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Tularemia

MedGen UID:
22520
•Concept ID:
C0041351
•
Disease or Syndrome
Synonyms: Deerfly fever; Francisella tularensis infection; Lemming fever; Ohara disease; Pahvant Valley plague; Rabbit fever; Yatobyo (Japan)
SNOMED CT: Deerfly fever (19265001); Francis' disease (19265001); O'Hara's disease (19265001); Tularemia (19265001); Infection by Francisella tularensis (19265001); Deer fly fever (19265001); Rabbit fever (19265001); Ohara's disease (19265001); Yatobyo (19265001); Pahvant Valley fever (19265001); Pahvant Valley plague (19265001)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018077
Orphanet: ORPHA3392

Definition

A rare bacterial infectious disease caused by <i>Francisella tularensis</i> and characterized by six major clinical presentations: ulceroglandular, glandular, oropharyngeal, oculoglandular, pneumonic, or typhoidal, depending on the route of infection. Early flu-like symptoms are common to all forms and are accompanied/followed by either a skin inoculation ulcer with localized lymphadenopathy; isolated lymphadenopathy; chronic pharyngitis with cervical lymphadenopathy; conjunctivitis with localized lymphadenopathy; lung involvement; severe systemic disease with neurological symptoms. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTularemia
Follow this link to review classifications for Tularemia in Orphanet.

Professional guidelines

PubMed

Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Tularemia: epidemiology, diagnosis, and treatment.
Harik NS
Pediatr Ann 2013 Jul;42(7):288-92. doi: 10.3928/00904481-20130619-13. PMID: 23805970
Tularemia: current diagnosis and treatment options.
Hepburn MJ, Simpson AJ
Expert Rev Anti Infect Ther 2008 Apr;6(2):231-40. doi: 10.1586/14787210.6.2.231. PMID: 18380605

Recent clinical studies

Etiology

Bioterrorism.
Rathjen NA, Shahbodaghi SD
Am Fam Physician 2021 Oct 1;104(4):376-385. PMID: 34652097
Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Chronic hand infections.
Al-Qattan MM, Helmi AA
J Hand Surg Am 2014 Aug;39(8):1636-45. doi: 10.1016/j.jhsa.2014.04.003. PMID: 25070033
Tularemia during pregnancy.
Ata N, Kılıç S, Övet G, Alataş N, Çelebi B
Infection 2013 Aug;41(4):753-6. Epub 2013 Apr 5 doi: 10.1007/s15010-013-0456-5. PMID: 23559358
Tularemia.
Feldman KA
J Am Vet Med Assoc 2003 Mar 15;222(6):725-30. doi: 10.2460/javma.2003.222.725. PMID: 12675294

Diagnosis

Biowarfare and bioterrorism.
Christian MD
Crit Care Clin 2013 Jul;29(3):717-56. doi: 10.1016/j.ccc.2013.03.015. PMID: 23830660Free PMC Article
Tularemia during pregnancy.
Ata N, Kılıç S, Övet G, Alataş N, Çelebi B
Infection 2013 Aug;41(4):753-6. Epub 2013 Apr 5 doi: 10.1007/s15010-013-0456-5. PMID: 23559358
Tularemia pneumonia.
Thomas LD, Schaffner W
Infect Dis Clin North Am 2010 Mar;24(1):43-55. doi: 10.1016/j.idc.2009.10.012. PMID: 20171544
Tularemia.
Feldman KA
J Am Vet Med Assoc 2003 Mar 15;222(6):725-30. doi: 10.2460/javma.2003.222.725. PMID: 12675294
Tularemia.
Ellis J, Oyston PC, Green M, Titball RW
Clin Microbiol Rev 2002 Oct;15(4):631-46. doi: 10.1128/CMR.15.4.631-646.2002. PMID: 12364373Free PMC Article

Therapy

Bioterrorism.
Rathjen NA, Shahbodaghi SD
Am Fam Physician 2021 Oct 1;104(4):376-385. PMID: 34652097
Tickborne Diseases: Diagnosis and Management.
Pace EJ, O'Reilly M
Am Fam Physician 2020 May 1;101(9):530-540. PMID: 32352736
Tularemia during pregnancy.
Ata N, Kılıç S, Övet G, Alataş N, Çelebi B
Infection 2013 Aug;41(4):753-6. Epub 2013 Apr 5 doi: 10.1007/s15010-013-0456-5. PMID: 23559358
The atypical pneumonias: clinical diagnosis and importance.
Cunha BA
Clin Microbiol Infect 2006 May;12 Suppl 3:12-24. doi: 10.1111/j.1469-0691.2006.01393.x. PMID: 16669925Free PMC Article
Tularemia pneumonia.
Gill V, Cunha BA
Semin Respir Infect 1997 Mar;12(1):61-7. PMID: 9097380

