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Classic Hodgkin lymphoma, lymphocyte-rich type

MedGen UID:
224769
•Concept ID:
C1266194
•
Neoplastic Process
Synonym: Hodgkin's lymphoma, lymphocytic-histiocytic predominance
SNOMED CT: Hodgkin lymphoma, lymphocyte-rich (clinical) (118607005); Classical Hodgkin lymphoma, lymphocyte-rich (128799007); Hodgkin lymphoma, lymphocyte-rich (128799007); Hodgkin lymphoma, lymphocyte-rich (118607005); Lymphocyte-rich classical Hodgkin lymphoma (118607005)
 
Monarch Initiative: MONDO:0004604
Orphanet: ORPHA98845

Definition

A subtype of classic Hodgkin lymphoma with scattered Hodgkin and Reed-Sternberg cells and a nodular or less often diffuse cellular background consisting of small lymphocytes and with an absence of neutrophils and eosinophils. (WHO, 2008) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClassic Hodgkin lymphoma, lymphocyte-rich type
Follow this link to review classifications for Classic Hodgkin lymphoma, lymphocyte-rich type in Orphanet.

Recent clinical studies

Etiology

Immunohistochemical assessment of the diagnostic utility of PD-L1: a preliminary analysis of anti-PD-L1 antibody (SP142) for lymphoproliferative diseases with tumour and non-malignant Hodgkin-Reed-Sternberg (HRS)-like cells.
Sakakibara A, Kohno K, Eladl AE, Klaisuwan T, Ishikawa E, Suzuki Y, Shimada S, Nakaguro M, Shimoyama Y, Takahara T, Kato S, Asano N, Nakamura S, Satou A
Histopathology 2018 Jun;72(7):1156-1163. Epub 2018 Mar 9 doi: 10.1111/his.13475. PMID: 29380399
Peripheral T-cell lymphomas of follicular helper T-cell type frequently display an aberrant CD3(-/dim)CD4(+) population by flow cytometry: an important clue to the diagnosis of a Hodgkin lymphoma mimic.
Alikhan M, Song JY, Sohani AR, Moroch J, Plonquet A, Duffield AS, Borowitz MJ, Jiang L, Bueso-Ramos C, Inamdar K, Menon MP, Gurbuxani S, Chan E, Smith SM, Nicolae A, Jaffe ES, Gaulard P, Venkataraman G
Mod Pathol 2016 Oct;29(10):1173-82. Epub 2016 Jun 17 doi: 10.1038/modpathol.2016.113. PMID: 27312067Free PMC Article
Pediatric lymphoma diagnosis: role of FNAC, biopsy, immunohistochemistry and molecular diagnostics.
Iyer VK
Indian J Pediatr 2013 Sep;80(9):756-63. Epub 2013 Aug 8 doi: 10.1007/s12098-013-1128-2. PMID: 23925793
Histiocyte-rich, T-cell-rich B-cell lymphoma: a distinct diffuse large B-cell lymphoma subtype showing characteristic morphologic and immunophenotypic features.
Achten R, Verhoef G, Vanuytsel L, De Wolf-Peeters C
Histopathology 2002 Jan;40(1):31-45. doi: 10.1046/j.1365-2559.2002.01291.x. PMID: 11903596

Diagnosis

Spectrum of common Hodgkin lymphoma and non-Hodgkin lymphomas subtypes in Zambia: a 3-year records review.
Polepole P, Mudenda VC, Munsaka SM, Zhang L
J Health Popul Nutr 2021 Aug 23;40(1):37. doi: 10.1186/s41043-021-00261-y. PMID: 34425908Free PMC Article
Pediatric lymphoma diagnosis: role of FNAC, biopsy, immunohistochemistry and molecular diagnostics.
Iyer VK
Indian J Pediatr 2013 Sep;80(9):756-63. Epub 2013 Aug 8 doi: 10.1007/s12098-013-1128-2. PMID: 23925793
GLUT1 expression patterns in different Hodgkin lymphoma subtypes and progressively transformed germinal centers.
Hartmann S, Agostinelli C, Diener J, Döring C, Fanti S, Zinzani PL, Gallamini A, Bergmann L, Pileri S, Hansmann ML
BMC Cancer 2012 Dec 10;12:586. doi: 10.1186/1471-2407-12-586. PMID: 23228169Free PMC Article
Hodgkin's disease: classification and differential diagnosis.
Harris NL
Mod Pathol 1999 Feb;12(2):159-75. PMID: 10071341
The many faces of Hodgkin's disease around the world: what have we learned from its pathology?
Harris NL
Ann Oncol 1998;9 Suppl 5:S45-56. doi: 10.1093/annonc/9.suppl_5.s45. PMID: 9926237

