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Porocarcinoma In Situ

MedGen UID:
226900
•Concept ID:
C1275212
•
Neoplastic Process
Synonyms: Hidroacanthoma Simplex; Hidroacanthoma simplex; Hidroacanthoma simplex of skin; Porocarcinoma in situ
SNOMED CT: Hidroacanthoma simplex (403937006); Hidroacanthoma simplex of skin (403937006); Porocarcinoma in situ (816978000); Porocarcinoma in situ (1293095009)

Definition

A rare intraepidermal neoplasia that arises from the acrosyringial portion of the eccrine duct. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPorocarcinoma In Situ

Professional guidelines

PubMed

Intraepidermal Poroma (Hidroacanthoma Simplex) Versus Clonal Seborrheic Keratosis: Will GATA3 Immunohistochemistry Help in the Differential Diagnosis?
Schukow C, McCalmont TH, Surprenant D, Yang HH
Am J Dermatopathol 2023 Oct 1;45(10):728-730. Epub 2023 Jul 28 doi: 10.1097/DAD.0000000000002503. PMID: 37506277

Recent clinical studies

Etiology

Clinical, dermoscopic and histopathological features of eccrine poroid neoplasms.
Sgouros D, Piana S, Argenziano G, Longo C, Moscarella E, Karaarslan IK, Akalin T, Ozdemir F, Zalaudek I
Dermatology 2013;227(2):175-9. Epub 2013 Sep 24 doi: 10.1159/000354152. PMID: 24080919
Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases.
Robson A, Greene J, Ansari N, Kim B, Seed PT, McKee PH, Calonje E
Am J Surg Pathol 2001 Jun;25(6):710-20. doi: 10.1097/00000478-200106000-00002. PMID: 11395548

Diagnosis

Ancillary immunohistochemical and molecular testing in the classification of cutaneous sweat gland/duct neoplasms: A validation study with emphasis on histomorphologic correlation and pathological diagnosis.
Nguyen AJ, Johnson E, Camilleri M, Wieland C, Lehman JS, Agrawal S, Comfere N, Fadra N, Knudson RA, Greipp P, Halling K, Ray Guo R
Hum Pathol 2024 Aug;150:1-8. Epub 2024 Jun 12 doi: 10.1016/j.humpath.2024.06.006. PMID: 38876201
Intraepidermal Poroma (Hidroacanthoma Simplex) Versus Clonal Seborrheic Keratosis: Will GATA3 Immunohistochemistry Help in the Differential Diagnosis?
Schukow C, McCalmont TH, Surprenant D, Yang HH
Am J Dermatopathol 2023 Oct 1;45(10):728-730. Epub 2023 Jul 28 doi: 10.1097/DAD.0000000000002503. PMID: 37506277
Clinical, dermoscopic and histopathological features of eccrine poroid neoplasms.
Sgouros D, Piana S, Argenziano G, Longo C, Moscarella E, Karaarslan IK, Akalin T, Ozdemir F, Zalaudek I
Dermatology 2013;227(2):175-9. Epub 2013 Sep 24 doi: 10.1159/000354152. PMID: 24080919
A carcinoma with features of porocarcinoma, dermal ductular carcinoma, and squamous cell carcinoma in situ.
Onodera H, Mihm MC Jr, Sato T, Matsuta M, Akasaka T, Nakamura S
Am J Dermatopathol 2007 Feb;29(1):75-8. doi: 10.1097/01.dad.0000246389.98258.21. PMID: 17284967
In situ porocarcinoma: a case with malignant expression in clear tumor cells.
Miyashita M, Suzuki H
Int J Dermatol 1993 Oct;32(10):749-50. doi: 10.1111/j.1365-4362.1993.tb02752.x. PMID: 8225722

Prognosis

Ancillary immunohistochemical and molecular testing in the classification of cutaneous sweat gland/duct neoplasms: A validation study with emphasis on histomorphologic correlation and pathological diagnosis.
Nguyen AJ, Johnson E, Camilleri M, Wieland C, Lehman JS, Agrawal S, Comfere N, Fadra N, Knudson RA, Greipp P, Halling K, Ray Guo R
Hum Pathol 2024 Aug;150:1-8. Epub 2024 Jun 12 doi: 10.1016/j.humpath.2024.06.006. PMID: 38876201
Poorly differentiated squamous cell carcinoma arising from an intraepidermal epithelioma.
Boyd AS, King LE Jr
Pathol Res Pract 2013 Apr;209(4):260-3. Epub 2013 Mar 11 doi: 10.1016/j.prp.2013.01.011. PMID: 23490238
Apocrine-eccrine carcinomas: molecular and immunohistochemical analyses.
Le LP, Dias-Santagata D, Pawlak AC, Cosper AK, Nguyen AT, Selim MA, Deng A, Horick NK, Iafrate AJ, Mihm MC Jr, Hoang MP
PLoS One 2012;7(10):e47290. Epub 2012 Oct 9 doi: 10.1371/journal.pone.0047290. PMID: 23056620Free PMC Article
Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases.
Robson A, Greene J, Ansari N, Kim B, Seed PT, McKee PH, Calonje E
Am J Surg Pathol 2001 Jun;25(6):710-20. doi: 10.1097/00000478-200106000-00002. PMID: 11395548

Clinical prediction guides

Ancillary immunohistochemical and molecular testing in the classification of cutaneous sweat gland/duct neoplasms: A validation study with emphasis on histomorphologic correlation and pathological diagnosis.
Nguyen AJ, Johnson E, Camilleri M, Wieland C, Lehman JS, Agrawal S, Comfere N, Fadra N, Knudson RA, Greipp P, Halling K, Ray Guo R
Hum Pathol 2024 Aug;150:1-8. Epub 2024 Jun 12 doi: 10.1016/j.humpath.2024.06.006. PMID: 38876201
Loss of YAP1 C-terminus expression as an ancillary marker for metaplastic thymoma: a potential pitfall in detecting YAP1::MAML2 gene rearrangement.
Wang X, Liu LL, Li Q, Xia QY, Li R, Ye SB, Zhang RS, Fang R, Chen H, Wu N, Rao Q
Histopathology 2023 Nov;83(5):798-809. Epub 2023 Aug 11 doi: 10.1111/his.15024. PMID: 37565303
Seborrheic Keratosis With Malignant Transformation (Invasive or Noninvasive Squamous Cell Carcinoma Arising in Seborrheic Keratosis): A Clinicopathologic and Immunohistochemical Study of 11 Cases.
Goto K, Ogawa K, Hishima T, Oishi N, Tomita O, Tsuyuki T, Oda T, Iwahashi Y, Inaba Y, Honma K
Am J Dermatopathol 2022 Dec 1;44(12):891-899. Epub 2022 Jul 6 doi: 10.1097/DAD.0000000000002245. PMID: 36395445
Epidermotropic Merkel cell carcinoma: a case series with histopathologic examination.
D'Agostino M, Cinelli C, Willard R, Hofmann J, Jellinek N, Robinson-Bostom L
J Am Acad Dermatol 2010 Mar;62(3):463-8. doi: 10.1016/j.jaad.2009.06.023. PMID: 20159312
Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases.
Robson A, Greene J, Ansari N, Kim B, Seed PT, McKee PH, Calonje E
Am J Surg Pathol 2001 Jun;25(6):710-20. doi: 10.1097/00000478-200106000-00002. PMID: 11395548

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