain FR, Venegas M, Yucra E, Li Y, Cruz A, Guelvez B, Victoria Plaza R, Tello Hoyos KY, Cardoso-Landivar J, Van Den Boom M, Andréjak C, Blanc FX, Dourmane S, Froissart A, Izadifar A, Rivière F, Schlemmer F, Manika K, Diallo BD, Hassane-Harouna S, Artiles N, Mejia LA, Gupta N, Ish P, Mishra G, Patel JM, Singla R, Udwadia ZF, Alladio F, Angeli F, Calcagno A, Centis R, Codecasa LR, De Lauretis A, Esposito SMR, Formenti B, Gaviraghi A, Giacomet V, Goletti D, Gualano G, Matteelli A, Migliori GB, Motta I, Palmieri F, Pontali E, Prestileo T, Riccardi N, Saderi L, Saporiti M, Sotgiu G, Spanevello A, Stochino C, Tadolini M, Torre A, Villa S, Visca D, Kurhasani X, Furjani M, Rasheed N, Danila E, Diktanas S, Ridaura RL, Luna López FL, Torrico MM, Rendon A, Akkerman OW, Chizaram O, Al-Abri S, Alyaquobi F, Althohli K, Aguirre S, Teixeira RC, De Egea V, Irala S, Medina A, Sequera G, Sosa N, Vázquez F, Llanos-Tejada FK, Manga S, Villanueva-Villegas R, Araujo D, Sales Marques RD, Socaci A, Barkanova O, Bogorodskaya M, Borisov S, Mariandyshev A, Kaluzhenina A, Vukicevic TA, Stosic M, Beh D, Ng D, Ong CWM, Solovic I, Dheda K, Gina P, Caminero JA, De Souza Galvão ML, Dominguez-Castellano A, García-García JM, Pinargote IM, Fernandez SQ, Sánchez-Montalvá A, Huguet ET, Murguiondo MZ, Bart PA, Mazza-Stalder J, D'Ambrosio L, Kamolwat P, Bakko F, Barnacle J, Bird S, Brown A, Chandran S, Killington K, Man K, Papineni P, Ritchie F, Tiberi S, Utjesanovic N, Zenner D, Hearn JL, Heysell S, Young L
Eur Respir J 2023 Nov;62(5) Epub 2023 Nov 29 doi: 10.1183/13993003.00925-2023. PMID: 37827576Free PMC Article
Pérez-Jacoiste Asín MA, Fernández-Ruiz M, López-Medrano F, Lumbreras C, Tejido Á, San Juan R, Arrebola-Pajares A, Lizasoain M, Prieto S, Aguado JM
Medicine (Baltimore) 2014 Oct;93(17):236-254. doi: 10.1097/MD.0000000000000119. PMID: 25398060Free PMC Article
Kathuria S, Ramesh V
G Ital Dermatol Venereol 2010 Apr;145(2):289-302. PMID: 20467401
Maltezou HC, Spyridis P, Kafetzis DA
Int J Tuberc Lung Dis 2000 May;4(5):414-9. PMID: 10815734

Recent systematic reviews

Garg RK, Paliwal V, Suvirya S, Malhotra HS, Verma A
Neuroradiol J 2024 Oct;37(5):556-563. Epub 2024 Mar 14 doi: 10.1177/19714009241240055. PMID: 38485688Free PMC Article
Getaneh Y, Khairunisa SQ, Husada D, Kuntaman K, Lusida MI
HIV Res Clin Pract 2023 Oct 17;24(1):2270822. Epub 2023 Nov 2 doi: 10.1080/25787489.2023.2270822. PMID: 37916817
Rajagopala S, Sankari S, Kancherla R, Ramanathan RP, Balalakshmoji D
Sarcoidosis Vasc Diffuse Lung Dis 2020;37(1):53-65. Epub 2020 Mar 15 doi: 10.36141/svdld.v37i1.7837. PMID: 33093769Free PMC Article
Mangtani P, Abubakar I, Ariti C, Beynon R, Pimpin L, Fine PE, Rodrigues LC, Smith PG, Lipman M, Whiting PF, Sterne JA
Clin Infect Dis 2014 Feb;58(4):470-80. Epub 2013 Dec 13 doi: 10.1093/cid/cit790. PMID: 24336911
Abubakar I, Pimpin L, Ariti C, Beynon R, Mangtani P, Sterne JA, Fine PE, Smith PG, Lipman M, Elliman D, Watson JM, Drumright LN, Whiting PF, Vynnycky E, Rodrigues LC
Health Technol Assess 2013 Sep;17(37):1-372, v-vi. doi: 10.3310/hta17370. PMID: 24021245Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...