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Chronic leukemia

MedGen UID:
220905
•Concept ID:
C1279296
•
Neoplastic Process
Synonyms: adult chronic leukaemia; adult chronic leukemia; Chronic blood cancer; Chronic leukaemia; chronic leukaemia (disease); Chronic Leukemia; chronic leukemia; chronic leukemia (disease); Chronic leukemia, disease; CLL; CML; leukaemia (disease), chronic; leukemia (disease), chronic
SNOMED CT: Chronic leukemia (92812005); Chronic leukemia, disease (92812005); Chronic leukemia (2557004)
 
HPO: HP:0005558
Monarch Initiative: MONDO:0001014

Definition

A slowly progressing leukemia characterized by a clonal (malignant) proliferation of maturing and mature myeloid cells or mature lymphocytes. When the clonal cellular population is composed of myeloid cells, the process is called chronic myelogenous leukemia. When the clonal cellular population is composed of lymphocytes, it is classified as chronic lymphocytic leukemia, hairy cell leukemia, or T-cell large granular lymphocyte leukemia. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic leukemia

Professional guidelines

PubMed

Best Practices in Chronic Myeloid Leukemia Monitoring and Management.
Soverini S, De Benedittis C, Mancini M, Martinelli G
Oncologist 2016 May;21(5):626-33. Epub 2016 Mar 31 doi: 10.1634/theoncologist.2015-0337. PMID: 27032870Free PMC Article
Diagnosis and treatment of chronic leukemia.
Collins PM
Semin Oncol Nurs 1990 Feb;6(1):31-43. doi: 10.1016/s0749-2081(05)80131-7. PMID: 2406827
Treatment of chronic leukemia.
WATKINS CH
Med Clin North Am 1956 Jul;40(4):1117-23. doi: 10.1016/s0025-7125(16)34538-2. PMID: 13333412

Recent clinical studies

Etiology

Treating Leukemia in the Time of COVID-19.
Paul S, Rausch CR, Jain N, Kadia T, Ravandi F, DiNardo CD, Welch MA, Dabaja BS, Daver N, Garcia-Manero G, Wierda W, Pemmaraju N, Montalban Bravo G, Thompson P, Verstovsek S, Konopleva M, Kantarjian H, Jabbour E
Acta Haematol 2021;144(2):132-145. Epub 2020 May 11 doi: 10.1159/000508199. PMID: 32392559Free PMC Article
Adherence trajectories in oral therapy for chronic myeloid leukemia: Overview of a research protocol.
Yeager KA, Waldrop-Valverde D, Paul S, Bruner DW, Klisovic R, Burns E, Mason TA, Patel N, Jennings BM
Res Nurs Health 2020 Sep;43(5):443-452. Epub 2020 Aug 31 doi: 10.1002/nur.22069. PMID: 32866350Free PMC Article
Acute lymphoblastic leukemia.
Chan KW
Curr Probl Pediatr Adolesc Health Care 2002 Feb;32(2):40-9. doi: 10.1067/mps.2002.121790. PMID: 11951089
Tissue misrepair hypothesis for radiation carcinogenesis.
Kondo S
J Radiat Res 1991 Dec;32 Suppl 2:1-13. doi: 10.1269/jrr.32.supplement2_1. PMID: 1823346
Preleukemias.
Nowell PC
Hum Pathol 1981 Jun;12(6):522-30. doi: 10.1016/s0046-8177(81)80066-4. PMID: 7275093

Diagnosis

Applications of (18)F-Fluorodesoxyglucose PET Imaging in Leukemia.
Dondi F, Bertagna F
PET Clin 2024 Oct;19(4):535-542. Epub 2024 Jun 21 doi: 10.1016/j.cpet.2024.05.007. PMID: 38909010
Pulmonary Manifestations of Lymphoma and Leukemia.
Bashoura L, Eapen GA, Faiz SA
Clin Chest Med 2017 Jun;38(2):187-200. doi: 10.1016/j.ccm.2016.12.003. PMID: 28477632
Leukocytosis and Leukemia.
Widick P, Winer ES
Prim Care 2016 Dec;43(4):575-587. Epub 2016 Oct 14 doi: 10.1016/j.pop.2016.07.007. PMID: 27866578
Bone marrow necrosis.
Ranaghan L, Morris TC, Desai ZR, Markey GM
Am J Hematol 1994 Nov;47(3):225-8. doi: 10.1002/ajh.2830470314. PMID: 7942788
The leukemias.
Preisler HD
Dis Mon 1994 Oct;40(10):525-79. PMID: 7924833

