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Proliferative Nodules in Congenital Melanocytic Nevus

MedGen UID:
220418
•Concept ID:
C1266117
•
Neoplastic Process
Synonyms: Proliferative Dermal Lesion in Congenital Nevus; Proliferative dermal lesion in congenital nevus
SNOMED CT: Proliferative dermal lesion in congenital nevus (128733006)

Definition

A benign proliferation of epithelioid or spindled melanocytes usually in the upper or mid dermis in a background of congenital melanocytic nevus. The congenital melanocytic nevus is usually of the deep type, involving the dermis and extending into the subcutaneous tissue. It presents as a dark plaque or nodule above a giant congenital melanocytic nevus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProliferative Nodules in Congenital Melanocytic Nevus

Professional guidelines

PubMed

Does the gene matter? Genotype-phenotype and genotype-outcome associations in congenital melanocytic naevi.
Polubothu S, McGuire N, Al-Olabi L, Baird W, Bulstrode N, Chalker J, Josifova D, Lomas D, O'Hara J, Ong J, Rampling D, Stadnik P, Thomas A, Wedgeworth E, Sebire NJ, Kinsler VA
Br J Dermatol 2020 Feb;182(2):434-443. Epub 2019 Aug 9 doi: 10.1111/bjd.18106. PMID: 31111470Free PMC Article
Clinical course, treatment modalities, and quality of life in patients with congenital melanocytic nevi - data from the German CMN registry.
Elisabeth Wramp M, Langenbruch A, Augustin M, Zillikens D, Krengel S
J Dtsch Dermatol Ges 2017 Feb;15(2):159-167. doi: 10.1111/ddg.12835. PMID: 28214318

Recent clinical studies

Etiology

Neurocutaneous melanocytosis (melanosis).
Ruggieri M, Polizzi A, Catanzaro S, Bianco ML, Praticò AD, Di Rocco C
Childs Nerv Syst 2020 Oct;36(10):2571-2596. Epub 2020 Oct 13 doi: 10.1007/s00381-020-04770-9. PMID: 33048248
Common and not so Common Melanocytic Lesions in Children and Adolescents.
Yang C, Gru AA, Dehner LP
Pediatr Dev Pathol 2018 Mar-Apr;21(2):252-270. doi: 10.1177/1093526617751720. PMID: 29607755
Paediatric melanoma.
Wood BA
Pathology 2016 Feb;48(2):155-65. Epub 2016 Jan 16 doi: 10.1016/j.pathol.2015.12.001. PMID: 27020388
Core concepts in congenital melanocytic nevi and infantile hemangiomas.
Warner C, Dinulos JG
Curr Opin Pediatr 2014 Feb;26(1):130-5. doi: 10.1097/MOP.0000000000000052. PMID: 24346182
Congenital melanocytic nevi.
Zayour M, Lazova R
Clin Lab Med 2011 Jun;31(2):267-80. doi: 10.1016/j.cll.2011.03.004. PMID: 21549240

Diagnosis

Neurocutaneous melanocytosis (melanosis).
Ruggieri M, Polizzi A, Catanzaro S, Bianco ML, Praticò AD, Di Rocco C
Childs Nerv Syst 2020 Oct;36(10):2571-2596. Epub 2020 Oct 13 doi: 10.1007/s00381-020-04770-9. PMID: 33048248
Common and not so Common Melanocytic Lesions in Children and Adolescents.
Yang C, Gru AA, Dehner LP
Pediatr Dev Pathol 2018 Mar-Apr;21(2):252-270. doi: 10.1177/1093526617751720. PMID: 29607755
Paediatric melanoma.
Wood BA
Pathology 2016 Feb;48(2):155-65. Epub 2016 Jan 16 doi: 10.1016/j.pathol.2015.12.001. PMID: 27020388
Core concepts in congenital melanocytic nevi and infantile hemangiomas.
Warner C, Dinulos JG
Curr Opin Pediatr 2014 Feb;26(1):130-5. doi: 10.1097/MOP.0000000000000052. PMID: 24346182
Congenital melanocytic nevi.
Zayour M, Lazova R
Clin Lab Med 2011 Jun;31(2):267-80. doi: 10.1016/j.cll.2011.03.004. PMID: 21549240

Prognosis

Melanoma on congenital melanocytic nevi.
Alos L, Carrasco A, Teixidó C, Szumera-Ciećkiewicz A, Vicente A, Massi D, Carrera C
Pathol Res Pract 2024 Apr;256:155262. Epub 2024 Mar 11 doi: 10.1016/j.prp.2024.155262. PMID: 38518732
Common and not so Common Melanocytic Lesions in Children and Adolescents.
Yang C, Gru AA, Dehner LP
Pediatr Dev Pathol 2018 Mar-Apr;21(2):252-270. doi: 10.1177/1093526617751720. PMID: 29607755
Proliferative Nodules vs Melanoma Arising in Giant Congenital Melanocytic Nevi During Childhood.
Vergier B, Laharanne E, Prochazkova-Carlotti M, de la Fouchardière A, Merlio JP, Kadlub N, Avril MF, Bodemer C, Lacoste C, Boralevi F, Taieb A, Ezzedine K, Fraitag S
JAMA Dermatol 2016 Oct 1;152(10):1147-1151. doi: 10.1001/jamadermatol.2016.2667. PMID: 27486690
Core concepts in congenital melanocytic nevi and infantile hemangiomas.
Warner C, Dinulos JG
Curr Opin Pediatr 2014 Feb;26(1):130-5. doi: 10.1097/MOP.0000000000000052. PMID: 24346182
Congenital melanocytic nevi.
Zayour M, Lazova R
Clin Lab Med 2011 Jun;31(2):267-80. doi: 10.1016/j.cll.2011.03.004. PMID: 21549240

Clinical prediction guides

A clinical and biologic review of congenital melanocytic nevi.
Tan S, Hu H, Xin X, Wu D
J Dermatol 2024 Jan;51(1):12-22. Epub 2023 Nov 13 doi: 10.1111/1346-8138.17025. PMID: 37955315
Proliferative Nodules vs Melanoma Arising in Giant Congenital Melanocytic Nevi During Childhood.
Vergier B, Laharanne E, Prochazkova-Carlotti M, de la Fouchardière A, Merlio JP, Kadlub N, Avril MF, Bodemer C, Lacoste C, Boralevi F, Taieb A, Ezzedine K, Fraitag S
JAMA Dermatol 2016 Oct 1;152(10):1147-1151. doi: 10.1001/jamadermatol.2016.2667. PMID: 27486690
5-Hydroxymethylcytosine Expression in Proliferative Nodules Arising within Congenital Nevi Allows Differentiation from Malignant Melanoma.
Pavlova O, Fraitag S, Hohl D
J Invest Dermatol 2016 Dec;136(12):2453-2461. Epub 2016 Jul 22 doi: 10.1016/j.jid.2016.07.015. PMID: 27456754
A comparative study of proliferative nodules and lethal melanomas in congenital nevi from children.
Yélamos O, Arva NC, Obregon R, Yazdan P, Wagner A, Guitart J, Gerami P
Am J Surg Pathol 2015 Mar;39(3):405-15. doi: 10.1097/PAS.0000000000000351. PMID: 25517953
Proliferative nodules in congenital melanocytic nevi: a clinicopathologic and immunohistochemical analysis.
Herron MD, Vanderhooft SL, Smock K, Zhou H, Leachman SA, Coffin C
Am J Surg Pathol 2004 Aug;28(8):1017-25. doi: 10.1097/01.pas.0000126785.61609.6e. PMID: 15252307

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