Prognosis

Immunohistochemical assessment of the diagnostic utility of PD-L1: a preliminary analysis of anti-PD-L1 antibody (SP142) for lymphoproliferative diseases with tumour and non-malignant Hodgkin-Reed-Sternberg (HRS)-like cells.
Sakakibara A, Kohno K, Eladl AE, Klaisuwan T, Ishikawa E, Suzuki Y, Shimada S, Nakaguro M, Shimoyama Y, Takahara T, Kato S, Asano N, Nakamura S, Satou A
Histopathology 2018 Jun;72(7):1156-1163. Epub 2018 Mar 9 doi: 10.1111/his.13475. PMID: 29380399
GLUT1 expression patterns in different Hodgkin lymphoma subtypes and progressively transformed germinal centers.
Hartmann S, Agostinelli C, Diener J, Döring C, Fanti S, Zinzani PL, Gallamini A, Bergmann L, Pileri S, Hansmann ML
BMC Cancer 2012 Dec 10;12:586. doi: 10.1186/1471-2407-12-586. PMID: 23228169Free PMC Article
T-cell/histiocyte-rich large B-cell lymphoma is a disseminated aggressive neoplasm: differential diagnosis from Hodgkin's lymphoma.
Fraga M, Sánchez-Verde L, Forteza J, García-Rivero A, Piris MA
Histopathology 2002 Sep;41(3):216-29. doi: 10.1046/j.1365-2559.2002.01466.x. PMID: 12207783
The many faces of Hodgkin's disease around the world: what have we learned from its pathology?
Harris NL
Ann Oncol 1998;9 Suppl 5:S45-56. doi: 10.1093/annonc/9.suppl_5.s45. PMID: 9926237

Clinical prediction guides

Immunohistochemical assessment of the diagnostic utility of PD-L1: a preliminary analysis of anti-PD-L1 antibody (SP142) for lymphoproliferative diseases with tumour and non-malignant Hodgkin-Reed-Sternberg (HRS)-like cells.
Sakakibara A, Kohno K, Eladl AE, Klaisuwan T, Ishikawa E, Suzuki Y, Shimada S, Nakaguro M, Shimoyama Y, Takahara T, Kato S, Asano N, Nakamura S, Satou A
Histopathology 2018 Jun;72(7):1156-1163. Epub 2018 Mar 9 doi: 10.1111/his.13475. PMID: 29380399
GLUT1 expression patterns in different Hodgkin lymphoma subtypes and progressively transformed germinal centers.
Hartmann S, Agostinelli C, Diener J, Döring C, Fanti S, Zinzani PL, Gallamini A, Bergmann L, Pileri S, Hansmann ML
BMC Cancer 2012 Dec 10;12:586. doi: 10.1186/1471-2407-12-586. PMID: 23228169Free PMC Article
CD95 ligand is expressed in Reed-Sternberg cells of Hodgkin's disease.
Sakuma I, Yoshino T, Omonishi K, Nishiuchi R, Teramoto N, Yanai H, Kawahara K, Kubonishi I, Matsuo Y, Akagi T
Pathol Int 1999 Feb;49(2):103-9. doi: 10.1046/j.1440-1827.1999.00830.x. PMID: 10355962

Supplemental Content

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    Clinical resources

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Pediatric Hodgkin Lymphoma, 2024
    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Hodgkin Lymphoma, 2024

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