Prognosis

Tick-Borne Diseases.
Eilbert W, Matella A
Emerg Med Clin North Am 2024 May;42(2):287-302. Epub 2024 Feb 29 doi: 10.1016/j.emc.2024.01.004. PMID: 38641392
Granulomatous lymphadenitis.
Asano S
J Clin Exp Hematop 2012;52(1):1-16. doi: 10.3960/jslrt.52.1. PMID: 22706525
Dermatoses from ticks.
McGinley-Smith DE, Tsao SS
J Am Acad Dermatol 2003 Sep;49(3):363-92; quiz 393-6. doi: 10.1067/s0190-9622(03)01868-1. PMID: 12963900
Tularemia.
Feldman KA
J Am Vet Med Assoc 2003 Mar 15;222(6):725-30. doi: 10.2460/javma.2003.222.725. PMID: 12675294
Tularemia--Oklahoma, 2000.
Centers for Disease Control and Prevention (CDC)
MMWR Morb Mortal Wkly Rep 2001 Aug 24;50(33):704-6. PMID: 11787577

Clinical prediction guides

Tularemia in Germany-A Re-emerging Zoonosis.
Faber M, Heuner K, Jacob D, Grunow R
Front Cell Infect Microbiol 2018;8:40. Epub 2018 Feb 16 doi: 10.3389/fcimb.2018.00040. PMID: 29503812Free PMC Article
Progress, challenges, and opportunities in Francisella vaccine development.
Elkins KL, Kurtz SL, De Pascalis R
Expert Rev Vaccines 2016 Sep;15(9):1183-96. Epub 2016 May 3 doi: 10.1586/14760584.2016.1170601. PMID: 27010448
Granulomatous lymphadenitis.
Asano S
J Clin Exp Hematop 2012;52(1):1-16. doi: 10.3960/jslrt.52.1. PMID: 22706525
The atypical pneumonias: clinical diagnosis and importance.
Cunha BA
Clin Microbiol Infect 2006 May;12 Suppl 3:12-24. doi: 10.1111/j.1469-0691.2006.01393.x. PMID: 16669925Free PMC Article
Tularemia.
Jensen WA, Kirsch CM
Semin Respir Infect 2003 Sep;18(3):146-58. PMID: 14505277

Recent systematic reviews

Epidemiology of tularemia in the countries of the WHO Eastern Mediterranean Region (EMRO): A systematic review and meta-analysis.
Sholeh M, Moradkasani S, Esmaeili S
PLoS Negl Trop Dis 2024 May;18(5):e0012141. Epub 2024 May 10 doi: 10.1371/journal.pntd.0012141. PMID: 38728365Free PMC Article
Systematic Review of Tularemia During Pregnancy.
Fleck-Derderian S, Davis KM, Winberg J, Nelson CA, Meaney-Delman D
Clin Infect Dis 2024 Jan 31;78(Suppl 1):S47-S54. doi: 10.1093/cid/ciad686. PMID: 38294114
Systematic Review: Clinical Features, Antimicrobial Treatment, and Outcomes of Human Tularemia, 1993-2023.
Nelson CA, Winberg J, Bostic TD, Davis KM, Fleck-Derderian S
Clin Infect Dis 2024 Jan 31;78(Suppl 1):S15-S28. doi: 10.1093/cid/ciad736. PMID: 38294108
Laboratory Methods for Detection of Infectious Agents and Serological Response in Humans With Tick-Borne Infections: A Systematic Review of Evaluations Based on Clinical Patient Samples.
Henningsson AJ, Aase A, Bavelaar H, Flottorp S, Forsberg P, Kirkehei I, Lövmar M, Nilsson K, Nyman D, Ornstein K, Sjöwall J, Skogman BH, Tjernberg I, Aaberge I
Front Public Health 2021;9:580102. Epub 2021 Sep 20 doi: 10.3389/fpubh.2021.580102. PMID: 34616701Free PMC Article
Seroprevalence of Q fever among human and animal in Iran; A systematic review and meta-analysis.
Mohabbati Mobarez A, Bagheri Amiri F, Esmaeili S
PLoS Negl Trop Dis 2017 Apr;11(4):e0005521. Epub 2017 Apr 10 doi: 10.1371/journal.pntd.0005521. PMID: 28394889Free PMC Article

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