Therapy

Chronic leukemia.
Greenberg EM, Probst A
Crit Care Nurs Clin North Am 2013 Dec;25(4):459-70, vi. doi: 10.1016/j.ccell.2013.09.003. PMID: 24267282
Acute lymphoblastic leukemia.
Chan KW
Curr Probl Pediatr Adolesc Health Care 2002 Feb;32(2):40-9. doi: 10.1067/mps.2002.121790. PMID: 11951089
The leukemias.
Preisler HD
Dis Mon 1994 Oct;40(10):525-79. PMID: 7924833
Tissue misrepair hypothesis for radiation carcinogenesis.
Kondo S
J Radiat Res 1991 Dec;32 Suppl 2:1-13. doi: 10.1269/jrr.32.supplement2_1. PMID: 1823346
Leukemia in pregnancy.
McLain CR Jr
Clin Obstet Gynecol 1974 Dec;17(4):185-94. doi: 10.1097/00003081-197412000-00013. PMID: 4615858

Prognosis

Acute lymphoblastic leukemia.
Chan KW
Curr Probl Pediatr Adolesc Health Care 2002 Feb;32(2):40-9. doi: 10.1067/mps.2002.121790. PMID: 11951089
Bone marrow necrosis.
Ranaghan L, Morris TC, Desai ZR, Markey GM
Am J Hematol 1994 Nov;47(3):225-8. doi: 10.1002/ajh.2830470314. PMID: 7942788
The leukemias.
Preisler HD
Dis Mon 1994 Oct;40(10):525-79. PMID: 7924833
Current therapy of acute and chronic leukemia in adults.
Henderson ES, Han T
CA Cancer J Clin 1986 Nov-Dec;36(6):322-50. doi: 10.3322/canjclin.36.6.322. PMID: 3096521
Radiotherapy in the management of leukemia.
King D
Can Med Assoc J 1967 Jun 24;96(25):1621-5. PMID: 5338330Free PMC Article

Clinical prediction guides

Chronic leukemia.
Greenberg EM, Probst A
Crit Care Nurs Clin North Am 2013 Dec;25(4):459-70, vi. doi: 10.1016/j.ccell.2013.09.003. PMID: 24267282
Acute lymphoblastic leukemia.
Chan KW
Curr Probl Pediatr Adolesc Health Care 2002 Feb;32(2):40-9. doi: 10.1067/mps.2002.121790. PMID: 11951089
Bone marrow necrosis.
Ranaghan L, Morris TC, Desai ZR, Markey GM
Am J Hematol 1994 Nov;47(3):225-8. doi: 10.1002/ajh.2830470314. PMID: 7942788
Preleukemias.
Nowell PC
Hum Pathol 1981 Jun;12(6):522-30. doi: 10.1016/s0046-8177(81)80066-4. PMID: 7275093
Radiotherapy in the management of leukemia.
King D
Can Med Assoc J 1967 Jun 24;96(25):1621-5. PMID: 5338330Free PMC Article

Recent systematic reviews

Clinical Insights into Structure, Regulation, and Targeting of ABL Kinases in Human Leukemia.
Wu A, Liu X, Fruhstorfer C, Jiang X
Int J Mol Sci 2024 Mar 14;25(6) doi: 10.3390/ijms25063307. PMID: 38542279Free PMC Article
A Systematic Review of Psychometric Properties of Health-Related Quality-of-Life and Symptom Instruments in Adult Acute Leukemia Survivors.
Bryant AL, Walton A, Shaw-Kokot J, Mayer DK, Reeve BB
Cancer Nurs 2016 Sep-Oct;39(5):375-82. doi: 10.1097/NCC.0000000000000327. PMID: 26645111Free PMC Article
Treatment for disseminated intravascular coagulation in patients with acute and chronic leukemia.
Martí-Carvajal AJ, Anand V, Solà I
Cochrane Database Syst Rev 2015 Jun 24;2015(6):CD008562. doi: 10.1002/14651858.CD008562.pub3. PMID: 26107113Free PMC Article
Treatment for disseminated intravascular coagulation in patients with acute and chronic leukemia.
Martí-Carvajal AJ, Simancas D, Cardona AF
Cochrane Database Syst Rev 2011 Jun 15;(6):CD008562. doi: 10.1002/14651858.CD008562.pub2. PMID: 21678379

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